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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLA2G15 Gene

protein-coding   GIFtS: 54
GCID: GC16P068279

Phospholipase A2, Group XV

(Previous name: lysophospholipase 3 (lysosomal phospholipase A2))
(Previous symbol: LYPLA3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase A2, Group XV1 2     1-O-Acylceramide Synthase2 3
LYPLA31 2 3 5     LCAT-Like Lysophospholipase2 3
ACS2 3 5     GXVPLA22
LLPL2 3 5     Group XV Phospholipase A22
LPLA22 3 5     EC 2.3.1.-3
Lysophospholipase 3 (Lysosomal Phospholipase A2)1 2     Lysophospholipase 33
Lysosomal Phospholipase A22 3     EC 2.3.1.438

External Ids:    HGNC: 171631   Entrez Gene: 236592   Ensembl: ENSG000001030667   OMIM: 6093625   UniProtKB: Q8NCC33   

Export aliases for PLA2G15 gene to outside databases

Previous GC identifers: GC16P066837 GC16P054152


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2G15 Gene:
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids.
The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty
acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later
paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of
a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. (provided by
RefSeq, Jul 2008)

GeneCards Summary for PLA2G15 Gene: 
PLA2G15 (phospholipase A2, group XV) is a protein-coding gene. Diseases associated with PLA2G15 include pulmonary alveolar proteinosis, and atherosclerosis, and among its related super-pathways are Glycerophospholipid biosynthesis. GO annotations related to this gene include phospholipid binding and calcium-independent phospholipase A2 activity. An important paralog of this gene is LCAT.

UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3
Function: Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of
1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak
lysophospholipase activity

Gene Wiki entry for PLA2G15 (LYPLA3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLA2G15 gene promoter:
         GR   Nkx2-5   NF-E2 p45   C/EBPalpha   SREBP-1b   SREBP-1a   COMP1   Zic1   GR-alpha   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G15 promoter sequence
   Search SABiosciences Chromatin IP Primers for PLA2G15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

PLA2G15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G15 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P068279:  view genomic region     (about GC identifiers)

Start:
68,279,207 bp from pter      End:
68,294,961 bp from pter
Size:
15,755 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3 (See protein sequence)
Recommended Name: Group XV phospholipase A2 precursor  
Size: 412 amino acids; 46658 Da
Subcellular location: Lysosome (By similarity). Secreted
Sequence caution: Sequence=CAB53675.1; Type=Erroneous initiation;
Secondary accessions: B3KMF3 Q53GZ1 Q9NPQ6 Q9UG04 Q9Y2B3

Explore the universe of human proteins at neXtProt for PLA2G15: NX_Q8NCC3

Explore proteomics data for PLA2G15 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCC3

  • 2 DME Specific Peptides for PLA2G15 (Q8NCC3)
     SLGAPWGG  LEAKLDKP 

    PLA2G15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PLA2G15 Protein Expression
    REFSEQ proteins: NP_036452.1  
    ENSEMBL proteins: 
     ENSP00000394197   ENSP00000454227   ENSP00000219345   ENSP00000457049   ENSP00000455461  
     ENSP00000457034   ENSP00000393610   ENSP00000454557  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005739mitochondrion IEA--
    GO:0005764lysosome NAS11790796

    PLA2G15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003386 LACT/PDAT_acylTrfase

    Graphical View of Domain Structure for InterPro Entry Q8NCC3

    ProtoNet protein and cluster: Q8NCC3

    UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    PLA2G15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAG15_HUMAN, Q8NCC3
    Function: Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of
    1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak
    lysophospholipase activity

         Enzyme Numbers (IUBMB): EC 2.3.1.432 EC 2.3.1.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004622lysophospholipase activity TAS10092508
    GO:0005543phospholipid binding TAS10092508
    GO:0008374O-acyltransferase activity ISS--
    GO:0047499calcium-independent phospholipase A2 activity ISS--
         
    PLA2G15 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pla2g15):
     cardiovascular system  cellular  hematopoietic system  homeostasis/metabolism  immune system 
     liver/biliary system  normal  renal/urinary system  reproductive system  respiratory system 

    PLA2G15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PLA2G15: Pla2g15tm1Ytan Pla2g15tm1.1Jash

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PLA2G15 
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    SwitchGear 3'UTR luciferase reporter plasmidPLA2G15 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PLA2G15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid metabolism0.62
    2Lysosome
    Lysosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for PLA2G15):
        Glycerophospholipid metabolism
    Lysosome


