Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



PLA2G12A Gene

protein-coding   GIFtS: 59
GCID: GC04M110631

Phospholipase A2, Group XIIA

(Previous names: phospholipase A2, group XII)
(Previous symbol: PLA2G12)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Phospholipase A2, Group XIIA1 2     ROSSY2 5
PLA2G121 2 3     Phospholipase A2, Group XII1
Phosphatidylcholine 2-Acylhydrolase 12A2 3     Group XII Secreted Phospholipase A22
GXII SPLA22 3     Group XIIA Secreted Phospholipase A22
sPLA2-XII2 3     Group XIIA Secretory Phospholipase A22
GXII2 5     EC 3.1.1.43

External Ids:    HGNC: 185541   Entrez Gene: 815792   Ensembl: ENSG000001237397   OMIM: 6116525   UniProtKB: Q9BZM13   

Export aliases for PLA2G12A gene to outside databases

Previous GC identifers: GC04M111093 GC04M110992 GC04M110854 GC04M106364


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for PLA2G12A Gene:
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of
eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have
relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al.,
2000 (PubMed 11031251)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PLA2G12A Gene:
PLA2G12A (phospholipase A2, group XIIA) is a protein-coding gene. GO annotations related to this gene include calcium-dependent phospholipase A2 activity and calcium ion binding. An important paralog of this gene is PLA2G12B.

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not
exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or
-phosphatidylethanolamine

summary for PLA2G12A Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G12A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2G12A gene promoter:
         USF1   ATF-2   FOXO3   Evi-1   C/EBPalpha   FOXO3b   POU2F1   USF-1   POU2F1a   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G12A promoter sequence
   Search Chromatin IP Primers for PLA2G12A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G12A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

PLA2G12A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G12A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M110631:  view genomic region     (about GC identifiers)

Start:
110,631,145 bp from pter      End:
110,651,242 bp from pter
Size:
20,098 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1 (See protein sequence)
Recommended Name: Group XIIA secretory phospholipase A2 precursor  
Size: 189 amino acids; 21067 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Mass spectrometry: Mass=18702.6; Mass_error=0.5; Method=MALDI; Range=22-189; Source=PubMed:11031251;
Secondary accessions: Q9BZ89

Explore the universe of human proteins at neXtProt for PLA2G12A: NX_Q9BZM1

Explore proteomics data for PLA2G12A at MOPED


See PLA2G12A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_110448.2  
ENSEMBL proteins: 
 ENSP00000243501   ENSP00000425274   ENSP00000424021  
Reactome Protein details: Q9BZM1

PLA2G12A Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for PLA2G12A
OriGene Protein Over-expression Lysate for PLA2G12A
OriGene MassSpec for PLA2G12A
OriGene Custom Protein Services for PLA2G12A
GenScript Custom Purified and Recombinant Proteins Services for PLA2G12A
Novus Biologicals PLA2G12A Proteins
Novus Biologicals PLA2G12A Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for PLA2G12A
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for PLA2G12A 

 
antibodies-online proteins for PLA2G12A (6 products) 

 
antibodies-online peptides for PLA2G12A

PLA2G12A Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for PLA2G12A
OriGene Custom Antibody Services for PLA2G12A
Novus Biologicals PLA2G12A Antibodies
Abcam antibodies for PLA2G12A
Browse Antibodies at Cloud-Clone Corp.
ThermoFisher Antibodies for PLA2G12A
antibodies-online antibodies for PLA2G12A (21 products) 

PLA2G12A Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for PLA2G12A
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for PLA2G12A
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.
Search eBioscience for ELISAs for PLA2G12A 
antibodies-online kits for PLA2G12A (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
IUPHAR Guide to PHARMACOLOGY protein family classification: sPLA2-12A
Phospholipase A2

