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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PKP2 Gene

protein-coding   GIFtS: 66
GCID: GC12M032943

Plakophilin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Plakophilin 21 2
ARVD92 5
plakophilin-22

External Ids:    HGNC: 90241   Entrez Gene: 53182   Ensembl: ENSG000000572947   OMIM: 6028615   UniProtKB: Q999593   

Export aliases for PKP2 gene to outside databases

Previous GC identifers: GC12M033434 GC12M033020 GC12M032844 GC12M032835 GC12M032834 GC12M032696


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PKP2 Gene:
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins
contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins
to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of
beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed
pseudogene with high similarity to this locus has been mapped to chromosome 12p13. (provided by RefSeq, Jul 2008)

GeneCards Summary for PKP2 Gene: 
PKP2 (plakophilin 2) is a protein-coding gene. Diseases associated with PKP2 include familial isolated arrhythmogenic ventricular dysplasia, biventricular form, and arrhythmogenic right ventricular dysplasia/cardiomyopathy 9, and among its related super-pathways are Hypertrophic cardiomyopathy (HCM) and Cytoskeleton remodeling Keratin filaments. GO annotations related to this gene include protein kinase C binding and molecular_function. An important paralog of this gene is PKP1.

UniProtKB/Swiss-Prot: PKP2_HUMAN, Q99959
Function: May play a role in junctional plaques

Gene Wiki entry for PKP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PKP2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPKP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PKP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11   Ensembl cytogenetic band:  12p11.21   HGNC cytogenetic band: 12p11

PKP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M032943:  view genomic region     (about GC identifiers)

Start:
32,943,679 bp from pter      End:
33,049,780 bp from pter
Size:
106,102 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKP2_HUMAN, Q99959 (See protein sequence)
Recommended Name: Plakophilin-2  
Size: 881 amino acids; 97415 Da
Subunit: Interacts with DSC2. Interacts with JUP and DSP
Subcellular location: Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes
1 PDB 3D structure from and Proteopedia for PKP2:
3TT9 (3D)    
Secondary accessions: A0AV37 D3DUW9 Q4VC01 Q99960
Alternative splicing: 2 isoforms:  Q99959-1   Q99959-2   

Explore the universe of human proteins at neXtProt for PKP2: NX_Q99959

Explore proteomics data for PKP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99959

  • PKP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PKP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001005242.2  NP_004563.2  

    ENSEMBL proteins: 
     ENSP00000342800   ENSP00000070846  

    Human Recombinant Protein Products for PKP2: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PKP2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS8922383
    GO:0005882intermediate filament ISS--
    GO:0005886plasma membrane TAS8922383
    GO:0005911cell-cell junction ISS--
    GO:0005912adherens junction ISS--

    PKP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARMC: Armadillo repeat containing

    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR000225 Armadillo
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q99959

    ProtoNet protein and cluster: Q99959

    1 Blocks protein domain: IPB000225 Armadillo repeat

    UniProtKB/Swiss-Prot: PKP2_HUMAN, Q99959
    Similarity: Belongs to the beta-catenin family
    Similarity: Contains 8 ARM repeats


    PKP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKP2_HUMAN, Q99959
    Function: May play a role in junctional plaques

         Genatlas biochemistry entry for PKP2:
    plakophilin 2,component of karyoplasm and desmosomal plaque protein of desmosomes in stratified epithelia,also
    expressed in the nucleus of non epithelial cells, homologous to Drosophila Armadillo segment polarity gene

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005080protein kinase C binding IPI18474624
    GO:0005488binding ----
    GO:0005515protein binding IPI10852826
    GO:0017080sodium channel regulator activity ISS--
         
    PKP2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PKP2:
     Increased S DNA content  Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pkp2):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    PKP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pkp2tm1Wbm for PKP2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PKP2 
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    SwitchGear 3'UTR luciferase reporter plasmidPKP2 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PKP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Arrhythmogenic right ventricular cardiomyopathy0.53
    2Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments0.91

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for PKP2
        Cytoskeleton remodeling Keratin filaments


    1 GeneGo (Thomson Reuters) Pathway for PKP2
        Cytoskeleton remodeling Keratin filaments

    1 BioSystems Pathway for PKP2
        Arrhythmogenic right ventricular cardiomyopathy



    1         Kegg Pathway  (Kegg details for PKP2):
        Arrhythmogenic right ventricular cardiomyopathy (ARVC)


    PKP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PKP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/69 Interacting proteins for PKP2 (Q999592, 3 ENSP000000708464) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MARK3P274482, 3, ENSP000004113974MINT-16617 MINT-16618 I2D: score=2 STRING: ENSP00000411397
    SMAD9O151982, 3MINT-62092 I2D: score=3 
    SFNP319472, 3MINT-3975132 I2D: score=2 
    YWHAZP631042, 3, ENSP000003095034MINT-8006476 I2D: score=2 STRING: ENSP00000309503
    DSC2Q024873, ENSP000002809044I2D: score=2 STRING: ENSP00000280904
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002159desmosome assembly IMP18474624
    GO:0007507heart development ISS--
    GO:0008285negative regulation of cell proliferation ISS--
    GO:0010765positive regulation of sodium ion transport ISS--
    GO:0016264gap junction assembly ISS--

    PKP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PKP2

    Search CenterWatch for drugs/clinical trials and news about PKP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PKP2 gene (2 alternative transcripts): 
    NM_001005242.2  NM_004572.3  

    Unigene Cluster for PKP2:

    Plakophilin 2
    Hs.164384  [show with all ESTs]
    Unigene Representative Sequence: NM_004572
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340811(uc001rlj.4 uc001rlk.4 uc010skj.2) ENST00000070846
    ENST00000546769 ENST00000549461 ENST00000552612 ENST00000546498 ENST00000546741

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    hsa-miR-516b hsa-miR-181c hsa-miR-513a-3p hsa-miR-509-5p hsa-miR-181a hsa-miR-181d hsa-miR-7 hsa-miR-889
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    Additional mRNA sequence: 

