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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PLA2G12A Gene

protein-coding   GIFtS: 59
GCID: GC04M110631

Phospholipase A2, Group XIIA

(Previous names: phospholipase A2, group XII)
(Previous symbol: PLA2G12)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phospholipase A2, Group XIIA1 2     ROSSY2 5
PLA2G121 2 3     Phospholipase A2, Group XII1
Phosphatidylcholine 2-Acylhydrolase 12A2 3     Group XII Secreted Phospholipase A22
GXII SPLA22 3     Group XIIA Secreted Phospholipase A22
sPLA2-XII2 3     Group XIIA Secretory Phospholipase A22
GXII2 5     EC 3.1.1.43

External Ids:    HGNC: 185541   Entrez Gene: 815792   Ensembl: ENSG000001237397   OMIM: 6116525   UniProtKB: Q9BZM13   

Export aliases for PLA2G12A gene to outside databases

Previous GC identifers: GC04M111093 GC04M110992 GC04M110854 GC04M106364


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PLA2G12A Gene:
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of
eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have
relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al.,
2000 (PubMed 11031251)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PLA2G12A Gene: 
PLA2G12A (phospholipase A2, group XIIA) is a protein-coding gene. Diseases associated with PLA2G12A include toxoplasmosis, and alcohol dependence, and among its related super-pathways are Acyl chain remodelling of PC and Glycerophospholipid biosynthesis. GO annotations related to this gene include calcium-dependent phospholipase A2 activity and calcium ion binding. An important paralog of this gene is PLA2G12B.

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not
exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or
-phosphatidylethanolamine

summary for PLA2G12A Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PLA2G12A gene promoter:
         USF1   ATF-2   FOXO3   Evi-1   C/EBPalpha   FOXO3b   POU2F1   USF-1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G12A promoter sequence
   Search SABiosciences Chromatin IP Primers for PLA2G12A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PLA2G12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

PLA2G12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G12A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M110631:  view genomic region     (about GC identifiers)

Start:
110,631,145 bp from pter      End:
110,651,242 bp from pter
Size:
20,098 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1 (See protein sequence)
Recommended Name: Group XIIA secretory phospholipase A2 precursor  
Size: 189 amino acids; 21067 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Secreted. Cytoplasm
Mass spectrometry: Mass=18702.6; Mass_error=0.5; Method=MALDI; Range=22-189; Source=PubMed:11031251;
Secondary accessions: Q9BZ89

Explore the universe of human proteins at neXtProt for PLA2G12A: NX_Q9BZM1

Explore proteomics data for PLA2G12A at MOPED 

PLA2G12A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

PLA2G12A Protein Expression

REFSEQ proteins: NP_110448.2  
ENSEMBL proteins: 
 ENSP00000243501   ENSP00000425274   ENSP00000424021  
Reactome Protein details: Q9BZM1
Human Recombinant Protein Products for PLA2G12A: 
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ProSpec Recombinant Protein for PLA2G12A
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005622intracellular ----
GO:0005783endoplasmic reticulum IEA--
GO:0005794Golgi apparatus IEA--

PLA2G12A for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
IUPHAR Guide to PHARMACOLOGY protein family classification: sPLA2-12A 
Phospholipase A2

3 InterPro protein domains:
 IPR010711 PLipase_A2_secretory_G12
 IPR016090 PLipase_A2_dom
 IPR013090 PLipase_A2_AS

Graphical View of Domain Structure for InterPro Entry Q9BZM1

ProtoNet protein and cluster: Q9BZM1

1 Blocks protein domain: IPB010711 Group XII secretory phospholipase A2

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1
Similarity: Belongs to the phospholipase A2 family


PLA2G12A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PG12A_HUMAN, Q9BZM1
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not
exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or
-phosphatidylethanolamine
Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

     Enzyme Number (IUBMB): EC 3.1.1.41

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004623phospholipase A2 activity ----
GO:0005509calcium ion binding IEA--
GO:0047498calcium-dependent phospholipase A2 activity NAS11031251
     
PLA2G12A for ontologies           About GeneDecksing


Animal Models:
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miRNA
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SwitchGear 3'UTR luciferase reporter plasmidPLA2G12A 3' UTR sequence
Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G12A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for PLA2G12A About   (see all 17)                                                                                              See pathways by source

SuperPathContained pathways About
1Acyl chain remodelling of PE
Acyl chain remodelling of PE0.85
Acyl chain remodelling of PG0.62
Acyl chain remodelling of PC0.85
Ether lipid metabolism0.46
Acyl chain remodelling of PS0.74
Synthesis of PA0.41
Acyl chain remodelling of PI0.65
2Glycerophospholipid biosynthesis
Glycerophospholipid biosynthesis0.64
Glycerophospholipid metabolism0.62
Phospholipid metabolism0.64
3Metabolism
Metabolism0.40
Metabolism of lipids and lipoproteins0.34
Metabolic pathways0.40
4Linoleic acid metabolism
Linoleic acid metabolism0.57
alpha-Linolenic acid metabolism0.57
5Activation of cAMP-Dependent PKA
cAMP Pathway0.77