3 InterPro protein domains:
 IPR010711 PLipase_A2_secretory_G12
 IPR016090 PLipase_A2_dom
 IPR013090 PLipase_A2_AS

Graphical View of Domain Structure for InterPro Entry Q9BZM1

ProtoNet protein and cluster: Q9BZM1

1 Blocks protein domain: IPB010711 Group XII secretory phospholipase A2

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1
Similarity: Belongs to the phospholipase A2 family


Find genes that share domains with PLA2G12A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: PG12A_HUMAN, Q9BZM1
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not
exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or
-phosphatidylethanolamine
Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

     Enzyme Number (IUBMB): EC 3.1.1.41

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004623phospholipase A2 activity ----
GO:0005509calcium ion binding IEA--
GO:0047498calcium-dependent phospholipase A2 activity NAS11031251
     
Find genes that share ontologies with PLA2G12A           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for PLA2G12A

miRNA
Products:
    
miRTarBase miRNAs that target PLA2G12A:
hsa-mir-92b-3p (MIRT040676)

Block miRNA regulation of human, mouse, rat PLA2G12A using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate PLA2G12A (see all 22):
hsa-miR-1178 hsa-miR-1258 hsa-miR-500a hsa-miR-515-5p hsa-miR-1323 hsa-miR-501-5p hsa-miR-7-1* hsa-miR-891b
SwitchGear 3'UTR luciferase reporter plasmidPLA2G12A 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for PLA2G12A
Predesigned siRNA for gene silencing in human, mouse, rat PLA2G12A

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for PLA2G12A

Clone
Products:
     
OriGene clones in human, mouse for PLA2G12A (see all 7)
OriGene ORF clones in mouse, rat for PLA2G12A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PLA2G12A (NM_030821)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G12A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G12A

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for PLA2G12A
Browse ESI BIO Cell Lines and PureStem Progenitors for PLA2G12A 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G12A


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
PG12A_HUMAN, Q9BZM1: Secreted. Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
endoplasmic reticulum2
golgi apparatus2

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005622intracellular ----
GO:0005783endoplasmic reticulum IEA--
GO:0005794Golgi apparatus IEA--

Find genes that share ontologies with PLA2G12A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for PLA2G12A About   (see all 17)  
See pathways by source

SuperPathContained pathways About
1Glycerophospholipid biosynthesis
Glycerophospholipid biosynthesis0.64
Synthesis of PA0.33
Phospholipid metabolism0.64
Acyl chain remodelling of PG0.00
Glycerophospholipid metabolism0.62
Acyl chain remodelling of PI0.00
2Acyl chain remodelling of PC
Acyl chain remodelling of PE0.85
Ether lipid metabolism0.48
Acyl chain remodelling of PC0.85
Acyl chain remodelling of PS0.00
3Metabolism
Metabolism0.38
Metabolism of lipids and lipoproteins0.37
Metabolic pathways0.38
4Arachidonic acid metabolism
Linoleic acid metabolism0.64
Arachidonic acid metabolism0.41
alpha-Linolenic acid metabolism0.64
5Activation of cAMP-Dependent PKA
cAMP Pathway0.77


Find genes that share SuperPaths with PLA2G12A           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLA2G12A (see all 7)
    Chemokine Signaling
DHA Signaling
Antioxidant Action of Vitamin-C
cAMP Pathway
Phospholipase-C Pathway

1 GeneGo (Thomson Reuters) Pathway for PLA2G12A
    Immune response CD16 signaling in NK cells

1 BioSystems Pathway for PLA2G12A
    phospholipases

Selected Reactome Pathways for PLA2G12A (see all 6)
    Acyl chain remodelling of PE
Acyl chain remodelling of PS
Synthesis of PA
Acyl chain remodelling of PC
Acyl chain remodelling of PG


Selected Kegg Pathways  (Kegg details for PLA2G12A) (see all 10):
    Glycerophospholipid metabolism
Ether lipid metabolism
Arachidonic acid metabolism
Linoleic acid metabolism
alpha-Linolenic acid metabolism

