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PKNOX1 Gene

protein-coding   GIFtS: 61
GCID: GC21P044394

PBX/Knotted 1 Homeobox 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
PBX/Knotted 1 Homeobox 11 2     PBX/Knotted Homeobox 12 3
Human Homeobox-Containing Protein2 11     Homeobox Protein PKNOX12
Homeobox Protein PREP-12 3     Pbx Regulating Protein-12
PREP12 3     pkonx1c2

External Ids:    HGNC: 90221   Entrez Gene: 53162   Ensembl: ENSG000001601997   OMIM: 6021005   UniProtKB: P553473   

Export aliases for PKNOX1 gene to outside databases

Previous GC identifers: GC21P040942 GC21P043289 GC21P043288 GC21P043267 GC21P029842


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PKNOX1 Gene:
PKNOX1 (PBX/knotted 1 homeobox 1) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is MEIS2.

Gene Wiki entry for PKNOX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the PKNOX1 gene promoter:
         HOXA9   HOXA9B   Meis-1a   Meis-1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PKNOX1 promoter sequence

   Search Chromatin IP Primers for PKNOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PKNOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
PKNOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKNOX1 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P044394:   GeneLoc Nature:405,311-319
Start:
44,394,620 bp from pter       29,971,758 bp from centromere
End:
44,453,691 bp from pter 29,999,360 bp from centromere
Size:
59,072 bases 27,603 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: U68727
genomic clones: KB1151C12


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PKNX1_HUMAN, P55347 (See protein sequence)
Recommended Name: Homeobox protein PKNOX1  
Size: 436 amino acids; 47607 Da
Sequence caution: Sequence=AAC51243.1; Type=Erroneous initiation; Sequence=BAA95533.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for PKNOX1:
1X2N (3D)    
Secondary accessions: O00528 Q8IWT7
Alternative splicing: 2 isoforms:  P55347-1   P55347-2   

Explore the universe of human proteins at neXtProt for PKNOX1: NX_P55347

Explore proteomics data for PKNOX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PKNOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273187.1  NP_004562.2  

    ENSEMBL proteins: 
     ENSP00000291547   ENSP00000453486   ENSP00000402243  

    PKNOX1 Human Recombinant Protein Products:

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    Novus Biologicals PKNOX1 Proteins
    Novus Biologicals PKNOX1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PKNOX1

     
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    antibodies-online proteins for PKNOX1 (8 products) 

     
    antibodies-online peptides for PKNOX1

    PKNOX1 Antibody Products:

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    antibodies-online antibodies for PKNOX1 (37 products) 

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    Cloud-Clone Corp. CLIAs for PKNOX1
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    antibodies-online kits for PKNOX1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    3 InterPro protein domains:
     IPR008422 Homeobox_KN_domain
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P55347

    ProtoNet protein and cluster: P55347

    UniProtKB/Swiss-Prot: PKNX1_HUMAN, P55347
    Similarity: Belongs to the TALE/MEIS homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with PKNOX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for PKNOX1:
    PBX regulating protein,64kDa,protein with an atypical homeo domain,homologous to PBX1,expressed in many
    tissues,involved in growth and morphogenesis,binding DNA cooperatively with the heterodimer E2A/myogenic
    transcription factors

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9143494
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with PKNOX1           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 7 alleles(MGI details for Pknox1) (see all 16):
     adipose tissue  cardiovascular system  cellular  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  no phenotypic analysis  normal  pigmentation  tumorigenesis 

    Find genes that share phenotypes with PKNOX1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pknox1tm1Ngc for PKNOX1

       genOway: Develop your customized and physiologically relevant rodent model for PKNOX1

    miRNA
    Products:
        
    miRTarBase miRNAs that target PKNOX1:
    hsa-mir-500a-5p (MIRT037993), hsa-mir-21-5p (MIRT030936)

    Block miRNA regulation of human, mouse, rat PKNOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PKNOX1 (see all 88):
    hsa-miR-100* hsa-miR-607 hsa-miR-106a hsa-miR-219-5p hsa-miR-374a hsa-miR-138-2* hsa-miR-3921 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidPKNOX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PKNOX1
    Predesigned siRNA for gene silencing in human, mouse, rat PKNOX1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: PKNOX1 (NM_004571)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PKNOX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKNOX1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for PKNOX1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKNOX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PKNX1_HUMAN, P55347: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PKNOX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PKNOX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ca-dependent events
    Development Role of Activin A in cell differentiation and proliferation0.32
    2SIDS Susceptibility Pathways
    SIDS Susceptibility Pathways

