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Aliases for PKP3 Gene

Aliases for PKP3 Gene

  • Plakophilin 3 2 3 5
  • Plakophilin 3b 3
  • Plakophilin-3 3

External Ids for PKP3 Gene

Previous GeneCards Identifiers for PKP3 Gene

  • GC11U990201
  • GC11M000795
  • GC11P000384
  • GC11P000354
  • GC11P000209

Summaries for PKP3 Gene

Entrez Gene Summary for PKP3 Gene

  • This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for PKP3 Gene

PKP3 (Plakophilin 3) is a Protein Coding gene. Diseases associated with PKP3 include Uterine Body Mixed Cancer. Among its related pathways are Keratinization and Developmental Biology. GO annotations related to this gene include binding and alpha-catenin binding. An important paralog of this gene is PKP2.

UniProtKB/Swiss-Prot for PKP3 Gene

  • May play a role in junctional plaques.

Gene Wiki entry for PKP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKP3 Gene

Genomics for PKP3 Gene

Regulatory Elements for PKP3 Gene

Enhancers for PKP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G000391 1.3 ENCODE dbSUPER 10.9 +2.0 1976 5.2 HDGF ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B GLIS2 ZNF766 SIGIRR DRD4 PKP3 ENSG00000255142 ENSG00000255158 PTDSS2 GC11P000395 GC11M000414
GH11G000574 1.4 Ensembl ENCODE 6.2 +185.8 185783 6.9 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 FEZF1 PHRF1 ENSG00000255158 SNORA52 TMEM80 ENSG00000255237 RIC8A DRD4 HRAS TSPAN4 ENSG00000254815
GH11G000559 1.3 ENCODE dbSUPER 5.3 +170.3 170317 7.5 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 FOS PHRF1 ENSG00000255237 SNORA52 HRAS RIC8A TMEM80 TSPAN4 LMNTD2 PKP3 RNH1
GH11G000390 0.5 dbSUPER 10.9 -1.2 -1195 0.9 ZFHX2 EGR1 HNRNPL EGR2 SIGIRR PKP3 TMEM80 GC11P000389
GH11G000386 0.6 ENCODE 8.5 -5.3 -5258 0.8 NFIC ZNF316 MAFG EMSY MAFK TRIM28 SIGIRR PSMD13 SIRT3 PKP3 GC11P000389 B4GALNT4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PKP3 on UCSC Golden Path with GeneCards custom track

Promoters for PKP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000262328 1901 601 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF766 FOS KLF13 SP5

Genomic Location for PKP3 Gene

Chromosome:
11
Start:
392,599 bp from pter
End:
404,908 bp from pter
Size:
12,310 bases
Orientation:
Plus strand

Genomic View for PKP3 Gene

Genes around PKP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKP3 Gene

Proteins for PKP3 Gene

  • Protein details for PKP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y446-PKP3_HUMAN
    Recommended name:
    Plakophilin-3
    Protein Accession:
    Q9Y446
    Secondary Accessions:
    • F8J390
    • Q53EX8

    Protein attributes for PKP3 Gene

    Size:
    797 amino acids
    Molecular mass:
    87082 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PKP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKP3 Gene

Post-translational modifications for PKP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PKP3 Gene

Domains & Families for PKP3 Gene

Gene Families for PKP3 Gene

Protein Domains for PKP3 Gene

Suggested Antigen Peptide Sequences for PKP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y446

UniProtKB/Swiss-Prot:

PKP3_HUMAN :
  • Belongs to the beta-catenin family.
Family:
  • Belongs to the beta-catenin family.
genes like me logo Genes that share domains with PKP3: view

Function for PKP3 Gene

Molecular function for PKP3 Gene

GENATLAS Biochemistry:
plakophilin 3,component of the plaque protein of desmosomes of most simple and almost all stratified epithelia with the exception of hepatocytes and hepatocellular carcinoma cell,homologous to Drosophila Armadillo segment polarity gene
UniProtKB/Swiss-Prot Function:
May play a role in junctional plaques.

Gene Ontology (GO) - Molecular Function for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 NOT RNA binding IDA 25225333
GO:0005515 protein binding IPI 25225333
GO:0019899 enzyme binding IPI 25225333
GO:0045182 NOT translation regulator activity IMP 25225333
GO:0045294 alpha-catenin binding IPI 23136403
genes like me logo Genes that share ontologies with PKP3: view
genes like me logo Genes that share phenotypes with PKP3: view

Animal Models for PKP3 Gene

MGI Knock Outs for PKP3:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PKP3 Gene

Localization for PKP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKP3 Gene

Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKP3 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope TAS --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction TAS 10374265
genes like me logo Genes that share ontologies with PKP3: view

Pathways & Interactions for PKP3 Gene

genes like me logo Genes that share pathways with PKP3: view

Pathways by source for PKP3 Gene

Gene Ontology (GO) - Biological Process for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002159 desmosome assembly IMP 20859650
GO:0006417 NOT regulation of translation IMP 25225333
GO:0007155 cell adhesion IEA --
GO:0010628 positive regulation of gene expression IMP 25225333
GO:0016337 single organismal cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with PKP3: view

No data available for SIGNOR curated interactions for PKP3 Gene

Drugs & Compounds for PKP3 Gene

No Compound Related Data Available

Transcripts for PKP3 Gene

Unigene Clusters for PKP3 Gene

Plakophilin 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1:
SP2: - - - -
SP3:
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP7:
SP8:
SP9: -
SP10:
SP11:

ExUns: 16 ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for PKP3 Gene

GeneLoc Exon Structure for
PKP3
ECgene alternative splicing isoforms for
PKP3

Expression for PKP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PKP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKP3 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.3), Skin - Sun Exposed (Lower leg) (x9.8), Skin - Not Sun Exposed (Suprapubic) (x9.3), and Vagina (x4.4).

