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Aliases for PLA2G12B Gene

Aliases for PLA2G12B Gene

  • Phospholipase A2, Group XIIB 2 3
  • Group XIII Secretory Phospholipase A2-Like Protein 3 4
  • Phospholipase A2, Group XIII 2 3
  • SPLA2-GXIIB 3 4
  • PLA2G13 3 4
  • GXIIB 3 4
  • Group XIII Secreted Phospholipase A2 3
  • GXIII SPLA2-Like 4
  • GXIIIsPLA2 3
  • FKSG71 3

External Ids for PLA2G12B Gene

Previous HGNC Symbols for PLA2G12B Gene

  • PLA2G13

Previous GeneCards Identifiers for PLA2G12B Gene

  • GC10M074039
  • GC10M074364
  • GC10M074694
  • GC10M068688

Summaries for PLA2G12B Gene

Entrez Gene Summary for PLA2G12B Gene

  • Phospholipase A2 (PLA2) enzymes catalyze hydrolysis of glycolipids to release free fatty acids and lysophospholipids. PLA2G12B belongs to the PLA2 family, but it is catalytically inactive due to an amino acid change in its active site and has altered phospholipid-binding properties (Rouault et al., 2003 [PubMed 14516201]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLA2G12B Gene

PLA2G12B (Phospholipase A2, Group XIIB) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G12A.

UniProtKB/Swiss-Prot for PLA2G12B Gene

  • Not known; does not seem to have catalytic activity

Tocris Summary for PLA2G12B Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G12B Gene

Genomics for PLA2G12B Gene

Regulatory Elements for PLA2G12B Gene

Genomic Location for PLA2G12B Gene

Chromosome:
10
Start:
72,935,170 bp from pter
End:
72,954,883 bp from pter
Size:
19,714 bases
Orientation:
Minus strand

Genomic View for PLA2G12B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA2G12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12B Gene

Proteins for PLA2G12B Gene

  • Protein details for PLA2G12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX93-PG12B_HUMAN
    Recommended name:
    Group XIIB secretory phospholipase A2-like protein
    Protein Accession:
    Q9BX93
    Secondary Accessions:
    • B7ZL23
    • Q52LB2
    • Q96Q99

    Protein attributes for PLA2G12B Gene

    Size:
    195 amino acids
    Molecular mass:
    21659 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA2G12B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA2G12B Gene

Proteomics data for PLA2G12B Gene at MOPED

Post-translational modifications for PLA2G12B Gene

No Post-translational modifications

Other Protein References for PLA2G12B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PLA2G12B Gene

Domains & Families for PLA2G12B Gene

Gene Families for PLA2G12B Gene

Protein Domains for PLA2G12B Gene

Suggested Antigen Peptide Sequences for PLA2G12B Gene

Graphical View of Domain Structure for InterPro Entry

Q9BX93

UniProtKB/Swiss-Prot:

PG12B_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12B: view

Function for PLA2G12B Gene

Molecular function for PLA2G12B Gene

UniProtKB/Swiss-Prot Function:
Not known; does not seem to have catalytic activity

Gene Ontology (GO) - Molecular Function for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity IEA --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view

Phenotypes for PLA2G12B Gene

genes like me logo Genes that share phenotypes with PLA2G12B: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G12B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLA2G12B Gene

Localization for PLA2G12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA2G12B Gene COMPARTMENTS Subcellular localization image for PLA2G12B gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view

Pathways & Interactions for PLA2G12B Gene

genes like me logo Genes that share pathways with PLA2G12B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PLA2G12B Gene

Gene Ontology (GO) - Biological Process for PLA2G12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016042 lipid catabolic process IEA --
GO:0042632 cholesterol homeostasis IEA --
GO:0070328 triglyceride homeostasis IEA --
genes like me logo Genes that share ontologies with PLA2G12B: view

No data available for SIGNOR curated interactions for PLA2G12B Gene

Drugs & Compounds for PLA2G12B Gene

(5) Drugs for PLA2G12B Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
arachidonic acid Experimental Nutra Potentiation, Activator 27
linoleic acid Pharma Channel blocker 0
Calcium Nutra 0
D609 Pharma PC-PLC inhibitor, Selective PC-PLC inhibitor 0

