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PKIA Gene

protein-coding   GIFtS: 60
GCID: GC08P079478

Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Alpha


(Previous symbol: PRKACN1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Alpha1 2
PRKACN11 2 3
PKI-alpha2 3
CAMP-Dependent Protein Kinase Inhibitor, Muscle/Brain Isoform2 3
CAMP-Dependent Protein Kinase Inhibitor Alpha2

External Ids:    HGNC: 90171   Entrez Gene: 55692   Ensembl: ENSG000001710337   OMIM: 6060595   UniProtKB: P619253   
ORGUL members:         

Export aliases for PKIA gene to outside databases

Previous GC identifers: GC08P078472 GC08P079465 GC08P079152 GC08P079590 GC08P074917


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PKIA Gene:
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This
protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic
subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported.
(provided by RefSeq, Jul 2008)

GeneCards Summary for PKIA Gene:
PKIA (protein kinase (cAMP-dependent, catalytic) inhibitor alpha) is a protein-coding gene. GO annotations related to this gene include cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding.

UniProtKB/Swiss-Prot: IPKA_HUMAN, P61925
Function: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts
with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains

Gene Wiki entry for PKIA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the PKIA gene promoter:
         Sox5   GATA-3   FOXD3   RelA   NF-kappaB1   NF-kappaB   GATA-1   GATA-2   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPKIA promoter sequence
   Search Chromatin IP Primers for PKIA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PKIA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.12   Ensembl cytogenetic band:  8q21.12   HGNC cytogenetic band: 8q21.11

PKIA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKIA gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P079478:  view genomic region     (about GC identifiers)

Start:
79,428,336 bp from pter      End:
79,517,502 bp from pter
Size:
89,167 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IPKA_HUMAN, P61925 (See protein sequence)
Recommended Name: cAMP-dependent protein kinase inhibitor alpha  
Size: 76 amino acids; 7989 Da
Miscellaneous: The inhibitory site contains regions very similar to the hinge regions (sites that directly
interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these
chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential
for inhibition and recognition of the enzyme active site
Selected PDB 3D structures from and Proteopedia for PKIA (see all 63):
1CMK (3D)        1JLU (3D)        1Q8T (3D)        1VEB (3D)        1XH4 (3D)        1XH5 (3D)    
Secondary accessions: P04541 Q6IAV2

Explore the universe of human proteins at neXtProt for PKIA: NX_P61925

Explore proteomics data for PKIA at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PKIA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006814.1  NP_862822.1  

    ENSEMBL proteins: 
     ENSP00000379696   ENSP00000336552   ENSP00000430887  

    PKIA Human Recombinant Protein Products:

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    Novus Biologicals PKIA Proteins
    Novus Biologicals PKIA Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for PKIA 

     
    antibodies-online proteins for PKIA (10 products) 

     
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    antibodies-online antibodies for PKIA (2 products) 

    PKIA Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    antibodies-online kits for PKIA (14 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004171 cAMP_dep_PKI

    Graphical View of Domain Structure for InterPro Entry P61925

    ProtoNet protein and cluster: P61925

    UniProtKB/Swiss-Prot: IPKA_HUMAN, P61925
    Similarity: Belongs to the PKI family


    Find genes that share domains with PKIA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IPKA_HUMAN, P61925
    Function: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts
    with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains

         Genatlas biochemistry entry for PKIA:
    protein kinase (CAMP-dependent,catalytic) inhibitor alpha,widely expressed,downregulated by CYP27B1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004862cAMP-dependent protein kinase inhibitor activity TAS1710219
    GO:0005515protein binding IPI--
    GO:0034236protein kinase A catalytic subunit binding IPI--
         
    Find genes that share ontologies with PKIA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PKIA:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pkia):
     normal 

    Find genes that share phenotypes with PKIA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pkiatm1Idz for PKIA

       genOway: Develop your customized and physiologically relevant rodent model for PKIA

    miRNA
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    miRTarBase miRNAs that target PKIA:
    hsa-mir-155-5p (MIRT006214), hsa-mir-26b-5p (MIRT030340)

    Block miRNA regulation of human, mouse, rat PKIA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PKIA (see all 111):
    hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-1914* hsa-miR-106a hsa-miR-485-3p hsa-miR-128 hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidPKIA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PKIA

