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Aliases for PKMYT1 Gene

Aliases for PKMYT1 Gene

  • Protein Kinase, Membrane Associated Tyrosine/Threonine 1 2 3 5
  • Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase 2 3
  • Protein Phosphatase 1, Regulatory Subunit 126 2 3
  • Myt1 Kinase 3 4
  • MyT1 3 4
  • EC 2.7.11.1 4
  • PPP1R126 3

External Ids for PKMYT1 Gene

Previous GeneCards Identifiers for PKMYT1 Gene

  • GC16M003043
  • GC16M003023
  • GC16M002962
  • GC16M003019
  • GC16M003020
  • GC16M002995

Summaries for PKMYT1 Gene

Entrez Gene Summary for PKMYT1 Gene

  • This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PKMYT1 Gene

PKMYT1 (Protein Kinase, Membrane Associated Tyrosine/Threonine 1) is a Protein Coding gene. Among its related pathways are Cyclin A/B1 associated events during G2/M transition and Cell Cycle Checkpoints. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is WEE1.

UniProtKB/Swiss-Prot for PKMYT1 Gene

  • Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on Thr-14. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on Tyr-15 to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Gene Wiki entry for PKMYT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKMYT1 Gene

Genomics for PKMYT1 Gene

Regulatory Elements for PKMYT1 Gene

Enhancers for PKMYT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F003052 1.3 Ensembl ENCODE 11.4 -74.1 -74062 4.4 ARID4B SIN3A DMAP1 ZNF2 ZNF302 ZNF143 ZNF207 KLF13 ZNF263 SP3 MMP25 BICDL2 IL32 CLDN6 TNFRSF12A ZNF205 CLDN9 PKMYT1 GC16P003092
GH16F002926 1.2 Ensembl ENCODE 11.5 +53.2 53159 1.7 ATF1 WRNIP1 KLF17 ARID4B THRB BRCA1 ZNF2 RAD21 YY1 RFX5 FLYWCH1 KREMEN2 PAQR4 PKMYT1 SRRM2-AS1 PRSS27 ENSG00000255513 LOC107984895 GC16P002923 GC16P002955
GH16F002662 1.2 Ensembl ENCODE 10.5 +316.4 316435 2.2 ATF1 PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF121 KLF7 SP3 TSHZ1 ENSG00000261613 ERVK13-1 TIGD7 NME3 ZNF213-AS1 CLUAP1 MTND1P8 ZNF174 FLYWCH2 ENSG00000269937
GH16F002750 1.1 ENCODE 10.3 +227.5 227467 4.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TIGD7 CLUAP1 ZNF213-AS1 ELOB PRSS33 ENSG00000221719 PRSS41 ZNF205 PRSS27 NME3
GH16F003128 1 ENCODE 10.5 -149.0 -149028 1.8 ATF1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ELK1 ZNF143 FOS REST RNU1-125P IL32 MMP25 BICDL2 LOC100128770 CLDN6 HCFC1R1 THOC6 PKMYT1 ERVK13-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PKMYT1 on UCSC Golden Path with GeneCards custom track

Promoters for PKMYT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000502658 39 1401 HDGF ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2
ENSR00001799071 1039 201 ATF1 L3MBTL2 RNF2 CREB3L1 NRF1 BHLHE40 REST SMARCA4 IKZF1 CREM

Genomic Location for PKMYT1 Gene

Chromosome:
16
Start:
2,968,024 bp from pter
End:
2,980,539 bp from pter
Size:
12,516 bases
Orientation:
Minus strand

Genomic View for PKMYT1 Gene

Genes around PKMYT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKMYT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKMYT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKMYT1 Gene

Proteins for PKMYT1 Gene

  • Protein details for PKMYT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99640-PMYT1_HUMAN
    Recommended name:
    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
    Protein Accession:
    Q99640
    Secondary Accessions:
    • B3KUN8
    • B4DXD4
    • D3DUA4
    • F8W164
    • I3L1V2
    • O14731
    • Q7LE24
    • Q8TCM9

    Protein attributes for PKMYT1 Gene

    Size:
    499 amino acids
    Molecular mass:
    54521 Da
    Quaternary structure:
    • Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.
    SequenceCaution:
    • Sequence=CAD28540.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PKMYT1 Gene

    Alternative splice isoforms for PKMYT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKMYT1 Gene

Post-translational modifications for PKMYT1 Gene

  • Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
  • Ubiquitination at Lys 42 and Lys 163
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PKMYT1 Gene

Domains & Families for PKMYT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q99640

UniProtKB/Swiss-Prot:

PMYT1_HUMAN :
  • The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Domain:
  • The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
genes like me logo Genes that share domains with PKMYT1: view

Function for PKMYT1 Gene

Molecular function for PKMYT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation.
UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on Thr-14. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on Tyr-15 to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Enzyme Numbers (IUBMB) for PKMYT1 Gene

Gene Ontology (GO) - Molecular Function for PKMYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA,TAS 9001210
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 10373560
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PKMYT1: view
genes like me logo Genes that share phenotypes with PKMYT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PKMYT1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PKMYT1 Gene