    PLA2G15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLA2G15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/25 Interacting proteins for PLA2G15 (Q8NCC32, 3 ENSP000002193454) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMMTQ168912, 3MINT-64996 I2D: score=5 
    RNF7Q9UBF63, ENSP000002734804I2D: score=1 STRING: ENSP00000273480
    LCATENSP000002640054STRING: ENSP00000264005
    PLA2G10ENSP000003938474STRING: ENSP00000393847
    PLA2G12BENSP000003621234STRING: ENSP00000362123
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0006672ceramide metabolic process IEA--
    GO:0009062fatty acid catabolic process TAS10092508
    GO:0046470phosphatidylcholine metabolic process IEA--

    PLA2G15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PLA2G15 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PLA2G15 (PAG15)

    10/990 HMDB Compounds for PLA2G15 (see all 990)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Glycerophosphocholine2-[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]-N,N,N-trimethyl-Ethanaminium inner salt (see all 21)28319-77-9--
    Glycerylphosphorylethanolamine2-aminoethyl ester 1-Glycerophosphoric acid (see all 10)1190-00-7--
    LysoPC(14:0)LysoPC(14:0) (see all 9)----
    LysoPC(14:1(9Z))LysoPC(14:1) (see all 17)----
    LysoPC(15:0)LyPC(15:0) (see all 9)----
    LysoPC(16:0)LysoPC(16:0/0:0) (see all 10)----
    LysoPC(16:1(9Z))LyPC(16:1w7/0:0) (see all 17)----
    LysoPC(18:0)Lysophosphatidylcholine(18:0/0:0) (see all 9)----
    LysoPC(18:1(11Z))Lysophosphatidylcholine(18:1/0:0) (see all 17)----

    5 Novoseek inferred chemical compound relationships for PLA2G15 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylethanolamine 58.5 1 17626977 (1)
    ceramide 47.7 1 14973367 (1)
    phosphatidylcholine 46.8 1 17626977 (1)
    fatty acid 30.9 2 15220243 (2)
    lipid 10.4 1 15781238 (1)

    Search CenterWatch for drugs/clinical trials and news about PLA2G15 / PAG15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PLA2G15 gene: 
    NM_012320.3  

    Unigene Cluster for PLA2G15:

    Phospholipase A2, group XV
    Hs.632199  [show with all ESTs]
    Unigene Representative Sequence: AK127898
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413021 ENST00000565744 ENST00000219345(uc002evr.3 uc010vld.2 uc010vle.2 uc010vlf.2)
    ENST00000566978 ENST00000564827 ENST00000566188 ENST00000444212 ENST00000562966
    ENST00000568082 ENST00000568599 ENST00000562449 ENST00000565460(uc002evs.3)

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    Additional mRNA sequence: 

    AB017494.1 AK001705.1 AK074828.1 AK127898.1 AK222790.1 AK296263.1 AK298494.1 AK300596.1 
    AL110209.1 AL389957.1 AY358425.1 BC011640.2 BC062605.1 

    12 DOTS entries:

    DT.450898  DT.120665005  DT.100733233  DT.100797669  DT.100797672  DT.100797667  DT.100797670  DT.120665148 
    DT.120664878  DT.102827151  DT.75182929  DT.91678558 

    24/150 AceView cDNA sequences (see all 150):

    AL389957 AB017494 CD675684 BM770745 BC011640 AU133126 CR598578 AY358425 
    BX372278 BM762443 BM771194 BI765008 BM837536 BX401485 BM771402 BM771795 
    CR609474 BM771852 BC062605 NM_012320 BM771227 BG056730 CR597665 BM771817 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G15 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
    SP1:                          -     -                 -     -     -     -                       -                                 
    SP2:                          -     -                 -     -     -     -                       -     -                           
    SP3:                          -     -                 -           -     -                                                         
    SP4:                          -     -                 -     -     -     -                                                         
    SP5:                          -     -                 -     -     -     -                 -     -                                 


    ECgene alternative splicing isoforms for PLA2G15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PLA2G15 expression in normal human tissues (normalized intensities)      PLA2G15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCTGAG
    PLA2G15 Expression
    About this image


    PLA2G15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             brain/midbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             monocyte-derived macrophage   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             lung ; pneumocytes   
             bronchoalveolar lavage cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See PLA2G15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PLA2G15

