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Aliases for PLA1A Gene

Aliases for PLA1A Gene

  • Phospholipase A1 Member A 2 3
  • PSPLA1 3 4 6
  • PS-PLA1 3 4
  • Phosphatidylserine-Specific Phospholipase A1alpha 3
  • Phosphatidylserine-Specific Phospholipase A1 4
  • EC 3.1.1.- 4
  • EC 3.1.1 63
  • NMD 4

External Ids for PLA1A Gene

Previous GeneCards Identifiers for PLA1A Gene

  • GC03P118945
  • GC03P120597
  • GC03P120637
  • GC03P120799
  • GC03P119316
  • GC03P116692

Summaries for PLA1A Gene

Entrez Gene Summary for PLA1A Gene

  • The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

GeneCards Summary for PLA1A Gene

PLA1A (Phospholipase A1 Member A) is a Protein Coding gene. Among its related pathways are Ras signaling pathway. GO annotations related to this gene include phosphatidylcholine 1-acylhydrolase activity. An important paralog of this gene is LPL.

UniProtKB/Swiss-Prot for PLA1A Gene

  • Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PLA1A Gene

Genomics for PLA1A Gene

Regulatory Elements for PLA1A Gene

Genomic Location for PLA1A Gene

Start:
119,597,842 bp from pter
End:
119,629,811 bp from pter
Size:
31,970 bases
Orientation:
Plus strand

Genomic View for PLA1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PLA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PLA1A Gene

Proteins for PLA1A Gene

  • Protein details for PLA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53H76-PLA1A_HUMAN
    Recommended name:
    Phospholipase A1 member A
    Protein Accession:
    Q53H76
    Secondary Accessions:
    • B2R8V2
    • B4DXA2
    • O95991
    • Q86WX6
    • Q9UPD2

    Protein attributes for PLA1A Gene

    Size:
    456 amino acids
    Molecular mass:
    49715 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PLA1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PLA1A Gene

Proteomics data for PLA1A Gene at MOPED

Post-translational modifications for PLA1A Gene

  • Glycosylation at Asn79 and Asn365
  • Modification sites at PhosphoSitePlus

Domains for PLA1A Gene

Protein Domains for PLA1A Gene

Graphical View of Domain Structure for InterPro Entry

Q53H76

UniProtKB/Swiss-Prot:

PLA1A_HUMAN :
  • Q53H76
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with PLA1A: view

No data available for Gene Families for PLA1A Gene

Function for PLA1A Gene

Molecular function for PLA1A Gene

UniProtKB/Swiss-Prot Function: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.

Enzyme Numbers (IUBMB) for PLA1A Gene

Gene Ontology (GO) - Molecular Function for PLA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008970 phosphatidylcholine 1-acylhydrolase activity IEA --
GO:0016787 hydrolase activity --
GO:0052689 carboxylic ester hydrolase activity --
genes like me logo Genes that share ontologies with PLA1A: view
genes like me logo Genes that share phenotypes with PLA1A: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PLA1A Gene

Localization for PLA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PLA1A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PLA1A Gene COMPARTMENTS Subcellular localization image for PLA1A gene
Compartment Confidence
extracellular 3
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PLA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005576 extracellular region --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PLA1A: view

Pathways for PLA1A Gene

SuperPathways for PLA1A Gene

Superpath Contained pathways
1 Ras signaling pathway
genes like me logo Genes that share pathways with PLA1A: view

Pathways by source for PLA1A Gene

1 KEGG pathway for PLA1A Gene

Interacting Proteins for PLA1A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000273371%0d%0a9606.ENSP00000215832%0d%0a9606.ENSP00000263025%0d%0a9606.ENSP00000346032%0d%0a
Selected Interacting proteins: ENSP00000273371 Q53H76-PLA1A_HUMAN for PLA1A Gene via STRING I2D

Gene Ontology (GO) - Biological Process for PLA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10196188
GO:0006658 phosphatidylserine metabolic process TAS 10196188
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with PLA1A: view

Compounds for PLA1A Gene

(503) HMDB Compounds for PLA1A Gene

Compound Synonyms Cas Number PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
Not Available
PI(16:0/16:0)
  • Phosphatidylinositol(32:0)
Not Available
PI(16:0/16:1(9Z))
  • Phosphatidylinositol(32:1)
Not Available
PI(16:0/16:2(9Z,12Z))
  • Phosphatidylinositol(16:0/16:2n4)
Not Available
PI(16:0/18:0)
  • Phosphatidylinositol(16:0/18:0)
Not Available

(2) Novoseek inferred chemical compound relationships for PLA1A Gene

Compound -log(P) Hits PubMed IDs
phosphatidylserine 50.8 7
lipid 19.4 2
genes like me logo Genes that share compounds with PLA1A: view

Transcripts for PLA1A Gene

Unigene Clusters for PLA1A Gene

Phospholipase A1 member A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PLA1A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PLA1A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PLA1A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -
SP3: -
SP4:
SP5: - -

Relevant External Links for PLA1A Gene

GeneLoc Exon Structure for
PLA1A
ECgene alternative splicing isoforms for
PLA1A

Expression for PLA1A Gene

mRNA expression in normal human tissues for PLA1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PLA1A Gene

This gene is overexpressed in Liver (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PLA1A Gene

SOURCE GeneReport for Unigene cluster for PLA1A Gene Hs.437451

mRNA Expression by UniProt/SwissProt for PLA1A Gene

Q53H76-PLA1A_HUMAN
Tissue specificity: Widely expressed. Expressed in placenta, prostate and liver. Weakly or not expressed in skin, leukocytes, platelets, colon, spleen, lung, muscle and kidney.
genes like me logo Genes that share expressions with PLA1A: view

In Situ Assay Products

Orthologs for PLA1A Gene

This gene was present in the common ancestor of animals.