    Pathway & Disease-focused RT2 Profiler PCR Arrays including PLA2G12A: 
          VEGF Signaling in human mouse rat
          Hepatotoxicity in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for PLA2G12A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for PLA2G12A (ENSP000002435014) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
InteractantInteraction Details
GeneCardExternal ID(s)
FADS2ENSP000002788404STRING: ENSP00000278840
LYPLA1ENSP000003200434STRING: ENSP00000320043
PLA2G7ENSP000002747934STRING: ENSP00000274793
PLB1ENSP000003304424STRING: ENSP00000330442
PTDSS2ENSP000003082584STRING: ENSP00000308258
About this table

Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006644phospholipid metabolic process TAS--
GO:0006654phosphatidic acid biosynthetic process TAS--
GO:0008150biological_process ND--
GO:0016042lipid catabolic process IEA--
GO:0036148phosphatidylglycerol acyl-chain remodeling TAS--

Find genes that share ontologies with PLA2G12A           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for PLA2G12A available from Tocris Bioscience    About this table
CompoundAction CAS #
FIPIPhospholipase D inhibitor[939055-18-2]
m-3M3FBSPhospholipase C activator[200933-14-8]
Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
D609Selective PC-PLC inhibitor[83373-60-8]

Selected HMDB Compounds for PLA2G12A (see all 2140)    About this table
CompoundSynonyms CAS #PubMed Ids
PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
Arachidic acidArachate (see all 10)506-30-9--
Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
CalciumCa (see all 2)7440-70-2--
Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for PLA2G12A gene: 
NM_030821.4  

Unigene Cluster for PLA2G12A:

Phospholipase A2, group XIIA
Hs.389452  [show with all ESTs]
Unigene Representative Sequence: NM_030821
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000243501(uc003hzp.3 uc010img.3) ENST00000502283 ENST00000507961
ENST00000502772
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat PLA2G12A using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate PLA2G12A (see all 22):
hsa-miR-1178 hsa-miR-1258 hsa-miR-500a hsa-miR-515-5p hsa-miR-1323 hsa-miR-501-5p hsa-miR-7-1* hsa-miR-891b
SwitchGear 3'UTR luciferase reporter plasmidPLA2G12A 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for PLA2G12A
Predesigned siRNA for gene silencing in human, mouse, rat PLA2G12A
Clone
Products:
     
OriGene clones in human, mouse for PLA2G12A (see all 7)
OriGene ORF clones in mouse, rat for PLA2G12A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: PLA2G12A (NM_030821)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for PLA2G12A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G12A
Primer
Products:
    
OriGene qPCR primer pairs and template standards for PLA2G12A
OriGene qSTAR qPCR primer pairs in human, mouse for PLA2G12A
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLA2G12A
  QuantiTect SYBR Green Assays in human, mouse, rat PLA2G12A
  QuantiFast Probe-based Assays in human, mouse, rat PLA2G12A

Additional mRNA sequence: 

AF306567.1 AF332892.1 AK075389.1 AK313081.1 AY359024.1 BC017218.2 

13 DOTS entries:

DT.446121  DT.97841910  DT.109599  DT.101983900  DT.410754  DT.95115200  DT.100767448  DT.99934299 
DT.121269731  DT.100833473  DT.100707334  DT.101959848  DT.97820352 

Selected AceView cDNA sequences (see all 436):

AA235373 AW590231 AA894657 BM312765 AI032926 CR616049 BE464619 BF219751 
AU137617 AA649828 T70841 AA626261 AI366754 BX508790 AI218487 CR621106 
BM790222 BP344737 F11345 BM787437 BM837197 BP345788 AA205188 BM675240 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12A (see all 6)    About this scheme

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1:                                -                                       
SP2:                          -     -                                       
SP3:                                -     -                                 
SP4:                                -           -                           
SP5:                                                                        