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    chloroplast1
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PKIA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PKIA About    
    See pathways by source

    SuperPathContained pathways About
    1Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    Calcium Regulation in the Cardiac Cell0.43
    2Activation of cAMP-Dependent PKA
    cAMP Pathway0.77
    3RNA Polymerase I Promoter Opening
    Alcoholism0.34
    4Signal transduction PKA signaling
    Signal transduction PKA signaling
    5Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    Find genes that share SuperPaths with PKIA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for PKIA
        cAMP Pathway

    1 GeneGo (Thomson Reuters) Pathway for PKIA
        Signal transduction PKA signaling

    3 BioSystems Pathways for PKIA
        Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    Integrated Breast Cancer Pathway


    1 Kegg Pathway  (Kegg details for PKIA):
        Alcoholism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PKIA
    Interactions:

        Search GeneGlobe Interaction Network for PKIA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for PKIA (P619251, 2, 3 ENSP000003365524) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRM1P308221, 2EBI-2682139,EBI-20589 MINT-7950099 MINT-7978909 MINT-7978934 MINT-7950122 MINT-7950225 MINT-7950070 MINT-7950160 MINT-7950799 MINT-7950045 MINT-7950778 MINT-7950269 MINT-7950141 MINT-7950746 MINT-7950762 MINT-7950200 MINT-7950796 MINT-7978948
    XPO1O149801, 2, 3EBI-2682139,EBI-355867 MINT-7950829 MINT-7950372 I2D: score=1 
    PASKQ96RG22, 3, ENSP000002340404MINT-8148557 I2D: score=1 STRING: ENSP00000234040
    PRKACAP176123, ENSP000003095914I2D: score=3 STRING: ENSP00000309591
    PRKXP518173, ENSP000002628484I2D: score=1 STRING: ENSP00000262848
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006469negative regulation of protein kinase activity ----
    GO:0010389regulation of G2/M transition of mitotic cell cycle IEA--
    GO:0042308negative regulation of protein import into nucleus IEA--
    GO:0043086negative regulation of catalytic activity ----

    Find genes that share ontologies with PKIA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PKIA (IPKA)

    1 HMDB Compound for PKIA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cyclic AMPCyclic AMP (see all 19)60-92-4--

    Selected DrugBank Compounds for PKIA (see all 30)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE-- --target--10592235
    (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE-- --target--10592235
    (1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE-- --target--10592235
    (2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE-- --target--10592235
    (2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE-- --target--10592235
    (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE-- --target--10592235
    (2S)-1-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}-3-PHENYLPROPAN-2-AMINE-- --target--10592235
    (2S)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE-- --target--10592235
    (4R,2S)-5'-(4-(4-CHLOROBENZYLOXY)PYRROLIDIN-2-YLMETHANESULFONYL)ISOQUINOLINE-- --target--10592235
    (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PKIA gene (2 alternative transcripts): 
    NM_006823.3  NM_181839.2  

    Unigene Cluster for PKIA:

    Protein kinase (cAMP-dependent, catalytic) inhibitor alpha
    Hs.433700  [show with all ESTs]
    Unigene Representative Sequence: NM_006823
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396418(uc003yba.3 uc003ybb.3 uc010lzo.3) ENST00000352966
    ENST00000518467
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PKIA (see all 111):
    hsa-miR-607 hsa-miR-520f hsa-miR-300 hsa-miR-1914* hsa-miR-106a hsa-miR-485-3p hsa-miR-128 hsa-miR-605
    SwitchGear 3'UTR luciferase reporter plasmidPKIA 3' UTR sequence
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    Additional mRNA sequence: 

    AK311857.1 BC022265.2 CR457052.1 S76965.1 

    9 DOTS entries:

    DT.95269502  DT.100655856  DT.445094  DT.100791911  DT.121493766  DT.97792036  DT.91981713  DT.91721599 
    DT.121493800 

    Selected AceView cDNA sequences (see all 215):

    BQ220816 CR614267 CR623358 AA628962 CB113641 BM716730 D82017 AL138112 
    BU622227 AA772332 AL539016 BQ719709 BM728769 BX109356 AA772144 AA327715 
    F16970 C20599 BX478161 AI685697 AA703776 CR607441 BI962797 BC022265 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PKIA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTTTTTCA
    PKIA Expression
    About this image


