Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PKMYT1 Gene

Aliases for PKMYT1 Gene

  • Protein Kinase, Membrane Associated Tyrosine/Threonine 1 2 3
  • MYT1 3 4 6
  • Membrane-Associated Tyrosine- And Threonine-Specific Cdc2-Inhibitory Kinase 2 3
  • Myt1 Kinase 3 4
  • Protein Phosphatase 1, Regulatory Subunit 126 3
  • Regulatory Subunit 126 2
  • Protein Phosphatase 1 2
  • EC 2.7.11.1 4
  • PPP1R126 3

External Ids for PKMYT1 Gene

Summaries for PKMYT1 Gene

Entrez Gene Summary for PKMYT1 Gene

  • This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for PKMYT1 Gene

PKMYT1 (Protein Kinase, Membrane Associated Tyrosine/Threonine 1) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is WEE2.

UniProtKB/Swiss-Prot for PKMYT1 Gene

  • Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on Thr-14. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on Tyr-15 to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Gene Wiki entry for PKMYT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKMYT1 Gene

Genomics for PKMYT1 Gene

Genomic Location for PKMYT1 Gene

Start:
2,968,024 bp from pter
End:
2,980,539 bp from pter
Size:
12,516 bases
Orientation:
Minus strand

Genomic View for PKMYT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PKMYT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKMYT1 Gene

Regulatory Elements for PKMYT1 Gene

Proteins for PKMYT1 Gene

  • Protein details for PKMYT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99640-PMYT1_HUMAN
    Recommended name:
    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
    Protein Accession:
    Q99640
    Secondary Accessions:
    • B3KUN8
    • B4DXD4
    • D3DUA4
    • F8W164
    • I3L1V2
    • O14731
    • Q7LE24
    • Q8TCM9

    Protein attributes for PKMYT1 Gene

    Size:
    499 amino acids
    Molecular mass:
    54521 Da
    Quaternary structure:
    • Interacts with CDC2-CCNB1 complex. Can also interact with PIN1 when phosphorylated by CDC2-CCNB1.
    SequenceCaution:
    • Sequence=CAD28540.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PKMYT1 Gene

    Alternative splice isoforms for PKMYT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKMYT1 Gene

Proteomics data for PKMYT1 Gene at MOPED

Post-translational modifications for PKMYT1 Gene

  • Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys42 and Lys163

No data available for DME Specific Peptides for PKMYT1 Gene

Domains for PKMYT1 Gene

UniProtKB/Swiss-Prot:

PMYT1_HUMAN
Domain:
  • The membrane-association motif is essential for the localization to membrane of Golgi stack. According to some authors, it is a transmembrane domain; the existence of a transmembrane region is however unproven:
    • Q99640
  • Contains 1 protein kinase domain.:
    • Q99640
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.:
    • Q99640
genes like me logo Genes that share domains with PKMYT1: view

Function for PKMYT1 Gene

Molecular function for PKMYT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation.
UniProtKB/Swiss-Prot Function: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on Thr-14. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on Tyr-15 to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Enzyme Numbers (IUBMB) for PKMYT1 Gene

Gene Ontology (GO) - Molecular Function for PKMYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9001210
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10373560
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PKMYT1: view
genes like me logo Genes that share phenotypes with PKMYT1: view

miRNA for PKMYT1 Gene

miRTarBase miRNAs that target PKMYT1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PKMYT1 Gene

Localization for PKMYT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKMYT1 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PKMYT1 Gene COMPARTMENTS Subcellular localization image for PKMYT1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 4
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PKMYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005783 endoplasmic reticulum TAS 9001210
genes like me logo Genes that share ontologies with PKMYT1: view

Pathways for PKMYT1 Gene

genes like me logo Genes that share pathways with PKMYT1: view

Pathways by source for PKMYT1 Gene

Gene Ontology (GO) - Biological Process for PKMYT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 9001210
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PKMYT1: view

Compounds for PKMYT1 Gene

(2) HMDB Compounds for PKMYT1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with PKMYT1: view

Transcripts for PKMYT1 Gene

Unigene Clusters for PKMYT1 Gene

Protein kinase, membrane associated tyrosine/threonine 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PKMYT1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - -
SP6:
SP7: - - - - -
SP8: - - - -
SP9: - - -
SP10: -
SP11: - - -
SP12: - -
SP13:

ExUns: 10 ^ 11
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PKMYT1 Gene

GeneLoc Exon Structure for
PKMYT1
ECgene alternative splicing isoforms for
PKMYT1

Expression for PKMYT1 Gene

mRNA expression in normal human tissues for PKMYT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKMYT1 Gene

This gene is overexpressed in Testis (19.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PKMYT1 Gene

SOURCE GeneReport for Unigene cluster for PKMYT1 Gene Hs.732385

genes like me logo Genes that share expressions with PKMYT1: view

Orthologs for PKMYT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PKMYT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKMYT1 36
  • 99.67 (n)
  • 99.6 (a)
PKMYT1 37
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PKMYT1 36
  • 88.64 (n)
  • 90.61 (a)
PKMYT1 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PKMYT1 36
  • 88.14 (n)
  • 91.41 (a)
PKMYT1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pkmyt1 36
  • 85.51 (n)
  • 89.39 (a)
Pkmyt1 16
Pkmyt1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PKMYT1 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PKMYT1 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pkmyt1 36
  • 85.96 (n)
  • 89.98 (a)
lizard
(Anolis carolinensis)
Reptilia PKMYT1 37
  • 43 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68436 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pkmyt1 36
  • 55.26 (n)
  • 52.25 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7419 36
zebrafish
(Danio rerio)
Actinopterygii Dr.11509 36
pkmyt1 36
  • 52.58 (n)
  • 49.3 (a)
pkmyt1 37
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myt1 37
  • 30 (a)
OneToOne
Myt1 38
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea wee-1.1 37
  • 23 (a)
OneToMany
wee-1.3 37
  • 23 (a)
OneToMany
wee-1.3 38
  • 40 (a)
wee-1.1 38
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWE1 37
  • 11 (a)
OneToMany
SWE1 39
Species with no ortholog for PKMYT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKMYT1 Gene

ENSEMBL:
Gene Tree for PKMYT1 (if available)
TreeFam:
Gene Tree for PKMYT1 (if available)

Paralogs for PKMYT1 Gene

Paralogs for PKMYT1 Gene

genes like me logo Genes that share paralogs with PKMYT1: view

Variants for PKMYT1 Gene

Sequence variations from dbSNP and Humsavar for PKMYT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2074528 -- 2,974,187(+) GTGGG(C/T)GGGCG intron-variant
rs4149764 -- 2,980,764(-) ATGGC(C/G)GTCCC upstream-variant-2KB
rs4149765 -- 2,980,693(-) TGGAG(A/G)GCAGT upstream-variant-2KB
rs4149766 -- 2,980,598(-) ATCCT(C/G)TGCGC upstream-variant-2KB
rs4149767 -- 2,980,420(-) CCTCA(A/C)GGGAG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PKMYT1 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv509588 CNV Insertion 20534489
nsv510673 CNV Loss 20534489
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
nsv827525 CNV Gain 20364138
nsv905193 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294

Relevant External Links for PKMYT1 Gene

HapMap Linkage Disequilibrium report
PKMYT1

Disorders for PKMYT1 Gene

Relevant External Links for PKMYT1

Genetic Association Database (GAD)
PKMYT1
genes like me logo Genes that share disorders with PKMYT1: view

No data available for UniProtKB/Swiss-Prot for PKMYT1 Gene

Publications for PKMYT1 Gene

  1. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. (PMID: 9001210) Liu F. … Piwnica-Worms H. (Mol. Cell. Biol. 1997) 2 3 4 23
  2. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. (PMID: 9268380) Booher R.N. … Fattaey A. (J. Biol. Chem. 1997) 3 4 23
  3. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. (PMID: 9499405) Shen M. … Lu K.P. (Genes Dev. 1998) 3 4 23
  4. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. (PMID: 10373560) Liu F. … Piwnica-Worms H. (Mol. Cell. Biol. 1999) 3 4 23
  5. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. (PMID: 10504341) Wells N.J. … Hunter T. (J. Cell Sci. 1999) 3 4 23

Products for PKMYT1 Gene

Sources for PKMYT1 Gene

Back to Top

Content