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Aliases for PKP3 Gene

Aliases for PKP3 Gene

  • Plakophilin 3 2 3 5

External Ids for PKP3 Gene

Previous GeneCards Identifiers for PKP3 Gene

  • GC11U990201
  • GC11M000795
  • GC11P000384
  • GC11P000354
  • GC11P000209

Summaries for PKP3 Gene

Entrez Gene Summary for PKP3 Gene

  • This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for PKP3 Gene

PKP3 (Plakophilin 3) is a Protein Coding gene. GO annotations related to this gene include binding and alpha-catenin binding. An important paralog of this gene is CTNND1.

UniProtKB/Swiss-Prot for PKP3 Gene

  • May play a role in junctional plaques.

Gene Wiki entry for PKP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKP3 Gene

Genomics for PKP3 Gene

Regulatory Elements for PKP3 Gene

Promoters for PKP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PKP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PKP3 Gene

Chromosome:
11
Start:
392,599 bp from pter
End:
404,908 bp from pter
Size:
12,310 bases
Orientation:
Plus strand

Genomic View for PKP3 Gene

Genes around PKP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKP3 Gene

Proteins for PKP3 Gene

  • Protein details for PKP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y446-PKP3_HUMAN
    Recommended name:
    Plakophilin-3
    Protein Accession:
    Q9Y446
    Secondary Accessions:
    • F8J390
    • Q53EX8

    Protein attributes for PKP3 Gene

    Size:
    797 amino acids
    Molecular mass:
    87082 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PKP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKP3 Gene

Proteomics data for PKP3 Gene at MOPED

Post-translational modifications for PKP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PKP3 Gene

Domains & Families for PKP3 Gene

Gene Families for PKP3 Gene

Protein Domains for PKP3 Gene

Suggested Antigen Peptide Sequences for PKP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y446

UniProtKB/Swiss-Prot:

PKP3_HUMAN :
  • Belongs to the beta-catenin family.
  • Contains 8 ARM repeats.
Family:
  • Belongs to the beta-catenin family.
Similarity:
  • Contains 8 ARM repeats.
genes like me logo Genes that share domains with PKP3: view

Function for PKP3 Gene

Molecular function for PKP3 Gene

GENATLAS Biochemistry:
plakophilin 3,component of the plaque protein of desmosomes of most simple and almost all stratified epithelia with the exception of hepatocytes and hepatocellular carcinoma cell,homologous to Drosophila Armadillo segment polarity gene
UniProtKB/Swiss-Prot Function:
May play a role in junctional plaques.

Gene Ontology (GO) - Molecular Function for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0045294 alpha-catenin binding IPI 23136403
genes like me logo Genes that share ontologies with PKP3: view
genes like me logo Genes that share phenotypes with PKP3: view

Animal Models for PKP3 Gene

MGI Knock Outs for PKP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PKP3 Gene

Localization for PKP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKP3 Gene

Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PKP3 Gene COMPARTMENTS Subcellular localization image for PKP3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 4
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 20859650
GO:0030057 desmosome IEA --
genes like me logo Genes that share ontologies with PKP3: view

Pathways & Interactions for PKP3 Gene

SuperPathways for PKP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002159 desmosome assembly IMP 20859650
genes like me logo Genes that share ontologies with PKP3: view

No data available for Pathways by source and SIGNOR curated interactions for PKP3 Gene

Drugs & Compounds for PKP3 Gene

No Compound Related Data Available

Transcripts for PKP3 Gene

Unigene Clusters for PKP3 Gene

Plakophilin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PKP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1:
SP2: - - - -
SP3:
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7:
SP8:
SP9: -
SP10:
SP11:

ExUns: 16 ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PKP3 Gene

GeneLoc Exon Structure for
PKP3
ECgene alternative splicing isoforms for
PKP3

Expression for PKP3 Gene

mRNA expression in normal human tissues for PKP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKP3 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.3), Skin - Sun Exposed (Lower leg) (x9.8), Skin - Not Sun Exposed (Suprapubic) (x9.3), and Vagina (x4.4).

