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Aliases for PKP3 Gene

Aliases for PKP3 Gene

  • Plakophilin 3 2 3

External Ids for PKP3 Gene

Previous GeneCards Identifiers for PKP3 Gene

  • GC11U990201
  • GC11M000795
  • GC11P000384
  • GC11P000354
  • GC11P000209

Summaries for PKP3 Gene

Entrez Gene Summary for PKP3 Gene

  • This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for PKP3 Gene

PKP3 (Plakophilin 3) is a Protein Coding gene. GO annotations related to this gene include binding and alpha-catenin binding. An important paralog of this gene is PKP2.

UniProtKB/Swiss-Prot for PKP3 Gene

  • May play a role in junctional plaques

Gene Wiki entry for PKP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKP3 Gene

Genomics for PKP3 Gene

Regulatory Elements for PKP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PKP3 Gene

392,599 bp from pter
404,908 bp from pter
12,310 bases
Plus strand

Genomic View for PKP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PKP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKP3 Gene

Proteins for PKP3 Gene

  • Protein details for PKP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • F8J390
    • Q53EX8

    Protein attributes for PKP3 Gene

    797 amino acids
    Molecular mass:
    87082 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PKP3 Gene


neXtProt entry for PKP3 Gene

Proteomics data for PKP3 Gene at MOPED

Post-translational modifications for PKP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PKP3 Gene

Domains & Families for PKP3 Gene

Gene Families for PKP3 Gene

Protein Domains for PKP3 Gene

Suggested Antigen Peptide Sequences for PKP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the beta-catenin family.
  • Contains 8 ARM repeats.
  • Belongs to the beta-catenin family.
  • Contains 8 ARM repeats.
genes like me logo Genes that share domains with PKP3: view

Function for PKP3 Gene

Molecular function for PKP3 Gene

GENATLAS Biochemistry:
plakophilin 3,component of the plaque protein of desmosomes of most simple and almost all stratified epithelia with the exception of hepatocytes and hepatocellular carcinoma cell,homologous to Drosophila Armadillo segment polarity gene
UniProtKB/Swiss-Prot Function:
May play a role in junctional plaques

Gene Ontology (GO) - Molecular Function for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding --
GO:0045294 alpha-catenin binding IPI 23136403
GO:0050839 cell adhesion molecule binding IPI 20859650
genes like me logo Genes that share ontologies with PKP3: view
genes like me logo Genes that share phenotypes with PKP3: view

Animal Models for PKP3 Gene

MGI Knock Outs for PKP3:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PKP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for PKP3 Gene

Localization for PKP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKP3 Gene

Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes.

Subcellular locations from

Jensen Localization Image for PKP3 Gene COMPARTMENTS Subcellular localization image for PKP3 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IDA 20859650
GO:0005911 cell-cell junction TAS 10374265
GO:0030057 desmosome IEA --
genes like me logo Genes that share ontologies with PKP3: view

Pathways & Interactions for PKP3 Gene

SuperPathways for PKP3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PKP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002159 desmosome assembly IMP 20859650
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0090002 establishment of protein localization to plasma membrane IMP 20859650
genes like me logo Genes that share ontologies with PKP3: view

No data available for Pathways by source and SIGNOR curated interactions for PKP3 Gene

Drugs & Compounds for PKP3 Gene

No Compound Related Data Available

Transcripts for PKP3 Gene

Unigene Clusters for PKP3 Gene

Plakophilin 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PKP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKP3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP2: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - -
SP9: -

ExUns: 16 ^ 17a · 17b

Relevant External Links for PKP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PKP3 Gene

mRNA expression in normal human tissues for PKP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKP3 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.3), Skin - Sun Exposed (Lower leg) (x9.8), Skin - Not Sun Exposed (Suprapubic) (x9.3), and Vagina (x4.4).