    PKIA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
    PKIA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PKIA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433700
        Custom PCR Arrays for PKIA
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKIA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PKIA gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkia1 , 5 protein kinase inhibitor, alpha1, 5 93.42(n)1
    97.37(a)1
      3 (1.96 cM)5
    187671  NM_008862.31  NP_032888.11 
     73666045 
    chicken
    (Gallus gallus)
    Aves PKIA1 protein kinase (cAMP-dependent, catalytic) inhibitor more 79.82(n)
    81.58(a)
      396333  NM_205374.1  NP_990705.1 
    lizard
    (Anolis carolinensis)
    Reptilia PKIA6
    protein kinase (cAMP-dependent, catalytic) inhibit...
    83(a)
    1 ↔ 1
    4(25466155-25468446)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pkia1 protein kinase (cAMP-dependent, catalytic) inhibitor more 72.81(n)
    64.47(a)
      594968  NM_001030409.1  NP_001025580.1 


    ENSEMBL Gene Tree for PKIA (if available)
    TreeFam Gene Tree for PKIA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PKIA gene
    2 SIMAP similar genes for PKIA using alignment to 1 protein entry:     IPKA_HUMAN:
    PKIB    PKIG

    Find genes that share paralogs with PKIA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PKIA (see all 1434)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1150995821,2
    C,F--79426493(+) TTCTGG/TTGGTA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1889287971,2
    --79426635(+) CCCCAA/GTCATG 2 -- us2k10--------
    rs1490420751,2
    --79426775(+) GAATGA/GGATAT 2 -- us2k10--------
    rs1445999851,2
    C--79427205(+) CTTTCA/GAAGAG 2 -- us2k10--------
    rs1181773261,2
    F--79427291(+) ACTGAT/CAGATG 2 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1387843781,2
    --79427298(+) GATGGA/GTGGAA 2 -- us2k10--------
    rs1418561931,2
    C--79427348(+) ATTGCA/GCTGTT 2 -- us2k10--------
    rs1455230101,2
    --79427380(+) AGTGTA/GAAGCT 2 -- us2k10--------
    rs1380478661,2
    --79427434(+) AAAAGA/TGGGAA 2 -- us2k10--------
    rs751364891,2
    C,F--79427479(+) CCCGAC/ATGGAA 2 -- us2k12Minor allele frequency- A:0.06CSA NA 122

    HapMap Linkage Disequilibrium report for PKIA (79428336 - 79517502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PKIA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1418655CNV Insertion17803354
    nsv891059CNV Loss21882294
    nsv891058CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PKIA
    DNA2.0 Custom Variant and Variant Library Synthesis for PKIA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606059    OMIM disorders: --


    Find genes that share disorders with PKIA           About GenesLikeMe

    Genetic Association Database (GAD): PKIA
    Human Genome Epidemiology (HuGE) Navigator: PKIA (1 document)

    Export disorders for PKIA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PKIA gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with PKIA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor. (PubMed id 1770951)1, 2, 3 Olsen S.R. and Uhler M.D. (Mol. Endocrinol. 1991)
    2. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. (PubMed id 20451256)1, 4 Djurovic S....Andreassen O.A. (J Affect Disord 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. (PubMed id 7836431)1, 9 Wen W....Meinkoth J.L. (J. Biol. Chem. 1995)
    5. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (Nat. Genet. 2012)
    6. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PubMed id 22219177)1 Tao S....Sun J. (Carcinogenesis 2012)
    7. Sequence and structural analyses of nuclear export signals in the NESdb database. (PubMed id 22833565)1 Xu D....Chook Y.M. (Mol. Biol. Cell 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PubMed id 21833088)1  ....Compston A. (Nature 2011)
    10. An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1. (PubMed id 20485264)1 Koyama M. and Matsuura Y. (EMBO J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 5569 HGNC: 9017 AceView: PKIA Ensembl:ENSG00000171033 euGenes: HUgn5569
    ECgene: PKIA Kegg: 5569 H-InvDB: PKIA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PKIA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PKIA gene:
    Search GeneIP for patents involving PKIA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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