PKN2 Gene
protein-coding GIFtS: 63
GCID: GC01P089149
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|
protein kinase N2(Previous name: protein kinase C-like 2 )
(Previous symbol: PRKCL2)
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Aliases
for PKN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Protein Kinase N21 2 | | EC 2.7.11.133 8 | | PRK21 2 3 5 | | PAK22 5 | | PRKCL21 2 3 5 | | PRO20422 | | Protein Kinase C-Like 21 2 3 | | Cardiolipin-Activated Protein Kinase Pak22 | | Pak-21 2 | | Serine/Threonine-Protein Kinase N22 | | Protein-Kinase C-Related Kinase 22 3 | | EC 2.7.118 | | PKN Gamma2 3 | | |
Export aliases for PKN2 gene to outside databasesPrevious GC identifers: GC01P088618 GC01P088862 GC01P087267 |
Summaries
for PKN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PKN2_HUMAN, Q16513Function: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signaltransduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeletonassembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes.Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentousactin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation ofthe maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/Mphases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYNkinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation.Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion.Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via thec-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication
Gene Wiki entry for PKN2
|
Genomic Views
for PKN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PKN2 gene promoter:
c-Fos AP-1 Olf-1 FOXD3 Nkx2-5 CREB MEF-2A deltaCREB aMEF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for PKN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p22.2 Ensembl cytogenetic band: 1p22.2 HGNC cytogenetic band: 1p22PKN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P089149: view genomic region
(about GC identifiers)
Start:
|
89,149,905 bp from pter |
End:
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89,301,938 bp from pter |
Size:
|
152,034 bases |
Orientation:
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plus strand |
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Proteins
for PKN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PKN2_HUMAN, Q16513 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase N2 Size: 984 amino acids; 112035 Da
Subunit: Interacts (via the REM repeats) with RHOA (GTP-bound form preferentially). Interacts (via the REM repeats)with RAC1 (GTP-bound form preferentially). Interacts with NCK1 (via SH3 domains). Interacts with CD44 (By similarity).Interacts with RHOA (GTP-bound form preferentially) and RAC1 (GTP-bound form preferentially); the interactions induceits autophosphorylation. Interacts (via C-terminal kinase domain) with PDPK1; the interaction stimulates PDPK1 kinaseactivity. Interacts with MAP3K2; the interaction activates PRK2 kinase activity in a MAP3K2-independent kinaseactivity. Interacts (via C-terminus domain) with AKT1; the interaction occurs with the C-terminus cleavage product ofPRK2 in apoptotic cells. Interacts (via C-terminus) with PTPN13 (via PDZ 3 domain). Interacts with HCV NS5B (viaN-terminus finger domain). Interacts with NCK1, NCK2 and RHOC
Subcellular location: Cytoplasm. Nucleus. Membrane (By similarity). Cell projection, lamellipodium. Cytoplasm,cytoskeleton. Cleavage furrow. Midbody. Cell junction. Note=Colocalizes with PTPN13 in lamellipodia-like structures,regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally aroundthe midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course ofviral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm
Secondary accessions: B4DQ21 B4DTP5 B4DVG1 D3DT24 Q08AF4 Q9H1W4Alternative splicing: 5 isoforms: Q16513-1 Q16513-2 Q16513-3 Q16513-4 Q16513-5 Explore the universe of human proteins at neXtProt for PKN2: NX_Q16513
Post-translational modifications:
Autophosphorylated. Phosphorylated during mitosis1
Activated by limited proteolysis with trypsin (By similarity). Proteolytically cleaved by caspase-3 during theinduction of apoptotic cell death1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q16513
4/19 DME Specific Peptides for PKN2 (Q16513) (see all 19)
PKN2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006247.1
ENSEMBL proteins: ENSP00000359552 ENSP00000317851 ENSP00000401125 ENSP00000389076 ENSP00000359544 ENSP00000359536 ENSP00000439643
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
PKN2 for ontologies About GeneDecksing
PKN2 Antibody Products:
Assay Products for PKN2: |
Protein
Domains /
Families
for PKN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PKN2 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q16513ProtoNet protein and cluster: Q16513 4 Blocks protein families: IPB000008 C2 domain IPB000861 PKN/rhophilin/rhotekin rho-binding repeat IPB000961 Protein kinase C-terminal domain IPB011072 Protein kinase PKN/PRK1
