Aliases for PLA2G12B Gene
External Ids for PLA2G12B Gene
Previous HGNC Symbols for PLA2G12B Gene
Previous GeneCards Identifiers for PLA2G12B Gene
Phospholipase A2 (PLA2) enzymes catalyze hydrolysis of glycolipids to release free fatty acids and lysophospholipids. PLA2G12B belongs to the PLA2 family, but it is catalytically inactive due to an amino acid change in its active site and has altered phospholipid-binding properties (Rouault et al., 2003 [PubMed 14516201]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PLA2G12B Gene
PLA2G12B (Phospholipase A2, Group XIIB) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include calcium ion binding and phospholipase A2 activity. An important paralog of this gene is PLA2G12A.
UniProtKB/Swiss-Prot for PLA2G12B Gene
Not known; does not seem to have catalytic activity
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.