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PLA2G15 Gene

protein-coding   GIFtS: 55
GCID: GC16P068279

Phospholipase A2, Group XV

(Previous name: lysophospholipase 3 (lysosomal phospholipase A2))
(Previous symbol: LYPLA3)
  Search for PLA2G15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase A2, Group XV1 2     1-O-Acylceramide Synthase2 3
LYPLA31 2 3 5     LCAT-Like Lysophospholipase2 3
ACS2 3 5     GXVPLA22
LLPL2 3 5     Group XV Phospholipase A22
LPLA22 3 5     EC 2.3.1.-3
Lysophospholipase 3 (Lysosomal Phospholipase A2)1 2     Lysophospholipase 33
Lysosomal Phospholipase A22 3     EC 2.3.1.438

External Ids:    HGNC: 171631   Entrez Gene: 236592   Ensembl: ENSG000001030667   OMIM: 6093625   UniProtKB: Q8NCC33   

Export aliases for PLA2G15 gene to outside databases

Previous GC identifers: GC16P066837 GC16P054152


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PLA2G15 Gene:
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids.
The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty
acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later
paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of
a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PLA2G15 Gene:
PLA2G15 (phospholipase A2, group XV) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is LCAT.

UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3
Function: Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of
1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak
lysophospholipase activity

Gene Wiki entry for PLA2G15 (LYPLA3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2G15 gene promoter:
         GR   Nkx2-5   NF-E2 p45   C/EBPalpha   SREBP-1b   SREBP-1a   COMP1   Zic1   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G15 promoter sequence
   Search Chromatin IP Primers for PLA2G15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

PLA2G15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G15 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P068279:  view genomic region     (about GC identifiers)

Start:
68,279,207 bp from pter      End:
68,294,961 bp from pter
Size:
15,755 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3 (See protein sequence)
Recommended Name: Group XV phospholipase A2 precursor  
Size: 412 amino acids; 46658 Da
Sequence caution: Sequence=CAB53675.1; Type=Erroneous initiation;
Secondary accessions: B3KMF3 Q53GZ1 Q9NPQ6 Q9UG04 Q9Y2B3

Explore the universe of human proteins at neXtProt for PLA2G15: NX_Q8NCC3

Explore proteomics data for PLA2G15 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn99, Asn273, Asn289, Asn398
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for PLA2G15 (Q8NCC3)
     SLGAPWGG  LEAKLDKP 


    See PLA2G15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036452.1  
    ENSEMBL proteins: 
     ENSP00000394197   ENSP00000454227   ENSP00000219345   ENSP00000457049   ENSP00000455461  
     ENSP00000457034   ENSP00000393610   ENSP00000454557  

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003386 LACT/PDAT_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q8NCC3

    ProtoNet protein and cluster: Q8NCC3

    UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    Find genes that share domains with PLA2G15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAG15_HUMAN, Q8NCC3
    Function: Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of
    1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak
    lysophospholipase activity

         Enzyme Numbers (IUBMB): EC 2.3.1.432 EC 2.3.1.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004622lysophospholipase activity TAS10092508
    GO:0005543phospholipid binding TAS10092508
    GO:0008374O-acyltransferase activity ISS--
    GO:0047499calcium-independent phospholipase A2 activity ISS--
         
    Find genes that share ontologies with PLA2G15           About GenesLikeMe


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pla2g15):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  normal  renal/urinary system  reproductive system  respiratory system 

    Find genes that share phenotypes with PLA2G15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PLA2G15: Pla2g15tm1Ytan Pla2g15tm1.1Jash

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PLA2G15
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    hsa-miR-137 hsa-let-7d hsa-miR-15a hsa-let-7c hsa-miR-449a hsa-miR-1205 hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G15 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PAG15_HUMAN, Q8NCC3: Lysosome (By similarity). Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome4
    vacuole4
    endoplasmic reticulum2
    mitochondrion2
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005739mitochondrion IEA--
    GO:0005764lysosome NAS11790796

    Find genes that share ontologies with PLA2G15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLA2G15 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    2Lysosome
    Lysosome


    Find genes that share SuperPaths with PLA2G15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for PLA2G15):
        Glycerophospholipid metabolism
    Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PLA2G15
    Interactions:

        Search GeneGlobe Interaction Network for PLA2G15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLA2G15 (Q8NCC32, 3 ENSP000002193454) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMMTQ168912, 3MINT-64996 I2D: score=5 
    RNF7Q9UBF63, ENSP000002734804I2D: score=1 STRING: ENSP00000273480
    LCATENSP000002640054STRING: ENSP00000264005
    LPCAT3ENSP000002614074STRING: ENSP00000261407
    PLA2G10ENSP000003938474STRING: ENSP00000393847
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006672ceramide metabolic process IEA--
    GO:0009062fatty acid catabolic process TAS10092508
    GO:0046470phosphatidylcholine metabolic process IEA--

    Find genes that share ontologies with PLA2G15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PLA2G15 (PAG15)

    Selected HMDB Compounds for PLA2G15 (see all 990)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
    Glycerylphosphorylethanolamine2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)1190-00-7--
    LysoPC(14:0)LysoPC(14:0) (see all 9)----
    LysoPC(14:1(9Z))LysoPC(14:1) (see all 17)----
    LysoPC(15:0)LyPC(15:0) (see all 9)----
    LysoPC(16:0)LysoPC(16:0/0:0) (see all 10)----
    LysoPC(16:1(9Z))LyPC(16:1w7/0:0) (see all 17)----
    LysoPC(18:0)Lysophosphatidylcholine(18:0/0:0) (see all 9)----
    LysoPC(18:1(11Z))Lysophosphatidylcholine(18:1/0:0) (see all 17)----

    5 Novoseek inferred chemical compound relationships for PLA2G15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylethanolamine 58.5 1 17626977 (1)
    ceramide 47.7 1 14973367 (1)
    phosphatidylcholine 46.8 1 17626977 (1)
    fatty acid 30.9 2 15220243 (2)
    lipid 10.4 1 15781238 (1)



    Find genes that share compounds with PLA2G15           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLA2G15 gene: 
    NM_012320.3  

    Unigene Cluster for PLA2G15:

    Phospholipase A2, group XV
    Hs.632199  [show with all ESTs]
    Unigene Representative Sequence: AK127898
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413021 ENST00000565744 ENST00000219345(uc002evr.3 uc010vld.2 uc010vle.2 uc010vlf.2)
    ENST00000566978 ENST00000564827 ENST00000566188 ENST00000444212 ENST00000562966
    ENST00000568082 ENST00000568599 ENST00000562449 ENST00000565460(uc002evs.3)

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    hsa-miR-137 hsa-let-7d hsa-miR-15a hsa-let-7c hsa-miR-449a hsa-miR-1205 hsa-let-7g hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidPLA2G15 3' UTR sequence
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    Additional mRNA sequence: 

    AB017494.1 AK001705.1 AK074828.1 AK127898.1 AK222790.1 AK296263.1 AK298494.1 AK300596.1 
    AL110209.1 AL389957.1 AY358425.1 BC011640.2 BC062605.1 

    12 DOTS entries:

    DT.450898  DT.120665005  DT.100733233  DT.100797669  DT.100797672  DT.100797667  DT.100797670  DT.120665148 
    DT.120664878  DT.102827151  DT.75182929  DT.91678558 

    Selected AceView cDNA sequences (see all 150):

    BU196223 AY358425 BM770153 BM771402 NM_012320 AL389957 CR598578 BM771795 
    BI765008 BM762443 BX372278 CR609474 CD675684 BM771227 BM771852 AK074828 
    BM771194 CO249839 BP353359 AB017494 AU133126 BX401485 BQ671096 BM770078 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G15 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -     -                 -     -     -     -                       -                                 
    SP2:                          -     -                 -     -     -     -                       -     -                           
    SP3:                          -     -                 -           -     -                                                         
    SP4:                          -     -                 -     -     -     -                                                         
    SP5:                          -     -                 -     -     -     -                 -     -                                 


    ECgene alternative splicing isoforms for PLA2G15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PLA2G15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCTGAG
    PLA2G15 Expression
    About this image


    PLA2G15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    PLA2G15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLA2G15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632199

    UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3
    Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower
    levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLA2G15 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g151 , 5 phospholipase A2, group XV1, 5 86.84(n)1
    91.58(a)1
      8 (53.10 cM)5
    1926541  NM_133792.21  NP_598553.11 
     1061503995 
    chicken
    (Gallus gallus)
    Aves PLA2G151 phospholipase A2, group XV 72.15(n)
    77.98(a)
      768530  XM_001231518.3  XP_001231519.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G156
    phospholipase A2, group XV
    65(a)
    1 ↔ 1
    LGc(6464056-6508624)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pla2g151 phospholipase A2, group XV 68.89(n)
    73.26(a)
      100124780  XM_004913499.1  XP_004913556.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11g042 wufa11g04 77.44(n)   335008  CD284253.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316831 CG31683 50.13(n)
    38.52(a)
      261623  NM_001273697.1  NP_001260626.1 
    worm
    (Caenorhabditis elegans)
    Secernentea M05B5.41 M05B5.4 47.85(n)
    46.24(a)
      172457  NM_059632.5  NP_492033.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G274801 AT1G27480 46.08(n)
    38.78(a)
      839639  NM_102512.2  NP_564286.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07300001 Os03g0730000 48.25(n)
    35.31(a)
      4333995  NM_001057695.1  NP_001051160.2 


    ENSEMBL Gene Tree for PLA2G15 (if available)
    TreeFam Gene Tree for PLA2G15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for PLA2G15 gene
    LCAT2  
    Selected SIMAP similar genes for PLA2G15 using alignment to 8 protein entries:     PAG15_HUMAN (see all proteins) (see all similar genes):
    EML2    PACSIN2    OK/SW-cl.41    AMN1    C14orf178    AHSA1
    NMRAL1    LRRC37A3    DNAPTP3    PKN1    C17orf51    CCT3
    FAM138C    FP6651    KIAA1651    ZNF843    PPP2R1A    UTY

    Find genes that share paralogs with PLA2G15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PLA2G15 (see all 367)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71845061,2
    H--68277271(+) ACCTCT/ATGATC 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1931524541,2
    --68277314(+) TTCTGC/TCCGTC 1 -- us2k10--------
    rs1496834021,2
    C--68277390(+) CTTCTA/GTTGGG 1 -- us2k10--------
    rs123255871,2
    C,F,H--68277441(+) GAGTTC/TTGAGC 1 -- us2k18Minor allele frequency- T:0.00NS EA NA 596
    rs1454724931,2
    --68277451(+) CCAGGG/TCCTTA 1 -- us2k10--------
    rs123249261,2
    C--68277518(+) gtaatC/Ttcagc 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1857207631,2
    --68277636(+) TTGGAA/GGTGTA 1 -- us2k10--------
    rs558527431,2
    C,F--68277719(+) TGAGCC/TGTGAT 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs71897941,2
    C,F,A--68277727(+) gattgT/Cgctac 1 -- us2k1 tfbs37Minor allele frequency- C:0.21NA WA CSA EA 365
    rs123249381,2
    C,F,H--68277760(+) cctttC/Ttcaaa 1 -- us2k13Minor allele frequency- T:0.02NS NA 344

    HapMap Linkage Disequilibrium report for PLA2G15 (68279207 - 68294961 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PLA2G15: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2G15
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2G15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609362    OMIM disorders: --


    Find genes that share disorders with PLA2G15           About GenesLikeMe

    Genetic Association Database (GAD): PLA2G15
    Human Genome Epidemiology (HuGE) Navigator: PLA2G15 (4 documents)

    Export disorders for PLA2G15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLA2G15 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with PLA2G15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. (PubMed id 10092508)1, 2, 3, 9 Taniyama Y.... Fujino M. (Biochem. Biophys. Res. Commun. 1999)
    2. Cloning and characterization of a lysosomal phospholipase A2, 1-O- acylceramide synthase. (PubMed id 11790796)1, 2, 9 Hiraoka M.... Shayman J.A. (J. Biol. Chem. 2002)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The phospholipase A2 superfamily and its group numbering system. (PubMed id 16973413)1, 3 Schaloske R.H. and Dennis E.A. (Biochim. Biophys. Acta 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    10. Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells. (PubMed id 14754907)1, 9 Abe A....Shayman J.A. (J. Lipid Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23659 HGNC: 17163 AceView: LYPLA3 Ensembl:ENSG00000103066 euGenes: HUgn23659
    ECgene: PLA2G15 Kegg: 23659 H-InvDB: PLA2G15

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLA2G15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PLA2G15 gene:
    Search GeneIP for patents involving PLA2G15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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