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for PLA2G12A
    Immune response CD16 signaling in NK cells

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PLA2G12A (see all 7)
    Chemokine Signaling
DHA Signaling
Antioxidant Action of Vitamin-C
cAMP Pathway
Phospholipase-C Pathway

1 GeneGo (Thomson Reuters) Pathway for PLA2G12A
    Immune response CD16 signaling in NK cells

1 BioSystems Pathway for PLA2G12A
    phospholipases

5/10        Reactome Pathways for PLA2G12A (see all 10)
    Acyl chain remodelling of PE
Synthesis of PA
Metabolism
Acyl chain remodelling of PC
Acyl chain remodelling of PG


5/9         Kegg Pathways  (Kegg details for PLA2G12A) (see all 9):
    Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism


PLA2G12A for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PLA2G12A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/77 Interacting proteins for PLA2G12A (ENSP000002435014) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
InteractantInteraction Details
GeneCardExternal ID(s)
FADS2ENSP000002788404STRING: ENSP00000278840
LYPLA1ENSP000003200434STRING: ENSP00000320043
PLA2G7ENSP000002747934STRING: ENSP00000274793
PLB1ENSP000003304424STRING: ENSP00000330442
PTDSS2ENSP000003082584STRING: ENSP00000308258
About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006644phospholipid metabolic process TAS--
GO:0006654phosphatidic acid biosynthetic process TAS--
GO:0008150biological_process ND--
GO:0016042lipid catabolic process IEA--
GO:0036148phosphatidylglycerol acyl-chain remodeling TAS--

PLA2G12A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for PLA2G12A:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Compounds for PLA2G12A available from Tocris Bioscience    About this table
CompoundAction CAS #
FIPIPhospholipase D inhibitor[939055-18-2]
m-3M3FBSPhospholipase C activator[200933-14-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
D609Selective PC-PLC inhibitor[83373-60-8]

10/2140 HMDB Compounds for PLA2G12A (see all 2140)    About this table
CompoundSynonyms CAS #PubMed Ids
PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
Arachidic acidArachate (see all 10)506-30-9--
Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
CalciumCa (see all 2)7440-70-2--
Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--

Search CenterWatch for drugs/clinical trials and news about PLA2G12A / PG12A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PLA2G12A gene: 
NM_030821.4  

Unigene Cluster for PLA2G12A:

Phospholipase A2, group XIIA
Hs.389452  [show with all ESTs]
Unigene Representative Sequence: NM_030821
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000243501(uc003hzp.3 uc010img.3) ENST00000502283 ENST00000507961
ENST00000502772
miRNA
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hsa-miR-1178 hsa-miR-1258 hsa-miR-500a hsa-miR-515-5p hsa-miR-1323 hsa-miR-501-5p hsa-miR-7-1* hsa-miR-891b
SwitchGear 3'UTR luciferase reporter plasmidPLA2G12A 3' UTR sequence
Inhib. RNA
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Clone
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GenScript: all cDNA clones in your preferred vector: PLA2G12A (NM_030821)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G12A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G12A
Sirion Biotech Customized lentivirus for stable overexpression of PLA2G12A 
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PLA2G12A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLA2G12A

Additional mRNA sequence: 

AF306567.1 AF332892.1 AK075389.1 AK313081.1 AY359024.1 BC017218.2 

13 DOTS entries:

DT.446121  DT.97841910  DT.109599  DT.101983900  DT.410754  DT.95115200  DT.100767448  DT.99934299 
DT.121269731  DT.100833473  DT.100707334  DT.101959848  DT.97820352 

24/436 AceView cDNA sequences (see all 436):

F11345 AU141634 AY359024 BC004460 BE045840 AA649828 BP344820 AI366754 
BG676262 CA950903 BM790222 BM787437 N56056 BE764579 BM837197 CR618232 
BP344737 BM312456 AF306567 AW891114 AF332892 CR621106 BX444550 CR610634 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12A (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:                                -                                       
SP2:                          -     -                                       
SP3:                                -     -                                 
SP4:                                -           -                           
SP5:                                                                        


ECgene alternative splicing isoforms for PLA2G12A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PLA2G12A expression in normal human tissues (normalized intensities)      PLA2G12A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACAAATGTCA
PLA2G12A Expression
About this image


PLA2G12A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/21 selected tissues (see all 21) fully expand
 
 Brain (Nervous System)    fully expand to see all 5 entries
         Cerebral Cortex
         ganglion/cranial   
 
 Heart (Cardiovascular System)    fully expand to see all 3 entries
         heart/ventricle   
 
 Nose (Sensory Organs)    fully expand to see all 2 entries
         sensory organ/nose/nasal cavity   
 
