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Aliases for PLA1A Gene

Aliases for PLA1A Gene

  • Phospholipase A1 Member A 2 3 5
  • PS-PLA1 3 4
  • PSPLA1 3 4
  • Phosphatidylserine-Specific Phospholipase A1alpha 3
  • Phosphatidylserine-Specific Phospholipase A1 4
  • EC 3.1.1.- 4
  • EC 3.1.1 61
  • NMD 4

External Ids for PLA1A Gene

Previous GeneCards Identifiers for PLA1A Gene

  • GC03P118945
  • GC03P120597
  • GC03P120637
  • GC03P120799
  • GC03P119316
  • GC03P116692

Summaries for PLA1A Gene

Entrez Gene Summary for PLA1A Gene

  • The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for PLA1A Gene

PLA1A (Phospholipase A1 Member A) is a Protein Coding gene. Among its related pathways are Metabolism and Acyl chain remodelling of PE. GO annotations related to this gene include hydrolase activity and phosphatidylcholine 1-acylhydrolase activity. An important paralog of this gene is LIPI.

UniProtKB/Swiss-Prot for PLA1A Gene

  • Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA1A Gene

Genomics for PLA1A Gene

Regulatory Elements for PLA1A Gene

Enhancers for PLA1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F119570 1.3 FANTOM5 Ensembl ENCODE 12.4 -26.8 -26842 2.0 PKNOX1 MTA2 PBX2 STAT2 IKZF1 EED EBF1 NR2F2 CD80 PLA1A ARHGAP31 ADPRH POPDC2 TMEM39A POGLUT1 COX17
GH03F119626 1.3 FANTOM5 Ensembl ENCODE 5.9 +31.5 31459 6.6 PKNOX1 KLF17 YY1 GATA2 SCRT2 CREM REST ZNF518A NR2F2 PBX2 ADPRH MAATS1 RPL10P7 COX17 CD80 POPDC2 ARHGAP31 PLA1A GPR156 GSK3B
GH03F119715 1 FANTOM5 ENCODE 5.2 +119.1 119132 2.5 SOX13 CTCF RAD21 RARA TEAD3 YY1 POLR2A HNF4G NFE2 MAFK MAATS1 ENSG00000239994 RPL10P7 PLA1A LRRC58 NR1I2
GH03F119699 0.8 ENCODE 5.1 +102.9 102918 2.0 HDGF ELF3 HDAC1 PKNOX1 ATF1 CBX3 ARNT BMI1 RAD21 CHAMP1 MAATS1 ENSG00000239994 LRRC58 PLA1A LOC105374064 PIR40954
GH03F119635 1.3 FANTOM5 Ensembl ENCODE 4.5 +40.3 40262 4.6 HDGF PKNOX1 ATF1 WRNIP1 SIN3A GATA2 ZNF143 FOS JUNB NCOA1 RPL10P7 ADPRH COX17 ARHGAP31 MAATS1 PLA1A GSK3B POPDC2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PLA1A on UCSC Golden Path with GeneCards custom track

Promoters for PLA1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001851397 -1742 201 PKNOX1 ZFP64 MAFG JUND ZNF316 POLR2A SMARCA4 PBX2 MLLT1 NFE2

Genomic Location for PLA1A Gene

Chromosome:
3
Start:
119,597,842 bp from pter
End:
119,629,811 bp from pter
Size:
31,970 bases
Orientation:
Plus strand

Genomic View for PLA1A Gene

Genes around PLA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PLA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PLA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA1A Gene

Proteins for PLA1A Gene

  • Protein details for PLA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H76-PLA1A_HUMAN
    Recommended name:
    Phospholipase A1 member A
    Protein Accession:
    Q53H76
    Secondary Accessions:
    • B2R8V2
    • B4DXA2
    • O95991
    • Q86WX6
    • Q9UPD2

    Protein attributes for PLA1A Gene

    Size:
    456 amino acids
    Molecular mass:
    49715 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA1A Gene

