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Aliases for PKM Gene

Aliases for PKM Gene

  • Pyruvate Kinase, Muscle 2 3 5
  • Cytosolic Thyroid Hormone-Binding Protein 3 4
  • Thyroid Hormone-Binding Protein 1 3 4
  • Pyruvate Kinase Muscle Isozyme 3 4
  • Pyruvate Kinase 2/3 3 4
  • Tumor M2-PK 3 4
  • EC 2.7.1.40 4 61
  • CTHBP 3 4
  • OIP-3 3 4
  • THBP1 3 4
  • PKM2 3 4
  • OIP3 3 4
  • P58 3 4
  • PK3 3 4
  • Thyroid Hormone-Binding Protein, Cytosolic 3
  • Epididymis Secretory Protein Li 30 3
  • Pyruvate Kinase Isozymes M1/M2 3
  • OPA-Interacting Protein 3 3
  • Opa-Interacting Protein 3 4
  • Pyruvate Kinase PKM 3
  • PK, Muscle Type 3
  • HEL-S-30 3
  • TCB 3
  • PK2 4

External Ids for PKM Gene

Previous HGNC Symbols for PKM Gene

  • PKM2

Previous GeneCards Identifiers for PKM Gene

  • GC15M072492

Summaries for PKM Gene

Entrez Gene Summary for PKM Gene

  • This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

GeneCards Summary for PKM Gene

PKM (Pyruvate Kinase, Muscle) is a Protein Coding gene. Diseases associated with PKM include Pyruvate Kinase Deficiency and Acute Diarrhea. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include poly(A) RNA binding and MHC class II protein complex binding. An important paralog of this gene is PKLR.

UniProtKB/Swiss-Prot for PKM Gene

  • Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Gene Wiki entry for PKM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKM Gene

Genomics for PKM Gene

Regulatory Elements for PKM Gene

Enhancers for PKM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F072225 1.5 FANTOM5 ENCODE 21.6 +2.6 2571 8.0 MLX YBX1 FEZF1 DMAP1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ENSG00000261187 BBS4 HEXA ARIH1 LOC105370888 RPL17P39 LOC105370887 PKM ENSG00000260672 TMEM202
GH15F072194 0.6 Ensembl ENCODE 12 +32.3 32303 9.6 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 ENSG00000261187 PARP6 BBS4 PKM LOC105370888 ARIH1 ENSG00000260672 RPL17P39 MYO9A HEXA
GH15F072271 0.2 ENCODE 11.5 -40.8 -40782 3.1 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A ZNF2 YY1 ZNF143 DEK ZNF263 PKM GRAMD2 PARP6 MYO9A BBS4
GH15F072175 1 FANTOM5 ENCODE 11.2 +55.5 55473 0.9 ZNF121 ZNF362 ZNF24 GRAMD2 PKM RNU2-65P BBS4 ENSG00000260173
GH15F072167 0.8 Ensembl ENCODE 11.2 +62.5 62525 4.0 HDGF CTCF PKNOX1 IRF2 TAL1 CEBPG RAD21 ZIC2 YY1 GATA3 PKM GRAMD2 RNU2-65P MYO9A ENSG00000260173
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PKM on UCSC Golden Path with GeneCards custom track

Genomic Location for PKM Gene

Chromosome:
15
Start:
72,199,029 bp from pter
End:
72,231,822 bp from pter
Size:
32,794 bases
Orientation:
Minus strand

Genomic View for PKM Gene

Genes around PKM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKM Gene

Proteins for PKM Gene

  • Protein details for PKM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14618-KPYM_HUMAN
    Recommended name:
    Pyruvate kinase PKM
    Protein Accession:
    P14618
    Secondary Accessions:
    • A6NFK3
    • B2R5N8
    • B3KRY0
    • B4DFX8
    • B4DUU6
    • P14786
    • Q53GK4
    • Q96E76
    • Q9BWB5
    • Q9UCV6
    • Q9UPF2

