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PKP3 Gene

protein-coding   GIFtS: 55
GCID: GC11P000394

Plakophilin 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Plakophilin 31 2
Plakophilin 3b2
plakophilin-32

External Ids:    HGNC: 90251   Entrez Gene: 111872   Ensembl: ENSG000001843637   OMIM: 6055615   UniProtKB: Q9Y4463   

Export aliases for PKP3 gene to outside databases

Previous GC identifers: GC11U990201 GC11M000795 GC11P000384 GC11P000354 GC11P000209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PKP3 Gene:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins
contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins
to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and
signaling pathways. (provided by RefSeq, Jul 2008)

GeneCards Summary for PKP3 Gene:
PKP3 (plakophilin 3) is a protein-coding gene. An important paralog of this gene is PKP1.

UniProtKB/Swiss-Prot: PKP3_HUMAN, Q9Y446
Function: May play a role in junctional plaques

Gene Wiki entry for PKP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PKP3 gene promoter:
         E2F-4   E2F-3a   AREB6   E2F-5   E2F-1   E2F   E2F-2   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PKP3 promoter sequence
   Search Chromatin IP Primers for PKP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PKP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15

PKP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKP3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000394:  view genomic region     (about GC identifiers)

Start:
392,614 bp from pter      End:
404,908 bp from pter
Size:
12,295 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PKP3_HUMAN, Q9Y446 (See protein sequence)
Recommended Name: Plakophilin-3  
Size: 797 amino acids; 87082 Da
Secondary accessions: F8J390 Q53EX8
Alternative promoter usage: 2 isoforms:  Q9Y446-1   Q9Y446-2   

Explore the universe of human proteins at neXtProt for PKP3: NX_Q9Y446

Explore proteomics data for PKP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PKP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009114.1  
    ENSEMBL proteins: 
     ENSP00000434517   ENSP00000435383   ENSP00000435522   ENSP00000434110   ENSP00000331678  
     ENSP00000435478   ENSP00000436847  

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    Cloud-Clone Corp. Proteins for PKP3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARMC: Armadillo repeat containing

    5 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR028434 Plakophilin-3
     IPR028435 Plakophilin/d_Catenin
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9Y446

    ProtoNet protein and cluster: Q9Y446

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: PKP3_HUMAN, Q9Y446
    Similarity: Belongs to the beta-catenin family
    Similarity: Contains 8 ARM repeats


    Find genes that share domains with PKP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKP3_HUMAN, Q9Y446
    Function: May play a role in junctional plaques

         Genatlas biochemistry entry for PKP3:
    plakophilin 3,component of the plaque protein of desmosomes of most simple and almost all stratified epithelia
    with the exception of hepatocytes and hepatocellular carcinoma cell,homologous to Drosophila Armadillo segment
    polarity gene

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0050839cell adhesion molecule binding IPI--
         
    Find genes that share ontologies with PKP3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for PKP3:
     Decreased TP53 protein express  Increased cilium length  Increased cilium length after  

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pkp3):
     cellular  growth/size/body  immune system  integument  normal 

    Find genes that share phenotypes with PKP3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pkp3tm1.1Fvr for PKP3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PKP3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PKP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PKP3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PKP3

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    Block miRNA regulation of human, mouse, rat PKP3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PKP3:
    hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidPKP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PKP3
    Predesigned siRNA for gene silencing in human, mouse, rat PKP3

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    GenScript: all cDNA clones in your preferred vector: PKP3 (NM_007183)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKP3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PKP3_HUMAN, Q9Y446: Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane IDA--
    GO:0005911cell-cell junction TAS10374265
    GO:0030057desmosome IEA--