    AK299139.1 BC070083.1 BC094762.1 BC126199.1 BC143966.1 BC143967.1 EU520483.1 EU520484.1 
    EU520485.1 EU520486.1 X97675.1 

    9 DOTS entries:

    DT.97773851  DT.448183  DT.40300054  DT.95335949  DT.86841173  DT.100653530  DT.75141910  DT.95213314 
    DT.97802710 

    24/166 AceView cDNA sequences (see all 166):

    CD723015 AL710066 BI335875 CF551781 AA115706 BF063284 BF000586 AU125826 
    AA699376 N56027 AI039176 W86622 BE540524 AI383723 BG252206 AI159789 
    AI368931 AL601426 BM977349 AI673678 AU125339 AA203430 AI871702 BU685504 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PKP2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b
    SP1:                    -                                                           -           -                       -                     
    SP2:                    -                             -                             -           -                       -                     
    SP3:                                                                                -                                                         
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for PKP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PKP2 expression in normal human tissues (normalized intensities)      PKP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAAGAAGA
    PKP2 Expression
    About this image


    PKP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             sigmoid colon mucosa   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiac Fibroblasts Myocardium
             atrial myocardium   
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Ovarian Fibroblasts (HOF)   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Human Pulmonary Artery Smooth Muscle Cells (HPASMC)   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See PKP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PKP2

    SOURCE GeneReport for Unigene cluster: Hs.164384

    UniProtKB/Swiss-Prot: PKP2_HUMAN, Q99959
    Tissue specificity: Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal
    plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node
    follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent
    from suprabasal strata

        SABiosciences Expression via Pathway-Focused PCR Array including PKP2: 
              Adherens Junctions in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PKP2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkp21 , 5 plakophilin 21, 5 81.13(n)1
    82.64(a)1
      16 (10.09 cM)5
    674511  NM_026163.21  NP_080439.11 
     162133185 
    chicken
    (Gallus gallus)
    Aves PKP21 plakophilin 2 67.03(n)
    63.43(a)
      418130  XM_416362.3  XP_416362.3 
    lizard
    (Anolis carolinensis)
    Reptilia PKP26
    Uncharacterized protein
    56(a)
    1 ↔ 1
    5(10084262-10129441)
    zebrafish
    (Danio rerio)
    Actinopterygii pkp21 plakophilin 2 50.11(n)
    41.22(a)
      568060  NM_001113433.1  NP_001106904.1 
    worm
    (Caenorhabditis elegans)
    Secernentea jac-16
    Juxtamembrane domain-associated catenin
    13(a)
    1 → many
    IV(15997665-16026847)


    ENSEMBL Gene Tree for PKP2 (if available)
    TreeFam Gene Tree for PKP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PKP2 gene
    PKP12  CTNND12  PKP32  CTNND22  ARVCF2  PKP42  
    5 SIMAP similar genes for PKP2 using alignment to 6 protein entries:     PKP2_HUMAN (see all proteins):
    PFKM    BIRC5    DKFZp666K083    OK/SW-cl.18    PKP1

    PKP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for PKP2
    PGOHUM00000239632


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1880/2267 SNPs in PKP2 are shown (see all 2267)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0211504
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0211502 K Q mis40--------
    VAR_0657164
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0657162 Y C mis40--------
    VAR_0657114
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0657112 F S mis40--------
    VAR_0657184
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0657182 L F mis40--------
    VAR_0211514
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0211512 C R mis40--------
    VAR_0657054
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0657052 E K mis40--------
    VAR_0657064
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0657062 S G mis40--------
    VAR_0211494
    Familial arrhythmogenic right ventricular dysplasia 9 (ARVD9)4--see VAR_0211492 S F mis40--------
    rs1461022411,2,4
    C,Fprobable-non-pathogenic132844443(+) ATGGAC/TCAGTG 4 I V mis12Minor allele frequency- T:0.00NA EU 5873
    rs1512124771,2
    Cuntested132863553(+) GTCTCA/GAACTC 3 R * int1 stg10--------
    rs1856818141,2
    Cunknown132899124(+) GTTACA/CTTCTT 2 -- int10--------
    rs1939226741,2
    Cother132823232(-) AAACAC/GATGCC 2 -- spa10--------
    VAR_0657074
    ----see VAR_0657072 A V mis40--------
    VAR_0657174
    ----see VAR_0657172 G V mis40--------
    VAR_0657124
    ----see VAR_0657122 G R mis40--------
    VAR_0657084
    ----see VAR_0657082 P S mis40--------
    VAR_0657104
    ----see VAR_0657102 A P mis40--------
    VAR_0657034
    ----see VAR_0657032 Q K mis40--------
    rs581071191,2
    C--32707611(+) TTTTT-/A/TAAATG 2 -- int10--------
    rs105599701,2
    C--32724966(+) CACAA-/CCCCCCCC 4 -- int1 cds11Minor allele frequency- CCC:0.00CSA 2
    rs342492581,2
    C--32724966(+) CACAA-/CCCCCCCC 2 -- int10--------
    rs1435258941,2
    C--32746513(+) GGGTT-/GGGGGG 2 -- int10--------
    rs2021987931,2
    --32798008(+) GGCGG-/CGGGGG 2 -- int10--------
    rs73122411,2
    C,F,A,H--32811010(+) TGTTCA/GTTCAC 2 -- ds500132Minor allele frequency- G:0.47NA NS EA WA CSA 2917
    rs73123781,2
    C,F,A--32811092(+) AGCACG/ATGGAA 2 -- ds50017Minor allele frequency- A:0.50WA NA CSA EA 366
    rs72980891,2
    C,F,A--32811093(+) GCACAG/TGGAAA 2 -- ds50017Minor allele frequency- T:0.49WA NA CSA EA 366
    rs1463429691,2
    --32811114(+) TCTGTA/CTTTTC 2 -- ds50010--------
    rs666860831,2
    C--32811195(+) TTTATGGTCA/
            
