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PLA2G10 Gene

protein-coding   GIFtS: 66
GCID: GC16M014767

Phospholipase A2, Group X

  See PLA2G10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phospholipase A2, Group X1 2     GXSPLA22 5
Group X Secretory Phospholipase A22 3     SPLA22 5
Phosphatidylcholine 2-Acylhydrolase 102 3     GXPLA22
GX SPLA22 3     Group 10 Secretory Phospholipase A22
sPLA2-X2 3     EC 3.1.1.43

External Ids:    HGNC: 90291   Entrez Gene: 83992   Ensembl: ENSG000000697647   OMIM: 6036035   UniProtKB: O154963   

Export aliases for PLA2G10 gene to outside databases

Previous GC identifers: GC16M014715 GC16P017772 GC16M014732 GC16M014673


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PLA2G10 Gene:
PLA2G10 (phospholipase A2, group X) is a protein-coding gene. Diseases associated with PLA2G10 include acute chest syndrome, and meconium aspiration syndrome. GO annotations related to this gene include phospholipase activity and calcium ion binding. An important paralog of this gene is ENSG00000258417.

UniProtKB/Swiss-Prot: PA2GX_HUMAN, O15496
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a
powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers
phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine

summary for PLA2G10 Gene:
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic
molecules. PLA is subdivided into PLA1 which cleave phospholipids at the sn-1 ester bond and PLA2, which
cleave at the sn-2 bond. Their most common substrate is phosphatidylcholine, which generates
lysophosphatidylcholine and arachidonic acid. PLA is regulated by phosphorylation and by intracellular Ca2+
concentrations. Phospholipases are ubiquitously expressed and have diverse biological functions including
roles in inflammation, cell growth, signaling and death and maintenance of membrane phospholipids.

Gene Wiki entry for PLA2G10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NT_187607.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PLA2G10 gene promoter:
         AhR   ER-alpha   Sp1   p53   AP-4   HNF-1A   Arnt   CREB   HNF-1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPLA2G10 promoter sequence
   Search Chromatin IP Primers for PLA2G10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PLA2G10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.1-p12   Ensembl cytogenetic band:  16p13.12   HGNC cytogenetic band: 16p13.1-p12

PLA2G10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PLA2G10 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M014767:  view genomic region     (about GC identifiers)

Start:
14,766,405 bp from pter      End:
14,788,526 bp from pter
Size:
22,122 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PA2GX_HUMAN, O15496 (See protein sequence)
Recommended Name: Group 10 secretory phospholipase A2 precursor  
Size: 165 amino acids; 18153 Da
Cofactor: Binds 1 calcium ion per subunit
2 PDB 3D structures from and Proteopedia for PLA2G10:
1LE6 (3D)        1LE7 (3D)    
Secondary accessions: Q14DU3 Q6NT23

Explore the universe of human proteins at neXtProt for PLA2G10: NX_O15496

Explore proteomics data for PLA2G10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn113

  • See PLA2G10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003552.1  
    ENSEMBL proteins: 
     ENSP00000393847   ENSP00000456433  
    Reactome Protein details: O15496

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: sPLA2-10
    Phospholipase A2

    3 InterPro protein domains:
     IPR016090 PLipase_A2_dom
     IPR001211 PLipase_A2
     IPR013090 PLipase_A2_AS

    Graphical View of Domain Structure for InterPro Entry O15496

    ProtoNet protein and cluster: O15496

    1 Blocks protein domain: IPB001211 Phospholipase A2

    UniProtKB/Swiss-Prot: PA2GX_HUMAN, O15496
    Similarity: Belongs to the phospholipase A2 family


    Find genes that share domains with PLA2G10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PA2GX_HUMAN, O15496
    Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a
    powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers
    phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine
    Catalytic activity: Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate

         Genatlas biochemistry entry for PLA2G10:
    phospholipase A2,group X,Ca2+ dependent,secreted,mainly expressed in spleen,thymus,peripheral blood lymphocytes
    (15kb transcript) pancreas,lung,colon (0.8kb),likely involved in the inflammatory process

         Enzyme Number (IUBMB): EC 3.1.1.41

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004620phospholipase activity ISS--
    GO:0004623phospholipase A2 activity IEA--
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with PLA2G10           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Pla2g10):
     cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  muscle  reproductive system 