(40) Additional Compounds for PLA2G12B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
LysoPC(14:0)
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
LysoPC(14:1(9Z))
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)
LysoPC(15:0)
  • 1-Pentadecanoyl-glycero-3-phosphocholine
  • LPC(15:0)
  • LPC(15:0/0:0)
  • LyPC(15:0)
  • LyPC(15:0/0:0)
LysoPC(16:0)
  • 1-Palmitoyl-glycero-3-phosphocholine
  • 1-Palmitoyl-lysophosphatidylcholine
  • LPC(16:0)
  • LPC(16:0/0:0)
  • LyPC(16:0)
LysoPC(16:1(9Z))
  • 1-Palmitoleoyl-glycero-3-phosphocholine
  • LPC(16:1)
  • LPC(16:1/0:0)
  • LPC(16:1n7/0:0)
  • LPC(16:1w7/0:0)
genes like me logo Genes that share compounds with PLA2G12B: view

Transcripts for PLA2G12B Gene

mRNA/cDNA for PLA2G12B Gene

Unigene Clusters for PLA2G12B Gene

Phospholipase A2, group XIIB:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA2G12B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c
SP1:
SP2:
SP3: -

Relevant External Links for PLA2G12B Gene

GeneLoc Exon Structure for
PLA2G12B
ECgene alternative splicing isoforms for
PLA2G12B

Expression for PLA2G12B Gene

mRNA expression in normal human tissues for PLA2G12B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA2G12B Gene

This gene is overexpressed in Liver (x33.7), Small Intestine - Terminal Ileum (x8.1), and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for PLA2G12B Gene

This gene is overexpressed in Fetal Liver (52.0) and Fetal gut (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G12B Gene



SOURCE GeneReport for Unigene cluster for PLA2G12B Gene Hs.333175

mRNA Expression by UniProt/SwissProt for PLA2G12B Gene

Q9BX93-PG12B_HUMAN
Tissue specificity: Strong expression in liver, small intestine and kidney.
genes like me logo Genes that share expression patterns with PLA2G12B: view

Protein tissue co-expression partners for PLA2G12B Gene

Primer Products

In Situ Assay Products

Orthologs for PLA2G12B Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA2G12B 35
  • 91.11 (n)
  • 92.31 (a)
PLA2G12B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA2G12B 35
  • 90.21 (n)
  • 95.36 (a)
PLA2G12B 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla2g12b 35
  • 86.5 (n)
  • 90.26 (a)
Pla2g12b 16
Pla2g12b 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA2G12B 35
  • 99.83 (n)
  • 100 (a)
PLA2G12B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla2g12b 35
  • 87.01 (n)
  • 90.77 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA2G12B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA2G12B 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G12B 35
  • 73.2 (n)
  • 77.84 (a)
PLA2G12B 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA2G12B 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g12b 35
  • 69.65 (n)
  • 75.26 (a)
Str.8191 35
zebrafish
(Danio rerio)
Actinopterygii pla2g12b 35
  • 69.11 (n)
  • 70.73 (a)
wufb26d02 35
pla2g12b 36
  • 51 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2894 35
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 36
  • 24 (a)
OneToMany
Species with no ortholog for PLA2G12B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G12B Gene

ENSEMBL:
Gene Tree for PLA2G12B (if available)
TreeFam:
Gene Tree for PLA2G12B (if available)

Paralogs for PLA2G12B Gene

Paralogs for PLA2G12B Gene

(1) SIMAP similar genes for PLA2G12B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PLA2G12B: view

Variants for PLA2G12B Gene

Sequence variations from dbSNP and Humsavar for PLA2G12B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs2452329 -- 72,940,081(+) CTCTG(C/T)AGAAA intron-variant
rs2461917 -- 72,935,529(-) CATTC(A/G)TTCTT utr-variant-3-prime
rs3829126 -- 72,954,419(+) CTGGG(G/T)CTGTC intron-variant
rs7070407 -- 72,955,950(+) ATCAC(C/G)AGTCT upstream-variant-2KB
rs7072218 -- 72,938,127(+) aaaaa(A/G)aaaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12B Gene

Variant ID Type Subtype PubMed ID
nsv528473 CNV Gain 19592680
esv2656992 CNV Deletion 23128226

Variation tolerance for PLA2G12B Gene

Residual Variation Intolerance Score: 28.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G12B Gene

HapMap Linkage Disequilibrium report
PLA2G12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G12B Gene

Disorders for PLA2G12B Gene

Relevant External Links for PLA2G12B

Genetic Association Database (GAD)
PLA2G12B
Human Genome Epidemiology (HuGE) Navigator
PLA2G12B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G12B
genes like me logo Genes that share disorders with PLA2G12B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA2G12B Gene

Publications for PLA2G12B Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients. (PMID: 19817957) Segat L. … Crovella S. (J. Gastroenterol. Hepatol. 2009) 67
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 67
  5. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PMID: 12486725) Kurz M. … Kramer W. (Proteins 2003) 26

Products for PLA2G12B Gene

Sources for PLA2G12B Gene

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