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for PKNOX1
        Development Role of Activin A in cell differentiation and proliferation

    1 BioSystems Pathway for PKNOX1
        SIDS Susceptibility Pathways


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PKNOX1
    Interactions:

        GeneGlobe Interaction Network for PKNOX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PKNOX1 (P553472, 3 ENSP000002915474) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237344P404252, 3, ENSP000003971774MINT-50133 I2D: score=3 STRING: ENSP00000397177
    PBX2P404252, 3, ENSP000003641904MINT-50133 I2D: score=3 STRING: ENSP00000364190
    ENSG00000206315P404252, 3MINT-50133 I2D: score=3 
    ENSG00000224952P404252, 3MINT-50133 I2D: score=3 
    ENSG00000225987P404252, 3MINT-50133 I2D: score=3 
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    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter TAS9479508
    GO:0030097hemopoiesis ----

    Find genes that share ontologies with PKNOX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PKNOX1 (PKNX1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PKNOX1 gene (2 alternative transcripts): 
    NM_001286258.1  NM_004571.4  

    Unigene Cluster for PKNOX1:

    PBX/knotted 1 homeobox 1
    Hs.431043  [show with all ESTs]
    Unigene Representative Sequence: NM_004571
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291547(uc002zcq.1 uc011aex.1) ENST00000418336 ENST00000480179(uc002zcr.3)
    ENST00000456957 ENST00000560448 ENST00000607049 ENST00000557820 ENST00000474336
    ENST00000607150 ENST00000558955 ENST00000432907
    miRNA
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    Block miRNA regulation of human, mouse, rat PKNOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PKNOX1 (see all 88):
    hsa-miR-100* hsa-miR-607 hsa-miR-106a hsa-miR-219-5p hsa-miR-374a hsa-miR-138-2* hsa-miR-3921 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidPKNOX1 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for PKNOX1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PKNOX1
      QuantiTect SYBR Green Assays in human, mouse, rat PKNOX1
      QuantiFast Probe-based Assays in human, mouse, rat PKNOX1

    Additional mRNA sequence: 

    AK222892.1 AK294794.1 AY142115.1 AY196965.1 AY566249.1 BC000735.2 BC007746.2 U68727.1 
    Y13613.1 

    9 DOTS entries:

    DT.100814669  DT.115250  DT.100814665  DT.100814668  DT.95275868  DT.100800330  DT.121140419  DT.87014426 
    DT.91953582 

    Selected AceView cDNA sequences (see all 218):

    AA227042 BQ015972 T16624 AI148365 CR605067 BM700345 BC000735 BU620391 
    BU152918 BC007746 AI224082 AI246646 AW628157 AA380605 AY142115 CB996126 
    AI393283 BQ189420 BM772118 BM673103 AI624427 BQ441007 CR603181 CR614253 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PKNOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PKNOX1 Expression
    About this image


    PKNOX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Testis (Reproductive System)
    PKNOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PKNOX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431043

    UniProtKB/Swiss-Prot: PKNX1_HUMAN, P55347
    Tissue specificity: Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PKNOX1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pknox11 , 5 Pbx/knotted 1 homeobox1, 5 87.61(n)1
    96.1(a)1
      17 (16.78 cM)5
    187711  NM_016670.31  NP_057879.21 
     315647495 
    chicken
    (Gallus gallus)
    Aves PKNOX11 PBX/knotted 1 homeobox 1 82.42(n)
    93.58(a)
      418542  XM_416750.4  XP_416750.3 
    lizard
    (Anolis carolinensis)
    Reptilia PKNOX16
    PBX/knotted 1 homeobox 1
    75(a)
    1 ↔ 1
    3(137350129-137395298)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.53932 Transcribed sequence with moderate similarity to protein more 76.11(n)    CF591150.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pknox1.12 pbx/knotted 1 homeobox 1.1 75.35(n)   170444  AF382393.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-626
    Protein UNC-62, isoform g
    24(a)
    1 → many
    V(4497463-4511449) WBGene00006796