    Find genes that share phenotypes with PLA2G10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for PLA2G10: Pla2g10tm1Kiku Pla2g10tm1Itl

       genOway: Develop your customized and physiologically relevant rodent model for PLA2G10

    miRNA
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    miRTarBase miRNAs that target PLA2G10:
    hsa-mir-335-5p (MIRT018251)

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    hsa-miR-19b hsa-miR-19a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PA2GX_HUMAN, O15496: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with PLA2G10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PLA2G10 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis0.64
    Synthesis of PA0.33
    Phospholipid metabolism0.64
    Acyl chain remodelling of PG0.00
    Glycerophospholipid metabolism0.62
    Acyl chain remodelling of PI0.00
    2Acyl chain remodelling of PC
    Acyl chain remodelling of PE0.85
    Ether lipid metabolism0.48
    Acyl chain remodelling of PC0.85
    Acyl chain remodelling of PS0.00
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4phospholipases
    phospholipases0.34
    Anandamide biosynthesis and metabolism0.34
    5Arachidonic acid metabolism
    Linoleic acid metabolism0.64
    Arachidonic acid metabolism0.41
    alpha-Linolenic acid metabolism0.64


    Find genes that share SuperPaths with PLA2G10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PLA2G10 (see all 7)
        Chemokine Signaling
    DHA Signaling
    Antioxidant Action of Vitamin-C
    cAMP Pathway
    Phospholipase-C Pathway

    2 GeneGo (Thomson Reuters) Pathways for PLA2G10
        Anandamide biosynthesis and metabolism
    Immune response CD16 signaling in NK cells

    2 BioSystems Pathways for PLA2G10
        MAPK signaling pathway
    phospholipases

    Selected Reactome Pathways for PLA2G10 (see all 6)
        Acyl chain remodelling of PE
    Acyl chain remodelling of PS
    Synthesis of PA
    Acyl chain remodelling of PC
    Acyl chain remodelling of PG


    Selected Kegg Pathways  (Kegg details for PLA2G10) (see all 10):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Arachidonic acid metabolism
    Linoleic acid metabolism
    alpha-Linolenic acid metabolism

        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G10: 
              VEGF Signaling in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for PLA2G10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PLA2G10 (O154962, 3 ENSP000003938474) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYO10Q9HD672, 3, ENSP000003911064MINT-63105 I2D: score=4 STRING: ENSP00000391106
    PLA2R1Q130183, ENSP000002832434I2D: score=1 STRING: ENSP00000283243
    ALOX12ENSP000002515354STRING: ENSP00000251535
    ALOX12BENSP000003151674STRING: ENSP00000315167
    ALOX15ENSP000002937614STRING: ENSP00000293761
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006654phosphatidic acid biosynthetic process TAS--
    GO:0007411axon guidance IDA15927955
    GO:0010744positive regulation of macrophage derived foam cell differentiation IC18511424
    GO:0010884positive regulation of lipid storage IMP18511424

    Find genes that share ontologies with PLA2G10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for PLA2G10 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    FIPIPhospholipase D inhibitor[939055-18-2]
    m-3M3FBSPhospholipase C activator[200933-14-8]
    Edelfosine Selective PI-PLC inhibitor, also PAF receptor agonist [77286-66-9]
    U 73343Inactive analog of U 73122 (Cat. No. 1268)[142878-12-4]
    D609Selective PC-PLC inhibitor[83373-60-8]

    Selected HMDB Compounds for PLA2G10 (see all 2264)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    Alpha-Linolenic acid(9,12,15)-linolenate (see all 23)463-40-1--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    CalciumCa (see all 2)7440-70-2--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Linoleic acid(9Z,12Z)-9,12-Octadecadienoate (see all 26)60-33-3--

    Selected Novoseek inferred chemical compound relationships for PLA2G10 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arachidonic acid 60.4 23 17148553 (7), 10567392 (2), 9421195 (2), 8365403 (2) (see all 9)
    phosphatidylcholine 59.3 17 18587072 (2), 12604528 (2), 10567392 (1), 12732938 (1) (see all 7)
    phosphatidylethanolamine 51.8 2 11294854 (1), 9421195 (1)
    phospholipid 51.6 9 12732938 (2), 17827229 (2), 17419625 (1), 14550557 (1) (see all 6)
    phosphatidylserine 51.3 1 9421195 (1)
    linoleic acid 35.1 1 17148553 (1)
    fmlp 25 2 11741884 (1)
    lipid 24.9 13 9555838 (3), 15379211 (1), 8999952 (1), 16305438 (1) (see all 9)
    txb2 23.7 2 8365403 (1), 9374427 (1)
    cholesterol 23.5 15 18037706 (6), 15692105 (2), 15379211 (1), 19449149 (1) (see all 5)



