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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PKMYT1 Gene

protein-coding GIFtS: 61
GCID: GC16M002995

protein kinase, membrane associated tyrosine/threonine 1

Explore 4 diseases affiliated with
PKMYT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Protein Kinase, Membrane Associated Tyrosine/Threonine 1¹ ²
MYT1¹ ² ³
Myt1 Kinase² ³
Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase²
EC 2.7.11.1³

External Ids:	HGNC: 29650¹	Entrez Gene: 9088²	Ensembl: ENSG00000127564⁷	OMIM: 602474⁵	UniProtKB: Q99640³

Export aliases for PKMYT1 gene to outside databases

Previous GC identifers: GC16M003043 GC16M003023 GC16M002962 GC16M003019 GC16M003020

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PKMYT1:

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated

kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating

cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively

spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, May

2012)

UniProtKB/Swiss-Prot: PMYT1_HUMAN, Q99640

Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase

specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also

involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however

tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during

eye development

Gene Wiki entry for PKMYT1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PKMYT1 gene promoter:
E2F-4 E2F-3a USF1 E2F-5 AP-1 E2F-2 E2F E2F-1 USF-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PKMYT1 promoter sequence

Search SABiosciences Chromatin IP Primers for PKMYT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKMYT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

PKMYT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKMYT1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M002995: view genomic region (about GC identifiers)

Start:	3,018,025 bp from pter	End:	3,030,540 bp from pter
Size:	12,516 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PMYT1_HUMAN, Q99640 (See protein sequence)

Recommended Name: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Size: 499 amino acids; 54521 Da

Subunit: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral

membrane protein

Sequence caution: Sequence=CAD28540.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;

1 PDB 3D structure from and Proteopedia for PKMYT1:

3P1A (3D)

Secondary accessions: D3DUA4 F8W164 O14731 Q7LE24 Q8TCM9

Alternative splicing: 2 isoforms: Q99640-1 Q99640-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PKMYT1: NX_Q99640

Post-translational modifications:

Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The

phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q99640

PKMYT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001245379.1 NP_001245380.1 NP_004194.3 NP_872629.1

ENSEMBL proteins:

ENSP00000392855 ENSP00000397739 ENSP00000262300 ENSP00000459880 ENSP00000458943

ENSP00000460868 ENSP00000459123 ENSP00000371675 ENSP00000458545 ENSP00000460598

ENSP00000461330 ENSP00000458842 ENSP00000461628

Reactome Protein details: Q99640
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for PKMYT1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	IEA	--
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	--	--

PKMYT1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for PKMYT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PKMYT1 for domains About GeneDecksing

5 InterPro domains/families:

IPR017441 Protein_kinase_ATP_BS

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_kinase_AS

IPR000719 Prot_kinase_cat_dom

IPR016235 Tyr/Thr_kinase_Cdc2_inhib

Graphical View of Domain Structure for InterPro Entry Q99640

ProtoNet protein and cluster: Q99640

UniProtKB/Swiss-Prot: PMYT1_HUMAN, Q99640

Domain: The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some

authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven

Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PMYT1_HUMAN, Q99640

Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase

specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also

involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however

tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during

eye development

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not

associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation

Enzyme Number (IUBMB): EC 2.7.11.1¹

miRNA Products:		miRTarBase miRNAs that target PKMYT1: hsa-mir-27a (MIRT001770)

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		hsa-miR-3671 hsa-miR-607
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKMYT1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	TAS	9001210
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005515	protein binding	IPI	10373560
GO:0005524	ATP binding	IEA	--
GO:0016301	kinase activity	IDA	9268380

PKMYT1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PKMYT1:

Downregulation of NF-kappaB pa

Animal Models:
1 MGI phenotypic allele

for Pkmyt1 (no phenotypes)

PKMYT1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Oocyte meiosis

Oocyte meiosis

1.00

Progesterone-mediated oocyte maturation

0.35

Cell cycle

Cell cycle

1.00

Cell cycle

0.57

G1/S Transition

G1/S Transition

1.00

Mitotic G1-G1/S phases

0.80

Recruitment of mitotic centrosome proteins and complexes

G2/M Transition

0.83

Mitotic G2-G2/M phases

0.81

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for PKMYT1

	Cell Cycle / Checkpoint Control
	DNA Damage

1 BioSystems Pathway for PKMYT1

Cell cycle

5/9 Reactome Pathways for PKMYT1 (see all 9)