    Find genes that share ontologies with PKP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including PKP3: 
              Adherens Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PKP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for PKP3 (Q9Y4462, 3 ENSP000003316784) via UniProtKB, MINT, STRING, and/or I2D (see all 658)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3, ENSP000003409894MINT-3975156 I2D: score=2 STRING: ENSP00000340989
    CCT2P783712, 3MINT-7945693 I2D: score=1 
    CCT3P493682, 3MINT-7945693 I2D: score=1 
    CCT5P486432, 3MINT-7945693 I2D: score=1 
    CCT7Q998322, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002159desmosome assembly IMP--
    GO:0016337cell-cell adhesion IEA--
    GO:0090002establishment of protein localization to plasma membrane IMP--

    Find genes that share ontologies with PKP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PKP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PKP3 gene: 
    NM_007183.2  

    Unigene Cluster for PKP3:

    Plakophilin 3
    Hs.534395  [show with all ESTs]
    Unigene Representative Sequence: NM_007183
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534401 ENST00000533249 ENST00000527442 ENST00000528036 ENST00000331563(uc021qbk.1 uc001lpc.3)
    ENST00000533069 ENST00000531857 ENST00000530695 ENST00000524646 ENST00000526971
    ENST00000525642
    miRNA
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    Block miRNA regulation of human, mouse, rat PKP3 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate PKP3:
    hsa-miR-324-3p
    SwitchGear 3'UTR luciferase reporter plasmidPKP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PKP3
    Predesigned siRNA for gene silencing in human, mouse, rat PKP3
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    GenScript: all cDNA clones in your preferred vector: PKP3 (NM_007183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PKP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKP3
    Primer
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    OriGene qPCR primer pairs and template standards for PKP3
    OriGene qSTAR qPCR primer pairs in human, mouse for PKP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PKP3
      QuantiTect SYBR Green Assays in human, mouse, rat PKP3
      QuantiFast Probe-based Assays in human, mouse, rat PKP3

    Additional mRNA sequence: 

    AF053719.1 AK025067.1 AK223511.1 BC000081.2 FN421477.1 Z98265.1 

    10 DOTS entries:

    DT.311176  DT.91730058  DT.97844198  DT.100791526  DT.120711083  DT.100791527  DT.101967967  DT.92427433 
    DT.97826501  DT.100805286 

    Selected AceView cDNA sequences (see all 182):

    BE999971 AI202573 R74498 BQ691847 AI346781 AW009869 BG676535 BQ689045 
    BX102928 BU621340 BQ631370 AI869046 CA454544 AF053719 BQ688254 BM781805 
    BF591265 AI337421 BU162874 BM998324 BU197168 BQ690079 AI538462 AW274145 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PKP3 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
    SP1:                                                                                                                                                            
    SP2:                    -     -     -                 -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:        -     -     -     -     -                 -                                                                                                         
    SP5:              -     -     -     -                 -                                                                                                         

    ExUns: 16 ^ 17a · 17b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for PKP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PKP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGTCAAA
    PKP3 Expression
    About this image


    PKP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Placenta (Extraembryonic Tissues)
    PKP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PKP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534395

    UniProtKB/Swiss-Prot: PKP3_HUMAN, Q9Y446
    Tissue specificity: Isoform PKP3a is found in desmosomes of most simple and stratified epithelia. Not found in
    foreskin fibroblasts and various sarcoma-derived cell lines. Beside dendritic reticular cells of lymphatic
    follicles not found in non-epithelial desmosome-bearing tissues. Isoform PKP3b is abundant in the desmosomes of
    stratified epithelial cell but absent in simple epithelial cells, it is also expressed in the colon and its
    tumors

        Pathway & Disease-focused RT2 Profiler PCR Array including PKP3: 
              Adherens Junctions in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PKP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PKP3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkp31 , 5 plakophilin 31, 5 86.53(n)1
    93.85(a)1
      7 (86.34 cM)5
    564601  NM_019762.21  NP_062736.21 
     1410782185 
    chicken
    (Gallus gallus)
    Aves PKP31 plakophilin 3 71.97(n)
    72.82(a)
      422994  XM_003641289.2  XP_003641337.1 
    lizard
    (Anolis carolinensis)
    Reptilia PKP36
    plakophilin 3
    68(a)
    1 ↔ 1
    1(76535279-76583974)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pkp31 plakophilin 3 64.9(n)
    66.49(a)
      100498319  XM_004913401.1  XP_004913458.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003303531 plakophilin-3-like 56.52(n)
    48.44(a)
      100330353  XM_002662838.2  XP_002662884.1 


