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PKMYT1 Gene

protein-coding   GIFtS: 61
GCID: GC16M002995

Protein Kinase, Membrane Associated Tyrosine/Threonine 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Protein Kinase, Membrane Associated Tyrosine/Threonine 11 2
MYT12 3 5
Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory
Kinase1 2
Myt1 Kinase2 3
EC 2.7.11.13

External Ids:    HGNC: 296501   Entrez Gene: 90882   Ensembl: ENSG000001275647   OMIM: 6024745   UniProtKB: Q996403   

Export aliases for PKMYT1 gene to outside databases

Previous GC identifers: GC16M003043 GC16M003023 GC16M002962 GC16M003019 GC16M003020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PKMYT1 Gene:
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a
membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and
inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1.
Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided
by RefSeq, May 2012)

GeneCards Summary for PKMYT1 Gene:
PKMYT1 (protein kinase, membrane associated tyrosine/threonine 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is WEE2.

UniProtKB/Swiss-Prot: PMYT1_HUMAN, Q99640
Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1
kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on
'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a
lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of
Notch signaling pathway during eye development

Gene Wiki entry for PKMYT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PKMYT1 gene promoter:
         E2F-4   E2F-3a   USF1   E2F-5   AP-1   E2F-2   E2F   E2F-1   USF-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPKMYT1 promoter sequence
   Search Chromatin IP Primers for PKMYT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PKMYT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

PKMYT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKMYT1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002995:  view genomic region     (about GC identifiers)

Start:
3,018,025 bp from pter      End:
3,030,540 bp from pter
Size:
12,516 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PMYT1_HUMAN, Q99640 (See protein sequence)
Recommended Name: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase  
Size: 499 amino acids; 54521 Da
Subunit: Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1
Sequence caution: Sequence=CAD28540.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA;
1 PDB 3D structure from and Proteopedia for PKMYT1:
3P1A (3D)    
Secondary accessions: B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9
Alternative splicing: 4 isoforms:  Q99640-1   Q99640-2   Q99640-3   Q99640-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PKMYT1: NX_Q99640

Explore proteomics data for PKMYT1 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The
    phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity1
  • Ubiquitination2 at Lys42, Lys163
  • Modification sites at PhosphoSitePlus

  • See PKMYT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001245379.1  NP_001245380.1  NP_004194.3  NP_872629.1  

    ENSEMBL proteins: 
     ENSP00000392855   ENSP00000397739   ENSP00000262300   ENSP00000459880   ENSP00000458943  
     ENSP00000460868   ENSP00000459123   ENSP00000371675   ENSP00000458545   ENSP00000460598  
     ENSP00000461330   ENSP00000458842   ENSP00000461628  
    Reactome Protein details: Q99640

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: protein kinase, membrane associated tyrosine/threonine 1
    WEE family

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom
     IPR016235 Tyr/Thr_kinase_Cdc2_inhib

    Graphical View of Domain Structure for InterPro Entry Q99640

    ProtoNet protein and cluster: Q99640

    UniProtKB/Swiss-Prot: PMYT1_HUMAN, Q99640
    Domain: The membrane-association motif is essential for the localization to membrane of Golgi stack. According to
    some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven
    Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with PKMYT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PMYT1_HUMAN, Q99640
    Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1
    kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on
    'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a
    lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of
    Notch signaling pathway during eye development
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does
    not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9001210
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI10373560
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with PKMYT1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PKMYT1:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         1 MGI phenotypic allele for Pkmyt1 (no phenotypes)

    Find genes that share phenotypes with PKMYT1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PKMYT1
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    2 qRT-PCR Assays for microRNAs that regulate PKMYT1:
    hsa-miR-3671 hsa-miR-607
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PMYT1_HUMAN, Q99640: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane;
    Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    nucleus4
    cytosol2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum TAS9001210

    Find genes that share ontologies with PKMYT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PKMYT1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2Regulation of PLK1 Activity at G2/M Transition
    G2/M Transition0.70
    Polo-like kinase mediated events0.00
    Mitotic G2-G2/M phases0.69
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4E2F mediated regulation of DNA replication
    G1/S Transition0.81
    Mitotic G1-G1/S phases0.81
    5CDK-mediated phosphorylation and removal of Cdc6
    Cyclin E associated events during G1/S transition0.86
    Cell Cycle Checkpoints0.58


