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Aliases for PLA2G15 Gene

Aliases for PLA2G15 Gene

  • Phospholipase A2 Group XV 2 3 5
  • Lysophospholipase 3 (Lysosomal Phospholipase A2) 2 3
  • LCAT-Like Lysophospholipase 3 4
  • Lysosomal Phospholipase A2 3 4
  • 1-O-Acylceramide Synthase 3 4
  • LYPLA3 3 4
  • LPLA2 3 4
  • LLPL 3 4
  • ACS 3 4
  • Phospholipase A2, Group XV 2
  • Group XV Phospholipase A2 3
  • Lysophospholipase 3 4
  • EC 2.3.1.43 61
  • EC 2.3.1.- 4
  • GXVPLA2 3

External Ids for PLA2G15 Gene

Previous HGNC Symbols for PLA2G15 Gene

  • LYPLA3

Previous GeneCards Identifiers for PLA2G15 Gene

  • GC16P066837
  • GC16P054152

Summaries for PLA2G15 Gene

Entrez Gene Summary for PLA2G15 Gene

  • Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]

GeneCards Summary for PLA2G15 Gene

PLA2G15 (Phospholipase A2 Group XV) is a Protein Coding gene. Among its related pathways are Lysosome and Glycerophospholipid biosynthesis. GO annotations related to this gene include phospholipid binding and O-acyltransferase activity. An important paralog of this gene is LCAT.

UniProtKB/Swiss-Prot for PLA2G15 Gene

  • Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).

Gene Wiki entry for PLA2G15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G15 Gene

Genomics for PLA2G15 Gene

Regulatory Elements for PLA2G15 Gene

Enhancers for PLA2G15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F068210 0.6 ENCODE 11.9 -34.0 -33996 1.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS KLF13 PRMT7 DUS2 ESRP2 MIR6773 PLA2G15 SLC7A6 NFATC3 SLC7A6OS EDC4 DPEP2
GH16F068201 0.5 ENCODE 11.4 -43.4 -43350 1.4 MLX ARID4B SIN3A FEZF1 ZNF2 ZNF48 YY1 ZNF121 GLIS2 SP3 MIR6773 ESRP2 PLA2G15 SLC7A6 PRMT7 SLC7A6OS ENSG00000279621 RPS12P27
GH16F067444 0.6 ENCODE 5.7 -796.4 -796397 8.5 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ATP6V0D1 ZDHHC1 AGRP FAM65A E2F4 EXOC3L1 KIAA0895L LRRC29 TMEM208 ACD
GH16F068061 0.8 Ensembl ENCODE 5.6 -181.4 -181386 5.3 HDAC1 PKNOX1 TBL1XR1 RAD21 GATA2 SCRT2 ZNF143 FOS CREM MIXL1 PRMT7 NFATC3 THAP11 DDX28 DUS2 RNU6-359P DPEP3 CENPT EDC4 PLA2G15
GH16F067780 1.2 Ensembl ENCODE 5.5 -463.6 -463603 2.2 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 YY1 SLC30A9 ZNF143 ZNF207 RANBP10 DPEP2 PLA2G15 ENSG00000270165
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLA2G15 on UCSC Golden Path with GeneCards custom track

Promoters for PLA2G15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000509124 -204 1801 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS KLF13 SP3

Genomic Location for PLA2G15 Gene

Chromosome:
16
Start:
68,245,304 bp from pter
End:
68,261,062 bp from pter
Size:
15,759 bases
Orientation:
Plus strand

Genomic View for PLA2G15 Gene

Genes around PLA2G15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G15 Gene

Proteins for PLA2G15 Gene

  • Protein details for PLA2G15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCC3-PAG15_HUMAN
    Recommended name:
    Group XV phospholipase A2
    Protein Accession:
    Q8NCC3
    Secondary Accessions:
    • B3KMF3
    • B4DUD1
    • Q53GZ1
    • Q9NPQ6
    • Q9UG04
    • Q9Y2B3

    Protein attributes for PLA2G15 Gene

    Size:
    412 amino acids
    Molecular mass:
    46658 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB53675.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PLA2G15 Gene

    Alternative splice isoforms for PLA2G15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G15 Gene

Selected DME Specific Peptides for PLA2G15 Gene

Q8NCC3:
  • LEAKLDKP
  • SLGAPWGG

Post-translational modifications for PLA2G15 Gene

  • N-glycosylated (PubMed:11790796, PubMed:23958596). N-glycosylation is important for maturation of the enzyme and normal subcellular location (PubMed:23958596).
  • Glycosylation at Asn 99, Asn 273, Asn 289, and Asn 398
  • Modification sites at PhosphoSitePlus

Domains & Families for PLA2G15 Gene

Gene Families for PLA2G15 Gene

Protein Domains for PLA2G15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCC3

UniProtKB/Swiss-Prot:

PAG15_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PLA2G15: view

Function for PLA2G15 Gene

Molecular function for PLA2G15 Gene

UniProtKB/Swiss-Prot Function:
Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).

