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Aliases for PLA2G12A Gene

Aliases for PLA2G12A Gene

  • Phospholipase A2 Group XIIA 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 12A 3 4
  • Phospholipase A2, Group XII 2 3
  • GXII SPLA2 3 4
  • SPLA2-XII 3 4
  • PLA2G12 3 4
  • Group XIIA Secretory Phospholipase A2 3
  • Group XIIA Secreted Phospholipase A2 3
  • Group XII Secreted Phospholipase A2 3
  • Phospholipase A2, Group XIIA 2
  • EC 3.1.1.4 4
  • ROSSY 3
  • GXII 3

External Ids for PLA2G12A Gene

Previous HGNC Symbols for PLA2G12A Gene

  • PLA2G12

Previous GeneCards Identifiers for PLA2G12A Gene

  • GC04M111093
  • GC04M110992
  • GC04M110854
  • GC04M110631
  • GC04M106364

Summaries for PLA2G12A Gene

Entrez Gene Summary for PLA2G12A Gene

  • Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PLA2G12A Gene

PLA2G12A (Phospholipase A2 Group XIIA) is a Protein Coding gene. Diseases associated with PLA2G12A include Macular Degeneration, Age-Related, 1. Among its related pathways are Linoleic acid metabolism and Vascular smooth muscle contraction. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipase A2 activity. An important paralog of this gene is PLA2G12B.

UniProtKB/Swiss-Prot for PLA2G12A Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Tocris Summary for PLA2G12A Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G12A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G12A Gene

Genomics for PLA2G12A Gene

Regulatory Elements for PLA2G12A Gene

Enhancers for PLA2G12A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G109701 1.6 FANTOM5 ENCODE dbSUPER 20 +27.1 27064 3.6 PKNOX1 AGO1 ARID4B SIN3A YBX1 FEZF1 ZNF2 ZNF766 FOS KLF13 PLA2G12A CASP6 RBMXP4 LRIT3 GC04M109692 GC04M109713
GH04G109727 1.3 ENCODE dbSUPER 22.4 +0.3 333 4.2 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 GTF3C2 PLA2G12A SEC24B SEC24B-AS1 CDC42P4 CFI SETP20 GAR1 CASP6
GH04G109734 1.2 ENCODE dbSUPER 18.8 -6.2 -6175 2.7 PKNOX1 ARNT YY1 TCF12 NCOA1 ZNF592 CREB3 SMARCA4 PBX2 NBN PLA2G12A CFI GAR1
GH04G109648 0.6 ENCODE 24 +80.4 80435 2.7 JUND NFIC ARID3A MTA2 NFIB JUNB ZNF507 PLA2G12A CASP6 HIGD1AP14 GC04P109564
GH04G109698 0.9 ENCODE dbSUPER 12.3 +30.4 30390 1.5 CTCF RNF2 SUZ12 CHD1 CBX2 RBBP5 ZIC2 ZNF664 HNF4A EZH2 PLA2G12A GAR1 GC04M109692 GC04M109713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PLA2G12A on UCSC Golden Path with GeneCards custom track

Promoters for PLA2G12A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000171848 386 2601 PKNOX1 ATF1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 GTF3C2 ZNF766 ZNF143

Genomic Location for PLA2G12A Gene

Chromosome:
4
Start:
109,709,989 bp from pter
End:
109,730,086 bp from pter
Size:
20,098 bases
Orientation:
Minus strand

Genomic View for PLA2G12A Gene

Genes around PLA2G12A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G12A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G12A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G12A Gene

Proteins for PLA2G12A Gene

  • Protein details for PLA2G12A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZM1-PG12A_HUMAN
    Recommended name:
    Group XIIA secretory phospholipase A2
    Protein Accession:
    Q9BZM1
    Secondary Accessions:
    • Q9BZ89

    Protein attributes for PLA2G12A Gene

    Size:
    189 amino acids
    Molecular mass:
    21067 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

neXtProt entry for PLA2G12A Gene

Post-translational modifications for PLA2G12A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PLA2G12A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G12A Gene

Domains & Families for PLA2G12A Gene

Gene Families for PLA2G12A Gene

Protein Domains for PLA2G12A Gene

Suggested Antigen Peptide Sequences for PLA2G12A Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZM1

UniProtKB/Swiss-Prot:

PG12A_HUMAN :
  • Belongs to the phospholipase A2 family.
Family:
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G12A: view

Function for PLA2G12A Gene

Molecular function for PLA2G12A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Enzyme Numbers (IUBMB) for PLA2G12A Gene

Gene Ontology (GO) - Molecular Function for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004623 phospholipase A2 activity TAS --
GO:0005509 calcium ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047498 calcium-dependent phospholipase A2 activity NAS 11031251
genes like me logo Genes that share ontologies with PLA2G12A: view

Phenotypes for PLA2G12A Gene

genes like me logo Genes that share phenotypes with PLA2G12A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G12A

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PLA2G12A Gene

Localization for PLA2G12A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G12A Gene