 Limb (Muscoskeletal System)    fully expand to see all 2 entries
         limb/hindlimb   
 
 Peripheral Nervous System (Nervous System)
         spinal/ganglion/dorsal root ganglion   

See PLA2G12A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PLA2G12A

SOURCE GeneReport for Unigene cluster: Hs.389452

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1
Tissue specificity: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas

    SABiosciences Expression via Pathway-Focused PCR Arrays including PLA2G12A: 
          VEGF Signaling in human mouse rat
          Hepatotoxicity in human mouse rat

Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PLA2G12A
In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G12A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12A gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pla2g12a1 , 5 phospholipase A2, group XIIA1, 5 83.99(n)1
93.3(a)1
  3 (59.40 cM)5
663501  NM_023196.31  NP_075685.21 
 1298786225 
chicken
(Gallus gallus)
Aves PLA2G12A1 phospholipase A2, group XIIA 76.37(n)
80.77(a)
  772082  XM_001235269.2  XP_001235270.2 
lizard
(Anolis carolinensis)
Reptilia PLA2G12A6
phospholipase A2, group XIIA
71(a)
1 ↔ 1
5(144431957-144443744)
African clawed frog
(Xenopus laevis)
Amphibia Xl.319282 Xenopus laevis transcribed sequence with weak similarity more 76.99(n)    AW639634.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.202712 Danio rerio, clone IMAGE5602294, mRNA, partial cds 73.82(n)    BC046040.1 
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA26
GXIVsPLA2
23(a)
1 → many
3L(15948196-15949565)


ENSEMBL Gene Tree for PLA2G12A (if available)
TreeFam Gene Tree for PLA2G12A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for PLA2G12A gene
PLA2G12B2  
1 SIMAP similar gene for PLA2G12A using alignment to 3 protein entries:     PG12A_HUMAN (see all proteins):
PLA2G12B

PLA2G12A for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for PLA2G12A
PGOHUM00000242902 PGOHUM00000248570 PGOHUM00000244721 PGOHUM00000245221


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/422 SNPs in PLA2G12A are shown (see all 422)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs751218451,2
C,F--110447985(+) AGTTCC/TAGCCC 1 -- us2k11Minor allele frequency- T:0.06WA 118
rs1807824331,2
--110630659(+) TTGCCA/CTCATA 1 -- ds50010--------
rs1843208051,2
--110630665(+) TCATAG/TCTCAA 1 -- ds50010--------
rs1394995431,2
C--110630673(+) CAATCA/GTGTCT 1 -- ds50010--------
rs1896884071,2
--110630722(+) AATAAA/GCAGCC 1 -- ds50010--------
rs764997251,2
F--110630771(+) GGAGAT/CAGGCA 1 -- ds50011Minor allele frequency- C:0.02EA 120
rs1817372061,2
--110630904(+) AATTCC/TACAAC 1 -- ds50010--------
rs1497225951,2
--110630919(+) AAATTC/TTGGTC 1 -- ds50010--------
rs1868636101,2
C--110631071(+) TGTTAC/TGGAAA 1 -- ds50010--------
rs1455564511,2
--110631180(+) TTTTCA/GTATAC 1 -- ut310--------

HapMap Linkage Disequilibrium report for PLA2G12A (110631145 - 110651242 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PLA2G12A:    About this table     
Variant IDTypeSubtypePubMed ID
nsv4463CNV Loss18451855

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 611652    OMIM disorders: --

5 diseases for PLA2G12A:    About MalaCards
toxoplasmosis    alcohol dependence    alcoholism    pancreatitis
neuronitis


PLA2G12A for disorders           About GeneDecksing

Genetic Association Database (GAD): PLA2G12A
Human Genome Epidemiology (HuGE) Navigator: PLA2G12A (5 documents)

Export disorders for PLA2G12A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for PLA2G12A gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with PLA2G12A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. (PubMed id 11031251)1, 2, 3 Gelb M.H.... Lambeau G. (2000)
  2. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
  3. Genetic variants near TIMP3 and high-density lipoprot ein-associated loci influence susceptibility to age-related macular degeneratio n. (PubMed id 20385819)1, 4 Chen W....Swaroop A. (2010)
  4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  5. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII). (PubMed id 12522102)1, 2 Murakami M.... Kudo I. (2003)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  9. Common variants near FRK/COL10A1 and VEGFA are associ ated with advanced age-related macular degeneration. (PubMed id 21665990)4 Yu Y....Seddon J.M. (2011)
  10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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  Query String
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NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 81579 HGNC: 18554 AceView: IFandCASP6andPLA2G12A Ensembl:ENSG00000123739 euGenes: HUgn81579
ECgene: PLA2G12A Kegg: 81579 H-InvDB: PLA2G12A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for PLA2G12A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for PLA2G12A gene:
Search GeneIP for patents involving PLA2G12A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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