Protein differential expression in normal tissues from HIPED for PKP3 Gene

This gene is overexpressed in Cervix (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PKP3 Gene



Protein tissue co-expression partners for PKP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PKP3 Gene:

PKP3

SOURCE GeneReport for Unigene cluster for PKP3 Gene:

Hs.534395

mRNA Expression by UniProt/SwissProt for PKP3 Gene:

Q9Y446-PKP3_HUMAN
Tissue specificity: Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.

Evidence on tissue expression from TISSUES for PKP3 Gene

  • Intestine(4.6)
  • Skin(2.7)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with PKP3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PKP3 Gene

Orthologs for PKP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PKP3 34 35
  • 88.99 (n)
dog
(Canis familiaris)
Mammalia PKP3 34 35
  • 86.76 (n)
mouse
(Mus musculus)
Mammalia Pkp3 34 16 35
  • 86.53 (n)
rat
(Rattus norvegicus)
Mammalia Pkp3 34
  • 86.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PKP3 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves PKP3 34 35
  • 71.97 (n)
lizard
(Anolis carolinensis)
Reptilia PKP3 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pkp3 34
  • 64.9 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330353 34
  • 56.52 (n)
PKP3 (2 of 2) 35
  • 43 (a)
OneToMany
pkp3a 35
  • 39 (a)
OneToMany
Species where no ortholog for PKP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PKP3 Gene

ENSEMBL:
Gene Tree for PKP3 (if available)
TreeFam:
Gene Tree for PKP3 (if available)

Paralogs for PKP3 Gene

Paralogs for PKP3 Gene

genes like me logo Genes that share paralogs with PKP3: view

Variants for PKP3 Gene

Sequence variations from dbSNP and Humsavar for PKP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000004966 -- 390,982(+) AGGAG(C/T)GCCGG upstream-variant-2KB
rs1000295694 -- 395,475(+) GGGTG(A/C)CCAGG intron-variant
rs1000396690 -- 399,224(+) CCTGT(C/T)CTTCC intron-variant
rs1000439916 -- 391,123(+) AGGGG(C/T)CATAC upstream-variant-2KB
rs1000728344 -- 399,629(+) CCTCC(A/G)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PKP3 Gene

Variant ID Type Subtype PubMed ID
dgv1012n100 CNV gain 25217958
dgv1505n54 CNV gain 21841781
dgv1508n54 CNV gain+loss 21841781
dgv1509n54 CNV gain 21841781
dgv1510n54 CNV loss 21841781
dgv1511n54 CNV loss 21841781
dgv1512n54 CNV gain+loss 21841781
dgv1513n54 CNV gain+loss 21841781
dgv1514n54 CNV gain 21841781
dgv1515n54 CNV gain 21841781
dgv1516n54 CNV loss 21841781
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv1656697 CNV deletion 17803354
esv2659206 CNV deletion 23128226
esv2664242 CNV deletion 23128226
esv28392 CNV gain+loss 19812545
nsv1069536 CNV deletion 25765185
nsv1070917 CNV deletion 25765185
nsv1077764 OTHER inversion 25765185
nsv1118198 CNV deletion 24896259
nsv1136119 CNV deletion 24896259
nsv1159790 CNV deletion 26073780
nsv39515 CNV deletion 16902084
nsv467633 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv527327 CNV loss 19592680
nsv552770 CNV gain 21841781
nsv552776 CNV loss 21841781
nsv552779 CNV gain 21841781
nsv552818 CNV loss 21841781
nsv552821 CNV loss 21841781
nsv552822 CNV loss 21841781
nsv951268 CNV deletion 24416366

Variation tolerance for PKP3 Gene

Residual Variation Intolerance Score: 96.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKP3 Gene

Human Gene Mutation Database (HGMD)
PKP3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKP3 Gene

Disorders for PKP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PKP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
uterine body mixed cancer
  • malignant mixed tumor of corpus uteri
- elite association - COSMIC cancer census association via MalaCards
Search PKP3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PKP3

Genetic Association Database (GAD)
PKP3
Human Genome Epidemiology (HuGE) Navigator
PKP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKP3
genes like me logo Genes that share disorders with PKP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PKP3 Gene

Publications for PKP3 Gene

  1. Plakophilin 3 -- a novel cell-type-specific desmosomal plaque protein. (PMID: 10374265) Schmidt A. … Franke W.W. (Differentiation 1999) 2 3 4 22 64
  2. Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. (PMID: 10381383) Bonne S. … van Roy F. (J. Cell Sci. 1999) 3 4 22 64
  3. An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b. (PMID: 24178805) Muhmer M. … Schmidt A. (Cell Tissue Res. 2014) 3 4 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer. (PMID: 18801625) Valladares-Ayerbes M. … AntA^n-Aparicio L.M. (Cancer Detect. Prev. 2008) 3 22 64

Products for PKP3 Gene

Sources for PKP3 Gene

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