    Find genes that share SuperPaths with PKMYT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PKMYT1
        Cyclins and Cell Cycle Regulation
    Mitotic Roles of Polo Like Kinases

    2 Cell Signaling Technology (CST) Pathways for PKMYT1
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 BioSystems Pathway for PKMYT1
        Cell cycle

    4 Reactome Pathways for PKMYT1
        Polo-like kinase mediated events
    Cyclin A/B1 associated events during G2/M transition
    G2/M DNA replication checkpoint
    Cyclin E associated events during G1/S transition


    3 Kegg Pathways  (Kegg details for PKMYT1):
        Cell cycle
    Oocyte meiosis
    Progesterone-mediated oocyte maturation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PKMYT1
    Interactions:

        Search GeneGlobe Interaction Network for PKMYT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PKMYT1 (Q996401, 2, 3 ENSP000002623004) via UniProtKB, MINT, STRING, and/or I2D (see all 265)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNB1P146351, 3, ENSP000002564424EBI-495308,EBI-495332 I2D: score=3 STRING: ENSP00000256442
    CDK1P064931, 3EBI-495308,EBI-444308 I2D: score=4 
    PIN1Q135263, ENSP000002479704I2D: score=4 STRING: ENSP00000247970
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    STEAP3Q658P33, ENSP000003768224I2D: score=2 STRING: ENSP00000376822
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity TAS9001210
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with PKMYT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for PKMYT1 (PMYT1)

    2 HMDB Compounds for PKMYT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PKMYT1 gene (4 alternative transcripts): 
    NM_001258450.1  NM_001258451.1  NM_004203.4  NM_182687.2  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000571102 ENST00000431515 ENST00000572832 ENST00000574333 ENST00000440027
    ENST00000262300(uc002csm.3 uc002csn.3 uc002cso.3 uc002csq.3)
    ENST00000575040 ENST00000575981 ENST00000574680 ENST00000574385 ENST00000574730
    ENST00000573944 ENST00000382240(uc010uwn.2 uc010bsy.1) ENST00000576268
    ENST00000574415 ENST00000575632 ENST00000572059 ENST00000572619
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    Selected AceView cDNA sequences (see all 230):

    BM763114 CR610333 AI671868 AK097642 CR622913 BM453895 BQ946076 NM_004203 
    BM461983 BQ880345 CR598569 CR597027 BM716321 BU500181 CR603670 BM480373 
    CR595647 BM918079 BU169151 CR601395 BQ053358 AK098452 AW135124 BX355219 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PKMYT1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^
    SP1:                                      -     -     -                       -     -                                                                           
    SP2:                                      -     -     -                 -     -     -                                                                           
    SP3:                                      -     -     -                       -     -     -     -                                                               
    SP4:                                      -     -     -           -     -     -     -                                                                           
    SP5:                                      -     -                             -     -                                                                           

    ExUns: 10 ^ 11
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for PKMYT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PKMYT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCAAAAAA
    PKMYT1 Expression
    About this image


    PKMYT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
    PKMYT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PKMYT1 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PKMYT1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkmyt11 , 5 protein kinase, membrane associated tyrosine/threonine more1, 5 85.51(n)1
    89.39(a)1
      17 (12.02 cM)5
    2689301  NM_023058.31  NP_075545.21 
     237263365 
    lizard
    (Anolis carolinensis)
    Reptilia PKMYT16
    protein kinase, membrane associated tyrosine/threo...
    43(a)
    1 ↔ 1
    GL343287.1(1241740-1250377)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684362 hypothetical protein MGC68436 73.56(n)    BC057703.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.115092 Transcribed sequence with weak similarity to protein more 70.05(n)    BM859485.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Myt13 protein amino acid phosphorylation
    protein kinase
    46(a)   64E7   --
    worm
    (Caenorhabditis elegans)
    Secernentea wee-1.33 serine/threonine kinase 40(a)
    (best of 2)
      II(9714012-9716372)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SWE1(YJL187C)4 Protein kinase that regulates the G2/M transition by more   --   10(79262-76803) 853252  NP_012348.1 