Localization for PKMYT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKMYT1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PKMYT1 gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for PKMYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum TAS 9001210
genes like me logo Genes that share ontologies with PKMYT1: view

Pathways & Interactions for PKMYT1 Gene

genes like me logo Genes that share pathways with PKMYT1: view

Pathways by source for PKMYT1 Gene

1 Cell Signaling Technology pathway for PKMYT1 Gene
1 BioSystems pathway for PKMYT1 Gene

SIGNOR curated interactions for PKMYT1 Gene

Inactivates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for PKMYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9001210
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PKMYT1: view

Drugs & Compounds for PKMYT1 Gene

(1) Drugs for PKMYT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for PKMYT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PKMYT1: view

Transcripts for PKMYT1 Gene

Unigene Clusters for PKMYT1 Gene

Protein kinase, membrane associated tyrosine/threonine 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKMYT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10: -
SP11: - - -
SP12: - -
SP13:

ExUns: 10 ^ 11
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PKMYT1 Gene

GeneLoc Exon Structure for
PKMYT1
ECgene alternative splicing isoforms for
PKMYT1

Expression for PKMYT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PKMYT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKMYT1 Gene

This gene is overexpressed in Testis (x19.2).

Protein differential expression in normal tissues from HIPED for PKMYT1 Gene

This gene is overexpressed in Testis (62.9) and Urine (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PKMYT1 Gene



Protein tissue co-expression partners for PKMYT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PKMYT1 Gene:

PKMYT1

SOURCE GeneReport for Unigene cluster for PKMYT1 Gene:

Hs.732385
genes like me logo Genes that share expression patterns with PKMYT1: view

No data available for mRNA Expression by UniProt/SwissProt for PKMYT1 Gene

Orthologs for PKMYT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PKMYT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKMYT1 34 35
  • 99.67 (n)
cow
(Bos Taurus)
Mammalia PKMYT1 34 35
  • 88.64 (n)
dog
(Canis familiaris)
Mammalia PKMYT1 34 35
  • 88.14 (n)
rat
(Rattus norvegicus)
Mammalia Pkmyt1 34
  • 85.96 (n)
mouse
(Mus musculus)
Mammalia Pkmyt1 34 16 35
  • 85.51 (n)
oppossum
(Monodelphis domestica)
Mammalia PKMYT1 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PKMYT1 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PKMYT1 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pkmyt1 34
  • 55.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68436 34
zebrafish
(Danio rerio)
Actinopterygii pkmyt1 34 35
  • 52.58 (n)
Dr.11509 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7419 34
fruit fly
(Drosophila melanogaster)
Insecta Myt1 36 35
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea wee-1.3 36 35
  • 40 (a)
wee-1.1 36 35
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWE1 35 37
  • 11 (a)
OneToMany
Species where no ortholog for PKMYT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKMYT1 Gene

ENSEMBL:
Gene Tree for PKMYT1 (if available)
TreeFam:
Gene Tree for PKMYT1 (if available)

Paralogs for PKMYT1 Gene

Paralogs for PKMYT1 Gene

genes like me logo Genes that share paralogs with PKMYT1: view

Variants for PKMYT1 Gene

Sequence variations from dbSNP and Humsavar for PKMYT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10546 -- 2,973,192(-) GGCTG(C/T)CCTGG reference, missense, utr-variant-3-prime
rs111732487 -- 2,973,472(+) AACTT(G/T)TAGTA intron-variant, utr-variant-3-prime
rs111899226 -- 2,979,872(+) CCAGG(A/C)AGGGC utr-variant-5-prime
rs112031903 -- 2,976,348(+) GCCAG(G/T)GCCAG intron-variant
rs112105306 -- 2,973,559(+) GCTAA(C/T)GGCAG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PKMYT1 Gene

Variant ID Type Subtype PubMed ID
nsv952906 CNV deletion 24416366
nsv827525 CNV gain 20364138
nsv571246 CNV loss 21841781
nsv510673 CNV deletion 20534489
nsv509588 CNV insertion 20534489

Variation tolerance for PKMYT1 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKMYT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKMYT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKMYT1 Gene

Disorders for PKMYT1 Gene

Relevant External Links for PKMYT1

Genetic Association Database (GAD)
PKMYT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKMYT1

No disorders were found for PKMYT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKMYT1 Gene

Publications for PKMYT1 Gene

  1. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. (PMID: 9001210) Liu F. … Piwnica-Worms H. (Mol. Cell. Biol. 1997) 2 3 4 22 64
  2. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. (PMID: 12606722) Passer B.J. … Telerman A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 22 64
  3. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. (PMID: 12738781) Nakajima H. … Nishida E. (J. Biol. Chem. 2003) 3 4 22 64
  4. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. (PMID: 10373560) Liu F. … Piwnica-Worms H. (Mol. Cell. Biol. 1999) 3 4 22 64
  5. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. (PMID: 10504341) Wells N.J. … Hunter T. (J. Cell Sci. 1999) 3 4 22 64

Products for PKMYT1 Gene

Sources for PKMYT1 Gene

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