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Aliases for PKIB Gene

Aliases for PKIB Gene

  • CAMP-Dependent Protein Kinase Inhibitor Beta 2 3
  • Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Beta 2 3 5
  • PKI-Beta 3 4
  • PRKACN2 3 4
  • CAMP-Dependent Protein Kinase Inhibitor 2 3

External Ids for PKIB Gene

Previous HGNC Symbols for PKIB Gene

  • PRKACN2

Previous GeneCards Identifiers for PKIB Gene

  • GC06P122701
  • GC06P122773
  • GC06P122834
  • GC06P120370

Summaries for PKIB Gene

Entrez Gene Summary for PKIB Gene

  • This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PKIB Gene

PKIB (CAMP-Dependent Protein Kinase Inhibitor Beta) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Signal transduction_PKA signaling. GO annotations related to this gene include cAMP-dependent protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for PKIB Gene

  • Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Wiki entry for PKIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKIB Gene

Genomics for PKIB Gene

Regulatory Elements for PKIB Gene

Enhancers for PKIB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F122710 0.8 Ensembl ENCODE 8.7 +238.6 238584 1.0 BRD4 ATF1 BMI1 EED ETV6 CREM CHD2 SMARCE1 MTA2 HLF SMPDL3A PKIB TRDN RN7SL564P ENSG00000272472
GH06F122694 1.3 Ensembl ENCODE 8.3 +224.8 224815 3.8 PKNOX1 JUN RAD21 HIC1 GATA3 CTBP1 POLR2A ZBTB48 RCOR1 FOSL2 SMPDL3A PKIB RN7SL564P ENSG00000272472
GH06F122711 0.9 Ensembl ENCODE 7.7 +241.0 240993 2.2 PKNOX1 ARNT TBL1XR1 CHAMP1 GATA2 CEBPB JUNB ZEB2 SMARCB1 KLF16 SMPDL3A PKIB RN7SL564P ENSG00000272472
GH06F122717 0.9 Ensembl ENCODE 6.6 +245.8 245753 0.7 SMPDL3A PKIB RN7SL564P ENSG00000272472
GH06F122670 1.2 Ensembl ENCODE 6.2 +201.3 201266 4.7 BMI1 ZNF2 ZNF335 GLIS2 ZNF366 SCRT2 ZNF263 ZBTB11 REST TBX21 PKIB SMPDL3A ENSG00000272472 RN7SL564P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PKIB on UCSC Golden Path with GeneCards custom track

Promoters for PKIB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001225979 -617 3000 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS

Genomic Location for PKIB Gene

Chromosome:
6
Start:
122,471,917 bp from pter
End:
122,726,373 bp from pter
Size:
254,457 bases
Orientation:
Plus strand

Genomic View for PKIB Gene

Genes around PKIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKIB Gene

Proteins for PKIB Gene

  • Protein details for PKIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C010-IPKB_HUMAN
    Recommended name:
    cAMP-dependent protein kinase inhibitor beta
    Protein Accession:
    Q9C010
    Secondary Accessions:
    • B2RCK2
    • Q567T9
    • Q5T0Z7

    Protein attributes for PKIB Gene

    Size:
    78 amino acids
    Molecular mass:
    8468 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PKIB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PKIB Gene

Post-translational modifications for PKIB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PKIB Gene

Domains & Families for PKIB Gene

Protein Domains for PKIB Gene

Graphical View of Domain Structure for InterPro Entry

Q9C010

UniProtKB/Swiss-Prot:

IPKB_HUMAN :
  • Belongs to the PKI family.
Family:
  • Belongs to the PKI family.
genes like me logo Genes that share domains with PKIB: view

No data available for Gene Families for PKIB Gene

Function for PKIB Gene

Molecular function for PKIB Gene

UniProtKB/Swiss-Prot Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Ontology (GO) - Molecular Function for PKIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004862 cAMP-dependent protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with PKIB: view
genes like me logo Genes that share phenotypes with PKIB: view

Animal Models for PKIB Gene

MGI Knock Outs for PKIB:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKIB Gene

Localization for PKIB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PKIB Gene COMPARTMENTS Subcellular localization image for PKIB gene
Compartment Confidence
nucleus 4
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PKIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PKIB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PKIB Gene

