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Aliases for PLA2G12B Gene

Aliases for PLA2G12B Gene

  • Phospholipase A2 Group XIIB 2 3 5
  • Phospholipase A2, Group XIII 2 3
  • SPLA2-GXIIB 3 4
  • PLA2G13 3 4
  • GXIIB 3 4
  • Group XIII Secretory Phospholipase A2-Like Protein 4
  • Group XIII Secreted Phospholipase A2 3
  • Phospholipase A2, Group XIIB 2
  • GXIII SPLA2-Like 4
  • GXIIIsPLA2 3
  • FKSG71 3

External Ids for PLA2G12B Gene

Previous HGNC Symbols for PLA2G12B Gene

  • PLA2G13

Previous GeneCards Identifiers for PLA2G12B Gene

  • GC10M074039
  • GC10M074364
  • GC10M074694
  • GC10M068688

Summaries for PLA2G12B Gene

Entrez Gene Summary for PLA2G12B Gene

  • The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for PLA2G12B Gene

PLA2G12B (Phospholipase A2 Group XIIB) is a Protein Coding gene. Diseases associated with PLA2G12B include hepatitis c virus. Among its related pathways are Metabolism and Fat digestion and absorption. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G12A.

UniProtKB/Swiss-Prot for PLA2G12B Gene

  • Not known; does not seem to have catalytic activity.

Tocris Summary for PLA2G12B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G12B Gene

Genomics for PLA2G12B Gene

Regulatory Elements for PLA2G12B Gene

Promoters for PLA2G12B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLA2G12B on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G12B Gene

Chromosome:
10
Start:
72,935,170 bp from pter
End:
72,954,883 bp from pter
Size:
19,714 bases
Orientation:
Minus strand

Genomic View for PLA2G12B Gene

Genes around PLA2G12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12B Gene

Proteins for PLA2G12B Gene

  • Protein details for PLA2G12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX93-PG12B_HUMAN
    Recommended name:
    Group XIIB secretory phospholipase A2-like protein
    Protein Accession:
    Q9BX93
    Secondary Accessions:
    • B7ZL23
    • Q52LB2
    • Q96Q99

    Protein attributes for PLA2G12B Gene

    Size:
    195 amino acids
    Molecular mass:
    21659 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G12B Gene

Proteomics data for PLA2G12B Gene at MOPED

Post-translational modifications for PLA2G12B Gene

No Post-translational modifications

Other Protein References for PLA2G12B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLA2G12B Gene

Domains & Families for PLA2G12B Gene

Gene Families for PLA2G12B Gene

Protein Domains for PLA2G12B Gene

Suggested Antigen Peptide Sequences for PLA2G12B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BX93

UniProtKB/Swiss-Prot:

PG12B_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12B: view

Function for PLA2G12B Gene

Molecular function for PLA2G12B Gene

UniProtKB/Swiss-Prot Function:
Not known; does not seem to have catalytic activity.

Gene Ontology (GO) - Molecular Function for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view
genes like me logo Genes that share phenotypes with PLA2G12B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G12B Gene

Localization for PLA2G12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G12B Gene COMPARTMENTS Subcellular localization image for PLA2G12B gene
Compartment Confidence
extracellular 5
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for PLA2G12B Gene

Pathways & Interactions for PLA2G12B Gene

genes like me logo Genes that share pathways with PLA2G12B: view

Interacting Proteins for PLA2G12B Gene

Gene Ontology (GO) - Biological Process for PLA2G12B Gene

None

No data available for SIGNOR curated interactions for PLA2G12B Gene

Drugs & Compounds for PLA2G12B Gene

(5) Drugs for PLA2G12B Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
arachidonic acid Experimental Nutra Activator 27
linoleic acid Pharma Full agonist, Agonist 0
calcium Nutra 0
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(40) Additional Compounds for PLA2G12B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
LysoPC(16:1(9Z))
  • 1-Palmitoleoyl-glycero-3-phosphocholine
  • LPC(16:1)
  • LPC(16:1/0:0)
  • LPC(16:1n7/0:0)
  • LPC(16:1w7/0:0)

(5) Tocris Compounds for PLA2G12B Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G12B: view