    GGTCA
    2 -- ds50011Minor allele frequency- -:0.50CSA 2
    rs1148004901,2
    F--32811240(+) GTCTCT/CTGGTA 2 -- ds50011Minor allele frequency- C:0.02WA 118
    rs73126211,2
    C,F,A,H--32811266(+) AATTAG/AGGGGA 2 -- ds500112Minor allele frequency- A:0.44NS NA WA CSA EA 573
    rs1911762831,2
    --32811342(+) TTTTAC/TGTCAA 2 -- ds50010--------
    rs107719951,2
    C,F,A,H--32811354(+) CATACT/CATATA 2 -- ds500113Minor allele frequency- C:0.50NA WA CSA EA 512
    rs10461541,2
    C,F--32811532(-) CTGATG/TATAAG 2 -- ut31 ese33Minor allele frequency- T:0.10NA 124
    rs10461501,2
    C,F,A,H--32811664(-) TTGAAA/GCAATT 2 -- ut31 ese321Minor allele frequency- G:0.42MN NA NS WA CSA EA 2014
    rs1125479241,2
    F--32811701(+) CAAAAT/ATTATT 2 -- ut311Minor allele frequency- A:0.50CSA 2
    rs123147961,2
    C,F,H--32811824(+) TAACTC/GTATAT 2 -- ut315Minor allele frequency- G:0.04NS EA NA 540
    rs1876188491,2
    --32811849(+) ATAGCA/GCAGTT 2 -- ut310--------
    rs10461381,2
    C--32811899(-) TAAATA/GGTTGA 2 -- ut31 ese31Minor allele frequency- G:0.00NA 2
    rs64880901,2
    C,F,A,H--32812151(+) TCTGAT/GAGAAG 2 -- ut31 ese315Minor allele frequency- G:0.09NA NS EA WA CSA 569
    rs93941,2
    C,F,A,H--32812283(-) AACAAC/TGCCGT 2 -- ut31 ese328Minor allele frequency- T:0.36MN NA NS EA WA CSA 3218
    rs1441101401,2
    --32812412(+) ATTTTA/GCTTTA 2 -- ut310--------
    rs1912809081,2
    --32812424(+) GTTCTA/GGGAGG 2 -- ut310--------
    rs1834567151,2
    --32812434(+) GAAAAG/TACTTC 2 -- ut310--------
    rs1449838911,2
    C--32812449(+) ATTTGC/TTATGA 2 -- ut310--------
    rs1877973901,2
    --32812488(+) AGTCAG/TGCATA 2 -- ut310--------
    rs1379473831,2
    C--32812511(+) ATTTC-/TTAAGT
            