    ENSEMBL Gene Tree for PKP3 (if available)
    TreeFam Gene Tree for PKP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PKP3 gene
    PKP12  CTNND12  PKP22  CTNND22  ARVCF2  PKP42  

    Find genes that share paralogs with PKP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PKP3 (see all 481)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs74826851,2
    C--392340(-) GGCCTC/TTGCAG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1895100451,2
    --392432(+) GGCGGA/GACCCA 1 -- us2k10--------
    rs1921516281,2
    --392466(+) AGGCCC/GGCTCT 1 -- us2k10--------
    rs1846739101,2
    --392596(+) CCGCCA/GCAGAG 1 -- us2k10--------
    rs1114478341,2
    F--392634(+) TGGAGT/CCCTGG 1 -- us2k12Minor allele frequency- C:0.05CSA WA 120
    rs1409738311,2
    --392646(+) CACCTC/TGGCCG 1 -- us2k10--------
    rs1437289401,2
    --392702(+) ACCACA/GAGCCG 1 -- us2k10--------
    rs1164672461,2
    F--392754(+) GGTGGC/ACCCAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1895352931,2
    --392812(+) CCCCCC/GACGCT 1 -- us2k10--------
    rs127886101,2
    C,F,H--392953(+) GACGGG/AGCTAG 1 -- us2k115Minor allele frequency- A:0.12NA NS WA CSA EA 1833

    HapMap Linkage Disequilibrium report for PKP3 (392614 - 404908 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PKP3 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    esv1656697CNV Deletion17803354
    esv2659206CNV Deletion23128226
    esv2664242CNV Deletion23128226
    dgv923n71CNV Loss21882294
    dgv931n71CNV Loss21882294
    nsv467633CNV Loss19166990
    nsv469923CNV Loss18288195
    dgv930n71CNV Loss21882294
    dgv918n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605561    OMIM disorders: --


    Find genes that share disorders with PKP3           About GenesLikeMe

    1 Novoseek inferred disease relationship for PKP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 2.99 2 16103059 (1), 18801625 (1)

    Genetic Association Database (GAD): PKP3
    Human Genome Epidemiology (HuGE) Navigator: PKP3 (3 documents)

    Export disorders for PKP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PKP3 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with PKP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Plakophilin 3 -- a novel cell-type-specific desmosomal plaque protein. (PubMed id 10374265)1, 2, 3, 9 Schmidt A....Franke W.W. (Differentiation 1999)
    2. Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells. (PubMed id 10381383)1, 2, 9 Bonne S.... van Roy F. (J. Cell Sci. 1999)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. (PubMed id 17391671)1, 9 Aigner K....Eger A. (FEBS Lett. 2007)
    7. Immunohistochemical localization of plakophilins (PKP1, PKP2, PKP3, and p0071) in primary oropharyngeal tumors: correlation with clinical parameters. (PubMed id 12827610)1, 9 Papagerakis S....Forest N. (Hum. Pathol. 2003)
    8. Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer. (PubMed id 18801625)1, 9 Valladares-Ayerbes M....AntA^n-Aparicio L.M. (Cancer Detect. Prev. 2008)
    9. Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. (PubMed id 10852826)1, 9 Hofmann I....Herrmann H. (J. Cell. Sci. 2000)
    10. An alternative promoter of the human plakophilin-3 gene controls the expression of the new isoform PKP3b. (PubMed id 24178805)2 Muhmer M.... Schmidt A. (Cell Tissue Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11187 HGNC: 9025 AceView: PKP3 Ensembl:ENSG00000184363 euGenes: HUgn11187
    ECgene: PKP3 H-InvDB: PKP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PKP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PKP3 gene:
    Search GeneIP for patents involving PKP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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