Secreted. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PLA2G12A gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with PLA2G12A: view

Pathways & Interactions for PLA2G12A Gene

genes like me logo Genes that share pathways with PLA2G12A: view

Interacting Proteins for PLA2G12A Gene

Gene Ontology (GO) - Biological Process for PLA2G12A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IEA --
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0008150 biological_process ND --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G12A: view

No data available for SIGNOR curated interactions for PLA2G12A Gene

Drugs & Compounds for PLA2G12A Gene

(11) Drugs for PLA2G12A Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(11) Additional Compounds for PLA2G12A Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2

(5) Tocris Compounds for PLA2G12A Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
U 73343 Analog of U 73122 (Cat. No. 1268) 142878-12-4
VU 0155069 Potent and selective PLD1 inhibitor 1130067-06-9
VU 0364739 hydrochloride Potent and selective PLD2 inhibitor 1244640-48-9
genes like me logo Genes that share compounds with PLA2G12A: view

Transcripts for PLA2G12A Gene

Unigene Clusters for PLA2G12A Gene

Phospholipase A2, group XIIA:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G12A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6: - - -

Relevant External Links for PLA2G12A Gene

GeneLoc Exon Structure for
PLA2G12A
ECgene alternative splicing isoforms for
PLA2G12A

Expression for PLA2G12A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PLA2G12A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PLA2G12A Gene

This gene is overexpressed in Liver (38.7), Peripheral blood mononuclear cells (12.6), and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PLA2G12A Gene



Protein tissue co-expression partners for PLA2G12A Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA2G12A Gene:

PLA2G12A

SOURCE GeneReport for Unigene cluster for PLA2G12A Gene:

Hs.389452

mRNA Expression by UniProt/SwissProt for PLA2G12A Gene:

Q9BZM1-PG12A_HUMAN
Tissue specificity: Abundantly expressed in heart, skeletal muscle, kidney, liver and pancreas.

Evidence on tissue expression from TISSUES for PLA2G12A Gene

  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with PLA2G12A: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PLA2G12A Gene

Orthologs for PLA2G12A Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G12A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA2G12A 34 35
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia PLA2G12A 34
  • 93.65 (n)
cow
(Bos Taurus)
Mammalia PLA2G12A 34 35
  • 90.53 (n)
mouse
(Mus musculus)
Mammalia Pla2g12a 34 16 35
  • 83.91 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA2G12A 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA2G12A 34 35
  • 77.19 (n)
lizard
(Anolis carolinensis)
Reptilia PLA2G12A 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pla2g12a 34
  • 73.96 (n)
Str.4030 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.31928 34
zebrafish
(Danio rerio)
Actinopterygii pla2g12a 34 35
  • 65.46 (n)
Dr.20271 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10570 34
fruit fly
(Drosophila melanogaster)
Insecta GXIVsPLA2 35
  • 22 (a)
OneToMany
Species where no ortholog for PLA2G12A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA2G12A Gene

ENSEMBL:
Gene Tree for PLA2G12A (if available)
TreeFam:
Gene Tree for PLA2G12A (if available)

Paralogs for PLA2G12A Gene

Paralogs for PLA2G12A Gene

(1) SIMAP similar genes for PLA2G12A Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PLA2G12A Gene

genes like me logo Genes that share paralogs with PLA2G12A: view

Variants for PLA2G12A Gene

Sequence variations from dbSNP and Humsavar for PLA2G12A Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000067548 -- 109,711,432(+) GAGCA(C/T)CTTGT utr-variant-3-prime
rs1000161169 -- 109,718,584(+) CTAAA(G/T)TATTT intron-variant
rs1000179770 -- 109,712,775(+) ATAGG(C/T)GTGAG utr-variant-3-prime
rs10004377 -- 109,726,968(+) CTTTC(G/T)TGCAA intron-variant
rs1000548245 -- 109,731,722(+) TACCA(-/C)AATGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PLA2G12A Gene

Variant ID Type Subtype PubMed ID
esv3569652 CNV loss 25503493
nsv4463 CNV deletion 18451855
nsv595142 CNV loss 21841781
nsv950375 CNV deletion 24416366

Variation tolerance for PLA2G12A Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G12A Gene

Human Gene Mutation Database (HGMD)
PLA2G12A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA2G12A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G12A Gene

Disorders for PLA2G12A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PLA2G12A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
macular degeneration, age-related, 1
  • macular degeneration, age-related, reduced risk of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G12A

Genetic Association Database (GAD)
PLA2G12A
Human Genome Epidemiology (HuGE) Navigator
PLA2G12A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA2G12A
genes like me logo Genes that share disorders with PLA2G12A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G12A Gene

Publications for PLA2G12A Gene

  1. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. (PMID: 11031251) Gelb M.H. … Lambeau G. (J. Biol. Chem. 2000) 2 3 4 64
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 64
  3. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. (PMID: 20385819) Chen W. … Swaroop A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64

Products for PLA2G12A Gene

Sources for PLA2G12A Gene

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