    ENSEMBL Gene Tree for PKMYT1 (if available)
    TreeFam Gene Tree for PKMYT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PKMYT1 gene
    WEE22  WEE12  
    10 SIMAP similar genes for PKMYT1 using alignment to 10 protein entries:     PMYT1_HUMAN (see all proteins):
    STK38L    STK25    STK11    MAP4K5    DKFZp564L2416    CCRK
    BRSK2    ULK1    NEK9    RPS6KA2

    Find genes that share paralogs with PKMYT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PKMYT1 (see all 241)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006008611,2
    C--3024001(+) CCCACC/TCTAGG 8 E G D mis10--------
    rs2006566821,2
    --3024011(+) GCTGTC/GGTCAT 8 H D mis10--------
    rs1457887031,2
    C--3024015(+) TCGTCA/CTCCCA 8 E D mis10--------
    rs1427452801,2
    C,F--3024025(+) AGTTGC/ATGGAG 8 /S /I mis11Minor allele frequency- A:0.00NA 4446
    rs41498011,2
    C,F--3024027(-) CTCTCC/TAGCAA 8 S syn1 ese32Minor allele frequency- T:0.00NS NA 4614
    rs41498001,2,,4
    C--3024061(-) CTCACC/GACCCT 8 P R mis1 ese33Minor allele frequency- G:0.01NS NA 176
    rs1450475061,2
    C--3024120(+) TGAGCC/TAGCCC 8 L syn11Minor allele frequency- T:0.00NA 2630
    rs20745281,2
    C,F,A--3024188(+) GTGGGC/TGGGCG 4 -- int116Minor allele frequency- T:0.29NS NA EA WA CSA 899
    rs1385034671,2
    --3024227(+) CAGCCA/GCCACT 4 -- int10--------
    rs1430663371,2
    --3024280(+) CCTCCA/GCTGCC 8 A V mis10--------

    HapMap Linkage Disequilibrium report for PKMYT1 (3018025 - 3030540 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PKMYT1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509588CNV Insertion20534489
    dgv2579n71CNV Loss21882294
    nsv510673CNV Loss20534489
    nsv905193CNV Loss21882294
    nsv905170CNV Loss21882294
    nsv905185CNV Loss21882294
    dgv2575n71CNV Loss21882294
    dgv2576n71CNV Loss21882294
    dgv2577n71CNV Loss21882294
    dgv2578n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PKMYT1
    DNA2.0 Custom Variant and Variant Library Synthesis for PKMYT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602474    OMIM disorders: --


    Find genes that share disorders with PKMYT1           About GenesLikeMe

    Genetic Association Database (GAD): PKMYT1

    Export disorders for PKMYT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PKMYT1 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with PKMYT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. (PubMed id 9001210)1, 2, 3, 9 Liu F.... Piwnica-Worms H. (Mol. Cell. Biol. 1997)
    2. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. (PubMed id 10504341)1, 2, 9 Wells N.J....Hunter T. (J. Cell Sci. 1999)
    3. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. (PubMed id 10373560)1, 2, 9 Liu F.... Piwnica-Worms H. (Mol. Cell. Biol. 1999)
    4. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. (PubMed id 9268380)1, 2, 9 Booher R.N.... Fattaey A. (J. Biol. Chem. 1997)
    5. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. (PubMed id 12738781)1, 2, 9 Nakajima H.... Nishida E. (J. Biol. Chem. 2003)
    6. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. (PubMed id 12606722)1, 3, 9 Passer B.J....Telerman A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. (PubMed id 9499405)1, 2, 9 Shen M.... Lu K.P. (Genes Dev. 1998)
    8. A genome-wide association study of the metabolic syndrome in Indian Asian men. (PubMed id 20694148)1, 4 Zabaneh D. and Balding D.J. (PLoS ONE 2010)
    9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9088 HGNC: 29650 AceView: PKMYT1 Ensembl:ENSG00000127564 euGenes: HUgn9088
    ECgene: PKMYT1 Kegg: 9088 H-InvDB: PKMYT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PKMYT1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/pkmyt1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PKMYT1 gene:
    Search GeneIP for patents involving PKMYT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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