Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PKN1 Gene

protein-coding   GIFtS: 68
GCID: GC19P014544

Protein Kinase N1

(Previous name: protein kinase C-like 1)
(Previous symbol: PRKCL1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Protein Kinase N11 2     PAK-12 3
PRKCL11 2 3 5     PKN2 3
Protein Kinase C-Like 11 2 3     EC 2.7.11.133 8
PAK12 3 5     DBK2
PRK12 3 5     PKN-ALPHA2
Protease-Activated Kinase 12 3     Protein Kinase C-Related Kinase 12
Protein Kinase C-Like PKN2 3     Serine-Threonine Kinase N2
Protein Kinase PKN-Alpha2 3     Serine/Threonine Protein Kinase N2
Protein-Kinase C-Related Kinase 12 3     Serine/Threonine-Protein Kinase N12
Serine-Threonine Protein Kinase N2 3     EC 2.7.118

External Ids:    HGNC: 94051   Entrez Gene: 55852   Ensembl: ENSG000001231437   OMIM: 6010325   UniProtKB: Q165123   

Export aliases for PKN1 gene to outside databases

Previous GC identifers: GC19P014400 GC19P014406 GC19P014121


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PKN1 Gene:
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho
family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by
phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is
reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The
proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in
signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms
have been observed. (provided by RefSeq, Jul 2008)

GeneCards Summary for PKN1 Gene: 
PKN1 (protein kinase N1) is a protein-coding gene. Diseases associated with PKN1 include paraneoplastic cerebellar degeneration, and cerebellar degeneration, and among its related super-pathways are Development Activation of ERK by Alpha-1 adrenergic receptors and G-protein signaling RhoB regulation pathway. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is ENSG00000258989.

UniProtKB/Swiss-Prot: PKN1_HUMAN, Q16512
Function: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the
intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription
regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins
NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669'
of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a
key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and
specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic
transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.
Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of
PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro

Gene Wiki entry for PKN1 (Protein kinase N1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PKN1 gene promoter:
         RelA   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PKN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PKN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.12   Ensembl cytogenetic band:  19p13.12   HGNC cytogenetic band: 19p13.12

PKN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKN1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P014544:  view genomic region     (about GC identifiers)

Start:
14,543,865 bp from pter      End:
14,582,679 bp from pter
Size:
38,815 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKN1_HUMAN, Q16512 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase N1  
Size: 942 amino acids; 103932 Da
Subunit: Interacts with ZA20D3 (By similarity). Interacts with ANDR. Interacts with PRKCB. Interacts (via REM 1
and REM 2 repeats) with RAC1. Interacts (via REM 1 repeat) with RHOA. Interacts with RHOB. In case of infection,
interacts with S.typhimurium protein sspH1. Interacts (via C-terminus) with PDPK1
Subcellular location: Cytoplasm. Nucleus. Endosome. Cell membrane; Peripheral membrane protein. Cleavage furrow.
Midbody. Note=Associates with chromatin in a ligand-dependent manner. Localization to endosomes is mediated via
its interaction with RHOB. Association to the cell membrane is dependent on Ser-374 phosphorylation. Accumulates
during telophase at the cleavage furrow and finally concentrates around the midbody in cytokinesis
3 PDB 3D structures from and Proteopedia for PKN1:
1CXZ (3D)        1URF (3D)        2RMK (3D)    
Secondary accessions: A8K7W5 B2R9R4 B3KVN3 Q15143 Q504U4 Q8IUV5 Q9UD44
Alternative splicing: 3 isoforms:  Q16512-1   Q16512-2   Q16512-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PKN1: NX_Q16512

Explore proteomics data for PKN1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated; preferably on serine. Phosphorylated during mitosis
  • UniProtKB: Activated by limited proteolysis with trypsin (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16512

  • 4/16 DME Specific Peptides for PKN1 (Q16512) (see all 16)
     EELRHHF  GVLLYEM  LEDFLDN  LTDTSYT 

    PKN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PKN1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002732.3  NP_998725.1  

