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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PKNOX2 Gene

protein-coding   GIFtS: 49
GCID: GC11P125034

PBX/knotted 1 homeobox 2
 Explore 3 diseases affiliated with
PKNOX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PKNOX2    

Aliases
for PKNOX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
PBX/Knotted 1 Homeobox 21 2
PREP22 3 5
Homeobox Protein PREP-22 3
PBX/Knotted Homeobox 22 3
Homeobox Protein PKNOX22

External Ids:    HGNC: 167141   Entrez Gene: 638762   Ensembl: ENSG000001654957   OMIM: 6130665   UniProtKB: Q96KN33   

Export aliases for PKNOX2 gene to outside databases

Previous GC identifers: GC11P127222 GC11P126734 GC11P125235 GC11P124572 GC11P124758 GC11P124539 GC11P120976


Summaries
for PKNOX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PKNOX2:
Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and
play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid
loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2
within the homeodomain (Imoto et al., 2001 (PubMed 11549286)).(supplied by OMIM, Oct 2009)




Genomic Views
for PKNOX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PKNOX2 gene promoter:
         MyoD   CUTL1   Nkx2-5   LCR-F1   NF-AT   E2F-1   E2F   HFH-1   Pax-4a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PKNOX2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PKNOX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKNOX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

PKNOX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKNOX2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P125034:  view genomic region     (about GC identifiers)

Start:
 125,034,559 bp from pter      End:
 125,303,285 bp from pter
Size:
 268,727 bases      Orientation:
 plus strand

Proteins
for PKNOX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PKNX2_HUMAN, Q96KN3 (See protein sequence)
Recommended Name: Homeobox protein PKNOX2  
Size: 472 amino acids; 52028 Da
Subcellular location: Nucleus
Sequence caution: Sequence=BAB83665.1; Type=Erroneous initiation;
Secondary accessions: Q63HL6 Q86XD1

Explore the universe of human proteins at neXtProt for PKNOX2: NX_Q96KN3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96KN3

    • PKNOX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_071345.2  
    ENSEMBL proteins: 
     ENSP00000434732   ENSP00000433971   ENSP00000298282   ENSP00000431599   ENSP00000434377  
     ENSP00000434255   ENSP00000453353   ENSP00000453374   ENSP00000441470  

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    Novus Biologicals PKNOX2 Proteins
    Novus Biologicals PKNOX2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PKNOX2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0015629actin cytoskeleton IEA--
    GO:0015630microtubule cytoskeleton IEA--


    PKNOX2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for PKNOX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PKNOX2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008422 Homeobox_KN_domain
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q96KN3

    ProtoNet protein and cluster: Q96KN3

    UniProtKB/Swiss-Prot: PKNX2_HUMAN, Q96KN3
    Similarity: Belongs to the TALE/MEIS homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for PKNOX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PKNOX2
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate PKNOX2 (see all 54):
    hsa-miR-579 hsa-miR-513a-5p hsa-miR-29a hsa-miR-3074-3p hsa-miR-30d hsa-miR-371-5p hsa-miR-570 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: PKNOX2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for PKNOX2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA12412021
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003785actin monomer binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0051015actin filament binding IEA--


    PKNOX2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for PKNOX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PKNOX2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/8 Interacting proteins for PKNOX2 (Q96KN33 ENSP000002982824) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXB1P146533, ENSP000003551404I2D: score=2 STRING: ENSP00000355140
    PBX1P404243I2D: score=2 
    FOSP011003I2D: score=1 
    HOXA6P312673I2D: score=1 
    HOXB8P174813I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006357regulation of transcription from RNA polymerase II promoter IEA--


    PKNOX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PKNOX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PKNOX2
    Search CenterWatch for drugs/clinical trials and news about PKNOX2 / PKNX2 

    Transcripts
    for PKNOX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PKNOX2 gene: 
    NM_022062.2  

    Unigene Cluster for PKNOX2:

    PBX/knotted 1 homeobox 2
    Hs.278564  [show with all ESTs]
    Unigene Representative Sequence: AK023792
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530517 ENST00000531116 ENST00000298282(uc001qbu.3 uc010saz.2 uc010sba.2 uc010sbb.2)
    ENST00000559662 ENST00000557814 ENST00000527238 ENST00000561399 ENST00000532623
    ENST00000531212 ENST00000559794 ENST00000558729 ENST00000561115 ENST00000558705
    ENST00000561298 ENST00000526955(uc001qbv.3) ENST00000542175

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PKNOX2
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate PKNOX2 (see all 54):
    hsa-miR-579 hsa-miR-513a-5p hsa-miR-29a hsa-miR-3074-3p hsa-miR-30d hsa-miR-371-5p hsa-miR-570 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: PKNOX2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PKNOX2 (see all 4)
    OriGene shRNA RFP: PKNOX2
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKNOX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKNOX2

    Additional cDNA sequence: 

    AB065001.1 AJ417081.1 AK023136.1 AK023792.1 AK056506.1 AK295857.1 AK298999.1 AK316001.1 
    AK316268.1 AL512682.1 BC045626.1 BX648615.1 

    9 DOTS entries:

    DT.92423737  DT.453733  DT.100673461  DT.91788071  DT.120729834  DT.120729863  DT.120729867  DT.65287436 
    DT.91668094 

    24/87 AceView cDNA sequences (see all 87):

    AI090660 AI381830 AI655868 BX648615 AW295715 AI797350 BX096841 Z44941 
    AA984725 BI460005 F03223 BM725768 AK056506 AW451229 BF203230 AK023792 
    AB065001 AU131015 BV199910 Z43992 BC045626 CN481680 AW952820 BU194298 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PKNOX2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                    -                           
    SP2:                    -     -     -     -                                                                                                         
    SP3:        -           -     -     -     -     -                             -     -     -                                                         
    SP4:                                -     -                                   -     -     -                                                         
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for PKNOX2

    Expression
    for PKNOX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PKNOX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGTGAATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PKNOX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PKNOX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PKNOX2

    SOURCE GeneReport for Unigene cluster: Hs.278564
        SABiosciences Custom PCR Arrays for PKNOX2
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    In Situ
    Assay Products:     
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    Orthologs
    for PKNOX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PKNOX2 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PKNOX21 PBX/knotted 1 homeobox 2 80.43(n)
    85.32(a)    		   374067  NM_204226.1  NP_989557.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PKNOX26
    		 --
    		 90(a)
    		 1 ↔ 1
    		 GL343367.1(908979-1014060)
    zebrafish
    (Danio rerio)    		 Actinopterygii wuft92g052 wuft92g05 79.55(n)   386959  AB086818.1 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0075391 AGAP007539-PA 59.67(n)
    59.16(a)    		   1269694  XM_308339.4  XP_308339.4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons BEL16
    BLH86
    (see all 13)    		 BEL1-like homeodomain 8
    (see all 13)    		 9(a)
    9(a)
    (see all 13)    		 many ↔ many
    many ↔ many
    (see all 13)    		 5(16580044-16584008)
    2(11921433-11924698)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 14)    		 homeodomain protein, putative, expressed
    (see all 14)    		 9(a)
    9(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 3(27050084-27056737)
    1(36443976-36448908)


    ENSEMBL Gene Tree for PKNOX2 (if available)
    TreeFam Gene Tree for PKNOX2 (if available) 

    Paralogs
    for PKNOX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PKNOX2 gene
    MEIS22  TGIF2LY2  PKNOX12  MEIS32  TGIF22  TGIF2LX2  MEIS12  TGIF12  
    12 SIMAP similar genes for PKNOX2 using alignment to 8 protein entries:     PKNX2_HUMAN (see all proteins):
    TGIF2    PKNOX1    TGIF1    HB103    meis1    TGIF2LY
    MEIS1    MEIS3    MEIS2    MEIS3P1    MEIS3P2    WUGSC