UniProtKB/Swiss-Prot: PKN2_HUMAN, Q16513Domain: The N-terminus region interferes with the interaction between AKT1 and the C-terminus region of PKN2Domain: The C1 domain does not bind the diacylglycerol (DAG)Domain: The apoptotic C-terminus cleavage product inhibits EGF-induced kinase activity of AKT1 phosphorylation at'Thr-308' and 'Ser-473' sites, PDPK1 autophosphorylation and kinases PRKCD and PRKCZ phosphorylationsSimilarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamilySimilarity: Contains 1 AGC-kinase C-terminal domainSimilarity: Contains 1 C2 domainSimilarity: Contains 1 protein kinase domainSimilarity: Contains 3 REM (Hr1) repeats |
Function
for PKN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PKN2_HUMAN, Q16513Function: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signaltransduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeletonassembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes.Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentousactin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation ofthe maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/Mphases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYNkinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation.Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion.Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via thec-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replicationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Kinase activity is activated upon binding to GTP-bound Rhoa/Rac1 GTPases. Activated by caspase-3(CASP3) cleavage during apoptosis. Activated by lipids, particularly cardiolipin and to a lesser extent by otheracidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain)and Thr-958 (turn motif), need to be phosphorylated for its full activationBiophysicochemical properties: Kinetic parameters: KM=15.83 uM for HDAC5;Induction: Up-regulated during keratinocyte differentiationEnzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PKN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PKN2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: PKN2 (NM_006256) | |  | Sino Biological Human cDNA Clone for PKN2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PKN2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKN2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKN2 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
PKN2 for ontologies About GeneDecksing
7 GenomeRNAi human phenotypes for PKN2:
|
Pathways & Interactions
for PKN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeletal Signaling | | | 2 | Ca, cAMP and Lipid Signaling | | | 3 | EGFR1 Signaling Pathway | | | 4 | RhoA signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for PKN2
2  BioSystems Pathways for PKN2
PKN2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PKN2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/761 Interacting proteins for PKN2 (Q165132, 3 ENSP000003595524) via UniProtKB, MINT, STRING, and/or I2D (see all 761)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
PKN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for PKN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PKN2 for compounds About GeneDecksing
 Browse Tocris compounds for PKN2
2 HMDB Compounds for PKN2 About this table
1 Novoseek chemical compound relationship for PKN2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
0 |
2 |
10026169 (1), 11777936 (1) |
Search CenterWatch for drugs/clinical trials and news about PKN2
|
Transcripts
for PKN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PKN2 gene: NM_006256.2 Unigene Cluster for PKN2: Protein kinase N2 Hs.440833 [show with all ESTs]Unigene Representative Sequence: NM_0062568 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370521(uc001dmn.3 uc010osp.2 uc010osq.2 uc009wcv.3 uc010osr.2)
ENST00000316005 ENST00000436111 ENST00000449189 ENST00000495119 ENST00000370513
ENST00000370505 ENST00000544045
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PKN2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PKN2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PKN2 (NM_006256) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PKN2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKN2 |
Additional cDNA sequence: AF118089.2 AK023692.1 AK298595.1 AK300304.1 AK301066.1 BC006993.1 BC029749.1 BC038832.1 BC046146.1 BC062620.1 BC125199.1 S75548.1 U33052.1 6 DOTS entries: DT.114439 DT.40278991 DT.95330823 DT.99947643 DT.99976184 DT.92452472 24/204 AceView cDNA sequences (see all 204): BQ023095 AL708612 NM_006256 AA765268 AA018656 AA252537 U33052 CB135700 BQ024300 AA648277 AU119685 BC046146 AV725625 BU677852 AA035285 AA970191 BM667662 BI438567 AA992720 BU633303 AI803566 BC006993 S75548 CB132754
GeneLoc Exon Structure
|
Expression
for PKN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PKN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAAGCACA
About this image
See PKN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PKN2
SOURCE GeneReport for Unigene cluster: Hs.440833
UniProtKB/Swiss-Prot: PKN2_HUMAN, Q16513Tissue specificity: Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells
SABiosciences Expression via Pathway-Focused PCR Array including PKN2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PKN2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PKN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKN2 |