    SOURCE GeneReport for Unigene cluster: Hs.632199

    UniProtKB/Swiss-Prot: PAG15_HUMAN, Q8NCC3
    Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower
    levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PLA2G15 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g151 , 5 phospholipase A2, group XV1, 5 85.44(n)1
    88.35(a)1
      8 (53.10 cM)5
    1926541  NM_133792.21  NP_598553.11 
     1061503995 
    chicken
    (Gallus gallus)
    Aves PLA2G151 phospholipase A2, group XV 70.53(n)
    75.56(a)
      768530  XM_001231518.2  XP_001231519.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G156
    phospholipase A2, group XV
    65(a)
    1 ↔ 1
    LGc(6464056-6508624)
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11g042 wufa11g04 77.44(n)   335008  CD284253.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316831 CG31683 49.96(n)
    39.1(a)
      261623  NM_165330.2  NP_724265.2 
    worm
    (Caenorhabditis elegans)
    Secernentea M05B5.41 Protein M05B5.4 47.89(n)
    46.36(a)
      172457  NM_059632.4  NP_492033.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LRO16
    Acyltransferase that catalyzes diacylglycerol este...
    14(a)
    1 → many
    XIV(640396-642381)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G274801 Lecithin-cholesterol acyltransferase-like 1 46.91(n)
    40.43(a)
      839639  NM_102512.2  NP_564286.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07300001 hypothetical protein 49.32(n)
    36.44(a)
      4333995  NM_001057695.1  NP_001051160.2 


    ENSEMBL Gene Tree for PLA2G15 (if available)
    TreeFam Gene Tree for PLA2G15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PLA2G15 gene
    LCAT2  
    18/27 SIMAP similar genes for PLA2G15 using alignment to 8 protein entries:     PAG15_HUMAN (see all proteins) (see all similar genes):
    EML2    PACSIN2    OK/SW-cl.41    AMN1    C14orf178    AHSA1
    NMRAL1    LRRC37A3    DNAPTP3    PKN1    C17orf51    CCT3
    FAM138A    FAM138B    FAM138C    FAM138F    FP6651    KIAA1651

    PLA2G15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/367 SNPs in PLA2G15 are shown (see all 367)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71845061,2
    H--68277271(+) ACCTCT/ATGATC 1 -- us2k14Minor allele frequency- A:0.00NS EA 420
    rs1931524541,2
    --68277314(+) TTCTGC/TCCGTC 1 -- us2k10--------
    rs1496834021,2
    C--68277390(+) CTTCTA/GTTGGG 1 -- us2k10--------
    rs123255871,2
    C,F,H--68277441(+) GAGTTC/TTGAGC 1 -- us2k18Minor allele frequency- T:0.00NS EA NA 596
    rs1454724931,2
    --68277451(+) CCAGGG/TCCTTA 1 -- us2k10--------
    rs123249261,2
    C--68277518(+) gtaatC/Ttcagc 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1857207631,2
    --68277636(+) TTGGAA/GGTGTA 1 -- us2k10--------
    rs558527431,2
    C,F--68277719(+) TGAGCC/TGTGAT 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs71897941,2
    C,F,A--68277727(+) gattgT/Cgctac 1 -- us2k1 tfbs37Minor allele frequency- C:0.21NA WA CSA EA 365
    rs123249381,2
    C,F,H--68277760(+) cctttC/Ttcaaa 1 -- us2k13Minor allele frequency- T:0.02NS NA 344

    HapMap Linkage Disequilibrium report for PLA2G15 (68279207 - 68294961 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for PLA2G15: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2G15
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2G15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609362    OMIM disorders: --

    6 diseases for PLA2G15:    About MalaCards
    pulmonary alveolar proteinosis    atherosclerosis    alcoholism    colon cancer
    adenocarcinoma    prostatitis


    PLA2G15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): PLA2G15
    Human Genome Epidemiology (HuGE) Navigator: PLA2G15 (4 documents)

    Export disorders for PLA2G15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PLA2G15 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with PLA2G15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. (PubMed id 10092508)1, 2, 3, 9 Taniyama Y.... Fujino M. (1999)
    2. Cloning and characterization of a lysosomal phospholipase A2, 1-O- acylceramide synthase. (PubMed id 11790796)1, 2, 9 Hiraoka M.... Shayman J.A. (2002)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The phospholipase A2 superfamily and its group numbering system. (PubMed id 16973413)1, 3 Schaloske R.H. and Dennis E.A. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    10. Induction of lysosomal phospholipase A2 through the r etinoid X receptor in THP-1 cells. (PubMed id 14754907)1, 9 Abe A....Shayman J.A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23659 HGNC: 17163 AceView: LYPLA3 Ensembl:ENSG00000103066 euGenes: HUgn23659
    ECgene: PLA2G15 Kegg: 23659 H-InvDB: PLA2G15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PLA2G15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PLA2G15 gene:
    Search GeneIP for patents involving PLA2G15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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