Protein differential expression in normal tissues from HIPED for PKP3 Gene

This gene is overexpressed in Cervix (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PKP3 Gene



SOURCE GeneReport for Unigene cluster for PKP3 Gene Hs.534395

mRNA Expression by UniProt/SwissProt for PKP3 Gene

Q9Y446-PKP3_HUMAN
Tissue specificity: Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.
genes like me logo Genes that share expression patterns with PKP3: view

Protein tissue co-expression partners for PKP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PKP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PKP3 35
  • 88.99 (n)
  • 93.19 (a)
PKP3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PKP3 35
  • 86.76 (n)
  • 91.22 (a)
PKP3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pkp3 35
  • 86.53 (n)
  • 93.85 (a)
Pkp3 16
Pkp3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pkp3 35
  • 86.22 (n)
  • 93.77 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia PKP3 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves PKP3 35
  • 71.97 (n)
  • 72.82 (a)
PKP3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PKP3 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pkp3 35
  • 64.9 (n)
  • 66.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100330353 35
  • 56.52 (n)
  • 48.44 (a)
PKP3 (2 of 2) 36
  • 43 (a)
OneToMany
pkp3a 36
  • 39 (a)
OneToMany
Species with no ortholog for PKP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PKP3 Gene

ENSEMBL:
Gene Tree for PKP3 (if available)
TreeFam:
Gene Tree for PKP3 (if available)

Paralogs for PKP3 Gene

Paralogs for PKP3 Gene

genes like me logo Genes that share paralogs with PKP3: view

Variants for PKP3 Gene

Sequence variations from dbSNP and Humsavar for PKP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs8858 -- 400,109(-) ATCTC(C/G/T)GCCTC reference, synonymous-codon
rs11748 -- 403,980(+) CTGCC(A/G)GGCAG reference, synonymous-codon
rs1128982 -- 400,040(+) CTCAC(A/G)GACCT reference, synonymous-codon
rs1134578 -- 404,317(+) GACTT(C/T)CGGGC reference, synonymous-codon
rs3210555 -- 397,609(+) TGCTG(A/G)GAGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PKP3 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv896488 CNV Loss 21882294
dgv923n71 CNV Loss 21882294
esv28392 CNV Gain+Loss 19812545
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv925n71 CNV Loss 21882294
dgv926n71 CNV Loss 21882294
nsv896514 CNV Gain 21882294
esv2659206 CNV Deletion 23128226
nsv39515 CNV Loss 16902084
esv1656697 CNV Deletion 17803354
nsv896516 CNV Loss 21882294
nsv896517 CNV Loss 21882294
nsv896518 CNV Gain+Loss 21882294
dgv927n71 CNV Loss 21882294
dgv928n71 CNV Gain+Loss 21882294
dgv929n71 CNV Loss 21882294
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
esv2664242 CNV Deletion 23128226

Variation tolerance for PKP3 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKP3 Gene

HapMap Linkage Disequilibrium report
PKP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKP3 Gene

Disorders for PKP3 Gene

Relevant External Links for PKP3

Genetic Association Database (GAD)
PKP3
Human Genome Epidemiology (HuGE) Navigator
PKP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKP3

No disorders were found for PKP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKP3 Gene

Publications for PKP3 Gene

  1. Plakophilin 3 -- a novel cell-type-specific desmosomal plaque protein. (PMID: 10374265) Schmidt A. … Franke W.W. (Differentiation 1999) 2 3 4 23 67
  2. Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer. (PMID: 18801625) Valladares-Ayerbes M. … AntA^n-Aparicio L.M. (Cancer Detect. Prev. 2008) 3 23
  3. The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. (PMID: 17391671) Aigner K. … Eger A. (FEBS Lett. 2007) 3 23
  4. Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters. (PMID: 12827610) Papagerakis S. … Forest N. (Hum. Pathol. 2003) 3 23
  5. Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. (PMID: 10852826) Hofmann I. … Herrmann H. (J. Cell. Sci. 2000) 3 23

Products for PKP3 Gene

Sources for PKP3 Gene

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