Enzyme Numbers (IUBMB) for PLA2G15 Gene

Gene Ontology (GO) - Molecular Function for PLA2G15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS 10092508
GO:0005543 phospholipid binding TAS 10092508
GO:0008374 O-acyltransferase activity IEA,ISS --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with PLA2G15: view
genes like me logo Genes that share phenotypes with PLA2G15: view

Animal Models for PLA2G15 Gene

MGI Knock Outs for PLA2G15:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G15

miRNA for PLA2G15 Gene

miRTarBase miRNAs that target PLA2G15

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G15 Gene

Localization for PLA2G15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G15 Gene

Lysosome. Secreted. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G15 Gene COMPARTMENTS Subcellular localization image for PLA2G15 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
endoplasmic reticulum 2
mitochondrion 2
nucleus 2
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLA2G15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 20410020
GO:0005739 mitochondrion IEA --
GO:0005764 lysosome NAS 11790796
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PLA2G15: view

Pathways & Interactions for PLA2G15 Gene

genes like me logo Genes that share pathways with PLA2G15: view

Pathways by source for PLA2G15 Gene

2 KEGG pathways for PLA2G15 Gene

Gene Ontology (GO) - Biological Process for PLA2G15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006650 glycerophospholipid metabolic process IDA 20410020
GO:0006672 ceramide metabolic process IEA,ISS --
GO:0009062 fatty acid catabolic process TAS 10092508
genes like me logo Genes that share ontologies with PLA2G15: view

No data available for SIGNOR curated interactions for PLA2G15 Gene

Drugs & Compounds for PLA2G15 Gene

(5) Drugs for PLA2G15 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Choline alfoscerate Experimental Pharma 0
calcium Nutra 0

(36) Additional Compounds for PLA2G15 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
genes like me logo Genes that share compounds with PLA2G15: view

Transcripts for PLA2G15 Gene

Unigene Clusters for PLA2G15 Gene

Phospholipase A2, group XV:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G15 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: -
SP10: - -
SP11:

Relevant External Links for PLA2G15 Gene

GeneLoc Exon Structure for
PLA2G15
ECgene alternative splicing isoforms for
PLA2G15

Expression for PLA2G15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA2G15 Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G15 Gene

This gene is overexpressed in Muscle - Skeletal (x4.8).

Protein differential expression in normal tissues from HIPED for PLA2G15 Gene

This gene is overexpressed in Liver (48.6) and Amniocyte (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLA2G15 Gene



NURSA nuclear receptor signaling pathways regulating expression of PLA2G15 Gene:

PLA2G15

SOURCE GeneReport for Unigene cluster for PLA2G15 Gene:

Hs.632199

mRNA Expression by UniProt/SwissProt for PLA2G15 Gene:

Q8NCC3-PAG15_HUMAN
Tissue specificity: Detected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes (PubMed:10092508).
genes like me logo Genes that share expression patterns with PLA2G15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for PLA2G15 Gene

Orthologs for PLA2G15 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PLA2G15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G15 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia PLA2G15 34 35
  • 89.83 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g15 34
  • 87.65 (n)
mouse
(Mus musculus)
Mammalia Pla2g15 34 16 35
  • 86.84 (n)
cow
(Bos Taurus)
Mammalia PLA2G15 34 35
  • 85.63 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2G15 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G15 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G15 34 35
  • 72.15 (n)
lizard
(Anolis carolinensis)
Reptilia PLA2G15 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g15 34
  • 68.89 (n)
zebrafish
(Danio rerio)
Actinopterygii pla2g15 34 35
  • 66.93 (n)
wufa11g04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9525 34
fruit fly
(Drosophila melanogaster)
Insecta CG31683 34 35
  • 50.13 (n)
CG18858 35
  • 36 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008990 34
  • 49.77 (n)
worm
(Caenorhabditis elegans)
Secernentea M05B5.4 34 35
  • 47.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G27480 34
  • 46.08 (n)
rice
(Oryza sativa)
Liliopsida Os03g0730000 34
  • 48.25 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9541 35
  • 37 (a)
OneToMany
Species where no ortholog for PLA2G15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G15 Gene

ENSEMBL:
Gene Tree for PLA2G15 (if available)
TreeFam:
Gene Tree for PLA2G15 (if available)

Paralogs for PLA2G15 Gene

Paralogs for PLA2G15 Gene

genes like me logo Genes that share paralogs with PLA2G15: view

Variants for PLA2G15 Gene

Sequence variations from dbSNP and Humsavar for PLA2G15 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10500543 -- 68,247,408(+) GTTAC(C/T)TGAGG intron-variant
rs10852439 -- 68,254,428(+) CTCCG(C/T)GTCAC intron-variant
rs11075670 -- 68,254,490(+) CGCCT(C/G)CCACG intron-variant
rs111425489 -- 68,248,057(+) GGTTC(-/A)GGGTG intron-variant
rs111480058 -- 68,246,946(+) GGGGC(C/G)TGGCA intron-variant

Variation tolerance for PLA2G15 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PLA2G15 Gene

Disorders for PLA2G15 Gene

Relevant External Links for PLA2G15

Genetic Association Database (GAD)
PLA2G15
Human Genome Epidemiology (HuGE) Navigator
PLA2G15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G15

No disorders were found for PLA2G15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G15 Gene

Publications for PLA2G15 Gene

  1. Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. (PMID: 10092508) Taniyama Y. … Fujino M. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 22 64
  2. Cloning and characterization of a lysosomal phospholipase A2, 1-O- acylceramide synthase. (PMID: 11790796) Hiraoka M. … Shayman J.A. (J. Biol. Chem. 2002) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. The measurement of lysosomal phospholipase A2 activity in plasma. (PMID: 20410020) Abe A. … Shayman J.A. (J. Lipid Res. 2010) 3 4 64

Products for PLA2G15 Gene

Sources for PLA2G15 Gene

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