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Aliases for PLA2G10 Gene

Aliases for PLA2G10 Gene

  • Phospholipase A2 Group X 2 3 5
  • Phosphatidylcholine 2-Acylhydrolase 10 3 4
  • Group X Secretory Phospholipase A2 3 4
  • Phospholipase A2, Group X 2 3
  • SPLA2-X 3 4
  • EC 4
  • GX SPLA2 4
  • GXSPLA2 3
  • GXPLA2 3
  • SPLA2 3

External Ids for PLA2G10 Gene

Previous GeneCards Identifiers for PLA2G10 Gene

  • GC16M014715
  • GC16P017772
  • GC16M014732
  • GC16M014673
  • GC16M014767

Summaries for PLA2G10 Gene

Entrez Gene Summary for PLA2G10 Gene

  • This gene encodes a member of the phospholipase A2 family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This calcium-dependent enzyme hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids. In one example, this enzyme catalyzes the release of arachidonic acid from cell membrane phospholipids, thus playing a role in the production of various inflammatory lipid mediators, such as prostaglandins. The encoded protein may promote the survival of breast cancer cells through its role in lipid metabolism. [provided by RefSeq, Nov 2015]

GeneCards Summary for PLA2G10 Gene

PLA2G10 (Phospholipase A2 Group X) is a Protein Coding gene. Diseases associated with PLA2G10 include Acute Chest Syndrome and Potter's Syndrome. Among its related pathways are Linoleic acid metabolism and Pancreatic secretion. GO annotations related to this gene include calcium ion binding and phospholipase activity. An important paralog of this gene is PLA2G2C.

UniProtKB/Swiss-Prot for PLA2G10 Gene

  • PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.

Tocris Summary for PLA2G10 Gene

  • Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic molecules. There are four major classes; phospholipase A, phospholipase B, phosphoinositide-specific phospholipase C and phospholipase D.

Gene Wiki entry for PLA2G10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA2G10 Gene

Genomics for PLA2G10 Gene

Regulatory Elements for PLA2G10 Gene

Enhancers for PLA2G10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA2G10 on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA2G10 Gene

14,672,545 bp from pter
14,694,669 bp from pter
22,125 bases
Minus strand

Genomic View for PLA2G10 Gene

Genes around PLA2G10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA2G10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA2G10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA2G10 Gene

Proteins for PLA2G10 Gene

  • Protein details for PLA2G10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Group 10 secretory phospholipase A2
    Protein Accession:
    Secondary Accessions:
    • Q14DU3
    • Q6NT23

    Protein attributes for PLA2G10 Gene

    165 amino acids
    Molecular mass:
    18153 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PLA2G10 Gene

neXtProt entry for PLA2G10 Gene

Proteomics data for PLA2G10 Gene at MOPED

Post-translational modifications for PLA2G10 Gene

Other Protein References for PLA2G10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PLA2G10 Gene

Domains & Families for PLA2G10 Gene

Gene Families for PLA2G10 Gene

Protein Domains for PLA2G10 Gene

Suggested Antigen Peptide Sequences for PLA2G10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phospholipase A2 family.
  • Belongs to the phospholipase A2 family.
genes like me logo Genes that share domains with PLA2G10: view

Function for PLA2G10 Gene

Molecular function for PLA2G10 Gene

GENATLAS Biochemistry:
phospholipase A2,group X,Ca2+ dependent,secreted,mainly expressed in spleen,thymus,peripheral blood lymphocytes (15kb transcript) pancreas,lung,colon (0.8kb),likely involved in the inflammatory process
UniProtKB/Swiss-Prot CatalyticActivity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
UniProtKB/Swiss-Prot Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.

Enzyme Numbers (IUBMB) for PLA2G10 Gene

genes like me logo Genes that share phenotypes with PLA2G10: view

Animal Models for PLA2G10 Gene

MGI Knock Outs for PLA2G10:

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA2G10

miRNA for PLA2G10 Gene

miRTarBase miRNAs that target PLA2G10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PLA2G10 Gene

Localization for PLA2G10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA2G10 Gene


Subcellular locations from

Jensen Localization Image for PLA2G10 Gene COMPARTMENTS Subcellular localization image for PLA2G10 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 2
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PLA2G10 Gene

Pathways & Interactions for PLA2G10 Gene

genes like me logo Genes that share pathways with PLA2G10: view

Gene Ontology (GO) - Biological Process for PLA2G10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IEA --
GO:0007411 axon guidance IDA 15927955
GO:0010744 positive regulation of macrophage derived foam cell differentiation IC 18511424
GO:0010884 positive regulation of lipid storage IMP 18511424
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA2G10: view

No data available for SIGNOR curated interactions for PLA2G10 Gene

Drugs & Compounds for PLA2G10 Gene

(14) Drugs for PLA2G10 Gene - From: DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alpha-linolenic acid Approved Nutra Full agonist, Agonist 0
arachidonic acid Experimental Nutra Activator 27
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0

(180) Additional Compounds for PLA2G10 Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
  • 1-Myristoyl-glycero-3-phosphocholine
  • LPC(14:0)
  • LPC(14:0/0:0)
  • LyPC(14:0)
  • LyPC(14:0/0:0)
  • 1-Myristoleoyl-glycero-3-phosphocholine
  • LPC(14:1)
  • LPC(14:1/0:0)
  • LPC(14:1n5/0:0)
  • LPC(14:1w5/0:0)