Orthologs
for PKN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PKN2 gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PKN21 |
protein kinase N2 |
84.37(n)
90.89(a) |
|
424519 XM_422357.2 XP_422357.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PKN26 |
-- |
89(a) |
1 ↔ 1 |
4(95915250-95955502) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.214372 |
Xenopus laevis protein kinase C-related kinase 2 (PRK2) more |
81.38(n) |
|
AF027183.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5719651 |
protein kinase N2-like |
69.56(n)
78.86(a) |
|
571965 XM_695612.5 XP_700704.3 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Pkn1 |
Protein kinase related to protein kinase N |
53.49(n)
57.85(a) |
|
35950 NM_176110.2 NP_788290.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
pkn-11 |
Protein PKN-1 |
49.93(n)
41.7(a) |
|
181244 NM_077341.4 NP_509742.2 |
ENSEMBL Gene Tree for PKN2 (if available)
TreeFam Gene Tree for PKN2 (if available) |
Paralogs
for PKN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PKN2 gene
- PRKCQ2 PRKCH2 PRKCB2 PRKCI2 PRKCE2 PKN12 PRKCA2 PRKCD2
- PRKCZ2 PKN32 PRKCG2
18/69 SIMAP similar genes for PKN2 using alignment to 6 protein entries: PKN2_HUMAN (see all proteins)
(see all similar genes):RPS6KA3 PRKCZ PKN1 PRKACA PRKACB RPS6KA2
AKT2 PRKCG SGK2 SGK1 AKT1 PRKCD
MAP3K11 RPS6KA1 RPS6KB1 IKBKB MARK2 PRKCH
PKN2 for paralogs About GeneDecksing
|
Genomic Variants
for PKN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PKN2 (89149905 - 89301938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for PKN2
4 CNVs: 74563 74564 53657 84358 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PKN2 |
|
Disorders
/ Diseases
for PKN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PKN2 for disorders About GeneDecksing
OMIM gene information: 602549
OMIM disorders: --
9  diseases for PKN2: About MalaCardscleft lip/palate cleft lip hepatitis c hepatitis
cerebritis hypoxia immunodeficiency neuronitis
carcinoma
Human Genome Epidemiology (HuGE) Navigator: PKN2 (10 documents)
Export disorders for PKN2 gene to outside databases
|
Publications
for PKN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PKN2 gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with PKN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression patterns of two members of a novel protein- kinase-C-related kinase family. (PubMed id 7851406)1, 2, 3, 9 Palmer R.H.... Parker P.J. (1995)
- Identification of multiple, novel, protein kinase C-related gene products. (PubMed id 7988719)1, 2, 3 Palmer R.H.... Parker P.J. (1994)
- Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. (PubMed id 9368003)1, 2, 9 Cryns V.L....Yuan J. (1997)
- The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. (PubMed id 18835241)1, 2, 9 Lim W.G....Duan W. (2008)
- Protein kinase C-related kinase targets nuclear local ization signals in a subset of class IIa histone deacetylases. (PubMed id 20188095)1, 2, 9 Harrison B.C....McKinsey T.A. (2010)
- Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. (PubMed id 10026169)1, 2, 9 Braverman L.E. and Quilliam L.A. (1999)
- The Rho target PRK2 regulates apical junction formati on in human bronchial epithelial cells. (PubMed id 20974804)1, 2 Wallace S.W....Hall A. (2011)
- Regulatory domain selectivity in the cell-type specific PKN- dependence of cell migration. (PubMed id 21754995)1, 2 Lachmann S.... Parker P.J. (2011)
- Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis. (PubMed id 17332740)1, 2 Schmidt A....Hall A. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
|
External Searches for PKN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PKN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PKN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PKN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PKN2 gene:
Search GeneIP for patents involving PKN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for PKN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for PKN2 | | OriGene shRNA RFP for PKN2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PKN2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PKN2 | | | OriGene Protein Over-expression Lysate for PKN2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PKN2 | | OriGene 3'-UTR Clone for PKN2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PKN2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PKN2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PKN2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PKN2 | | OriGene Custom Protein Services for PKN2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PKN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PKN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PKN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKN2 |
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| | Antibodies & Assays for PKN2 |
| | | | Search Tocris compounds for PKN2 |
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 | | | PKN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKN2 |
|  |  |  | | | | ThermoFisher Antibody for PKN2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKN2 |
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