	Mitotic G1-G1/S phases
	Cell Cycle
	Cyclin E associated events during G1/S transition
	G1/S Transition
	G2/M Transition

3 Kegg Pathways (Kegg details for PKMYT1):

	Cell cycle
	Oocyte meiosis
	Progesterone-mediated oocyte maturation

PKMYT1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PKMYT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/19 Interacting proteins for PKMYT1 (Q99640^{1, 2, 3} ENSP00000262300⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK1	P06493¹^,³	EBI-495308,EBI-444308 I2D: score=4
CCNB1	P14635¹^,³, ENSP00000256442⁴	EBI-495308,EBI-495332 I2D: score=3 STRING: ENSP00000256442
BCL2	P10415³, ENSP00000329623⁴	I2D: score=2 STRING: ENSP00000329623
PIN1	Q13526³, ENSP00000247970⁴	I2D: score=4 STRING: ENSP00000247970
PLK1	P53350³, ENSP00000300093⁴	I2D: score=2 STRING: ENSP00000300093

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS	9001210
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006468	protein phosphorylation	--	--

PKMYT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PKMYT1

2 HMDB Compounds for PKMYT1 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

Search CenterWatch for drugs/clinical trials and news about PKMYT1 / PMYT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PKMYT1 gene (4 alternative transcripts):

NM_001258450.1 NM_001258451.1 NM_004203.4 NM_182687.2

Unigene Cluster for PKMYT1:

Protein kinase, membrane associated tyrosine/threonine 1

Hs.732385 [show with all ESTs]

Unigene Representative Sequence: AK303005

18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000571102 ENST00000431515 ENST00000572832 ENST00000574333 ENST00000440027

ENST00000262300(uc002csm.3 uc002csn.3 uc002cso.3 uc002csq.3)

ENST00000575040 ENST00000575981 ENST00000574680 ENST00000574385 ENST00000574730

ENST00000573944 ENST00000382240(uc010uwn.2 uc010bsy.1) ENST00000576268

ENST00000574415 ENST00000575632 ENST00000572059 ENST00000572619

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		hsa-miR-3671 hsa-miR-607
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Additional cDNA sequence:

AK097642.1 AK098452.1 AK294379.1 AK301926.1 AK303005.1 AK309964.1 BC121161.1 BC121162.1

BC130011.1 BC153823.1 U56816.1

21 DOTS entries:

DT.95361207 DT.92446228 DT.101982529 DT.100031034 DT.120674069 DT.452892 DT.95361206 DT.97855467

DT.100881190 DT.100719132 DT.120674018 DT.120674091 DT.75141164 DT.100881170 DT.100881175 DT.100881186

DT.120674039 DT.120674066 DT.100881160 DT.120674031 DT.95230750

24/230 AceView cDNA sequences (see all 230):

BQ896903 BQ687776 CR610333 AA916609 BM918079 BM553217 AA478066 BQ946076

BQ065693 BM716321 AL558055 BQ883823 CR622913 BU500181 BM453895 BM461983

AI671868 BQ053358 BI829290 BQ070052 NM_182687 BG388524 BM480373 BQ685140

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for PKMYT1 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9	^
SP1:													-		-		-								-		-
SP2:													-		-		-						-		-		-
SP3:													-		-		-								-		-		-		-
SP4:													-		-		-				-		-		-		-
SP5:													-		-										-		-

ExUns:	10	^	11
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for PKMYT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PKMYT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCAAAAAA

About this image

PKMYT1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See PKMYT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PKMYT1

SOURCE GeneReport for Unigene cluster: Hs.732385

SABiosciences Custom PCR Arrays for PKMYT1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for PKMYT1 gene from 6/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pkmyt1^{1 , 5}	protein kinase, membrane associated tyrosine/threonine more^{1, 5}	85.55(n)¹ 89.57(a)¹		17 (12.02 cM)⁵ 268930¹ NM_023058.3¹ NP_075545.2¹ 23726336⁵
lizard (Anolis carolinensis)	Reptilia	PKMYT1⁶	--	50(a)	1 ↔ 1	GL343287.1(1242243-1246428)
African clawed frog (Xenopus laevis)	Amphibia	MGC68436²	hypothetical protein MGC68436	73.56(n)		BC057703.1
zebrafish (Danio rerio)	Actinopterygii	Dr.11509²	Transcribed sequence with weak similarity to protein more	70.05(n)		BM859485.1
fruit fly (Drosophila melanogaster)	Insecta	Myt1³	protein amino acid phosphorylation protein kinase	46(a)		64E7 --
worm (Caenorhabditis elegans)	Secernentea	wee-1.3³	serine/threonine kinase	40(a) (best of 2)		II(9714012-9716372) --