(5) Tocris Compounds for PLA2G10 Gene

Compound Action Cas Number
D609 Selective PC-PLC inhibitor 83373-60-8
m-3M3FBS Phospholipase C activator 200933-14-8
o-3M3FBS Inactive analog of m-3M3FBS (Cat. No. 1941) 313981-55-4
OBAA Phospholipase A2 inhibitor 221632-26-4
U 73122 Phospholipase C inhibitor 112648-68-7
genes like me logo Genes that share compounds with PLA2G10: view

Transcripts for PLA2G10 Gene

mRNA/cDNA for PLA2G10 Gene

(9) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PLA2G10 Gene

Phospholipase A2, group X:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for PLA2G10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PLA2G10 Gene

mRNA expression in normal human tissues for PLA2G10 Gene

mRNA differential expression in normal tissues according to GTEx for PLA2G10 Gene

This gene is overexpressed in Colon - Transverse (x18.5), Stomach (x7.7), and Pancreas (x4.3).

Protein differential expression in normal tissues from HIPED for PLA2G10 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA2G10 Gene

SOURCE GeneReport for Unigene cluster for PLA2G10 Gene Hs.567366

mRNA Expression by UniProt/SwissProt for PLA2G10 Gene

Tissue specificity: Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon.
genes like me logo Genes that share expression patterns with PLA2G10: view

Protein tissue co-expression partners for PLA2G10 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PLA2G10 Gene

Orthologs for PLA2G10 Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA2G10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PLA2G10 35
  • 76.33 (n)
  • 68.12 (a)
PLA2G10 36
  • 67 (a)
(Canis familiaris)
Mammalia PLA2G10 35
  • 82.15 (n)
  • 78.74 (a)
PLA2G10 36
  • 69 (a)
(Mus musculus)
Mammalia Pla2g10 35
  • 76.12 (n)
  • 70.9 (a)
Pla2g10 16
Pla2g10 36
  • 72 (a)
(Pan troglodytes)
Mammalia PLA2G10 35
  • 98.28 (n)
  • 97.06 (a)
PLA2G10 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Pla2g10 35
  • 76.37 (n)
  • 69.4 (a)
(Monodelphis domestica)
Mammalia PLA2G10 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
-- 36
  • 36 (a)
-- 36
  • 46 (a)
-- 36
  • 41 (a)
-- 36
  • 39 (a)
(Gallus gallus)
Aves PLA2G10 35
  • 57.6 (n)
  • 51.2 (a)
-- 36
  • 44 (a)
PLA2G10 36
  • 46 (a)
(Anolis carolinensis)
Reptilia PLA2G10 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492785 35
  • 55.56 (n)
  • 48.41 (a)
(Danio rerio)
Actinopterygii zgc:92162 35
  • 51.88 (n)
  • 48.87 (a)
PLA2G10 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea C07E3.9 36
  • 27 (a)
Species with no ortholog for PLA2G10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PLA2G10 Gene

Gene Tree for PLA2G10 (if available)
Gene Tree for PLA2G10 (if available)

Paralogs for PLA2G10 Gene

(6) SIMAP similar genes for PLA2G10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA2G10: view

Variants for PLA2G10 Gene

Sequence variations from dbSNP and Humsavar for PLA2G10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3900822 -- 14,676,589(-) cgatt(C/T)tcctg intron-variant
rs4003232 -- 14,690,768(+) ttcct(A/G)gctgt intron-variant
rs12934401 -- 14,677,910(+) gaatg(A/G)atgga intron-variant
rs13335845 -- 14,675,543(+) ccaca(G/T)aatgg intron-variant
rs4780753 -- 14,679,428(-) cgcct(C/T)ggcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA2G10 Gene

Variant ID Type Subtype PubMed ID
dgv810e1 CNV Complex 17122850
dgv811e1 CNV Complex 17122850
nsv833144 CNV Gain 17160897
nsv905356 CNV Gain 21882294
nsv1740 CNV Loss 18451855
essv16469 CNV CNV 17122850
dgv812e1 CNV Complex 17122850
nsv905357 CNV Gain 21882294
nsv821150 CNV Deletion 20802225
esv1008243 CNV Gain 20482838
esv28787 CNV Gain+Loss 19812545
nsv9353 CNV Gain+Loss 18304495

Variation tolerance for PLA2G10 Gene

Gene Damage Index Score: 0.04; 1.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA2G10 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA2G10 Gene

Disorders for PLA2G10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for PLA2G10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute chest syndrome
  • acute chest syndrome in sickle cell disease
potter's syndrome
  • potter syndrome
acute endometritis
meconium aspiration syndrome
  • meconium aspiration
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PLA2G10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PLA2G10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PLA2G10 Gene

Publications for PLA2G10 Gene

  1. Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. (PMID: 9188469) Cupillard L. … Lambeau G. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s. (PMID: 18587072) Kuksis A. … Pruzanski W. (J. Lipid Res. 2008) 3 23
  3. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. (PMID: 11741884) Degousee N. … Rubin B.B. (J. Biol. Chem. 2002) 3 23
  4. PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk. (PMID: 25583995) Guardiola M. … Talmud P.J. (Circ Cardiovasc Genet 2015) 3
  5. Phospholipase A2 Group III and Group X Have Opposing Associations with Prognosis in Colorectal Cancer. (PMID: 25964585) Kazama S. … Watanabe T. (Anticancer Res. 2015) 3

Products for PLA2G10 Gene

Sources for PLA2G10 Gene