    ENSEMBL proteins: 
     ENSP00000467422   ENSP00000242783   ENSP00000465842   ENSP00000466367   ENSP00000343325  
     ENSP00000466819   ENSP00000465867   ENSP00000468497  

    Human Recombinant Protein Products for PKN1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PKN1
    OriGene Protein Over-expression Lysate for PKN1
    OriGene MassSpec for PKN1 
    OriGene Custom Protein Services for PKN1
    GenScript Custom Purified and Recombinant Proteins Services for PKN1
    Novus Biologicals PKN1 Proteins
    Novus Biologicals PKN1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PKN1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12514133
    GO:0005737cytoplasm IDA12514133
    GO:0005768endosome IDA9478917
    GO:0005886plasma membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    PKN1 for ontologies           About GeneDecksing



    PKN1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of PKN1
    R&D Systems Antibodies for PKN1
    Cell Signaling Technology (CST) Antibodies for PKN1 
    OriGene Antibodies for PKN1
    OriGene Custom Antibody Services for PKN1
    GenScript Custom Superior Antibodies Services for PKN1
    Novus Biologicals PKN1 Antibodies
    Abcam antibodies for PKN1
    Cloud-Clone Corp. Antibodies for PKN1 
    ThermoFisher Antibodies for PKN1
    LSBio Antibodies in human, mouse, rat for PKN1 

    Assay Products for PKN1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PKN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PKN1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PKN1 
    Cloud-Clone Corp. CLIAs for PKN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase N1 
    Protein kinase N (PKN) family
    Other AGC kinases

    5/10 InterPro protein domains (see all 10):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR017892 Pkinase_C
     IPR008271 Ser/Thr_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q16512

    ProtoNet protein and cluster: Q16512

    4 Blocks protein domains:
    IPB000008 C2 domain
    IPB000861 PKN/rhophilin/rhotekin rho-binding repeat
    IPB000961 Protein kinase C-terminal domain
    IPB011072 Protein kinase PKN/PRK1


    UniProtKB/Swiss-Prot: PKN1_HUMAN, Q16512
    Domain: The C1 domain does not bind the diacylglycerol (DAG)
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily
    Similarity: Contains 1 AGC-kinase C-terminal domain
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 3 REM (Hr1) repeats


    PKN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKN1_HUMAN, Q16512
    Function: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the
    intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription
    regulation. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins
    NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669'
    of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a
    key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and
    specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic
    transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C.
    Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of
    PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Kinase activity is activated upon binding to Rho proteins (RHOA, RHOB and RAC1). Activated by
    lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids. Activated by caspase-3
    (CASP3) cleavage during apoptosis. Two specific sites, Thr-774 (activation loop of the kinase domain) and Ser-916
    (turn motif), need to be phosphorylated for its full activation
    Biophysicochemical properties: Kinetic parameters: KM=20.6 uM for HDAC5;

         Enzyme Numbers (IUBMB): EC 2.7.11.131 2 EC 2.7.112

         Gene Ontology (GO): 5/16 molecular function terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA18066052
    GO:0004672protein kinase activity TAS10792047
    GO:0004674protein serine/threonine kinase activity IDA--
    GO:0004697protein kinase C activity IEA--
    GO:0004713protein tyrosine kinase activity ----
         
    PKN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PKN1:
     Gemcitabine induced cell-death  Increased cell death in HCC-19 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pkn1):
     cellular  hematopoietic system  immune system  renal/urinary system 