Pathways & Interactions for PKIB Gene

genes like me logo Genes that share pathways with PKIB: view

Pathways by source for PKIB Gene

1 GeneGo (Thomson Reuters) pathway for PKIB Gene
1 Qiagen pathway for PKIB Gene

Gene Ontology (GO) - Biological Process for PKIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0032212 positive regulation of telomere maintenance via telomerase IMP 21531765
GO:0051973 positive regulation of telomerase activity IMP 21531765
GO:0071901 negative regulation of protein serine/threonine kinase activity IEA --
GO:1904355 positive regulation of telomere capping IMP 21531765
genes like me logo Genes that share ontologies with PKIB: view

No data available for SIGNOR curated interactions for PKIB Gene

Drugs & Compounds for PKIB Gene

(1) Drugs for PKIB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0
genes like me logo Genes that share compounds with PKIB: view

Transcripts for PKIB Gene

Unigene Clusters for PKIB Gene

Protein kinase (cAMP-dependent, catalytic) inhibitor beta:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKIB Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for PKIB Gene

GeneLoc Exon Structure for
PKIB
ECgene alternative splicing isoforms for
PKIB

Expression for PKIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PKIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKIB Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x17.9), Brain - Cerebellum (x12.6), and Colon - Transverse (x5.5).

Protein differential expression in normal tissues from HIPED for PKIB Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PKIB Gene



Protein tissue co-expression partners for PKIB Gene

NURSA nuclear receptor signaling pathways regulating expression of PKIB Gene:

PKIB

SOURCE GeneReport for Unigene cluster for PKIB Gene:

Hs.744965
genes like me logo Genes that share expression patterns with PKIB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PKIB Gene

Orthologs for PKIB Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKIB 34 35
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia PKIB 34 35
  • 82.48 (n)
dog
(Canis familiaris)
Mammalia PKIB 34 35
  • 80.95 (n)
mouse
(Mus musculus)
Mammalia Pkib 34 16 35
  • 76.59 (n)
rat
(Rattus norvegicus)
Mammalia Pkib 34
  • 74.21 (n)
chicken
(Gallus gallus)
Aves PKIB 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pkib 35
  • 42 (a)
OneToOne
Species where no ortholog for PKIB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PKIB Gene

ENSEMBL:
Gene Tree for PKIB (if available)
TreeFam:
Gene Tree for PKIB (if available)

Paralogs for PKIB Gene

(1) SIMAP similar genes for PKIB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PKIB: view

No data available for Paralogs for PKIB Gene

Variants for PKIB Gene

Sequence variations from dbSNP and Humsavar for PKIB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10452643 -- 122,677,296(+) GAAGC(A/C)AGGCC intron-variant
rs10456947 -- 122,471,944(+) ACGAC(A/G)CGGCT upstream-variant-2KB, utr-variant-5-prime
rs10457435 -- 122,589,022(+) TTTTA(A/G)TGCTG intron-variant
rs10457436 -- 122,613,918(+) agatg(A/G)cacca intron-variant
rs10457437 -- 122,658,334(+) TGAAT(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PKIB Gene

Variant ID Type Subtype PubMed ID
esv2557344 CNV insertion 19546169
esv2759467 CNV loss 17122850
esv3305666 CNV mobile element insertion 20981092
esv3309506 CNV mobile element insertion 20981092
esv3437628 CNV insertion 20981092
esv3440768 CNV insertion 20981092
esv3571381 CNV loss 25503493
esv3610612 CNV loss 21293372
esv3610615 CNV loss 21293372
esv8540 CNV gain 19470904
nsv1018215 CNV loss 25217958
nsv1027182 CNV gain 25217958
nsv1161448 CNV duplication 26073780
nsv830791 CNV gain 17160897
nsv965761 CNV duplication 23825009

Variation tolerance for PKIB Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKIB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKIB Gene

Disorders for PKIB Gene

Relevant External Links for PKIB

Genetic Association Database (GAD)
PKIB
Human Genome Epidemiology (HuGE) Navigator
PKIB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKIB

No disorders were found for PKIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKIB Gene

Publications for PKIB Gene

  1. Cloning and mapping of human PKIB and PKIG, and comparison of tissue expression patterns of three members of the protein kinase inhibitor family, including PKIA. (PMID: 10880337) Zheng L. … Zhao S. (Biochem. J. 2000) 2 3 4 22 64
  2. Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking between PKA and Akt pathways. (PMID: 19483721) Chung S. … Nakagawa H. (Oncogene 2009) 3 22 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. (PMID: 25464930) Shen C. … Zhong N. (J. Mol. Neurosci. 2015) 3 64

Products for PKIB Gene

Sources for PKIB Gene

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