Transcripts for PLA2G12B Gene

mRNA/cDNA for PLA2G12B Gene

Unigene Clusters for PLA2G12B Gene

Phospholipase A2, group XIIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: -

Relevant External Links for PLA2G12B Gene

GeneLoc Exon Structure for
PLA2G12B
ECgene alternative splicing isoforms for
PLA2G12B

Expression for PLA2G12B Gene

mRNA expression in normal human tissues for PLA2G12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G12B Gene

This gene is overexpressed in Liver (x33.7), Small Intestine - Terminal Ileum (x8.1), and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for PLA2G12B Gene

This gene is overexpressed in Fetal Liver (52.0) and Fetal gut (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G12B Gene



SOURCE GeneReport for Unigene cluster for PLA2G12B Gene Hs.333175

mRNA Expression by UniProt/SwissProt for PLA2G12B Gene

Q9BX93-PG12B_HUMAN
Tissue specificity: Strong expression in liver, small intestine and kidney.
genes like me logo Genes that share expression patterns with PLA2G12B: view

Protein tissue co-expression partners for PLA2G12B Gene

Primer Products

In Situ Assay Products

Orthologs for PLA2G12B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G12B 35
  • 91.11 (n)
  • 92.31 (a)
PLA2G12B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G12B 35
  • 90.21 (n)
  • 95.36 (a)
PLA2G12B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g12b 35
  • 86.5 (n)
  • 90.26 (a)
Pla2g12b 16
Pla2g12b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G12B 35
  • 99.83 (n)
  • 100 (a)
PLA2G12B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g12b 35
  • 87.01 (n)
  • 90.77 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G12B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G12B 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G12B 35
  • 73.2 (n)
  • 77.84 (a)
PLA2G12B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G12B 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g12b 35
  • 69.65 (n)
  • 75.26 (a)
Str.8191 35
zebrafish
(Danio rerio)
Actinopterygii pla2g12b 35
  • 69.11 (n)
  • 70.73 (a)
wufb26d02 35
pla2g12b 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2894 35
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 36
  • 24 (a)
OneToMany
Species with no ortholog for PLA2G12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G12B Gene

ENSEMBL:
Gene Tree for PLA2G12B (if available)
TreeFam:
Gene Tree for PLA2G12B (if available)

Paralogs for PLA2G12B Gene

Paralogs for PLA2G12B Gene

(1) SIMAP similar genes for PLA2G12B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G12B: view

Variants for PLA2G12B Gene

Sequence variations from dbSNP and Humsavar for PLA2G12B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2452329 -- 72,940,081(+) CTCTG(C/T)AGAAA intron-variant
rs2461917 -- 72,935,529(-) CATTC(A/G)TTCTT utr-variant-3-prime
rs3829126 -- 72,954,419(+) CTGGG(G/T)CTGTC intron-variant
rs7070407 -- 72,955,950(+) ATCAC(C/G)AGTCT upstream-variant-2KB
rs7074597 -- 72,956,574(+) cgtct(C/G)tacta upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12B Gene

Variant ID Type Subtype PubMed ID
nsv528473 CNV Gain 19592680
esv2656992 CNV Deletion 23128226

Variation tolerance for PLA2G12B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G12B Gene

HapMap Linkage Disequilibrium report
PLA2G12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G12B Gene

Disorders for PLA2G12B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G12B Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G12B

Genetic Association Database (GAD)
PLA2G12B
Human Genome Epidemiology (HuGE) Navigator
PLA2G12B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G12B
genes like me logo Genes that share disorders with PLA2G12B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G12B Gene

Publications for PLA2G12B Gene

  1. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PMID: 19817957) Segat L. … Crovella S. (J. Gastroenterol. Hepatol. 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Hepatocyte Nuclear Factor 4I+ and Downstream Secreted Phospholipase A2 GXIIB Regulate Production of Infectious Hepatitis C Virus. (PMID: 24173221) Li X. … Peng T. (J. Virol. 2014) 3
  4. Lung mast cells are a source of secreted phospholipases A2. (PMID: 19541351) Triggiani M. … Marone G. (J. Allergy Clin. Immunol. 2009) 3
  5. Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate. (PMID: 18212756) Mounier C.M. … Lambeau G. (Br. J. Cancer 2008) 3

Products for PLA2G12B Gene

Sources for PLA2G12B Gene

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