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Aliases for PKP4 Gene

Aliases for PKP4 Gene

  • Plakophilin 4 2 3 5
  • P0071 3 4
  • Plakophilin-4 3
  • Catenin 4 3

External Ids for PKP4 Gene

Previous GeneCards Identifiers for PKP4 Gene

  • GC02P157245
  • GC02P157842
  • GC02P159277
  • GC02P159515
  • GC02P159484
  • GC02P159138
  • GC02P159021
  • GC02P151277
  • GC02P159313

Summaries for PKP4 Gene

Entrez Gene Summary for PKP4 Gene

  • Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

GeneCards Summary for PKP4 Gene

PKP4 (Plakophilin 4) is a Protein Coding gene. Among its related pathways are Cell adhesion_Endothelial cell contacts by junctional mechanisms. GO annotations related to this gene include binding. An important paralog of this gene is CTNND2.

UniProtKB/Swiss-Prot for PKP4 Gene

  • Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.

Gene Wiki entry for PKP4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKP4 Gene

Genomics for PKP4 Gene

Regulatory Elements for PKP4 Gene

Enhancers for PKP4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PKP4 on UCSC Golden Path with GeneCards custom track

Promoters for PKP4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PKP4 Gene

158,456,880 bp from pter
158,682,879 bp from pter
226,000 bases
Plus strand

Genomic View for PKP4 Gene

Genes around PKP4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKP4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKP4 Gene

Proteins for PKP4 Gene

  • Protein details for PKP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q86W91

    Protein attributes for PKP4 Gene

    1192 amino acids
    Molecular mass:
    131868 Da
    Quaternary structure:
    • Interacts with PDZD2 (By similarity). Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain). Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at the midbody.
    • Sequence=CAA57478.1; Type=Erroneous termination; Positions=1193; Note=Translated as stop.; Evidence={ECO:0000305}; Sequence=CAA57478.1; Type=Frameshift; Positions=334, 337, 864, 874; Evidence={ECO:0000305};

    Alternative splice isoforms for PKP4 Gene


neXtProt entry for PKP4 Gene

Post-translational modifications for PKP4 Gene

  • Ubiquitination at Lys 573, Lys 611, Lys 683, and Lys 1175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PKP4 Gene

Domains & Families for PKP4 Gene

Gene Families for PKP4 Gene

Protein Domains for PKP4 Gene

Suggested Antigen Peptide Sequences for PKP4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta-catenin family.
  • Contains 9 ARM repeats.
  • Belongs to the beta-catenin family.
  • Contains 9 ARM repeats.
genes like me logo Genes that share domains with PKP4: view

Function for PKP4 Gene

Molecular function for PKP4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.

Gene Ontology (GO) - Molecular Function for PKP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12047349
genes like me logo Genes that share ontologies with PKP4: view

Phenotypes for PKP4 Gene

genes like me logo Genes that share phenotypes with PKP4: view

Animal Model Products

CRISPR Products

miRNA for PKP4 Gene

miRTarBase miRNAs that target PKP4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PKP4 Gene

Localization for PKP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKP4 Gene

Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.

Subcellular locations from

Jensen Localization Image for PKP4 Gene COMPARTMENTS Subcellular localization image for PKP4 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PKP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 17115030
GO:0005737 cytoplasm IDA 22965878
GO:0005856 cytoskeleton IDA 8937994
GO:0005886 plasma membrane IDA 8937994
GO:0005911 cell-cell junction IDA 8937994
genes like me logo Genes that share ontologies with PKP4: view

Pathways & Interactions for PKP4 Gene

genes like me logo Genes that share pathways with PKP4: view

Pathways by source for PKP4 Gene

1 GeneGo (Thomson Reuters) pathway for PKP4 Gene

Gene Ontology (GO) - Biological Process for PKP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007043 cell-cell junction assembly IEA,ISS --
GO:0007267 cell-cell signaling NAS 8937994
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0030155 regulation of cell adhesion NAS 8937994
GO:0032467 positive regulation of cytokinesis IMP 17115030
genes like me logo Genes that share ontologies with PKP4: view

No data available for SIGNOR curated interactions for PKP4 Gene

Drugs & Compounds for PKP4 Gene

No Compound Related Data Available

Transcripts for PKP4 Gene

Unigene Clusters for PKP4 Gene

Plakophilin 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKP4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ·
SP1: - - -
SP3: -
SP8: - - -
SP9: - - -
SP11: -

ExUns: 15d ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23
SP4: - -
SP5: - -
SP10: - - -

Relevant External Links for PKP4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PKP4 Gene

mRNA expression in normal human tissues for PKP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKP4 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.2) and Brain - Substantia nigra (x4.6).