    Protein attributes for PKM Gene

    Size:
    531 amino acids
    Molecular mass:
    57937 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Monomer and homotetramer. Exists as a monomer in the absence of D-fructose 1,6-bisphosphate (FBP), and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. Exists in a nearly inactive dimeric form in tumor cells and the dimeric form has less affinity for the substrate. Binding to certain oncoproteins such as HPV-16 E7 oncoprotein can trigger dimerization. FBP stimulates the formation of tetramers from dimers. Interacts with HERC1, POU5F1 and PML. Interacts (isoform M2) with EGLN3; the interaction hydroxylates PKM under hypoxia and enhances binding to HIF1A. Interacts (isoform M2) with HIF1A; the interaction is enhanced by binding of EGLN3, promoting enhanced transcription activity under hypoxia. Interacts (isoform M2, but not isoform M1) with TRIM35; this interaction prevents FGFR1-dependent tyrosine phosphorylation (PubMed:25263439).
    Miscellaneous:
    • There are 4 isozymes of pyruvate kinase in mammals (L, R, M1, M2) encoded by 2 different genes: PKLR and PKM. The L and R isozymes are generated from the PKLR by differential splicing of RNA; the M1 and M2 forms are produced from the PKM gene by differential splicing. L type is major isozyme in the liver, R is found in red cells, M1 is the main form in muscle, heart and brain, and M2 is found in early fetal tissues as well as in most cancer cells.
    SequenceCaution:
    • Sequence=BAG57589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PKM Gene

    Alternative splice isoforms for PKM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKM Gene

Selected DME Specific Peptides for PKM Gene

P14618:
  • VDMVFASFIR
  • GKARGFFK
  • AAMADTFLEH
  • EIPAEKV
  • LEHMCRL
  • ICATQMLESM
  • QTARQAHLYRG
  • GPASRSV
  • GAVEASFKC
  • IAREAEAA
  • KGVNLPG
  • RYRPRAPIIAVTRN
  • VANAVLDG
  • IKIISKIE
  • DDGLISL
  • SDGIMVARGD
  • VDLPAVS
  • MVARGDLG
  • NFSHGTH
  • LWLDYKNICKVVEVGSK
  • ATESFASDPI
  • EVENGGSLGS
  • ATQMLESMI
  • NAVLDGAD
  • PRPTRAE
  • LDTKGPEIR
  • TEVENGG
  • GSKKGVN
  • RLNFSHG
  • MLSGETA
  • TGWRPGSG

Post-translational modifications for PKM Gene

  • Acetylation at Lys-305 is stimulated by high glucose concentration, it decreases enzyme activity and promotes its lysosomal-dependent degradation via chaperone-mediated autophagy.
  • FGFR1-dependent tyrosine phosphorylation is reduced by interaction with TRIM35.
  • ISGylated.
  • Under hypoxia, hydroxylated by EGLN3.
  • Ubiquitination at Lys 66, Lys 89, Lys 125, Lys 151, Lys 166, Lys 188, Lys 207, Lys 266, Lys 270, Lys 367, Lys 475, and Lys 498
  • Modification sites at PhosphoSitePlus

Domains & Families for PKM Gene

Suggested Antigen Peptide Sequences for PKM Gene

Graphical View of Domain Structure for InterPro Entry

P14618

UniProtKB/Swiss-Prot:

KPYM_HUMAN :
  • Belongs to the pyruvate kinase family.
Family:
  • Belongs to the pyruvate kinase family.
genes like me logo Genes that share domains with PKM: view

No data available for Gene Families for PKM Gene

Function for PKM Gene

Molecular function for PKM Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.7 mM for phosphoenolpyruvate (at 32 degrees Celsius, pH 8.0) {ECO:0000269 PubMed:15996096, ECO:0000269 PubMed:1854723}; KM=0.17 mM for phosphoenolpyruvate (in the presence of 2 mM D- fructose 1,6-bisphosphate (FBP), at 32 degrees Celsius, pH 8.0) {ECO:0000269 PubMed:15996096, ECO:0000269 PubMed:1854723}; KM=0.34 mM for ADP (at 32 degrees Celsius, pH 8.0) {ECO:0000269 PubMed:15996096, ECO:0000269 PubMed:1854723}; KM=0.24 mM for ADP (in the presence of 2 mM FBP, at 32 degrees Celsius, pH 8.0) {ECO:0000269 PubMed:15996096, ECO:0000269 PubMed:1854723}; KM=0.13 mM for phosphoenolpyruvate (in the presence of 2 mM FBP, at 25 degrees Celsius) {ECO:0000269 PubMed:15996096, ECO:0000269 PubMed:1854723}; KM=0.63 mM for ADP (in the presence of 2 mM FBP, at 25 degrees Celsius) {ECO:0000269 PubMed:15996096, ECO:0000269 PubMed:1854723}; pH dependence: Optimum pH for T3 binding is 6.0-6.5. Increase in pH causes T3 binding to drop, does not bind T3 above pH 9.0 or below pH 5.0. {ECO:0000269 PubMed:15996096, ECO:0000269 PubMed:1854723};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + pyruvate = ADP + phosphoenolpyruvate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Isoform M2 is allosterically activated by D-fructose 1,6-bisphosphate (FBP). Inhibited by oxalate and 3,3,5-triiodo-L-thyronine (T3). The activity of the tetrameric form is inhibited by PML. Selective binding to tyrosine-phosphorylated peptides releases the allosteric activator FBP, leading to inhibition of PKM enzymatic activity, this diverts glucose metabolites from energy production to anabolic processes when cells are stimulated by certain growth factors. Glycolytic flux are highly dependent on de novo biosynthesis of serine and glycine, and serine is a natural ligand and allosteric activator of isoform M2.
UniProtKB/Swiss-Prot Function:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Enzyme Numbers (IUBMB) for PKM Gene