    TTAAG
    2 -- cds10--------
    rs1486939241,2
    C--32812792(+) ATTTAC/TTGGAT 2 -- ut310--------
    rs785406321,2
    C,F--32812814(+) CCACAT/CGAATT 2 -- ut311Minor allele frequency- C:0.01NA 120
    rs126121,2
    C,F,A,H--32812844(-) TGGTAG/CATGGC 2 -- ut31 ese326Minor allele frequency- C:0.49MN NA NS EA WA CSA 1727
    rs779883821,2
    F--32812893(+) TGGCCA/GGTATC 2 -- ut311Minor allele frequency- G:0.00CSA 1
    rs1922933071,2
    C--32813056(+) TTCCTC/TTGGGG 2 -- ut310--------
    rs2020944671,2
    C--32813110(+) AGGGAG/TGGTAG 4 Q H mis11Minor allele frequency- T:0.00EU 1323
    rs750176961,2
    C--32813196(+) AAGGTA/GACAAA 2 -- int12Minor allele frequency- G:0.03CSA WA 119
    rs1134935461,2
    C,F--32813223(+) ATGCAG/TTTTTT 2 -- int14Minor allele frequency- T:0.04WA NA 242
    rs79568241,2
    C,F,A,H--32813232(+) TTTAGC/TGATTT 2 -- int128Minor allele frequency- T:0.45NA NS EA WA CSA 2492
    rs1999006321,2
    C--32813339(+) AGTTCC/TGTGTG 4 T syn10--------
    rs1174253571,2
    C--32813349(+) GTGCCC/GACAGA 4 S W mis12Minor allele frequency- G:0.00NA 4672
    rs64880911,2
    C,F,A,H--32813458(+) GATGCG/TGCCTG 2 -- int128Minor allele frequency- T:0.45NS EA NA WA CSA 2493
    rs64880921,2
    C,F,A--32813506(+) ACTCCC/GCAGCA 2 -- int113Minor allele frequency- G:0.50NA WA CSA EA 378
    rs79574601,2
    C,F,A--32813572(+) AAGGCG/AGGGAC 2 -- int116Minor allele frequency- A:0.50NA WA CSA EA 516
    rs1512189191,2
    --32813660(+) CTCACA/GCCTGT 2 -- int10--------
    rs1411600791,2
    --32813759(+) ATACAA/GAATCT 2 -- int10--------
    rs1851263091,2
    --32813766(+) ATCTAC/GCTGGG 2 -- int10--------
    rs1900274291,2
    --32813772(+) CTGGGC/TGTGGC 2 -- int10--------
    rs1469247211,2
    --32813823(+) AGGAGA/CATCAC 2 -- int10--------
    rs1927300631,2
    --32813841(+) CGGGAA/GGCGGA 2 -- int10--------
    rs1178939021,2
    F--32813949(+) ATTTAT/CACAGA 2 -- int11Minor allele frequency- C:0.01NA 120
    rs1847511821,2
    --32813977(+) TAAGGA/CATGTA 2 -- int10--------
    rs1475941881,2
    C--32814024(+) GAATAC/TAATCT 2 -- int10--------
    rs1420260251,2
    C--32814094(+) AAATAC/TATACG 2 -- int10--------
    rs1882409821,2
    --32814174(+) TTAAAA/GCAGTT 2 -- int10--------
    rs1807653411,2
    --32814194(+) CTTTAC/TGTTTC 2 -- int10--------
    rs1864147211,2
    --32814230(+) TCTTGA/CTATAA 2 -- int10--------
    rs1504585261,2
    --32814255(+) TGCATG/TTGAAC 2 -- int10--------
    rs64880931,2
    C,F,A--32814329(+) tggagT/Cgatct 2 -- int14Minor allele frequency- C:0.38NA WA 8
    rs571662151,2
    C,F--32814491(+) TCGATC/TTCCTG 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1434145381,2
    --32814564(+) CCCAGC/TCCATG 2 -- int10--------
    rs107720001,2
    C,F,A--32814690(+) AGATTC/ATTTTT 2 -- int1 trp36Minor allele frequency- A:0.33NA WA EA 364
    rs1892989911,2
    --32814708(+) TATCAC/TAGGCA 2 -- int10--------
    rs777849661,2
    C,F--32814823(+) AGGGAG/AGAGCA 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1821915111,2
    --32814847(+) TTATTA/GGTAAC 2 -- int10--------
    rs37899781,2
    C,F,H--32814930(+) ATTCAA/GAACTG 2 -- int119Minor allele frequency- G:0.35NS EA NA WA CSA 2338
    rs1390078691,2
    C--32815072(+) AACGGC/TAGGTC 2 -- int10--------
    rs1163862061,2
    F--32815187(+) ACACTC/TGGAAA 2 -- int11Minor allele frequency- T:0.01WA 118
    rs128252171,2
    C,F,H--32815297(+) ATACTC/TGAATA 2 -- int124Minor allele frequency- T:0.12EA NA NS CSA 2437
    rs566865141,2
    C,F--32815354(+) ACTATT/CTGGAA 2 -- int13Minor allele frequency- C:0.10WA CSA 122
    rs1444798191,2
    C--32815385(+) AACAG-/TTAATT 2 -- int10--------
    rs1867769441,2
    --32815431(+) ATCTGC/TCAGCC 2 -- int10--------
    rs748469731,2
    C,F--32815542(+) CTGCAG/AAGTGG 2 -- int11Minor allele frequency- A:0.09WA 118
    rs1916598291,2
    --32815580(+) GGGTGA/GGGCTG 2 -- int10--------
    rs72997361,2
    C,F,H--32815597(+) AGGTAA/GCATGT 2 -- int19Minor allele frequency- G:0.09NA NS EA WA 682
    rs1419832831,2
    --32815710(+) GGTTAG/TTTACA 2 -- int10--------
    rs740729361,2
    C,F--32815740(+) TAATAA/TGTCAA 2 -- int12Minor allele frequency- T:0.15WA 120
    rs1462943481,2
    --32815884(+) GAAAAC/GTTGAA 2 -- int10--------
    rs1383374381,2
    --32815902(+) ACACAG/TATGTG 2 -- int10--------
    rs110522361,2
    C,F,H--32815953(+) AGATGC/TGGAAG 2 -- int125Minor allele frequency- T:0.22NS EA NA WA 2910
    rs1830598451,2
    --32815971(+) ACAGAA/GAAAAA 2 -- int10--------
    rs1418723851,2
    --32816167(+) AAACCC/TCAGTC 2 -- int10--------
    rs1505638681,2
    C--32816198(+) AGACAC/TGCACC 2 -- int10--------
    rs1855825391,2
    --32816271(+) GGTCTC/TGAACT 2 -- int10--------
    rs1395895381,2
    --32816389(+) CATCCC/TCTCCT 2 -- int10--------
    rs1899507141,2
    --32816439(+) GACTCC/TTGCTT 2 -- int10--------
    rs566714441,2
    C--32816454(+) TACATT/CCTGCT 2 -- int12Minor allele frequency- C:0.17WA 120
    rs122281931,2
    C,F,A,H--32816671(+) TTTGCT/CGCCAT 2 -- int128Minor allele frequency- C:0.34NS EA NA WA CSA 2908
    rs1497143511,2
    --32816688(+) CATGAC/TGGTCA 2 -- int10--------
    rs1474380871,2
    --32816698(+) ATGACC/TGCACA 2 -- int10--------
    rs779911871,2