    PKNOX2 for paralogs           About GeneDecksing



    Genomic Variants
    for PKNOX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5082 NCBI SNPs in PKNOX2 are shown (see all 5082)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1893733801,2
    		C,unknown125190058(+) GTTCCA/GGTGCT 1 -- int10--------
    rs1405900461,2
    		C,unknown125260075(+) GGTACC/G/TGTTCC 1 -- int10--------
    rs118288691,2
    		C,F,A,H,--125032589(+) TATTTG/AAAGAC 1 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1904854081,2
    		C,--125032595(+) AAGACG/TCCAAA 1 -- us2k10--------
    rs800498651,2
    		--125032601(+) CCAAAA/GATTAA 1 -- us2k10--------
    rs1923617941,2
    		--125032620(+) GGCAAA/C/TGGATC 1 -- us2k10--------
    rs1464281131,2
    		--125032644(+) AAGTGC/TTGGGC 1 -- us2k10--------
    rs748541381,2
    		F,--125032752(+) CTGATG/AGGGTG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1145119241,2
    		F,--125032866(+) AATGGA/GTCTCC 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs795016801,2
    		F,--125033111(+) TTTTGA/GAGGTT 1 -- us2k11Minor allele frequency- G:0.08WA 118

    HapMap Linkage Disequilibrium report for PKNOX2 (125034559 - 125284559 bp, first 250kb of PKNOX2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for PKNOX2
         9 CNVs: 48713 5037 48716 2960 10380 48715 66087 48714 66088
         5 Indels: 86067 24646 39868 86066 11587

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    Disorders / Diseases
    for PKNOX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PKNOX2 for disorders           About GeneDecksing

    OMIM gene information: 613066    OMIM disorders: --

    3 diseases for PKNOX2:    About MalaCards
    substance dependence    alcohol dependence    alcoholism

    1 disease from the University of Copenhagen DISEASES database for PKNOX2:
    Substance dependence
    Human Genome Epidemiology (HuGE) Navigator: PKNOX2 (6 documents)

    Export disorders for PKNOX2 gene to outside databases

    Publications
    for PKNOX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PKNOX2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with PKNOX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human PKNOX2, a novel homeobox-containing gene. (PubMed id 11549286)1, 2, 3 Imoto I.... Inazawa J. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors. (PubMed id 11972344)1, 2 Fognani C.... Blasi F. (2002)
    4. PKNOX2 is associated with formal thought disorder in s chizophrenia: a meta-analysis of two genome-wide association studies. (PubMed id 22648509)1 Wang K.S....Zeng M. (2012)
    5. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence. (PubMed id 22488850)1 Zuo L....Luo X. (2012)
    6. Genome-wide association study of alcohol dependence im plicates KIAA0040 on chromosome 1q. (PubMed id 21956439)1 Zuo L....Luo X. (2012)
    7. Genome-wide study links MTMR7 gene to variant Creutzfe ldt-Jakob risk. (PubMed id 22137330)1 Sanchez-Juan P....van Duijn C.M. (2012)
    8. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared wit h bipolar disorder. (PubMed id 22688191)1 Bergen S.E....Sullivan P.F. (2012)
    9. The nuclear transcription factor PKNOX2 is a candidat e gene for substance dependence in European-origin women. (PubMed id 21298047)1 Chen X....Zhang H. (2011)
    10. A meta-analysis of two genome-wide association studie s identifies 3 new loci for alcohol dependence. (PubMed id 21703634)1 Wang K.S....Zeng M. (2011)

    External Searches for PKNOX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PKNOX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63876 HGNC: 16714 AceView: PKNOX2 Ensembl:ENSG00000165495 euGenes: HUgn63876
    ECgene: PKNOX2 H-InvDB: PKNOX2

    Other Databases showing PKNOX2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PKNOX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PKNOX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PKNOX2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PKNOX2 gene:
    Search GeneIP for patents involving PKNOX2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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