    Find genes that share compounds with PLA2G10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PLA2G10 gene: 
    NM_003561.1  

    Unigene Cluster for PLA2G10:

    Phospholipase A2, group X
    Hs.567366  [show with all ESTs]
    Unigene Representative Sequence: NM_003561
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438167(uc002dcq.3) ENST00000567462
    miRNA
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    Additional mRNA sequence: 

    BC069539.1 BC106731.1 BC106732.1 BC111804.1 CR456885.1 U95301.1 

    2 DOTS entries:

    DT.105886  DT.120707583 

    4 AceView cDNA sequences:

    BC069539 NM_003561 U95301 CR456885 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PLA2G10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for PLA2G10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PLA2G10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACGACTG
    PLA2G10 Expression
    About this image

    PLA2G10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PLA2G10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567366

    UniProtKB/Swiss-Prot: PA2GX_HUMAN, O15496
    Tissue specificity: Found in spleen, thymus, peripheral blood leukocytes, pancreas, lung, and colon

        Pathway & Disease-focused RT2 Profiler PCR Array including PLA2G10: 
              VEGF Signaling in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PLA2G10 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pla2g101 , 5 phospholipase A2, group X1, 5 76.12(n)1
    70.9(a)1
      16 (9.50 cM)5
    265651  NM_011987.21  NP_036117.11 
     137150575 
    chicken
    (Gallus gallus)
    Aves PLA2G101 phospholipase A2, group X 57.6(n)
    51.2(a)
      416425  NM_001184757.1  NP_001171686.1 
    lizard
    (Anolis carolinensis)
    Reptilia PLA2G106
    phospholipase A2, group X
    40(a)
    1 ↔ 1
    3(176343572-176350914)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004927851 group 10 secretory phospholipase A2-like 55.56(n)
    48.41(a)
      100492785  XM_002935475.1  XP_002935521.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:921621 zgc:92162 51.88(n)
    48.87(a)
      436622  NM_001002350.1  NP_001002350.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C07E3.96
    Protein C07E3.9 (C07E3.9) mRNA, complete cds
    27(a)
    1 → many
    II(10350760-10351617) WBGene00007419


    ENSEMBL Gene Tree for PLA2G10 (if available)
    TreeFam Gene Tree for PLA2G10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PLA2G10 gene
    ENSG000002584172  PLA2G2F2  PLA2G2E2  PLA2G2A2  PLA2G1B2  PLA2G2D2  OC902  PLA2G52  
    PLA2G2C2  
    6 SIMAP similar genes for PLA2G10 using alignment to 3 protein entries:     PA2GX_HUMAN (see all proteins):
    PLA2G2E    PLA2G2F    PLA2G1B    PLA2G5    PLA2G2A    PLA2G2D

    Find genes that share paralogs with PLA2G10           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for PLA2G10 (see all 26)
    PGOHUM00000262273 PGOHUM00000248727 PGOHUM00000262275 PGOHUM00000262276 PGOHUM00000248740


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PLA2G10 (see all 283)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149942451,2
    C--14765949(+) CATTGA/TGCTGG 1 -- int10--------
    rs1412491311,2
    --14765959(+) GGCTTA/GCAGAA 1 -- int10--------
    rs1508046861,2
    --14766062(+) TTCACC/TGGGTG 1 -- int10--------
    rs1391973911,2
    --14766141(+) TGTTCA/GTTCAC 1 -- int10--------
    rs725463401,2
    C,F--14766165(+) CCATCC/GAAGCA 1 -- int12Minor allele frequency- G:0.02EU NA 3918
    rs725463391,2
    C,F--14766204(+) AGATGG/TAACCT 1 -- int13Minor allele frequency- T:0.05EU WA NA 4024
    rs1833499281,2
    --14766222(+) GGAACC/TGACCC 1 -- int10--------
    rs1440092411,2
    --14766305(+) ATGGGC/TTCCAG 1 -- int10--------
    rs1876486691,2
    --14766330(+) ATTGGG/TAGGGA 1 -- int10--------
    rs1464103551,2
    --14766332(+) TGGGAC/GGGAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for PLA2G10 (14766405 - 14788526 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PLA2G10 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv821150CNV Deletion20802225
    nsv1740CNV Loss18451855
    nsv905357CNV Gain21882294
    nsv833144CNV Gain17160897
    nsv905356CNV Gain21882294
    esv1008243CNV Gain20482838
    esv28787CNV Gain+Loss19812545
    nsv9353CNV Gain+Loss18304495
    essv16469CNV CNV17122850
    dgv811e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): PLA2G10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PLA2G10
    DNA2.0 Custom Variant and Variant Library Synthesis for PLA2G10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603603    OMIM disorders: --