ECgene alternative splicing isoforms for PLA2G12A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

PLA2G12A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ACAAATGTCA
PLA2G12A Expression
About this image


PLA2G12A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebral Cortex
 
 Thymus (Hematopoietic System)
         Thymus
 
 Kidney (Urinary System)
         Metanephros
 
 Neural Tube (Nervous System)
         Telencephalon
PLA2G12A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

PLA2G12A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.389452

UniProtKB/Swiss-Prot: PG12A_HUMAN, Q9BZM1
Tissue specificity: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas

    Pathway & Disease-focused RT2 Profiler PCR Arrays including PLA2G12A: 
          VEGF Signaling in human mouse rat
          Hepatotoxicity in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for PLA2G12A
OriGene qSTAR qPCR primer pairs in human, mouse for PLA2G12A
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLA2G12A
QuantiTect SYBR Green Assays in human, mouse, rat PLA2G12A
QuantiFast Probe-based Assays in human, mouse, rat PLA2G12A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G12A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12A gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Pla2g12a1 , 5 phospholipase A2, group XIIA1, 5 83.91(n)1
93.1(a)1
  3 (59.40 cM)5
663501  NM_023196.41  NP_075685.21 
 1298786225 
chicken
(Gallus gallus)
Aves PLA2G12A1 phospholipase A2, group XIIA 77.19(n)
81.29(a)
  772082  XM_001235269.3  XP_001235270.2 
lizard
(Anolis carolinensis)
Reptilia PLA2G12A6
phospholipase A2, group XIIA
70(a)
1 ↔ 1
5(144431957-144443744)
African clawed frog
(Xenopus laevis)
Amphibia Xl.319282 Xenopus laevis transcribed sequence with weak similarity more 76.99(n)    AW639634.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.202712 Danio rerio, clone IMAGE5602294, mRNA, partial cds 73.82(n)    BC046040.1 
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA26
GXIVsPLA2
22(a)
1 → many
3L(15948196-15949565)


ENSEMBL Gene Tree for PLA2G12A (if available)
TreeFam Gene Tree for PLA2G12A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for PLA2G12A gene
PLA2G12B2  
1 SIMAP similar gene for PLA2G12A using alignment to 3 protein entries:     PG12A_HUMAN (see all proteins):
PLA2G12B

Find genes that share paralogs with PLA2G12A           About GenesLikeMe


4 Pseudogenes.org Pseudogenes for PLA2G12A
PGOHUM00000242902 PGOHUM00000248570 PGOHUM00000244721 PGOHUM00000245221


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for PLA2G12A (see all 422)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs751218451,2
C,F--110447985(+) AGTTCC/TAGCCC 1 -- us2k11Minor allele frequency- T:0.06WA 118
rs1807824331,2
--110630659(+) TTGCCA/CTCATA 1 -- ds50010--------
rs1843208051,2
--110630665(+) TCATAG/TCTCAA 1 -- ds50010--------
rs1394995431,2
C--110630673(+) CAATCA/GTGTCT 1 -- ds50010--------
rs1896884071,2
--110630722(+) AATAAA/GCAGCC 1 -- ds50010--------
rs764997251,2
F--110630771(+) GGAGAT/CAGGCA 1 -- ds50011Minor allele frequency- C:0.02EA 120
rs1817372061,2
--110630904(+) AATTCC/TACAAC 1 -- ds50010--------
rs1497225951,2
--110630919(+) AAATTC/TTGGTC 1 -- ds50010--------
rs1868636101,2
C--110631071(+) TGTTAC/TGGAAA 1 -- ds50010--------
rs1455564511,2
--110631180(+) TTTTCA/GTATAC 1 -- ut310--------

HapMap Linkage Disequilibrium report for PLA2G12A (110631145 - 110651242 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for PLA2G12A:    About this table    
Variant IDTypeSubtypePubMed ID
nsv4463CNV Loss18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing PLA2G12A
DNA2.0 Custom Variant and Variant Library Synthesis for PLA2G12A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 611652    OMIM disorders: --