    C--32816707(+) CATTCA/TCAACC 2 -- int10--------
    rs619277691,2
    C--32816708(+) ATTCAT/CAACCG 2 -- int11Minor allele frequency- C:0.00NA 2
    rs2015941621,2
    --32816764(+) GGCAG-/AAACTG 2 -- int10--------
    rs1499688521,2
    C--32816766(+) CAGAA-/GCTGAA 2 -- int10--------
    rs664757431,2
    C--32816767(+) AGAAC-/GTGAAG 2 -- int10--------
    rs1115174711,2
    C--32816779(+) ACTTAC/G/TGCATC 2 -- spd10--------
    rs1423629331,2
    F--32816782(+) TACGCA/GTCGCC 4 D syn11Minor allele frequency- G:0.00NA 4548
    rs1512649591,2
    C,F--32816784(+) CGCATC/TGCCTG 4 N D mis11Minor allele frequency- T:0.00NA 4550
    rs1453246311,2
    C,F--32816805(+) CATAAA/C/TTTTCT 6 I V F mis12NA EU 5873
    rs2009477671,2
    C--32816835(+) AAGGTC/TGCGTG 4 N D mis10--------
    rs1397343281,2
    C,F--32816838(+) GTCGCG/TTGCAT 4 S R mis12Minor allele frequency- T:0.00NA EU 5873
    rs2002723881,2
    --32816857(+) CTGTTC/TTGGAT 4 Q syn10--------
    rs1125928551,2
    C,F--32816877(+) CAATGT/CGTAAC 4 /T /A mis12Minor allele frequency- C:0.00CSA NA 4552
    rs2019101181,2
    --32816962(+) AGAGTA/TTCTTT 4 E D mis10--------
    rs2014874211,2
    --32816966(+) TTTCTG/TTGGCT 4 K T mis10--------
    rs2002662701,2
    C--32816989(+) AAAAA-/ACAAAAC 2 -- int10--------
    rs576900551,2
    C--32816990(+) AAAAA-/CAAAAC 2 -- int10--------
    rs2017322221,2
    C,F--32816990(+) AAAAAC/AAAAAC 2 -- int11Minor allele frequency- A:0.02EU 723
    rs1880527831,2
    C--32817018(+) GTTTCC/TTAATC 2 -- int10--------
    rs71387581,2
    C,F,A,H--32817164(+) TTCTCT/CTGCCT 2 -- int16Minor allele frequency- C:0.38NA WA CSA 13
    rs1420679421,2
    --32817202(+) GCACCC/TGCCAC 2 -- int10--------
    rs1910189011,2
    --32817210(+) CACCAC/TGCCTG 2 -- int10--------
    rs71387871,2
    C,F,A,H--32817235(+) TTTTTA/TATTTT 2 -- int14Minor allele frequency- T:0.43NA WA CSA 7
    rs1838642411,2
    --32817278(+) TGTTAA/GCCAGG 2 -- int10--------
    rs1511670501,2
    C--32817321(+) AGCCTA/CGGCCT 2 -- int10--------
    rs1884402481,2
    --32817429(+) TTTCCC/GTAATA 2 -- int10--------
    rs1930560011,2
    --32817444(+) ATTTTA/TAAAAA 2 -- int10--------
    rs1410626131,2
    --32817624(+) GAGATA/CTTTAT 2 -- int10--------
    rs1502399771,2
    --32817684(+) ATAGGA/GCTATG 2 -- int10--------
    rs118342861,2
    C,F,H--32817740(+) TATCTA/GTGAAG 2 -- int15Minor allele frequency- G:0.01NS EA NA 420
    rs1848893011,2
    --32818053(+) CAGAAC/GTGGCA 2 -- int10--------
    rs110522421,2
    C--32818104(+) AGAGAG/CAGACC 2 -- int12Minor allele frequency- C:0.11NA 122
    rs1869538581,2
    --32818295(+) GATCTC/TGGCTC 2 -- int10--------
    rs1914524871,2
    --32818355(+) CCGAGC/TAGCTG 2 -- int10--------
    rs1836216001,2
    --32818363(+) CTGGGA/GTTACA 2 -- int10--------
    rs128217271,2
    C--32818375(+) gtgccT/Cgccac 2 -- int13Minor allele frequency- C:0.00NA 6
    rs1456440461,2
    C--32818386(+) CACGCC/TGGGCT 2 -- int10--------
    rs12688111,2
    C--32818387(-) tagccA/C/Gggcgt 2 -- int10--------
    rs128232201,2
    C,A--32818459(+) cctgaC/Tcttgt 2 -- int17Minor allele frequency- T:0.00NA WA CSA 12
    rs1495625191,2
    --32818474(+) CGCCCA/GCCTGG 2 -- int10--------
    rs1443027461,2
    C--32818480(+) CCTGGA/GCCTCC 2 -- int10--------
    rs110522431,2
    C,F--32818506(+) AGAAGC/TGTGAG 2 -- int15Minor allele frequency- T:0.38NA EA 246
    rs110522441,2
    C--32818820(+) atggcA/Gcgatc 2 -- int10--------
    rs108443541,2
    C,A--32818840(+) tgcaaA/Cctccg 2 -- int10--------
    rs1879715621,2
    --32818844(+) ACCTCC/TGCCTC 2 -- int10--------
    rs1821691711,2
    --32818884(+) CTCCCA/GAGTAG 2 -- int10--------
    rs108443551,2
    C,A--32818887(+) ccgagT/Cagcta 2 -- int12Minor allele frequency- C:0.00NA 4
    rs1855418291,2
    --32818910(+) CGCACA/CACCAT 2 -- int10--------
    rs122284891,2
    --32818936(+) tgtatA/Gttttt 2 -- int11Minor allele frequency- G:0.00NA 2
    rs2001425961,2
    C--32818936(+) TGTAT-/ATTTTT 2 -- int10--------
    rs1435929931,2
    C--32818937(+) GTATA-/TTTTTT 2 -- int10--------
    rs1817085081,2
    --32819024(+) CCTCCC/GAAACT 2 -- int10--------
    rs108443561,2
    C,A--32819028(+) CCAAAC/GTGCTG 2 -- int13Minor allele frequency- G:0.17NA WA 6
    rs1858244981,2
    --32819056(+) CACTGC/TGCCTG 2 -- int10--------
    rs1902069441,2
    --32819127(+) ACTTCC/TTGGTT 2 -- int10--------
    rs1452717591,2
    --32819136(+) TTATAA/CGTTTT 2 -- int10--------
    rs1399360791,2
    C--32819151(+) TTTTT-/TGTACT 2 -- int10--------
    rs108443571,2
    C,F,A,H--32819176(+) AGAAAG/AGTATT 2 -- int18Minor allele frequency- A:0.30NS NA WA EA 586
    rs1472179211,2
    --32819178(+) AAAGGC/TATTAA 2 -- int10--------
    rs1394850141,2
    --32819182(+) GTATTA/TAAAAA 2 -- int10--------
    rs108443581,2
    C,F,A,H--32819220(+) TATAGA/TAAATA 2 -- int19Minor allele frequency- T:0.36NS EA NA WA 750
    rs1810651951,2
    --32819642(+) AGCAGA/CGTAAA 2 -- int10--------
    rs79602911,2
    C,F,A,H--32819691(+) gcattC/Tgacaa 2 -- int110Minor allele frequency- T:0.32NS EA NA WA 654
    rs1455280871,2
    --32819716(+) GAATCC/TACAAG 2 -- int10--------
    rs79752101,2
    C,F,A,H--32819724(+) aaggaT/Actcaa 2 -- int18Minor allele frequency- A:0.36NA WA EA 368