Protein differential expression in normal tissues from HIPED for PKP3 Gene

This gene is overexpressed in Cervix (55.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PKP3 Gene

SOURCE GeneReport for Unigene cluster for PKP3 Gene Hs.534395

mRNA Expression by UniProt/SwissProt for PKP3 Gene

Tissue specificity: Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its tumors.
genes like me logo Genes that share expression patterns with PKP3: view

Protein tissue co-expression partners for PKP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PKP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PKP3 35
  • 88.99 (n)
  • 93.19 (a)
PKP3 36
  • 93 (a)
(Canis familiaris)
Mammalia PKP3 35
  • 86.76 (n)
  • 91.22 (a)
PKP3 36
  • 85 (a)
(Mus musculus)
Mammalia Pkp3 35
  • 86.53 (n)
  • 93.85 (a)
Pkp3 16
Pkp3 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Pkp3 35
  • 86.22 (n)
  • 93.77 (a)
(Ornithorhynchus anatinus)
Mammalia PKP3 36
  • 70 (a)
(Gallus gallus)
Aves PKP3 35
  • 71.97 (n)
  • 72.82 (a)
PKP3 36
  • 69 (a)
(Anolis carolinensis)
Reptilia PKP3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pkp3 35
  • 64.9 (n)
  • 66.49 (a)
(Danio rerio)
Actinopterygii LOC100330353 35
  • 56.52 (n)
  • 48.44 (a)
PKP3 (2 of 2) 36
  • 43 (a)
pkp3a 36
  • 39 (a)
Species with no ortholog for PKP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PKP3 Gene

Gene Tree for PKP3 (if available)
Gene Tree for PKP3 (if available)

Paralogs for PKP3 Gene

Paralogs for PKP3 Gene

genes like me logo Genes that share paralogs with PKP3: view

Variants for PKP3 Gene

Sequence variations from dbSNP and Humsavar for PKP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8858 -- 400,109(-) ATCTC(C/G/T)GCCTC reference, synonymous-codon
rs11748 -- 403,980(+) CTGCC(A/G)GGCAG synonymous-codon, reference
rs1128982 -- 400,040(+) CTCAC(A/G)GACCT reference, synonymous-codon
rs1134578 -- 404,317(+) GACTT(C/T)CGGGC reference, synonymous-codon
rs3210555 -- 397,609(+) TGCTG(A/G)GAGCG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PKP3 Gene

Variant ID Type Subtype PubMed ID
dgv911n71 CNV Gain 21882294
dgv916n71 CNV Loss 21882294
nsv896463 CNV Gain 21882294
nsv527327 CNV Loss 19592680
dgv918n71 CNV Loss 21882294
dgv182e199 CNV Deletion 23128226
dgv919n71 CNV Loss 21882294
dgv920n71 CNV Loss 21882294
dgv921n71 CNV Loss 21882294
dgv922n71 CNV Loss 21882294
nsv896488 CNV Loss 21882294
dgv923n71 CNV Loss 21882294
esv28392 CNV Gain+Loss 19812545
dgv924n71 CNV Loss 21882294
nsv467633 CNV Loss 19166990
nsv896502 CNV Loss 21882294
nsv469923 CNV Loss 18288195
dgv925n71 CNV Loss 21882294
dgv926n71 CNV Loss 21882294
nsv896514 CNV Gain 21882294
esv2659206 CNV Deletion 23128226
nsv39515 CNV Loss 16902084
esv1656697 CNV Deletion 17803354
nsv896516 CNV Loss 21882294
nsv896517 CNV Loss 21882294
nsv896518 CNV Gain+Loss 21882294
dgv927n71 CNV Loss 21882294
dgv928n71 CNV Gain+Loss 21882294
dgv929n71 CNV Loss 21882294
dgv930n71 CNV Loss 21882294
dgv931n71 CNV Loss 21882294
esv2664242 CNV Deletion 23128226

Variation tolerance for PKP3 Gene

Residual Variation Intolerance Score: 96.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKP3 Gene

Disorders for PKP3 Gene

Relevant External Links for PKP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PKP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKP3 Gene

Publications for PKP3 Gene

  1. Plakophilin 3 -- a novel cell-type-specific desmosomal plaque protein. (PMID: 10374265) Schmidt A. … Franke W.W. (Differentiation 1999) 2 23 67
  2. Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer. (PMID: 18801625) Valladares-Ayerbes M. … AntA^n-Aparicio L.M. (Cancer Detect. Prev. 2008) 23 67
  3. The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. (PMID: 17391671) Aigner K. … Eger A. (FEBS Lett. 2007) 23 67
  4. Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer. (PMID: 16103059) Furukawa C. … Nakamura Y. (Cancer Res. 2005) 23 67
  5. Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters. (PMID: 12827610) Papagerakis S. … Forest N. (Hum. Pathol. 2003) 23 67

Products for PKP3 Gene

Sources for PKP3 Gene

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