ENSEMBL Gene Tree for PKMYT1 (if available)
TreeFam Gene Tree for PKMYT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for PKMYT1 gene

WEE2² WEE1²

13 SIMAP similar genes for PKMYT1 using alignment to 12 protein entries: PMYT1_HUMAN (see all proteins):

STK11 MAP4K5 STK38L DKFZp564L2416 CCRK STK25

BRSK2 WEE1 NEK9 PRKCH ULK1 RPS6KA2

CDK1

PKMYT1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78853482^1,2		--	3022294(+)	`CAGGCC/TGCCAG`	5	--	ut3¹ ds500¹		1		WA	118
rs149801113^1,2		--	3022295(+)	`AGGCCA/GCCAGC`	5	--	ds500¹ ut3¹		0	--	--	--	--
rs145743474^1,2		--	3022330(+)	`TTCCTC/GCCACC`	5	--	ut3¹ ds500¹		0	--	--	--	--
rs190250606^1,2		--	3022484(+)	`GACCCA/GTCTTG`	5	--	ut3¹ ds500¹		0	--	--	--	--
rs4149811^1,2	C,H,	--	3022513(-)	`GCAGCC/TCTTGT`	5	--	ut3¹ ds500¹		5		NS EA	582
rs115619502^1,2		--	3022530(+)	`TTCTTC/TCAGGA`	5	--	ds500¹ ut3¹		1		WA	118
rs4149810^1,2	C,F,	--	3022558(-)	`TGAGGC/TCGCTG`	5	--	ds500¹ ut3¹		2		NS EA	298
rs4149809^1,2	C	--	3022636(-)	`CCCCCG/AGTGGG`	5	--	ut3¹ ds500¹		2		NS NA	180
rs4149808^1,2	F,H	--	3022665(-)	`GAGCAG/AAGAGG`	5	--	ds500¹ ut3¹		5		NS EA	586
rs115073835^1,2	C,F,	--	3022738(+)	`TCAGCC/TTCAGG`	5	--	ut3¹ ds500¹		1		WA	118

HapMap Linkage Disequilibrium report for PKMYT1 (3018025 - 3030540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PKMYT1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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PKMYT1 for disorders           About GeneDecksing

OMIM gene information: 602474    OMIM disorders: --

4 diseases for PKMYT1:    About MalaCards

kaposi's sarcoma skin cancer sarcoma melanoma

Export disorders for PKMYT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PKMYT1 gene, integrated from 9 sources (see all 59):
(articles sorted by number of sources associating them with PKMYT1)

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The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. (PubMed id 9001210)^{1, 2, 3, 9} Liu F.... Piwnica-Worms H. (1997)
The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. (PubMed id 10504341)^{1, 2, 9} Wells N.J....Hunter T. (1999)
Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. (PubMed id 10373560)^{1, 2, 9} Liu F.... Piwnica-Worms H. (1999)
Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. (PubMed id 9268380)^{1, 2, 9} Booher R.N....Fattaey A. (1997)
Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. (PubMed id 12738781)^{1, 2, 9} Nakajima H.... Nishida E. (2003)
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. (PubMed id 12606722)^{1, 3, 9} Passer B.J....Telerman A. (2003)
The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. (PubMed id 9499405)^{1, 2, 9} Shen M.... Lu K.P. (1998)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation. (PubMed id 15175024)^{1, 9} Dai X....Hashimoto K. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9088	HGNC: 29650	AceView: PKMYT1	Ensembl:ENSG00000127564	euGenes: HUgn9088
ECgene: PKMYT1	Kegg: 9088	H-InvDB: PKMYT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PKMYT1	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/pkmyt1/

Intellectual Property for PKMYT1 gene
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Patent Information for PKMYT1 gene:
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protein kinase, membrane associated tyrosine/threonine 1

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PKMYT1 Gene

protein kinase, membrane associated tyrosine/threonine 1

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