    rs1853212721,2
    --32819763(+) ATCAAA/TAAGTG 2 -- int10--------
    rs1909024091,2
    C--32819837(+) TGATAC/TGCCTC 2 -- int10--------
    rs79630341,2
    C,A,H--32819864(+) gctcaG/Acatca 2 -- int11Minor allele frequency- A:0.00NA 2
    rs1438167761,2
    C--32819865(+) CTCAAC/TATCAC 2 -- int10--------
    rs110522461,2
    C,F,A--32820142(+) tatgaC/Aaaaga 2 -- int13Minor allele frequency- A:0.50NA 6
    rs1839754601,2
    --32820150(+) AGACAA/CTTGTA 2 -- int10--------
    rs1167054051,2
    F--32820222(+) TCAACC/GAACGA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1407204461,2
    --32820235(+) GGATAA/CAGGAA 2 -- int10--------
    rs1889679661,2
    --32820262(+) CCATGA/GAATAC 2 -- int10--------
    rs1917284121,2
    --32820305(+) CTTTGC/TGGCAA 2 -- int10--------
    rs1836400301,2
    --32820307(+) TTGCGG/TCAAAT 2 -- int10--------
    rs1871920261,2
    --32820313(+) CAAATG/TGGATG 2 -- int10--------
    rs38509721,2
    C,F,A,H--32820423(+) AGGAAC/TAAGAG 2 -- int114Minor allele frequency- T:0.35NS EA NA WA 922
    rs1459219841,2
    --32820425(+) GAACAA/CGAGTT 2 -- int10--------
    rs1916999011,2
    --32820451(+) GGGACC/TTGGGG 2 -- int10--------
    rs1466302561,2
    --32820465(+) AGGTAC/GGAAGG 2 -- int10--------
    rs1409506341,2
    --32820508(+) GTGTAC/TACTGC 2 -- int10--------
    rs38509731,2
    C,F,A--32820524(+) TGACAT/CGTGCA 2 -- int17Minor allele frequency- C:0.35NA WA EA 366
    rs38509741,2
    C,F,A--32820609(+) AAATTC/TTTAAA 2 -- int19Minor allele frequency- T:0.34NA WA EA 504
    rs1501852911,2
    --32820617(+) AAAAGC/GTGTTA 2 -- int10--------
    rs1838422251,2
    --32820640(+) TCCACG/TGGAAC 2 -- int10--------
    rs358263241,2
    C,F--32820651(+) TTGTCC/GTATGG 2 -- int17Minor allele frequency- G:0.10NA CSA EA 249
    rs2006978911,2
    C--32820719(+) GTATG-/TTT   
      TCCTCT
    TTTTC
    2 -- int10--------
    rs1866988181,2
    --32820751(+) AGACTC/TTTCTT 2 -- int10--------
    rs1926096991,2
    --32820754(+) CTCTTC/TTTAAA 2 -- int10--------
    rs39070421,2
    C,F,A,H--32820772(+) GAGCAC/TGCATC 2 -- int128Minor allele frequency- N:0.00NS EA NA WA 2980
    rs116159321,2
    C,F,H--32820813(+) AATACG/ATGTTG 2 -- int118Minor allele frequency- A:0.05NS EA NA WA CSA 2002
    rs1856535711,2
    --32820830(+) TCAGCA/TATTAA 2 -- int10--------
    rs594042921,2
    C,F--32820977(+) AGCCAA/CTTATC 2 -- int12Minor allele frequency- C:0.22WA 120
    rs1905632241,2
    --32820980(+) CAATTA/TTCTTA 2 -- int10--------
    rs1388191871,2
    --32821006(+) ACAGCA/GTTGAT 2 -- int10--------
    rs1818787651,2
    --32821192(+) CCAGAA/GTGCTG 2 -- int10--------
    rs1493659801,2
    C--32821234(+) CTCTAC/TGGCCT 2 -- int10--------
    rs71332911,2
    C,F,A,H--32821257(+) TAATGT/CCTCTA 2 -- int120Minor allele frequency- C:0.33NS EA NA WA 2342
    rs1469842171,2
    --32821305(+) TCTACA/GTCACA 2 -- int10--------
    rs71335351,2
    C,A--32821416(+) TTTAGT/CAAGTT 2 -- int15Minor allele frequency- C:0.35NA WA EA 362
    rs73025861,2
    C,F,A,H--32821417(+) TTAGTA/GAGTTA 2 -- int19Minor allele frequency- G:0.36NS EA NA WA 744
    rs745846161,2
    C,F--32821497(+) AATCTG/ATTATT 2 -- int11Minor allele frequency- A:0.09WA 118
    rs1381566351,2
    --32821579(+) GTAAGC/TAAAAC 2 -- int10--------
    rs1845210651,2
    --32821585(+) AAAACA/GTAACA 2 -- int10--------
    rs124273301,2
    H--32821638(+) AAGCTC/GTCATG 2 -- int14Minor allele frequency- G:0.00NS EA 418
    rs1436183361,2
    --32821663(+) TGTGTC/TCAAGC 2 -- int10--------
    rs733017181,2
    C,F--32821727(+) ACTTAT/CATATT 2 -- int14Minor allele frequency- C:0.05WA NA 242
    rs1888801771,2
    --32821905(+) CATTTC/TTGCCC 2 -- int10--------
    rs1813044291,2
    --32821969(+) AAAGAC/TGGAGT 2 -- int10--------
    rs567989111,2
    C,F--32822025(+) ACTGCC/TATTGA 2 -- int15Minor allele frequency- T:0.36WA NA EA 362
    rs794997051,2
    --32822044(+) ACAAAA/CGACCA 2 -- int10--------
    rs1434388101,2
    C--32822049(+) GACCA-/CTGGGG 2 -- int10--------
    rs577882791,2
    C--32822050(+) GACCAC/G/TGGGGA 2 -- int10--------
    rs1486850391,2
    --32822192(+) GCTGGC/TTTTGA 2 -- int10--------
    rs1411627921,2
    --32822257(+) GTGCAC/TATTTA 2 -- int10--------
    rs733017211,2
    C,F--32822290(+) GCAAAA/CTATTG 2 -- int15Minor allele frequency- C:0.36WA NA EA 362
    rs1908969021,2
    --32822317(+) AATGTA/GAAAAA 2 -- int10--------
    rs1808320901,2
    C--32822324(+) AAAACC/TGAATT 2 -- int10--------
    rs1873858101,2
    --32822344(+) AGAAAC/TGACCG 2 -- int10--------
    rs1922881451,2
    --32822348(+) ACGACC/TGATTA 2 -- int10--------
    rs3768521311,2
    C--32822474(+) AAAAA-/ATTATGTTA
    TTTGATAATGT
    AGTAC
    2 -- int10--------
    rs740729371,2
    C--32822476(+) AAAAAA/G/TTACCG 2 -- int11WA 2
    rs1507102591,2
    --32822530(+) CATCAC/TAGTTA 2 -- int10--------
    rs796448771,2
    F--32822590(+) TTTTAT/ATGTGA 2 -- int11Minor allele frequency- A:0.01WA 118
    rs619277711,2
    F--32822739(+) ATATGG/AATTAG 2 -- int11Minor allele frequency- A:0.50NA 2
    rs79618381,2
    C,F,H--32822810(+) ACTTAT/CCTTGT 2 -- int14Minor allele frequency- C:0.01NS NA WA 342
    rs114597351,2
    C--32822854(+) AGTAA-/T/TT  
            
