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Aliases for PLA1A Gene

Aliases for PLA1A Gene

  • Phospholipase A1 Member A 2 3 5
  • PS-PLA1 3 4
  • PSPLA1 3 4
  • Phosphatidylserine-Specific Phospholipase A1alpha 3
  • Phosphatidylserine-Specific Phospholipase A1 4
  • EC 3.1.1.- 4
  • EC 3.1.1 63
  • NMD 4

External Ids for PLA1A Gene

Previous GeneCards Identifiers for PLA1A Gene

  • GC03P118945
  • GC03P120597
  • GC03P120637
  • GC03P120799
  • GC03P119316
  • GC03P116692

Summaries for PLA1A Gene

Entrez Gene Summary for PLA1A Gene

  • The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for PLA1A Gene

PLA1A (Phospholipase A1 Member A) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include hydrolase activity and phosphatidylcholine 1-acylhydrolase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for PLA1A Gene

  • Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA1A Gene

Genomics for PLA1A Gene

Regulatory Elements for PLA1A Gene

Enhancers for PLA1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PLA1A on UCSC Golden Path with GeneCards custom track

Promoters for PLA1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PLA1A on UCSC Golden Path with GeneCards custom track

Genomic Location for PLA1A Gene

Chromosome:
3
Start:
119,597,842 bp from pter
End:
119,629,811 bp from pter
Size:
31,970 bases
Orientation:
Plus strand

Genomic View for PLA1A Gene

Genes around PLA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA1A Gene

Proteins for PLA1A Gene

  • Protein details for PLA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H76-PLA1A_HUMAN
    Recommended name:
    Phospholipase A1 member A
    Protein Accession:
    Q53H76
    Secondary Accessions:
    • B2R8V2
    • B4DXA2
    • O95991
    • Q86WX6
    • Q9UPD2

    Protein attributes for PLA1A Gene

    Size:
    456 amino acids
    Molecular mass:
    49715 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA1A Gene

Proteomics data for PLA1A Gene at MOPED

Post-translational modifications for PLA1A Gene

  • Glycosylation at Asn 79 and Asn 365
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for PLA1A Gene

Gene Families for PLA1A Gene

Protein Domains for PLA1A Gene

Graphical View of Domain Structure for InterPro Entry

Q53H76

UniProtKB/Swiss-Prot:

PLA1A_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PLA1A: view

Function for PLA1A Gene

Molecular function for PLA1A Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

Enzyme Numbers (IUBMB) for PLA1A Gene

genes like me logo Genes that share phenotypes with PLA1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA1A

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLA1A Gene

Localization for PLA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA1A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA1A Gene COMPARTMENTS Subcellular localization image for PLA1A gene
Compartment Confidence
extracellular 5
cytosol 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PLA1A Gene

Pathways & Interactions for PLA1A Gene

SuperPathways for PLA1A Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with PLA1A: view

Pathways by source for PLA1A Gene

1 KEGG pathway for PLA1A Gene

Interacting Proteins for PLA1A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273371%0d%0a9606.ENSP00000215832%0d%0a9606.ENSP00000263025%0d%0a9606.ENSP00000346032%0d%0a
Selected Interacting proteins: Q53H76-PLA1A_HUMAN ENSP00000273371 for PLA1A Gene via I2D STRING

Gene Ontology (GO) - Biological Process for PLA1A Gene

None

No data available for SIGNOR curated interactions for PLA1A Gene

Drugs & Compounds for PLA1A Gene

(1) Drugs for PLA1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(504) Additional Compounds for PLA1A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with PLA1A: view

Transcripts for PLA1A Gene

Unigene Clusters for PLA1A Gene

Phospholipase A1 member A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PLA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -
SP4:
SP5: - -

Relevant External Links for PLA1A Gene

GeneLoc Exon Structure for
PLA1A
ECgene alternative splicing isoforms for
PLA1A

Expression for PLA1A Gene

mRNA expression in normal human tissues for PLA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA1A Gene

This gene is overexpressed in Liver (x5.1).

