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Aliases for PKIA Gene

Aliases for PKIA Gene

  • CAMP-Dependent Protein Kinase Inhibitor Alpha 2 3
  • Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Alpha 2 3 5
  • CAMP-Dependent Protein Kinase Inhibitor, Muscle/Brain Isoform 3 4
  • PKI-Alpha 3 4
  • PRKACN1 3 4

External Ids for PKIA Gene

Previous HGNC Symbols for PKIA Gene

  • PRKACN1

Previous GeneCards Identifiers for PKIA Gene

  • GC08P079465
  • GC08P079152
  • GC08P079478
  • GC08P079590
  • GC08P074917

Summaries for PKIA Gene

Entrez Gene Summary for PKIA Gene

  • The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PKIA Gene

PKIA (CAMP-Dependent Protein Kinase Inhibitor Alpha) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include protein kinase A catalytic subunit binding and cAMP-dependent protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for PKIA Gene

  • Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Wiki entry for PKIA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKIA Gene

Genomics for PKIA Gene

Regulatory Elements for PKIA Gene

Enhancers for PKIA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F078524 0.7 Ensembl ENCODE 57.7 +9.6 9608 1.7 JUN JUNB CEBPB JUND GATA3 POLR2A SMARCA4 MAFK PKIA PKIA-AS1
GH08F078560 0.2 ENCODE 56.1 +44.8 44834 1.3 JUND FOXP2 MAFK PKIA PKIA-AS1 ENSG00000260398
GH08F078555 1 Ensembl ENCODE 41.5 +40.3 40256 1.7 JUND JUN CUX1 FOS FOSL2 MAFK PKIA PKIA-AS1
GH08F078535 0.4 ENCODE 36 +19.3 19345 0.7 SPI1 PKIA PKIA-AS1
GH08F078520 0.6 Ensembl 29.1 +4.9 4921 0.4 PKIA PKIA-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PKIA on UCSC Golden Path with GeneCards custom track

Promoters for PKIA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001394767 799 3000 HDGF PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 ZNF143 ZNF207 KLF7 ZNF263

Genomic Location for PKIA Gene

Chromosome:
8
Start:
78,516,101 bp from pter
End:
78,605,267 bp from pter
Size:
89,167 bases
Orientation:
Plus strand

Genomic View for PKIA Gene

Genes around PKIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKIA Gene

Proteins for PKIA Gene

  • Protein details for PKIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61925-IPKA_HUMAN
    Recommended name:
    cAMP-dependent protein kinase inhibitor alpha
    Protein Accession:
    P61925
    Secondary Accessions:
    • P04541
    • Q6IAV2

    Protein attributes for PKIA Gene

    Size:
    76 amino acids
    Molecular mass:
    7989 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.

    Three dimensional structures from OCA and Proteopedia for PKIA Gene

neXtProt entry for PKIA Gene

Post-translational modifications for PKIA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PKIA Gene

No data available for DME Specific Peptides for PKIA Gene

Domains & Families for PKIA Gene

Protein Domains for PKIA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PKIA Gene

Graphical View of Domain Structure for InterPro Entry

P61925

UniProtKB/Swiss-Prot:

IPKA_HUMAN :
  • Belongs to the PKI family.
Family:
  • Belongs to the PKI family.
genes like me logo Genes that share domains with PKIA: view

No data available for Gene Families for PKIA Gene

Function for PKIA Gene

Molecular function for PKIA Gene

GENATLAS Biochemistry:
protein kinase (CAMP-dependent,catalytic) inhibitor alpha,widely expressed,downregulated by CYP27B1
UniProtKB/Swiss-Prot Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Ontology (GO) - Molecular Function for PKIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IEA --
GO:0004862 cAMP-dependent protein kinase inhibitor activity IDA,TAS 1710219
GO:0005515 protein binding IPI 20485264
GO:0016301 kinase activity IEA --
GO:0034236 protein kinase A catalytic subunit binding IPI 21812984
genes like me logo Genes that share ontologies with PKIA: view
genes like me logo Genes that share phenotypes with PKIA: view

Animal Models for PKIA Gene

MGI Knock Outs for PKIA:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKIA Gene