    TTTTT
    2 -- int1 trp31CSA 2
    rs733017241,2
    C,F--32822895(+) CTCTGG/CTGAGA 2 -- int15Minor allele frequency- C:0.36WA CSA NA EA 362
    rs1859110211,2
    --32822997(+) GTGAAC/TGGGAG 2 -- int10--------
    rs1145616831,2
    C,F--32823011(+) ATACAG/AACAAC 2 -- int11Minor allele frequency- A:0.02WA 118
    rs2005172041,2
    C--32823034(+) TGTATC/TTTCAG 2 -- int10--------
    rs1389263541,2
    C--32823049(+) TACAT-/ATTACA 2 -- int10--------
    rs740729381,2
    C,F--32823071(+) ATACCG/AACTCA 2 -- int14Minor allele frequency- A:0.03WA NA EU 1563
    rs1390986751,2
    C--32823124(+) AGCAGC/TGAGAT 4 S syn11Minor allele frequency- T:0.00NA 4552
    rs1435037981,2
    C,F--32823155(+) GGTCAC/ACAACA 4 /G /V mis11Minor allele frequency- A:0.00NA 4552
    rs1440183201,2
    C--32823227(+) ATGTCA/GGCATC 4 P L mis10--------
    rs118325261,2
    C,F,A,H--32823338(+) tatctC/Tattta 2 -- int12Minor allele frequency- T:0.25WA NA 4
    rs122992761,2
    C,F--32823383(+) GGCTGA/GAGTGC 2 -- int13Minor allele frequency- G:0.40WA NA CSA 5
    rs79758241,2
    C,F,A--32823388(+) gagtgA/Cagtgg 2 -- int19Minor allele frequency- C:0.13NA WA CSA 15
    rs122991881,2
    C--32823416(+) ACAACG/CTCCAC 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1121510821,2
    C,F--32823766(+) GGGGCC/TGGGTG 2 -- int13Minor allele frequency- T:0.09WA CSA 122
    rs1492085711,2
    C--32823783(+) CTCACA/CCCTGT 2 -- int10--------
    rs125802161,2
    C,F,H--32823791(+) tgtaaC/Tcccag 2 -- int12Minor allele frequency- T:0.50WA NA 4
    rs1903723771,2
    --32823918(+) TGGCAC/TGTGCC 2 -- int10--------
    rs1457818711,2
    C--32824044(+) TGTCT-/AAAC  
            
