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Aliases for PLA2G12B Gene

Aliases for PLA2G12B Gene

  • Phospholipase A2 Group XIIB 2 3 5
  • Phospholipase A2, Group XIII 2 3
  • SPLA2-GXIIB 3 4
  • PLA2G13 3 4
  • GXIIB 3 4
  • Group XIIB Secretory Phospholipase A2-Like Protein 3
  • Group XIII Secretory Phospholipase A2-Like Protein 4
  • Group XIII Secreted Phospholipase A2 3
  • Phospholipase A2, Group XIIB 2
  • GXIII SPLA2-Like 4
  • GXIIIsPLA2 3
  • FKSG71 3

External Ids for PLA2G12B Gene

Previous HGNC Symbols for PLA2G12B Gene

  • PLA2G13

Previous GeneCards Identifiers for PLA2G12B Gene

  • GC10M074039
  • GC10M074364
  • GC10M074694
  • GC10M068688

Summaries for PLA2G12B Gene

Entrez Gene Summary for PLA2G12B Gene

  • The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for PLA2G12B Gene

PLA2G12B (Phospholipase A2 Group XIIB) is a Protein Coding gene. Diseases associated with PLA2G12B include Hepatitis C Virus. Among its related pathways are Linoleic acid metabolism and Vascular smooth muscle contraction. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G12A.

UniProtKB/Swiss-Prot for PLA2G12B Gene

  • Not known; does not seem to have catalytic activity.

Tocris Summary for PLA2G12B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G12B Gene

Genomics for PLA2G12B Gene

Regulatory Elements for PLA2G12B Gene

Enhancers for PLA2G12B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G072951 0.9 ENCODE 0.7 +1.0 962 4.2 ELF3 ATF1 FOXA2 ARID4B DMAP1 RAD21 YY1 SCRT2 CREM MIXL1 CFAP70 NUDT13 OIT3 ECD DNAJB12 DNAJC9-AS1 PLA2G12B NPM1P24
GH10G072934 0.6 ENCODE 0.4 +19.5 19544 1.4 FOSL1 PKNOX1 JUND RNF2 PBX2 IKZF1 NFE2 FOS ZNF24 OIT3 DNAJB12 PLA2G12B NPM1P24
GH10G072941 0.4 ENCODE 0.4 +13.0 12966 0.2 ZSCAN4 OIT3 ENSG00000237768 ENSG00000226163 PLA2G12B NPM1P24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2G12B on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G12B Gene

Chromosome:
10
Start:
72,935,170 bp from pter
End:
72,954,883 bp from pter
Size:
19,714 bases
Orientation:
Minus strand

Genomic View for PLA2G12B Gene

Genes around PLA2G12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12B Gene

Proteins for PLA2G12B Gene

  • Protein details for PLA2G12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX93-PG12B_HUMAN
    Recommended name:
    Group XIIB secretory phospholipase A2-like protein
    Protein Accession:
    Q9BX93
    Secondary Accessions:
    • B7ZL23
    • Q52LB2
    • Q96Q99

    Protein attributes for PLA2G12B Gene

    Size:
    195 amino acids
    Molecular mass:
    21659 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G12B Gene

Post-translational modifications for PLA2G12B Gene

No Post-translational modifications

Other Protein References for PLA2G12B Gene

No data available for DME Specific Peptides for PLA2G12B Gene

Domains & Families for PLA2G12B Gene

Gene Families for PLA2G12B Gene

Protein Domains for PLA2G12B Gene

Suggested Antigen Peptide Sequences for PLA2G12B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BX93

UniProtKB/Swiss-Prot:

PG12B_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12B: view

Function for PLA2G12B Gene

Molecular function for PLA2G12B Gene

UniProtKB/Swiss-Prot Function:
Not known; does not seem to have catalytic activity.