Protein differential expression in normal tissues from HIPED for PKP4 Gene

This gene is overexpressed in Plasma (18.2), Lung (10.2), and Frontal cortex (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PKP4 Gene

NURSA nuclear receptor signaling pathways regulating expression of PKP4 Gene:


SOURCE GeneReport for Unigene cluster for PKP4 Gene:

genes like me logo Genes that share expression patterns with PKP4: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PKP4 Gene

Orthologs for PKP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for PKP4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PKP4 34
  • 94.16 (n)
  • 97.82 (a)
PKP4 35
  • 96 (a)
(Canis familiaris)
Mammalia PKP4 34
  • 94.38 (n)
  • 98.32 (a)
PKP4 35
  • 98 (a)
(Mus musculus)
Mammalia Pkp4 34
  • 91.48 (n)
  • 96.64 (a)
Pkp4 16
Pkp4 35
  • 97 (a)
(Pan troglodytes)
Mammalia PKP4 34
  • 99.58 (n)
  • 99.75 (a)
PKP4 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Pkp4 34
  • 91.6 (n)
  • 96.64 (a)
(Monodelphis domestica)
Mammalia PKP4 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia PKP4 35
  • 92 (a)
(Gallus gallus)
Aves PKP4 34
  • 80.31 (n)
  • 89.81 (a)
PKP4 35
  • 89 (a)
(Anolis carolinensis)
Reptilia PKP4 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pkp4 34
  • 75.05 (n)
  • 82.97 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398570 34
(Danio rerio)
Actinopterygii pkp4 34
  • 62.75 (n)
  • 66.64 (a)
pkp4 35
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta p120ctn 36
  • 49 (a)
p120ctn 35
  • 38 (a)
(Caenorhabditis elegans)
Secernentea jac-1 36
  • 34 (a)
jac-1 35
  • 22 (a)
Species where no ortholog for PKP4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKP4 Gene

Gene Tree for PKP4 (if available)
Gene Tree for PKP4 (if available)

Paralogs for PKP4 Gene

Paralogs for PKP4 Gene Pseudogenes for PKP4 Gene

genes like me logo Genes that share paralogs with PKP4: view

Variants for PKP4 Gene

Sequence variations from dbSNP and Humsavar for PKP4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1029592 -- 158,639,595(+) TGTGA(A/G)CCATT intron-variant
rs1029593 -- 158,639,756(+) ATTAT(A/G)TATTC intron-variant
rs1056576 -- 158,640,676(+) TGCTT(C/G)AGCAC reference, missense
rs1057570 -- 158,643,449(+) ctcac(A/G)cctgt intron-variant
rs1110506 -- 158,507,514(+) ACTTT(C/G)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PKP4 Gene

Variant ID Type Subtype PubMed ID
esv21462 CNV gain 19812545
esv3302752 CNV tandem duplication 20981092
esv3560418 CNV deletion 23714750
esv3593079 CNV loss 21293372
nsv1143962 CNV deletion 24896259
nsv459885 CNV loss 19166990
nsv583442 CNV loss 21841781
nsv834434 CNV gain 17160897
nsv961901 CNV duplication 23825009

Variation tolerance for PKP4 Gene

Residual Variation Intolerance Score: 10.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKP4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKP4 Gene

Disorders for PKP4 Gene

Relevant External Links for PKP4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PKP4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKP4 Gene

Publications for PKP4 Gene

  1. Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. (PMID: 8937994) Hatzfeld M. … Nachtsheim C. (J. Cell Sci. 1996) 2 3 4 22 65
  2. Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. (PMID: 9342840) Paffenholz R. … Franke W.W. (Differentiation 1997) 2 3 22 65
  3. Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules. (PMID: 19830446) Walter B. … Hofmann I. (Histochem. Cell Biol. 2010) 3 22 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Targeting of p0071 to the midbody depends on KIF3. (PMID: 19339549) Keil R. … Hatzfeld M. (J. Cell. Sci. 2009) 3 22 65

Products for PKP4 Gene

Sources for PKP4 Gene

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