    PKN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pkn1tm1Kik for PKN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for PKN1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PKN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PKN1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PKN1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target PKN1:
    hsa-mir-7 (MIRT000668), mmu-mir-465a-5p (MIRT005336), hsa-mir-377 (MIRT000991)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PKN1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PKN1:
    hsa-miR-3142 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PKN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PKN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PKN1
    Sirion Biotech Customized adenovirus for overexpression of PKN1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PKN1 (see all 12)
    OriGene ORF clones in mouse, rat for PKN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PKN1 (NM_002741)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PKN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKN1
    Sirion Biotech Customized lentivirus for stable overexpression of PKN1 
                         Customized lentivirus expression plasmids for stable overexpression of PKN1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PKN1
    Search LifeMap BioReagents cell lines for PKN1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKN1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PKN1 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Translation Translation regulation by Alpha-1 adrenergic receptors
    Translation Translation regulation by Alpha-1 adrenergic receptors0.64
    2G-protein signaling RhoB regulation pathway
    G-protein signaling RhoB regulation pathway1.00
    3G-protein signaling RhoA regulation pathway
    G-protein signaling RhoA regulation pathway1.00
    4G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins0.40
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for PKN1
        G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    Translation Translation regulation by Alpha-1 adrenergic receptors
    G-protein signaling RhoB regulation pathway
    G-protein signaling RhoA regulation pathway


    1 Cell Signaling Technology (CST) Pathway for PKN1
        Ca, cAMP and Lipid Signaling

    4 GeneGo (Thomson Reuters) Pathways for PKN1
        G-protein signaling RhoB regulation pathway
    G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins
    G-protein signaling RhoA regulation pathway
    Translation Translation regulation by Alpha-1 adrenergic receptors

    5 BioSystems Pathways for PKN1
        G13 Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway
    Regulation of Androgen receptor activity
    Signaling mediated by p38-gamma and p38-delta
    RhoA signaling pathway


    2         Kegg Pathways  (Kegg details for PKN1):
        PI3K-Akt signaling pathway
    Salmonella infection


    PKN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PKN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for PKN1 (Q165121, 2, 3 ENSP000003433254) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC85BQ158341, 2, 3, ENSP000003116954EBI-602382,EBI-739674 MINT-67214 I2D: score=6 STRING: ENSP00000311695
    MAPK12P537781, 3, ENSP000002156594EBI-602382,EBI-602406 I2D: score=2 STRING: ENSP00000215659
    SPRR2DP225322, 3, ENSP000003535424MINT-8266634 I2D: score=2 STRING: ENSP00000353542
    ZNF282Q9UDV72, 3, ENSP000002620854MINT-8266645 I2D: score=2 STRING: ENSP00000262085
    HIST2H3CQ71DI33, ENSP000003581544I2D: score=1 STRING: ENSP00000358154
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IMP18066052
    GO:0006468protein phosphorylation IDA17332740
    GO:0006972hyperosmotic response IEA--
    GO:0007165signal transduction TAS8135837

    PKN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PKN1 for compounds           About GeneDecksing

    EMD Millipore small molecules for PKN1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for PKN1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    (5Z)-7-OxozeaenolPotent and selective TAK1 MAPKKK inhibitor[66018-38-0]
    GSK 650394Serum- and glucocorticoid-regulated kinase (SGK) inhibitor[890842-28-1]
    IPA 3Group I p21-activated kinase (PAK) inhibitor[42521-82-4]
    CGP 57380Selective inhibitor of Mnk1[522629-08-9]
    AZ 3146Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor[1124329-14-1]

    2 HMDB Compounds for PKN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/17 Novoseek inferred chemical compound relationships for PKN1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 71.6 26 12761194 (2), 8038606 (1), 9125115 (1), 9736660 (1) (see all 24)
    serine 66.3 28 8038606 (2), 12761194 (2), 7945381 (1), 9125115 (1) (see all 25)
    6 thioguanine 51.3 4 7714918 (1), 1309569 (1), 7680248 (1)
    arachidonic acid 51.3 15 10467162 (3), 7945381 (2), 7711077 (2), 9637778 (1) (see all 8)
    purine 44.2 7 1309569 (2), 1400478 (1), 20132472 (1), 7680248 (1) (see all 5)
    sodium arsenite 43.2 1 9837746 (1)
    fatty acid 27.5 6 9751706 (1), 11134534 (1), 9030526 (1), 9570957 (1) (see all 6)
    phosphatidylinositol 20.8 6 10995762 (1), 7673228 (1)
    tyrosine 19.7 11 17726028 (2), 8038606 (1), 8798379 (1), 17229154 (1) (see all 6)
    adenine 12.6 1 1309569 (1)