Gene Ontology (GO) - Molecular Function for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view
genes like me logo Genes that share phenotypes with PLA2G12B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G12B Gene

Localization for PLA2G12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G12B gene
Compartment Confidence
extracellular 5
lysosome 1

Gene Ontology (GO) - Cellular Components for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view

Pathways & Interactions for PLA2G12B Gene

genes like me logo Genes that share pathways with PLA2G12B: view

Gene Ontology (GO) - Biological Process for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0016042 lipid catabolic process IEA --
GO:0050482 arachidonic acid secretion IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view

No data available for SIGNOR curated interactions for PLA2G12B Gene

Drugs & Compounds for PLA2G12B Gene

(7) Drugs for PLA2G12B Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
arachidonic acid Experimental Nutra Activator 30
linoleic acid Pharma Full agonist, Agonist 0
calcium Nutra 0

(38) Additional Compounds for PLA2G12B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
LysoPC(16:1(9Z))
  • 1-Palmitoleoyl-glycero-3-phosphocholine
  • LPC(16:1)
  • LPC(16:1/0:0)
  • LPC(16:1n7/0:0)
  • LPC(16:1w7/0:0)

(5) Tocris Compounds for PLA2G12B Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9
genes like me logo Genes that share compounds with PLA2G12B: view

Transcripts for PLA2G12B Gene

mRNA/cDNA for PLA2G12B Gene

Unigene Clusters for PLA2G12B Gene

Phospholipase A2, group XIIB:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: -

Relevant External Links for PLA2G12B Gene

GeneLoc Exon Structure for
PLA2G12B
ECgene alternative splicing isoforms for
PLA2G12B

Expression for PLA2G12B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G12B Gene

This gene is overexpressed in Liver (x33.7), Small Intestine - Terminal Ileum (x8.1), and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for PLA2G12B Gene

This gene is overexpressed in Fetal Liver (52.0) and Fetal gut (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G12B Gene



Protein tissue co-expression partners for PLA2G12B Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2G12B Gene:

PLA2G12B

SOURCE GeneReport for Unigene cluster for PLA2G12B Gene:

Hs.333175

mRNA Expression by UniProt/SwissProt for PLA2G12B Gene:

Q9BX93-PG12B_HUMAN
Tissue specificity: Strong expression in liver, small intestine and kidney.

Evidence on tissue expression from TISSUES for PLA2G12B Gene

  • Liver(2.2)
genes like me logo Genes that share expression patterns with PLA2G12B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G12B Gene

Orthologs for PLA2G12B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G12B 34 35
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia PLA2G12B 34 35
  • 91.11 (n)
dog
(Canis familiaris)
Mammalia PLA2G12B 34 35
  • 90.21 (n)
rat
(Rattus norvegicus)
Mammalia Pla2g12b 34
  • 87.01 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2G12B 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g12b 34 16 35
  • 86.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G12B 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G12B 34 35
  • 73.2 (n)
lizard
(Anolis carolinensis)
Reptilia PLA2G12B 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g12b 34
  • 69.65 (n)
Str.8191 34
zebrafish
(Danio rerio)
Actinopterygii pla2g12b 34 35
  • 69.11 (n)
wufb26d02 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2894 34
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 35
  • 24 (a)
OneToMany
Species where no ortholog for PLA2G12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G12B Gene

ENSEMBL:
Gene Tree for PLA2G12B (if available)
TreeFam:
Gene Tree for PLA2G12B (if available)

Paralogs for PLA2G12B Gene

Paralogs for PLA2G12B Gene

(1) SIMAP similar genes for PLA2G12B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G12B: view

Variants for PLA2G12B Gene

Sequence variations from dbSNP and Humsavar for PLA2G12B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000379177 -- 72,938,138(+) AAGAA(A/G)GAAAG intron-variant
rs1000381886 -- 72,937,839(+) TTCAC(A/G)ATAAA intron-variant
rs1000490062 -- 72,945,413(+) GCCAA(C/T)AGCCA intron-variant
rs1000580585 -- 72,952,478(+) TCTGC(C/G)CTCCA intron-variant
rs1000841054 -- 72,944,957(+) TCTGG(C/T)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12B Gene

Variant ID Type Subtype PubMed ID
esv2656992 CNV deletion 23128226
esv3623806 CNV loss 21293372
esv3623807 CNV loss 21293372
nsv528473 CNV gain 19592680

Variation tolerance for PLA2G12B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G12B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G12B Gene

Disorders for PLA2G12B Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G12B Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G12B

Genetic Association Database (GAD)
PLA2G12B
Human Genome Epidemiology (HuGE) Navigator
PLA2G12B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G12B
genes like me logo Genes that share disorders with PLA2G12B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G12B Gene

Publications for PLA2G12B Gene

  1. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PMID: 19817957) Segat L. … Crovella S. (J. Gastroenterol. Hepatol. 2009) 3 46 64
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. (PMID: 14516201) Rouault M. … Lambeau G. (Biochemistry 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for PLA2G12B Gene

Sources for PLA2G12B Gene

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