Protein differential expression in normal tissues from HIPED for PLA1A Gene

This gene is overexpressed in Blymphocyte (47.7) and Prostate (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA1A Gene



SOURCE GeneReport for Unigene cluster for PLA1A Gene Hs.437451

mRNA Expression by UniProt/SwissProt for PLA1A Gene

Q53H76-PLA1A_HUMAN
Tissue specificity: Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
genes like me logo Genes that share expression patterns with PLA1A: view

Protein tissue co-expression partners for PLA1A Gene

Primer Products

In Situ Assay Products

Orthologs for PLA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PLA1A 35
  • 84.94 (n)
  • 82.89 (a)
PLA1A 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA1A 35
  • 86.48 (n)
  • 83.55 (a)
PLA1A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla1a 35
  • 82.53 (n)
  • 81.36 (a)
Pla1a 16
Pla1a 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PLA1A 35
  • 99.49 (n)
  • 99.78 (a)
PLA1A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla1a 35
  • 82.09 (n)
  • 80.04 (a)
oppossum
(Monodelphis domestica)
Mammalia PLA1A 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA1A 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA1A 35
  • 63.44 (n)
  • 59.12 (a)
PLA1A 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA1A 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12104 35
zebrafish
(Danio rerio)
Actinopterygii pla1a 35
  • 54.74 (n)
  • 46.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10116 36
  • 25 (a)
ManyToMany
CG10357 36
  • 25 (a)
ManyToMany
CG13282 36
  • 19 (a)
ManyToMany
CG14034 36
  • 27 (a)
ManyToMany
CG18258 36
  • 16 (a)
ManyToMany
CG18641 36
  • 23 (a)
ManyToMany
CG1986 36
  • 25 (a)
ManyToMany
CG34447 36
  • 24 (a)
ManyToMany
CG34448 36
  • 27 (a)
ManyToMany
CG4267 36
  • 23 (a)
ManyToMany
CG4582 36
  • 20 (a)
ManyToMany
CG5162 36
  • 21 (a)
ManyToMany
CG5665 36
  • 20 (a)
ManyToMany
CG6271 36
  • 26 (a)
ManyToMany
CG6277 36
  • 25 (a)
ManyToMany
CG6283 36
  • 24 (a)
ManyToMany
CG6295 36
  • 26 (a)
ManyToMany
CG6296 36
  • 15 (a)
ManyToMany
CG6431 36
  • 23 (a)
ManyToMany
CG6472 36
  • 24 (a)
ManyToMany
CG6675 36
  • 23 (a)
ManyToMany
CG6847 36
  • 12 (a)
ManyToMany
CG7367 36
  • 20 (a)
ManyToMany
sxe2 36
  • 25 (a)
ManyToMany
Yp1 36
  • 17 (a)
ManyToMany
Yp2 36
  • 16 (a)
ManyToMany
Yp3 36
  • 18 (a)
ManyToMany
CG17292 36
  • 21 (a)
ManyToMany
CG17192 36
  • 24 (a)
ManyToMany
CG17191 36
  • 25 (a)
ManyToMany
Species with no ortholog for PLA1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA1A Gene

ENSEMBL:
Gene Tree for PLA1A (if available)
TreeFam:
Gene Tree for PLA1A (if available)

Paralogs for PLA1A Gene

Paralogs for PLA1A Gene

(7) SIMAP similar genes for PLA1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA1A: view

Variants for PLA1A Gene

Sequence variations from dbSNP and Humsavar for PLA1A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_030126 -
rs61733987 - 119,608,823(+) TCTGC(A/G)TGCAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2692622 - 119,618,115(-) TGTAG(C/T)TGGCA nc-transcript-variant, reference, missense
rs12023 -- 119,629,739(+) CATTC(G/T)TACTT nc-transcript-variant, utr-variant-3-prime
rs1032131 -- 119,619,174(-) GGTGG(A/G)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA1A Gene

Variant ID Type Subtype PubMed ID
nsv829695 CNV Loss 17160897
nsv3963 CNV Loss 18451855
esv2725824 CNV Deletion 23290073
esv2725825 CNV Deletion 23290073

Variation tolerance for PLA1A Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA1A Gene

HapMap Linkage Disequilibrium report
PLA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA1A Gene

Disorders for PLA1A Gene

Relevant External Links for PLA1A

Genetic Association Database (GAD)
PLA1A
Human Genome Epidemiology (HuGE) Navigator
PLA1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA1A

No disorders were found for PLA1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA1A Gene

Publications for PLA1A Gene

  1. An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans. (PMID: 10196188) Nagai Y. … Inoue K. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 (PSPLA1). (PMID: 12436198) Wang J. … Hegele R.A. (J. Hum. Genet. 2002) 3 23
  3. Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation. (PMID: 25505071) Guo M. … Chen X. (J. Virol. 2015) 3
  4. Phosphatidylserine-specific phospholipase A1 (PS-PLA1) expression in colorectal cancer correlates with tumor invasion and hematogenous metastasis. (PMID: 25750298) Iida Y. … Watanabe T. (Anticancer Res. 2015) 3
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard S.M. … Kanmogne G.D. (J. Cereb. Blood Flow Metab. 2014) 3

Products for PLA1A Gene

Sources for PLA1A Gene

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