    2 diseases for PLA2G10:    
    About MalaCards
    acute chest syndrome    meconium aspiration syndrome

    3 diseases from the University of Copenhagen DISEASES database for PLA2G10:
    Acute chest syndrome     Meconium aspiration syndrome     Atherosclerosis

    Find genes that share disorders with PLA2G10           About GenesLikeMe

    10 Novoseek inferred disease relationships for PLA2G10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    embolism fat 49.9 1 8630425 (1)
    atherosclerosis 31.7 5 19222850 (1), 10323781 (1), 11786516 (1), 14726411 (1)
    sickle cell disease 29.3 3 15040432 (1)
    inflammation 27.6 9 12637261 (2), 15479689 (1), 16079166 (1), 17008322 (1) (see all 8)
    rheumatoid arthritis 26.4 3 16079166 (1), 15742431 (1), 8991975 (1)
    coronary artery disease 16.5 3 19449149 (2), 15692105 (1)
    necrosis 1.01 3 10905622 (1), 15479689 (1), 8991975 (1)
    cardiovascular diseases 0.925 5 19222850 (1), 17303774 (1), 17070102 (1)
    tumors 0 18 7585570 (4), 17970059 (3), 10905622 (1), 8707313 (1) (see all 7)
    cancer 0 3 16305438 (2), 19663381 (1)

    Genetic Association Database (GAD): PLA2G10
    Human Genome Epidemiology (HuGE) Navigator: PLA2G10 (3 documents)

    Export disorders for PLA2G10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PLA2G10 gene, integrated from 10 sources (see all 119):
    (articles sorted by number of sources associating them with PLA2G10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2. (PubMed id 9188469)1, 2, 3, 9 Cupillard L.... Lambeau G. (J. Biol. Chem. 1997)
    2. Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. (PubMed id 19336475)1, 4 Drenos F....Hingorani A.D. (Hum. Mol. Genet. 2009)
    3. Lp-PLA2 activity and PLA2G7 A379V genotype in patients with diabetes mellitus. (PubMed id 16438975)1, 4 Wootton P.T....Talmud P.J. (Atherosclerosis 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes. (PubMed id 12161451)1, 2 Pan Y.H.... Bahnson B.J. (J. Biol. Chem. 2002)
    6. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. (PubMed id 11741884)1, 9 Degousee N....Rubin B.B. (J. Biol. Chem. 2002)
    7. Phase composition of lipoprotein SM/cholesterol/PtdCho affects FA specificity of sPLA2s. (PubMed id 18587072)1, 9 Kuksis A. and Pruzanski W. (J. Lipid Res. 2008)
    8. Regulation and function of epithelial secreted phospholipase A2 group X in asthma. (PubMed id 23614662)1 Hallstrand T.S....Gelb M.H. (Am. J. Respir. Crit. Care Med. 2013)
    9. Molecular details of membrane fluidity changes during apoptosis and relationship to phospholipase A(2) activity. (PubMed id 22967861)1 Gibbons E....Bell J.D. (Biochim. Biophys. Acta 2013)
    10. Secretory phospholipase A2 activity in serum and cerebrospinal fluid of patients with relapsing-remitting multiple sclerosis. (PubMed id 23859159)1 Siroos B....Harirchian M.H. (J. Neuroimmunol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8399 HGNC: 9029 AceView: PLA2G10 Ensembl:ENSG00000069764 euGenes: HUgn8399
    ECgene: PLA2G10 Kegg: 8399 H-InvDB: PLA2G10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PLA2G10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PLA2G10 gene:
    Search GeneIP for patents involving PLA2G10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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