    Search CenterWatch for drugs/clinical trials and news about PKN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PKN1 gene (2 alternative transcripts): 
    NM_002741.3  NM_213560.1  

    Unigene Cluster for PKN1:

    Protein kinase N1
    Hs.466044  [show with all ESTs]
    Unigene Representative Sequence: BC094766
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585619 ENST00000585839 ENST00000242783(uc002myp.3) ENST00000586557
    ENST00000587429 ENST00000590097 ENST00000342216(uc002myq.3) ENST00000592794
    ENST00000588200 ENST00000586900 ENST00000586237 ENST00000587215 ENST00000591461
    ENST00000586039 ENST00000592960
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PKN1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate PKN1:
    hsa-miR-3142 hsa-miR-548d-3p hsa-miR-548am hsa-miR-548x
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PKN1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PKN1
    Clone
    Products:
         
    OriGene clones in human, mouse for PKN1 (see all 12)
    OriGene ORF clones in mouse, rat for PKN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PKN1 (NM_002741)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PKN1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKN1
    Sirion Biotech Customized lentivirus for stable overexpression of PKN1 
                         Customized lentivirus expression plasmids for stable overexpression of PKN1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PKN1
    OriGene qSTAR qPCR primer pairs in human, mouse for PKN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PKN1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKN1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKN1

    Additional mRNA sequence: 

    AK123007.1 AK292130.1 AK313886.1 BC018575.1 BC040061.1 BC094766.1 D26181.1 S75546.1 
    U33053.1 

    16 DOTS entries:

    DT.448711  DT.92443533  DT.100799316  DT.100651656  DT.101960711  DT.121444057  DT.92443507  DT.95168737 
    DT.92443502  DT.99975317  DT.100651662  DT.75154951  DT.100038449  DT.100868188  DT.92443504  DT.95168731 

    24/509 AceView cDNA sequences (see all 509):

    BM822953 BM983146 AI142414 BQ640709 BQ058160 BQ922282 BM756803 BX279836 
    BE906385 CD615544 AW162061 AW198073 BM461782 BQ051454 BU527120 CD615549 
    AL524895 AW327964 CB216708 CR620491 BG758209 BU621976 BU931946 BM562849 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PKN1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
    SP1:                                      -     -                 -                                                           -                                 
    SP2:                                                              -                                                           -                                 
    SP3:                                      -     -                 -                                                           -                                 
    SP4:                                                                                                                                                            
    SP5:                                            -                 -                                                                                             

    ExUns: 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27
    SP1:  -                                                                             -         
    SP2:  -                                                                             -         
    SP3:                                                                                -         
    SP4:                                                  -     -                                 
    SP5:                                                                                          


    ECgene alternative splicing isoforms for PKN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PKN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGGCTGC
    PKN1 Expression
    About this image


    See PKN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PKN1

    SOURCE GeneReport for Unigene cluster: Hs.466044

    UniProtKB/Swiss-Prot: PKN1_HUMAN, Q16512
    Tissue specificity: Found ubiquitously. Expressed in heart, brain, placenta, lung, skeletal muscle, kidney and
    pancreas. Expressed in numerous tumor cell lines, especially in breast tumor cells

        SABiosciences Custom PCR Arrays for PKN1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PKN1
    OriGene qSTAR qPCR primer pairs in human, mouse for PKN1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PKN1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKN1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PKN1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkn11 , 5 protein kinase N11, 5 85.36(n)1
    91.99(a)1
      8 (40.22 cM)5
    3207951  NM_177262.41  NP_796236.21 
     836697625 
    lizard
    (Anolis carolinensis)
    Reptilia PKN16
    protein kinase N1
    67(a)
    1 ↔ 1
    2(102437478-102505830)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154602 Transcribed sequence with moderate similarity to protein more 77.8(n)    BX713437.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.169852 Transcribed sequence with moderate similarity to protein more 81.23(n)    BM026089.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pkn6
    Protein kinase related to protein kinase N
    32(a)
    1 → many
    2R(5139815-5172602)
    worm
    (Caenorhabditis elegans)
    Secernentea pkn-16
    Protein PKN-1, isoform b
    31(a)
    1 → many
    X(10397243-10402576)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PKC16
    Protein serine/threonine kinase essential for cell...
    22(a)
    1 → many
    II(14241-17696)


