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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PKP4 Gene

protein-coding GIFtS: 57
GCID: GC02P159313

plakophilin 4

Explore 7 diseases affiliated with
PKP4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Plakophilin 4¹ ²
P0071¹
Catenin 4²
Plakophilin-4¹

External Ids:	HGNC: 9026¹	Entrez Gene: 8502²	Ensembl: ENSG00000144283⁷	OMIM: 604276⁵	UniProtKB: Q99569³

Export aliases for PKP4 gene to outside databases

Previous GC identifers: GC02P157245 GC02P157842 GC02P159277 GC02P159515 GC02P159484 GC02P159138 GC02P159021 GC02P151277

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PKP4:

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo'

gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based

on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their

sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1,

PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be

involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been

found for this gene, but the full-length nature of only two of them have been described so far. These two variants

encode distinct isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PKP4_HUMAN, Q99569

Function: Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques

Gene Wiki entry for PKP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PKP4 gene promoter:
Elk-1 p53 HNF-4alpha2 CUTL1 HNF-4alpha1 PPAR-gamma1 FAC1 CP1A PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PKP4 promoter sequence

Search SABiosciences Chromatin IP Primers for PKP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24.1

PKP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKP4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P159313: view genomic region (about GC identifiers)

Start:	159,313,476 bp from pter	End:	159,539,391 bp from pter
Size:	225,916 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PKP4_HUMAN, Q99569 (See protein sequence)

Recommended Name: Plakophilin-4

Size: 1192 amino acids; 131868 Da

Subunit: Interacts with PDZD2 (By similarity). Interacts (via the C-terminus) with FRMPD2 (via the PDZ 2 domain).

Interacts with RHOA; the interaction is detected at the midbody. Interacts with ECT2; the interaction is detected at

the midbody

Subcellular location: Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle

pole. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in

interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the

central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis.

Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in

cultured epithelial cells

Sequence caution: Sequence=CAA57478.1; Type=Erroneous termination; Positions=1193; Note=Translated as stop;

Sequence=CAA57478.1; Type=Frameshift; Positions=334, 337, 864, 874;

Secondary accessions: Q86W91

Alternative splicing: 2 isoforms: Q99569-1 Q99569-2

Explore the universe of human proteins at neXtProt for PKP4: NX_Q99569

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99569

PKP4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001005476.1 NP_003619.2

ENSEMBL proteins:

ENSP00000396827 ENSP00000374407 ENSP00000374409 ENSP00000391658 ENSP00000407218

ENSP00000392515 ENSP00000393872 ENSP00000437815

Human Recombinant Protein Products for PKP4:

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	Novus Biologicals PKP4 Protein Novus Biologicals PKP4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PKP4

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	17115030
GO:0005737	cytoplasm	IDA	--
GO:0005856	cytoskeleton	IDA	8937994
GO:0005886	plasma membrane	IDA	8937994
GO:0005911	cell-cell junction	IDA	8937994

PKP4 for ontologies About GeneDecksing

PKP4 Antibody Products:

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	Uscn ELISAs and CLIAs for PKP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PKP4 for domains About GeneDecksing

3 InterPro domains/families:

IPR011989 ARM-like

IPR000225 Armadillo

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q99569

ProtoNet protein and cluster: Q99569

1 Blocks protein family: IPB000225 Armadillo repeat

UniProtKB/Swiss-Prot: PKP4_HUMAN, Q99569

Similarity: Belongs to the beta-catenin family

Similarity: Contains 9 ARM repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PKP4_HUMAN, Q99569

Function: Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

PKP4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for PKP4:

Increased HPV18 LCR reporter a

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Pkp4):

normal

PKP4 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PKP4

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PKP4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PKP4
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PKP4 (see all 21):
		hsa-miR-3942-5p hsa-miR-449a hsa-miR-218 hsa-miR-192 hsa-miR-371-5p hsa-miR-641 hsa-miR-3613-3p hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: PKP4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PKP4 (see all 7) OriGene shRNA RFP: PKP4 OriGene siRNA: PKP4
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKP4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion Endothelial cell contacts by junctional mechanisms