Orthologs for PLA1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLA1A 35
  • 99.49 (n)
  • 99.78 (a)
PLA1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLA1A 35
  • 84.94 (n)
  • 82.89 (a)
PLA1A 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLA1A 35
  • 86.48 (n)
  • 83.55 (a)
PLA1A 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pla1a 35
  • 82.53 (n)
  • 81.36 (a)
Pla1a 16
Pla1a 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLA1A 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLA1A 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pla1a 35
  • 82.09 (n)
  • 80.04 (a)
chicken
(Gallus gallus)
Aves PLA1A 35
  • 63.44 (n)
  • 59.12 (a)
PLA1A 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLA1A 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12104 35
zebrafish
(Danio rerio)
Actinopterygii pla1a 35
  • 54.74 (n)
  • 46.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10116 36
  • 25 (a)
ManyToMany
CG10357 36
  • 25 (a)
ManyToMany
CG13282 36
  • 19 (a)
ManyToMany
CG14034 36
  • 27 (a)
ManyToMany
CG17191 36
  • 25 (a)
ManyToMany
CG17192 36
  • 24 (a)
ManyToMany
CG17292 36
  • 21 (a)
ManyToMany
CG18258 36
  • 16 (a)
ManyToMany
CG18641 36
  • 23 (a)
ManyToMany
CG1986 36
  • 25 (a)
ManyToMany
CG34447 36
  • 24 (a)
ManyToMany
CG34448 36
  • 27 (a)
ManyToMany
CG4267 36
  • 23 (a)
ManyToMany
CG4582 36
  • 20 (a)
ManyToMany
CG5162 36
  • 21 (a)
ManyToMany
CG5665 36
  • 20 (a)
ManyToMany
CG6271 36
  • 26 (a)
ManyToMany
CG6277 36
  • 25 (a)
ManyToMany
CG6283 36
  • 24 (a)
ManyToMany
CG6295 36
  • 26 (a)
ManyToMany
CG6296 36
  • 15 (a)
ManyToMany
CG6431 36
  • 23 (a)
ManyToMany
CG6472 36
  • 24 (a)
ManyToMany
CG6675 36
  • 23 (a)
ManyToMany
CG6847 36
  • 12 (a)
ManyToMany
CG7367 36
  • 20 (a)
ManyToMany
sxe2 36
  • 25 (a)
ManyToMany
Yp1 36
  • 17 (a)
ManyToMany
Yp2 36
  • 16 (a)
ManyToMany
Yp3 36
  • 18 (a)
ManyToMany
Species with no ortholog for PLA1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PLA1A Gene

ENSEMBL:
Gene Tree for PLA1A (if available)
TreeFam:
Gene Tree for PLA1A (if available)

Paralogs for PLA1A Gene

Paralogs for PLA1A Gene

Selected SIMAP similar genes for PLA1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PLA1A: view

Variants for PLA1A Gene

Sequence variations from dbSNP and Humsavar for PLA1A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12023 -- 119,629,739(+) CATTC(G/T)TACTT utr-variant-3-prime, nc-transcript-variant
rs474926 -- 119,614,592(-) GTCTC(A/G)CTCTG intron-variant
rs483349 -- 119,625,846(-) GGTTC(C/T)TTGCC intron-variant
rs485257 -- 119,602,912(+) GCCAT(A/G)TAGAT intron-variant
rs487124 -- 119,603,100(+) ATTGT(C/T)AGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PLA1A Gene

Variant ID Type Subtype PubMed ID
nsv829695 CNV Loss 17160897
nsv3963 CNV Loss 18451855
esv2725824 CNV Deletion 23290073
esv2725825 CNV Deletion 23290073

Relevant External Links for PLA1A Gene

HapMap Linkage Disequilibrium report
PLA1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PLA1A Gene

Disorders for PLA1A Gene

Relevant External Links for PLA1A

Genetic Association Database (GAD)
PLA1A
Human Genome Epidemiology (HuGE) Navigator
PLA1A
genes like me logo Genes that share disorders with PLA1A: view

No data available for UniProtKB/Swiss-Prot for PLA1A Gene

Publications for PLA1A Gene

  1. An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans. (PMID: 10196188) Nagai Y. … Inoue K. (J. Biol. Chem. 1999) 2 3 4 23
  2. Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 (PSPLA1). (PMID: 12436198) Wang J. … Hegele R.A. (J. Hum. Genet. 2002) 3 4 23
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipases. (PMID: 9074642) van Groningen J.J.M. … Swart G.W.M. (FEBS Lett. 1997) 3 4

Products for PLA1A Gene

Sources for PLA1A Gene

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