Gene Ontology (GO) - Molecular Function for PKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004743 pyruvate kinase activity IEA,TAS 2040271
GO:0005515 protein binding IPI 12620389
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PKM: view
genes like me logo Genes that share phenotypes with PKM: view

Animal Model Products

miRNA for PKM Gene

miRTarBase miRNAs that target PKM

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PKM Gene

Localization for PKM Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKM Gene

Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic activity.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PKM Gene COMPARTMENTS Subcellular localization image for PKM gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytoskeleton 2
lysosome 1

Gene Ontology (GO) - Cellular Components for PKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17308100
GO:0005737 cytoplasm IEA,IDA 18298799
GO:0005739 mitochondrion IEA,IDA 20833797
GO:0005829 cytosol NAS,TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with PKM: view

Pathways & Interactions for PKM Gene

genes like me logo Genes that share pathways with PKM: view

UniProtKB/Swiss-Prot P14618-KPYM_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

SIGNOR curated interactions for PKM Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PKM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0001889 liver development IEA --
GO:0006006 glucose metabolic process IEA --
GO:0006096 glycolytic process IEA --
GO:0006754 ATP biosynthetic process IEA --
genes like me logo Genes that share ontologies with PKM: view

Drugs & Compounds for PKM Gene

(33) Drugs for PKM Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pyruvic acid Approved Nutra Target 0
Carbon dioxide Approved, Vet_approved Pharma 0
Potassium Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
phosphoenolpyruvate Experimental Pharma 0

(11) Additional Compounds for PKM Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate
2793-06-8
dGDP
  • 2'-Deoxy-GDP
  • 2'-Deoxyguanosine-5'-diphosphate
  • 5'-dGDP
  • Deoxyguanosine 5'-diphosphate
  • Deoxyguanosine diphosphate
3493-09-2
IDP
  • 5'-IDP
  • IDP
  • Inosine 5'-(trihydrogen diphosphate)
  • Inosine 5'-(trihydrogen pyrophosphate)
  • Inosine 5'-diphosphate
86-04-4
inosine triphosphate
  • 2'-Inosine-5'-triphosphate
  • 5'-ITP
  • 5-ITP
  • Inosine 5
  • Inosine 5'-(tetrahydrogen triphosphate)
132-06-9

(1) ApexBio Compounds for PKM Gene

Compound Action Cas Number
DASA-58 activator of pyruvate kinase M2 (PKM2) 1203494-49-8
genes like me logo Genes that share compounds with PKM: view

Transcripts for PKM Gene

Unigene Clusters for PKM Gene

Pyruvate kinase, muscle:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKM Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: -
SP8: - - - - - - - - - - - -
SP9: -
SP10:
SP11:
SP12: - - -
SP13:

ExUns: 13a · 13b ^ 14a · 14b · 14c · 14d ^ 15
SP1: - -
SP2: - - -
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PKM Gene

GeneLoc Exon Structure for
PKM
ECgene alternative splicing isoforms for
PKM

Expression for PKM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PKM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PKM Gene

This gene is overexpressed in Bone marrow stromal cell (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PKM Gene



Protein tissue co-expression partners for PKM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PKM Gene:

PKM

SOURCE GeneReport for Unigene cluster for PKM Gene:

Hs.534770

mRNA Expression by UniProt/SwissProt for PKM Gene:

P14618-KPYM_HUMAN
Tissue specificity: Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.
genes like me logo Genes that share expression patterns with PKM: view