Find genes that share disorders with PLA2G12A           About GenesLikeMe

Genetic Association Database (GAD): PLA2G12A
Human Genome Epidemiology (HuGE) Navigator: PLA2G12A (5 documents)

Export disorders for PLA2G12A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for PLA2G12A gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with PLA2G12A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. (PubMed id 11031251)1, 2, 3 Gelb M.H.... Lambeau G. (J. Biol. Chem. 2000)
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
  3. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. (PubMed id 20385819)1, 4 Chen W....Swaroop A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII). (PubMed id 12522102)1, 2 Murakami M.... Kudo I. (J. Biol. Chem. 2003)
  8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
  9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
  10. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. (PubMed id 21665990)4 Yu Y....Seddon J.M. (Hum. Mol. Genet. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 81579 HGNC: 18554 AceView: IFandCASP6andPLA2G12A Ensembl:ENSG00000123739 euGenes: HUgn81579
ECgene: PLA2G12A Kegg: 81579 H-InvDB: PLA2G12A

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for PLA2G12A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for PLA2G12A gene:
Search GeneIP for patents involving PLA2G12A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for PLA2G12A   OriGene RNAi products in human, mouse, rat for PLA2G12A  
 OriGene qPCR primer pairs and template standards for PLA2G12A   OriGene Protein Over-expression Lysate for PLA2G12A  
 OriGene MassSpec for PLA2G12A   OriGene clones in human, mouse for PLA2G12A  
 OriGene qSTAR qPCR primer pairs in human, mouse for PLA2G12A   OriGene Purified Protein for PLA2G12A  
 OriGene ORF clones in mouse, rat for PLA2G12A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for PLA2G12A   OriGene Custom Protein Services for PLA2G12A  

 
 
 Block miRNA regulation of human, mouse, rat PLA2G12A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing PLA2G12A
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G12A Predesigned siRNA for gene silencing in human, mouse, rat PLA2G12A
 QuantiFast Probe-based Assays in human, mouse, rat PLA2G12A QuantiTect SYBR Green Assays in human, mouse, rat PLA2G12A
 PCR Arrays including human, mouse, rat PLA2G12A Search Chromatin IP Primers for PLA2G12A
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PLA2G12A  Search GeneGlobe Interaction Network for PLA2G12A
 Regulatory tfbs in PLA2G12A promoter
 GenScript Custom Purified and Recombinant Proteins Services for PLA2G12A GenScript cDNA clones with any tag delivered in your preferred vector for PLA2G12A
 GenScript Custom Assay Services for PLA2G12A GenScript Custom overexpressing Cell Line Services for PLA2G12A
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Tocris compounds for PLA2G12A
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 PLA2G12A antibodies
 PLA2G12A proteins
 PLA2G12A lysates
 Antibodies for PLA2G12A
 See all of Abcam's Antibodies, Kits and Proteins for PLA2G12A
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Recombinant Protein for PLA2G12A
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for PLA2G12A
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PLA2G12A
 SwitchGear 3'UTR luciferase reporter plasmids for PLA2G12A
 SwitchGear Promoter luciferase reporter plasmids for PLA2G12A
 ThermoFisher Antibodies for PLA2G12A
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PLA2G12A
 Browse compounds at ApexBio
 Search Addgene for plasmids for PLA2G12A
  Search eBioscience for proteins for PLA2G12A
  Search eBioscience for elisas for PLA2G12A
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for PLA2G12A
 antibodies-online antibodies for PLA2G12A (21 products)
 antibodies-online kits for PLA2G12A (4 products)
 antibodies-online peptides for PLA2G12A
 antibodies-online proteins for PLA2G12A (6 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      PLA2G12A gene at Home site.
Version: 3.12.258 10 Dec 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4