Selected DME Specific Peptides for PLA1A Gene

Q53H76:
  • LGVSESSIHIIG
  • ANVIAVDW
  • CLDCFNPFLLSCPRIGLVE
  • YLICDHMRAVHLYISALEN
  • KVYLLTT
  • DALFVEAIHTD
  • GGVKIEPLPKEV
  • GLDPAGP
  • GVSLGAH

Post-translational modifications for PLA1A Gene

  • Glycosylation at Asn 79 and Asn 365
  • Modification sites at PhosphoSitePlus

Domains & Families for PLA1A Gene

Gene Families for PLA1A Gene

Protein Domains for PLA1A Gene

Graphical View of Domain Structure for InterPro Entry

Q53H76

UniProtKB/Swiss-Prot:

PLA1A_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PLA1A: view

Function for PLA1A Gene

Molecular function for PLA1A Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

Enzyme Numbers (IUBMB) for PLA1A Gene

Gene Ontology (GO) - Molecular Function for PLA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008970 phosphatidylcholine 1-acylhydrolase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with PLA1A: view
genes like me logo Genes that share phenotypes with PLA1A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PLA1A

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PLA1A Gene

Localization for PLA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA1A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA1A Gene COMPARTMENTS Subcellular localization image for PLA1A gene
Compartment Confidence
extracellular 5
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PLA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PLA1A: view

Pathways & Interactions for PLA1A Gene

genes like me logo Genes that share pathways with PLA1A: view

Pathways by source for PLA1A Gene

Interacting Proteins for PLA1A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273371%0d%0a9606.ENSP00000263025%0d%0a9606.ENSP00000215832%0d%0a9606.ENSP00000346032%0d%0a
Selected Interacting proteins: Q53H76-PLA1A_HUMAN ENSP00000273371 for PLA1A Gene via IID STRING

Gene Ontology (GO) - Biological Process for PLA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA,TAS 10196188
GO:0006658 phosphatidylserine metabolic process TAS 10196188
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA1A: view

No data available for SIGNOR curated interactions for PLA1A Gene

Drugs & Compounds for PLA1A Gene

(1) Drugs for PLA1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(504) Additional Compounds for PLA1A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with PLA1A: view

Transcripts for PLA1A Gene

Unigene Clusters for PLA1A Gene

Phospholipase A1 member A:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -
SP4:
SP5: - -

Relevant External Links for PLA1A Gene

GeneLoc Exon Structure for
PLA1A
ECgene alternative splicing isoforms for
PLA1A

Expression for PLA1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PLA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA1A Gene

This gene is overexpressed in Liver (x5.1).

Protein differential expression in normal tissues from HIPED for PLA1A Gene

This gene is overexpressed in Blymphocyte (47.7) and Prostate (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PLA1A Gene



Protein tissue co-expression partners for PLA1A Gene

NURSA nuclear receptor signaling pathways regulating expression of PLA1A Gene:

PLA1A

SOURCE GeneReport for Unigene cluster for PLA1A Gene:

Hs.437451

mRNA Expression by UniProt/SwissProt for PLA1A Gene:

Q53H76-PLA1A_HUMAN
Tissue specificity: Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
genes like me logo Genes that share expression patterns with PLA1A: view