Primer Products

No data available for mRNA differential expression in normal tissues for PKM Gene

Orthologs for PKM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PKM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKM 34 35
  • 99.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PKM 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PKM2 35
  • 94 (a)
OneToOne
PKM 34
  • 88.83 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 91 (a)
OneToMany
PKM 34
  • 89.57 (n)
-- 35
  • 83 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pkm 34
  • 90.02 (n)
mouse
(Mus musculus)
Mammalia Pkm 34 16 35
  • 87.19 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves PKM 35
  • 87 (a)
OneToOne
PKM2 34
  • 80.19 (n)
lizard
(Anolis carolinensis)
Reptilia PKM 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pkm 34
  • 77.69 (n)
Str.373 34
zebrafish
(Danio rerio)
Actinopterygii pkma 34 35
  • 75.37 (n)
pkmb 35
  • 66 (a)
OneToMany
pkm2 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7227 34
fruit fly
(Drosophila melanogaster)
Insecta PyK 34 35
  • 65.3 (n)
CG2964 35
  • 40 (a)
ManyToMany
CG7069 35
  • 29 (a)
ManyToMany
CG7362 35
  • 22 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004596 34
  • 61.02 (n)
worm
(Caenorhabditis elegans)
Secernentea pyk-1 34 35
  • 57.53 (n)
pyk-2 35
  • 57 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC19 34 35 37
  • 55.42 (n)
PYK2 35
  • 46 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F23397g 34
  • 54.82 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR368W 34
  • 54.3 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G63680 34
  • 53.35 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1458 34
rice
(Oryza sativa)
Liliopsida Os04g0677500 34
  • 54.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 68 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pyk1 34
  • 58.85 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06075 34
  • 57.53 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4710 34
Species where no ortholog for PKM was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKM Gene

ENSEMBL:
Gene Tree for PKM (if available)
TreeFam:
Gene Tree for PKM (if available)

Paralogs for PKM Gene

Paralogs for PKM Gene

(2) SIMAP similar genes for PKM Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with PKM: view

Variants for PKM Gene

Sequence variations from dbSNP and Humsavar for PKM Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs879255367 Uncertain significance 72,208,664(-) AGAAC(A/G)TCAAG nc-transcript-variant, reference, missense
rs10152494 -- 72,209,441(+) tatat(A/G)tatat intron-variant
rs1037680 -- 72,221,978(+) GTTAG(C/T)TACAT intron-variant
rs10514 -- 72,209,800(-) GATAA(C/T)GCCTA nc-transcript-variant, reference, synonymous-codon
rs1062430 -- 72,199,186(-) GCTCT(C/T)TAGGC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PKM Gene

Variant ID Type Subtype PubMed ID
nsv479183 CNV novel sequence insertion 20440878
nsv833051 CNV gain 17160897

Variation tolerance for PKM Gene

Residual Variation Intolerance Score: 18.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKM Gene

Human Gene Mutation Database (HGMD)
PKM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKM Gene

Disorders for PKM Gene

MalaCards: The human disease database

(7) MalaCards diseases for PKM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pyruvate kinase deficiency
  • pyruvate kinase deficiency of red cells
acute diarrhea
gastric diffuse adenocarcinoma
  • adenocarcinoma of linitis plastica type
pigmentation disease
  • pigmentation disorders
linitis plastica
  • leather-bottle stomach
- elite association - COSMIC cancer census association via MalaCards
Search PKM in MalaCards View complete list of genes associated with diseases

Relevant External Links for PKM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKM
genes like me logo Genes that share disorders with PKM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PKM Gene

Publications for PKM Gene

  1. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. (PMID: 18191611) Lee J. … Kim J. (Int. J. Biochem. Cell Biol. 2008) 3 4 22 64
  2. Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein. (PMID: 18298799) Shimada N. … Ishii S. (Genes Cells 2008) 3 4 22 64
  3. Pyruvate kinase M2 is a phosphotyrosine-binding protein. (PMID: 18337815) Christofk H.R. … Cantley L.C. (Nature 2008) 3 4 22 64
  4. Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. (PMID: 17308100) Stetak A. … Ullrich A. (Cancer Res. 2007) 3 4 25 64
  5. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. (PMID: 15996096) Dombrauckas J.D. … Mesecar A.D. (Biochemistry 2005) 3 4 22 64

Products for PKM Gene

Sources for PKM Gene

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