    AAACA
    2 -- int10--------
    rs1825979601,2
    --32824420(+) TGAAAA/TTCATT 2 -- int10--------
    rs1512356481,2
    --32824447(+) CTTACA/GCTCAT 2 -- int10--------
    rs110522471,2
    C,F,H--32824470(+) ATTTTA/GTCCAA 2 -- int110Minor allele frequency- G:0.37NS EA NA WA 782
    rs110522481,2
    H--32824641(+) CTTACA/CCTTAC 2 -- int14Minor allele frequency- C:0.00NS EA 396
    rs110522491,2
    C,F,H--32824642(+) TTACAC/GTTACA 2 -- int17Minor allele frequency- G:0.27NS EA WA NA 772
    rs797803221,2
    C--32824808(+) GTGTTC/TTGATG 2 -- int10--------
    rs1150209981,2
    C,F--32825018(+) GGATGT/CGTAGG 2 -- int11Minor allele frequency- C:0.09WA 118
    rs733017321,2
    C,F--32825044(+) AATGTG/ATACCA 2 -- int14Minor allele frequency- A:0.04NA WA EA 360
    rs110522501,2
    C,A--32825075(+) CATCCA/CATCAC 2 -- int14Minor allele frequency- C:0.17NA 126
    rs1150147231,2
    F--32825098(+) CCCAGC/TGCCCA 2 -- int11Minor allele frequency- T:0.01WA 118
    rs110522511,2
    C,F,A,H--32825118(+) CTTCCA/GGTGAT 2 -- int119Minor allele frequency- G:0.40NS EA NA WA 2234
    rs1383794371,2
    --32825148(+) CAGGCA/CCCAGT 2 -- int10--------
    rs1881699491,2
    --32825220(+) GGCCAC/TGTGGT 2 -- int10--------
    rs110522521,2
    C,A--32825269(+) ACAGCC/TTCCAG 2 -- int12Minor allele frequency- T:0.00NA 4
    rs1459200621,2
    C--32825297(+) CAAAGA/GACATG 2 -- int10--------
    rs1386553531,2
    --32825370(+) TCAATC/GTATCA 2 -- int10--------
    rs1924468021,2
    --32825428(+) GCTGCA/TATGAA 2 -- int10--------
    rs1145837381,2
    C,F--32825462(+) AAGAGG/AACGAT 2 -- int13Minor allele frequency- A:0.35WA NA EA 358
    rs1157253841,2
    C,F--32825465(+) AGGACG/AATTTA 2 -- int12Minor allele frequency- A:0.36WA EA 238
    rs1493138211,2
    C--32825485(+) GGGTAC/TATACC 2 -- int10--------
    rs1827856061,2
    --32825635(+) CAGCAA/TCTGTT 2 -- int10--------
    rs1444450131,2
    C--32825647(+) TTTTTC/TTGACT 2 -- int10--------
    rs1889595131,2
    --32825736(+) ATGTTG/TAGCTT 2 -- int10--------
    rs1484159321,2
    --32825739(+) TTGAGA/CTTTTT 2 -- int10--------
    rs1161543691,2
    C,F--32825750(+) TTCACG/CTTTGT 2 -- int12Minor allele frequency- C:0.12WA NA 238
    rs1932566041,2
    --32825804(+) CTTTGC/TCCACT 2 -- int10--------
    rs1423457361,2
    --32825952(+) AGTTTC/TTTTTG 2 -- int10--------
    rs107720021,2
    C,F,A,H--32826012(+) TTTCAT/CTGCTA 2 -- int13Minor allele frequency- C:0.34WA NA EA 358
    rs108443601,2
    C,A,H--32826099(+) GGTTTT/GTATAG 2 -- int11Minor allele frequency- G:0.00NA 2
    rs108443611,2
    C,A,H--32826119(+) TTACAT/CTTAAG 2 -- int11Minor allele frequency- C:0.00NA 2
    rs1444152331,2
    C--32826198(+) TATGAC/TTAGCC 2 -- int10--------
    rs42728621,2
    C,H--32826317(+) ttctcT/Cattca 2 -- int14Minor allele frequency- C:0.40NA WA EA 360
    rs110522531,2
    C,F,A,H--32826325(+) tcaatT/Cccatt 2 -- int13Minor allele frequency- C:0.35WA NA EA 358
    rs1510785411,2
    --32826381(+) ATGGTA/GGCCCT 2 -- int10--------
    rs110522551,2
    C,A--32826391(+) TGTAAC/TACAGT 2 -- int15Minor allele frequency- T:0.35NA WA EA 362
    rs1847505431,2
    --32826407(+) GTCAGG/TTAGCA 2 -- int10--------
    rs1891603251,2
    --32826504(+) TTTCCA/TATTCT 2 -- int10--------
    rs108443621,2
    C,F,A,H--32826535(+) TCTAAC/TGGGGA 2 -- int110Minor allele frequency- T:0.31NS EA NA WA 638
    rs733017531,2
    C,F--32826601(+) GAAGCG/AATGTC 2 -- int13Minor allele frequency- A:0.08WA CSA 122
    rs1131725221,2
    C,F--32826692(+) TTTATC/TGATTT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1164813581,2
    F--32826699(+) ATTTGC/TGAATG 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1158719741,2
    F--32826742(+) CACTTG/TATGGT 2 -- int11Minor allele frequency- T:0.05WA 118
    rs1498640141,2
    --32826971(+) TACCCA/GCTCTT 2 -- int10--------
    rs1181670881,2
    F--32827071(+) CTCATT/AATTGG 2 -- int11Minor allele frequency- A:0.01EA 120
    rs1920763571,2
    --32827092(+) GATTCA/GATTTC 2 -- int10--------
    rs1842991791,2
    --32827127(+) GTATGC/TGTCCA 2 -- int10--------
    rs1162420631,2
    C,F--32827139(+) GAGTTT/GATCCA 2 -- int13Minor allele frequency- G:0.35WA NA EA 358
    rs1458606071,2
    --32827174(+) TGTGCA/CTAGAG 2 -- int10--------
    rs1898134211,2
    C--32827228(+) TCAGTA/GGTGAT 2 -- int10--------
    rs3712358361,2
    C--32827360(+) GGGTT-/TGTGTGTGTG/TGTG
    TGTGTGTGTGTGTGTGTG
    TGTGT
    2 -- int10--------
    rs1404844311,2
    C--32827361(+) GGGTT-/TGTGTGT 2 -- int10--------
    rs115347641,2
    C,F,H--32827410(+) ATCTTG/CGCTAT 2 -- int110Minor allele frequency- C:0.41EA NS NA WA 636
    rs115347651,2
    C,F,H--32827438(+) GTTTGG/CTCTGG 2 -- int110Minor allele frequency- C:0.39NS EA NA WA 652
    rs733017561,2
    C,F--32827477(+) GGTTGA/GTACCT 2 -- int14Minor allele frequency- G:0.05WA NA 242
    rs115612181,2
    C,F--32827520(+) TAGTGC/TTACAA 2 -- int16Minor allele frequency- T:0.35NA WA EA 364
    rs2007900531,2
    C--32827576(+) ACACT-/GTCTCT 2 -- int10--------
    rs73146211,2
    C,F,H--32827682(+) acttgT/Ggtggt 2 -- int113Minor allele frequency- G:0.46NA WA CSA EA 380
    rs1116919681,2
    C,F--32827709(+) AATCTC/TGAGTT 2 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1453385881,2
    C--32827896(+) AGGTCC/TGCTTG 2 -- int10--------
    rs1810777441,2
    --32827897(+) GGTCCA/GCTTGA 2 -- int10--------
    rs1861039551,2
    --32827921(+) TAACTC/GTTCTT 2 -- int10--------
    rs107720031,2
    C,A,H--32827985(+) CTTTGC/TTGGTG 2 -- int15Minor allele frequency- T:0.36NA WA EA 364
    rs1890232921,2
    --32828002(+) CTGTTG/TTGTCA 2 -- int10--------
    rs1166410891,2
    F--32828011(+) CAGAAC/GTAGGA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1476993721,2
    --32828029(+) CCTTGC/GTTTTT 2 -- int10--------
    rs1423969991,2
    --32828041(+) CTGTTC/TTCCAT 2 -- int10--------
    rs1482347161,2
    C--32828194(+) TAGCCC/TGTTTA 2 -- int10--------
    rs108443641,2
    C,F,A,H--32828195(+) AGCCCG/ATTTAC 2 -- int15Minor allele frequency- A:0.33NA WA EA 128
    rs181942036