Primer Products

Orthologs for PLA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA1A 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia PLA1A 34 35
  • 86.48 (n)
cow
(Bos Taurus)
Mammalia PLA1A 34 35
  • 84.94 (n)
mouse
(Mus musculus)
Mammalia Pla1a 34 16 35
  • 82.53 (n)
rat
(Rattus norvegicus)
Mammalia Pla1a 34
  • 82.09 (n)
oppossum
(Monodelphis domestica)
Mammalia PLA1A 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA1A 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLA1A 34 35
  • 63.44 (n)
lizard
(Anolis carolinensis)
Reptilia PLA1A 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12104 34
zebrafish
(Danio rerio)
Actinopterygii pla1a 34
  • 54.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14034 35
  • 27 (a)
ManyToMany
CG34448 35
  • 27 (a)
ManyToMany
CG6271 35
  • 26 (a)
ManyToMany
CG6295 35
  • 26 (a)
ManyToMany
CG10116 35
  • 25 (a)
ManyToMany
CG10357 35
  • 25 (a)
ManyToMany
CG17191 35
  • 25 (a)
ManyToMany
CG1986 35
  • 25 (a)
ManyToMany
CG6277 35
  • 25 (a)
ManyToMany
sxe2 35
  • 25 (a)
ManyToMany
CG17192 35
  • 24 (a)
ManyToMany
CG34447 35
  • 24 (a)
ManyToMany
CG6283 35
  • 24 (a)
ManyToMany
CG6472 35
  • 24 (a)
ManyToMany
CG18641 35
  • 23 (a)
ManyToMany
CG4267 35
  • 23 (a)
ManyToMany
CG6431 35
  • 23 (a)
ManyToMany
CG6675 35
  • 23 (a)
ManyToMany
CG17292 35
  • 21 (a)
ManyToMany
CG5162 35
  • 21 (a)
ManyToMany
CG4582 35
  • 20 (a)
ManyToMany
CG5665 35
  • 20 (a)
ManyToMany
CG7367 35
  • 20 (a)
ManyToMany
CG13282 35
  • 19 (a)
ManyToMany
Yp3 35
  • 18 (a)
ManyToMany
Yp1 35
  • 17 (a)
ManyToMany
CG18258 35
  • 16 (a)
ManyToMany
Yp2 35
  • 16 (a)
ManyToMany
CG6296 35
  • 15 (a)
ManyToMany
CG6847 35
  • 12 (a)
ManyToMany
Species where no ortholog for PLA1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA1A Gene

ENSEMBL:
Gene Tree for PLA1A (if available)
TreeFam:
Gene Tree for PLA1A (if available)

Paralogs for PLA1A Gene

Paralogs for PLA1A Gene

(7) SIMAP similar genes for PLA1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA1A: view

Variants for PLA1A Gene

Sequence variations from dbSNP and Humsavar for PLA1A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1032131 -- 119,619,174(-) GGTGG(A/G)GAGAG intron-variant
rs1032132 -- 119,619,164(-) GGGCA(C/T)TCTGG intron-variant
rs10433338 -- 119,614,072(+) TGGGT(G/T)CAGGG intron-variant
rs10511392 -- 119,599,560(-) CGACA(G/T)ATGAG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111370741 -- 119,628,009(+) TCTGG(-/A/C)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA1A Gene

Variant ID Type Subtype PubMed ID
esv2725824 CNV deletion 23290073
esv2725825 CNV deletion 23290073
nsv3963 CNV deletion 18451855
nsv591363 CNV loss 21841781
nsv591364 CNV loss 21841781
nsv829695 CNV loss 17160897

Variation tolerance for PLA1A Gene

Residual Variation Intolerance Score: 68.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PLA1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PLA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA1A Gene

Disorders for PLA1A Gene

Relevant External Links for PLA1A

Genetic Association Database (GAD)
PLA1A
Human Genome Epidemiology (HuGE) Navigator
PLA1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PLA1A

No disorders were found for PLA1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PLA1A Gene

Publications for PLA1A Gene

  1. An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans. (PMID: 10196188) Nagai Y. … Inoue K. (J. Biol. Chem. 1999) 2 3 4 22 64
  2. Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 (PSPLA1). (PMID: 12436198) Wang J. … Hegele R.A. (J. Hum. Genet. 2002) 3 4 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipases. (PMID: 9074642) van Groningen J.J.M. … Swart G.W.M. (FEBS Lett. 1997) 3 4 64

Products for PLA1A Gene

Sources for PLA1A Gene

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