    ENSEMBL Gene Tree for PKN1 (if available)
    TreeFam Gene Tree for PKN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PKN1 gene
    ENSG000002589892  PRKCQ2  PRKCH2  PRKCB2  PRKCI2  PRKCE2  PRKCA2  PRKCZ2  
    PRKCD2  PKN32  PRKCG2  PKN22  
    18/128 SIMAP similar genes for PKN1 using alignment to 7 protein entries:     PKN1_HUMAN (see all proteins) (see all similar genes):
    EML2    IDNK    PACSIN2    LOC100996577    PLA2G6    RNF217
    CHID1    LINC00269    WARS    ZNF546    APOD    TMEM44
    LOC100996426    DCTN5    FAM175A    NF2    TMEM14B    ZNF564

    PKN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1056 SNPs in PKN1 are shown (see all 1056)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0423454
    A colorectal adenocarcinoma sample4--see VAR_0423452 A V mis40--------
    VAR_0423444
    A breast infiltrating ductal carcinoma sample4--see VAR_0423442 F L mis40--------
    VAR_0423374
    A metastatic melanoma sample4--see VAR_0423372 R C mis40--------
    VAR_0423384
    ----see VAR_0423382 A E mis40--------
    rs1400495331,2
    C--14119342(+) TCGAC-/ACTCACT 1 -- us2k10--------
    rs1440281331,2
    C--14119343(+) CTCGA-/ACCTCAC 1 -- us2k10--------
    rs1492538281,2
    C--14119486(+) AGGCTC/GGTCTT 1 -- us2k10--------
    rs1180936841,2
    F--14119563(+) CACCAC/TGCCCG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1115452011,2
    C--14119746(+) TTGTAT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1139092541,2
    C,F--14119770(+) AGAGAC/TGGGGT 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for PKN1 (14543865 - 14582679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for PKN1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911127CNV Loss21882294
    nsv828456CNV Loss20364138
    nsv911122CNV Loss21882294
    nsv833764CNV Loss17160897
    nsv527867CNV Loss19592680
    nsv911121CNV Loss21882294
    nsv470127CNV Loss18288195
    dgv3745n71CNV Loss21882294
    nsv817814CNV Loss17921354
    nsv911123CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PKN1
    DNA2.0 Custom Variant and Variant Library Synthesis for PKN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601032    OMIM disorders: --

    14 diseases for PKN1:    About MalaCards
    paraneoplastic cerebellar degeneration    cerebellar degeneration    pheochromocytoma    prostate cancer
    hepatitis b    hypoxia    prostatitis    gastric cancer
    endotheliitis    breast cancer    alzheimer's disease    melanoma
    hepatitis    neuronitis


    PKN1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    9 Novoseek inferred disease relationships for PKN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 22 4 1400478 (1), 1309569 (1), 20132472 (1)
    colorectal carcinoma 21.1 8 15161701 (3), 19620048 (2), 16845324 (1)
    metastasis 1.4 6 15161701 (4), 19610058 (1), 19620048 (1)
    breast cancer 0.695 10 10766836 (3), 17604944 (2), 10945974 (2)
    shock 0 6 9837746 (4), 9237690 (1)
    tumors 0 6 17604944 (2), 15688034 (1), 16845324 (1), 19610058 (1) (see all 5)
    carcinoma 0 12 19427017 (7), 15161701 (1)
    prostate cancer 0 2 19427017 (1), 12514133 (1)
    cancer 0 1 10766836 (1)

    Genetic Association Database (GAD): PKN1
    Human Genome Epidemiology (HuGE) Navigator: PKN1 (4 documents)