    ENSEMBL Gene Tree for PKNOX1 (if available)
    TreeFam Gene Tree for PKNOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PKNOX1 gene
    MEIS22  TGIF2LY2  MEIS32  TGIF22  PKNOX22  TGIF2LX2  MEIS12  TGIF12  
    11 SIMAP similar genes for PKNOX1 using alignment to 5 protein entries:     PKNX1_HUMAN (see all proteins):
    HB103    meis1    PKNOX2    TGIF2    TGIF1    MEIS1
    MEIS2    TGIF2LY    MEIS3    MEIS3P1    WUGSC

    Find genes that share paralogs with PKNOX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PKNOX1 (see all 1678)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364404
    A colorectal cancer sample4--see VAR_0364402 V I mis40--------
    rs1448798411,2
    --44392678(+) TTGGAA/GATGGA 1 -- us2k10--------
    rs1870905761,2
    --44392681(+) GAGATA/GGAGTC 1 -- us2k10--------
    rs1895004951,2
    --44392696(+) TCGTTG/TCCCAG 1 -- us2k10--------
    rs1808015411,2
    --44392784(+) CCCAAA/GTAGCT 1 -- us2k10--------
    rs2347491,2
    C,F,A--44392868(+) tggccA/Gtgctg 1 -- us2k18Minor allele frequency- G:0.38NA WA CSA 16
    rs9141911,2
    C,F,A--44392967(+) TTTAGG/ACAATG 1 -- us2k12Minor allele frequency- A:0.08CSA NA 121
    rs1393435111,2
    C--44393067(+) GTGTAC/TAATCA 1 -- us2k10--------
    rs1851233871,2
    --44393134(+) GCCGGC/GTTCTT 1 -- us2k10--------
    rs1500167971,2
    --44393190(+) GTTCCG/TACCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PKNOX1 (44394620 - 44453691 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PKNOX1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666871CNV Deletion23128226
    esv1545426CNV Insertion17803354
    esv1004750CNV Insertion20482838
    esv1053373CNV Insertion17803354
    nsv834105CNV Loss17160897
    nsv913822CNV Loss21882294
    nsv510800CNV Loss20534489
    nsv913821CNV Loss21882294
    nsv913824CNV Loss21882294
    nsv913823CNV Loss21882294

    Human Gene Mutation Database (HGMD): PKNOX1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PKNOX1
    DNA2.0 Custom Variant and Variant Library Synthesis for PKNOX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602100    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PKNOX1:
    Down syndrome

    Find genes that share disorders with PKNOX1           About GenesLikeMe

    3 Novoseek inferred disease relationships for PKNOX1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia pre-b-cell 88.9 1 15187018 (1)
    down syndrome 30.9 1 9143494 (1)
    leukemia 21.2 3 14764605 (1), 12529389 (1)

    Genetic Association Database (GAD): PKNOX1
    Human Genome Epidemiology (HuGE) Navigator: PKNOX1 (1 document)

    Export disorders for PKNOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PKNOX1 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with PKNOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C. (PubMed id 9479508)1, 2, 3, 9 Berthelsen J.... Blasi F. (Genomics 1998)
    2. Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3. (PubMed id 9143494)1, 2, 9 Chen H....Antonarakis S.E. (Genomics 1997)
    3. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PubMed id 21130836)1, 4 Luciano M....Deary I.J. (Biol Psychol 2011)
    4. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    5. Genome-wide association study of biochemical traits in Korcula Island, Croatia. (PubMed id 19260141)1, 4 Zemunik T....Rudan I. (Croat. Med. J. 2009)
    6. Molecular cloning for an alternatively splicing cDNA of human PKNOX1 gene and it's expression analysis. (PubMed id 15468914)1, 2 Ni B.... Li H. (Yi Chuan Xue Bao 2004)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    8. PREP1, MEIS1 homolog protein, regulates PF4 gene expression. (PubMed id 12732210)1, 9 Okada Y....Doi T. (Biochem. Biophys. Res. Commun. 2003)
    9. Prep1, a novel functional partner of Pbx proteins. (PubMed id 9482739)1, 9 Berthelsen J....Blasi F. (EMBO J. 1998)
    10. Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia. (PubMed id 22347417)1 Bol S.M....van 't Wout A.B. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5316 HGNC: 9022 AceView: PKNOX1 Ensembl:ENSG00000160199 euGenes: HUgn5316
    ECgene: PKNOX1 H-InvDB: PKNOX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PKNOX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PKNOX1 gene:
    Search GeneIP for patents involving PKNOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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