Cell adhesion Endothelial cell contacts by junctional mechanisms

1.00

Cell adhesion_Endothelial cell contacts by junctional mechanisms

0.97

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for PKP4

Cell adhesion Endothelial cell contacts by junctional mechanisms

1 GeneGo (Thomson Reuters) Pathway for PKP4

Cell adhesion Endothelial cell contacts by junctional mechanisms

PKP4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PKP4

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/22 Interacting proteins for PKP4 (Q99569^{2, 3} ENSP00000374409⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ERBB2IP	Q96RT1²^,³, ENSP00000370330⁴	MINT-1773305 MINT-1773355 MINT-1777626 MINT-1778254 MINT-1777568 MINT-1777596 I2D: score=5 STRING: ENSP00000370330
PSEN1	P49768²^,³, ENSP00000326366⁴	MINT-14193 MINT-14192 MINT-14194 I2D: score=5 STRING: ENSP00000326366
OSGEP	Q9NPF4²^,³, ENSP00000206542⁴	MINT-8265216 I2D: score=2 STRING: ENSP00000206542
GABARAP	O95166²^,³	MINT-65281 I2D: score=4
DSP	P15924²^,³, ENSP00000369129⁴	MINT-1792815 I2D: score=4 STRING: ENSP00000369129

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007043	cell-cell junction assembly	ISS	--
GO:0007155	cell adhesion	IEA	--
GO:0007267	cell-cell signaling	NAS	8937994
GO:0010628	positive regulation of gene expression	ISS	--
GO:0030155	regulation of cell adhesion	NAS	8937994

PKP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PKP4
Search CenterWatch for drugs/clinical trials and news about PKP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PKP4 gene (2 alternative transcripts):

NM_001005476.1 NM_003628.3

Unigene Cluster for PKP4:

Plakophilin 4

Hs.407580 [show with all ESTs]

Unigene Representative Sequence: NM_003628

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000426248(uc002tzt.1 uc002tzu.3) ENST00000389757(uc002tzw.3)

ENST00000389759(uc002tzz.1 uc002tzv.3 uc002tzx.3 uc002uaa.3)

ENST00000457109 ENST00000479398 ENST00000452162 ENST00000411900 ENST00000421462(uc002tzy.1)

ENST00000462335 ENST00000481115 ENST00000494945 ENST00000492496 ENST00000480171(uc002uac.3)

ENST00000495123 ENST00000483881 ENST00000486254(uc002uae.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): PKP4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PKP4
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate PKP4 (see all 21):
		hsa-miR-3942-5p hsa-miR-449a hsa-miR-218 hsa-miR-192 hsa-miR-371-5p hsa-miR-641 hsa-miR-3613-3p hsa-miR-23a

		SwitchGear 3'UTR luciferase reporter plasmid: PKP4 3' UTR sequence

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Additional cDNA sequence:

AK054911.1 AK055015.1 AK055823.1 AK124237.1 AK128720.1 AL050364.1 BC034473.1 BC041163.1

BC048013.1 BC050308.1 U60472.1 U81005.1 X81889.1

24/26 DOTS entries (see all 26):

DT.100795947 DT.453867 DT.101984212 DT.100795949 DT.75188951 DT.97831360 DT.91796778 DT.97789520

DT.101984211 DT.97780913 DT.91987891 DT.404991 DT.99989460 DT.100754494 DT.100795941 DT.100795943

DT.100795946 DT.120978037 DT.120978118 DT.91797036 DT.97848190 DT.120977956 DT.40108784 DT.40301228

24/336 AceView cDNA sequences (see all 336):

AI989338 BU184189 AA417386 AA463856 BM710158 BU844697 R74508 AI280499

BU158735 BM853667 BX282142 BG742943 AA319100 BM905366 AL045003 CB158747

CA392287 BC034473 BM788529 BM544787 BQ648545 CR602334 BM700007 BM825389

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for PKP4 (see all 11) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	·	15c	·
SP1:																											-		-																		-
SP2:
SP3:																																															-
SP4:
SP5:

ExUns:	15d	^	16	^	17	^	18a	·	18b	·	18c	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23
SP1:
SP2:
SP3:
SP4:							-														-
SP5:																			-		-

ECgene alternative splicing isoforms for PKP4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PKP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCATTCCTC

About this image

PKP4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PKP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PKP4

SOURCE GeneReport for Unigene cluster: Hs.407580

SABiosciences Expression via Pathway-Focused PCR Arrays including PKP4:

Adherens Junctions in human mouse rat

Alzheimer's Disease in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKP4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PKP4 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PKP4¹	plakophilin 4	80.31(n) 89.81(a)		424328 NM_001006529.1 NP_001006529.1
lizard (Anolis carolinensis)	Reptilia	PKP4⁶	--	88(a)	1 ↔ 1	GL343379.1(606674-721986)
African clawed frog (Xenopus laevis)	Amphibia	LOC398570²	similar to plakophilin 4	76.4(n)		BC048023.1
zebrafish (Danio rerio)	Actinopterygii	pkp4¹	plakophilin 4	62.88(n) 66.34(a)		561566 XM_684979.5 XP_690071.3
fruit fly (Drosophila melanogaster)	Insecta	p120ctn³	--	49(a)		--
worm (Caenorhabditis elegans)	Secernentea	jac-1³	--	34(a)		IV(15998290-16017650) --

ENSEMBL Gene Tree for PKP4 (if available)
TreeFam Gene Tree for PKP4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PKP4 gene

PKP2² PKP1² CTNND1² PKP3² CTNND2² ARVCF²

5 SIMAP similar genes for PKP4 using alignment to 8 protein entries: PKP4_HUMAN (see all proteins):

ps1ly2h-25 CTNND2 CTNND1 DKFZp781O2021 ARVCF

PKP4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for PKP4
PGOHUM00000241096

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192897774^1,2		--	159311554(+)	`AGACCC/TATTTT`	4	--	us2k¹ int¹		0	--	--	--	--
rs55873205^1,2	C	--	159311576(+)	`AGACAC/GAACTT`	4	--	us2k¹ int¹		3		NA EA	242
rs141516079^1,2		--	159311595(+)	`TTGATA/GTTATT`	4	--	int¹ us2k¹		0	--	--	--	--
rs6722328^1,2	C,A	--	159311613(+)	`AAAAGC/AAGCAA`	4	--	us2k¹ int¹		1		WA	2
rs10432566^1,2	C,F,A,H	--	159311645(+)	`AAACAT/CGTGTC`	4	--	us2k¹ int¹		21		NS EA NA WA	2322
rs138480154^1,2		--	159311689(+)	`CTATAA/CACAAA`	4	--	int¹ us2k¹		0	--	--	--	--
rs185094802^1,2		--	159311863(+)	`TAGGAC/TTGTCA`	4	--	int¹ us2k¹		0	--	--	--	--
rs144065831^1,2		--	159311950(+)	`GTTACA/GTCTTT`	4	--	int¹ us2k¹		0	--	--	--	--
rs147330140^1,2		--	159311987(+)	`AACCAA/GTAGCA`	4	--	int¹ us2k¹		0	--	--	--	--
rs140284316^1,2		--	159312098(+)	`AATCCC/TATCAG`	4	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PKP4 (159313476 - 159539391 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PKP4
1 Indel: 68192

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PKP4 for disorders           About GeneDecksing

OMIM gene information: 604276    OMIM disorders: --

7 diseases for PKP4:    About MalaCards

axonal neuropathy renal cell carcinoma alzheimer's disease neuropathy

cardiomyopathy carcinoma schizophrenia

Human Genome Epidemiology (HuGE) Navigator: PKP4 (2 documents)

Export disorders for PKP4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PKP4 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with PKP4)

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world of online information

Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. (PubMed id 8937994)^{1, 2, 3, 9} Hatzfeld M. and Nachtsheim C. (1996)
Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family. (PubMed id 9342840)^{1, 3, 9} Paffenholz R. and Franke W.W. (1997)
PDZ-domain-directed basolateral targeting of the peri pheral membrane protein FRMPD2 in epithelial cells. (PubMed id 19706687)^{1, 2} Stenzel N....Erdmann K.S. (2009)
Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)^{1, 2} Denis N.J.... Figeys D. (2007)
The armadillo protein p0071 regulates Rho signalling during cytokinesis. (PubMed id 17115030)^{1, 2} Wolf A.... Hatzfeld M. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Targeting of p0071 to the midbody depends on KIF3. (PubMed id 19339549)^{1, 9} Keil R....Hatzfeld M. (2009)
Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. (PubMed id 12615965)^{1, 9} Hatzfeld M....Sauter H. (2003)
p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle. (PubMed id 11206135)^{1, 9} Schroder R....Hatzfeld M. (2000)
Protein p0071, an armadillo plaque protein of adheren s junctions, is predominantly expressed in distal renal tubules. (PubMed id 19830446)^{1, 9} Walter B....Hofmann I. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8502	HGNC: 9026	AceView: PKP4	Ensembl:ENSG00000144283	euGenes: HUgn8502
ECgene: PKP4	H-InvDB: PKP4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PKP4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PKP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PKP4 gene:
Search GeneIP for patents involving PKP4

GeneCards and IP:
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