    Export disorders for PKN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PKN1 gene, integrated from 9 sources (see all 174):
    (articles sorted by number of sources associating them with PKN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1). (PubMed id 14514689)1, 2, 9 Owen D.... Mott H.R. (2003)
    2. Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. (PubMed id 9751706)1, 2, 9 Takahashi M....Ono Y. (1998)
    3. A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase C. (PubMed id 8135837)1, 2, 9 Mukai H. and Ono Y. (1994)
    4. The Rac1 polybasic region is required for interaction with its effector PRK1. (PubMed id 18006505)1, 2, 9 Modha R....Mott H.R. (2008)
    5. The protein kinase N (PKN) gene PRKCL1/Prkcl1 maps to human chromosome 19p12-p13.1 and mouse chromosome 8 with close linkage to the myodystrophy (myd) mutation. (PubMed id 9570957)1, 3, 9 Bartsch J.W....Ono Y. (1998)
    6. A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. (PubMed id 12514133)1, 2, 9 Metzger E....Schule R. (2003)
    7. PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163. (PubMed id 8557118)1, 2, 9 Palmer R.H....Parker P.J. (1996)
    8. Cloning and expression patterns of two members of a novel protein- kinase-C-related kinase family. (PubMed id 7851406)1, 2, 9 Palmer R.H.... Parker P.J. (1995)
    9. Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA. (PubMed id 10388627)1, 2, 9 Maesaki R....Hakoshima T. (1999)
    10. Protein kinase C-related kinase targets nuclear local ization signals in a subset of class IIa histone deacetylases. (PubMed id 20188095)1, 2, 9 Harrison B.C....McKinsey T.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5585 HGNC: 9405 AceView: PKN1 Ensembl:ENSG00000123143 euGenes: HUgn5585
    ECgene: PKN1 Kegg: 5585 H-InvDB: PKN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PKN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PKN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PKN1 gene:
    Search GeneIP for patents involving PKN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of PKN1
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore small molecules (inhibitor) for PKN1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for PKN1 (PKN1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PKN1   OriGene RNAi products in human, mouse, rat for PKN1  
     OriGene qPCR primer pairs and template standards for PKN1   OriGene Protein Over-expression Lysate for PKN1  
     OriGene MassSpec something-or-other for PKN1   OriGene clones in human, mouse for PKN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for PKN1   OriGene Purified Protein for PKN1  
     OriGene ORF clones in mouse, rat for PKN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PKN1   OriGene Custom Protein Services for PKN1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PKN1
     QIAGEN SeqTarget long-range PCR primers for resequencing PKN1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKN1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PKN1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKN1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKN1
     GenScript Custom Purified and Recombinant Proteins Services for PKN1 GenScript cDNA clones with any tag delivered in your preferred vector for PKN1
     GenScript Custom Assay Services for PKN1 GenScript Custom Superior Antibodies Services for PKN1
     GenScript Custom overexpressing Cell Line Services for PKN1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PKN1 

     Regulatory tfbs in PKN1 promoter
     Search Chromatin IP Primers for PKN1
     RT2 qPCR Primer Assay in human, mouse, rat PKN1
     GNC Network for PKN1
     SABiosciences Custom PCR Arrays for PKN1
     Tocris compounds for PKN1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PKN1 antibodies
     PKN1 proteins
     PKN1 lysates
     Antibodies for PKN1
     See all of Abcam's Antibodies, Kits and Proteins for PKN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PKN1
     Antibodies for PKN1
     ELISAs for PKN1
     CLIAs for PKN1
     Search LifeMap BioReagents cell lines for PKN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKN1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PKN1
     SwitchGear Promoter luciferase reporter plasmids for PKN1
     ThermoFisher Antibodies for PKN1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PKN1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PKN1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PKN1
    Customized:
     lentivirus for stable overexpression of PKN1
     lentivirus expression plasmids for stable overexpression of PKN1
     adenovirus for overexpression of PKN1
     LSBio Antibodies in human, mouse, rat for PKN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PKN1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4