Localization for PKIA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PKIA Gene COMPARTMENTS Subcellular localization image for PKIA gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PKIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PKIA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PKIA Gene

Pathways & Interactions for PKIA Gene

genes like me logo Genes that share pathways with PKIA: view

Pathways by source for PKIA Gene

1 GeneGo (Thomson Reuters) pathway for PKIA Gene
1 Qiagen pathway for PKIA Gene

SIGNOR curated interactions for PKIA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PKIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle IEA --
GO:0016310 phosphorylation IEA --
GO:0042308 negative regulation of protein import into nucleus IEA --
genes like me logo Genes that share ontologies with PKIA: view

Drugs & Compounds for PKIA Gene

(31) Drugs for PKIA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE Experimental Pharma Target 0
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE Experimental Pharma Target 0
(1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE Experimental Pharma Target 0
(2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE Experimental Pharma Target 0
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PKIA: view

Transcripts for PKIA Gene

Unigene Clusters for PKIA Gene

Protein kinase (cAMP-dependent, catalytic) inhibitor alpha:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKIA Gene

No ASD Table

Relevant External Links for PKIA Gene

GeneLoc Exon Structure for
PKIA
ECgene alternative splicing isoforms for
PKIA

Expression for PKIA Gene

mRNA expression in normal human tissues for PKIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKIA Gene

This gene is overexpressed in Muscle - Skeletal (x10.2), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for PKIA Gene

This gene is overexpressed in Heart (48.3) and Fetal Brain (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PKIA Gene



Protein tissue co-expression partners for PKIA Gene

NURSA nuclear receptor signaling pathways regulating expression of PKIA Gene:

PKIA

SOURCE GeneReport for Unigene cluster for PKIA Gene:

Hs.433700
genes like me logo Genes that share expression patterns with PKIA: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PKIA Gene

Orthologs for PKIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKIA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PKIA 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia PKIA 34 35
  • 99.12 (n)
cow
(Bos Taurus)
Mammalia PKIA 34 35
  • 97.37 (n)
rat
(Rattus norvegicus)
Mammalia Pkia 34
  • 94.3 (n)
mouse
(Mus musculus)
Mammalia Pkia 34 16 35
  • 93.42 (n)
oppossum
(Monodelphis domestica)
Mammalia PKIA 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PKIA 35
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves PKIA 34 35
  • 79.82 (n)
lizard
(Anolis carolinensis)
Reptilia PKIA 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pkia 34
  • 72.81 (n)
Species where no ortholog for PKIA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PKIA Gene

ENSEMBL:
Gene Tree for PKIA (if available)
TreeFam:
Gene Tree for PKIA (if available)

Paralogs for PKIA Gene

(2) SIMAP similar genes for PKIA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PKIA: view

No data available for Paralogs for PKIA Gene

Variants for PKIA Gene

Sequence variations from dbSNP and Humsavar for PKIA Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10094507 -- 78,595,898(+) aatgt(A/G)attgc intron-variant
rs10097605 -- 78,594,443(+) TTCTA(C/T)AGGCT intron-variant
rs10111756 -- 78,557,842(+) TGCTT(G/T)TCCTT intron-variant, upstream-variant-2KB
rs10453115 -- 78,522,541(+) ATACT(A/G)TAAGG intron-variant
rs10453116 -- 78,523,130(+) AAAGA(C/T)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PKIA Gene

Variant ID Type Subtype PubMed ID
esv1418655 CNV insertion 17803354
esv3617735 CNV loss 21293372
nsv1129809 CNV tandem duplication 24896259

Variation tolerance for PKIA Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKIA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PKIA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKIA Gene

Disorders for PKIA Gene

Relevant External Links for PKIA

Genetic Association Database (GAD)
PKIA
Human Genome Epidemiology (HuGE) Navigator
PKIA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKIA

No disorders were found for PKIA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKIA Gene

Publications for PKIA Gene

  1. Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor. (PMID: 1770951) Olsen S.R. … Uhler M.D. (Mol. Endocrinol. 1991) 2 3 4 64
  2. A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample. (PMID: 20451256) Djurovic S. … Andreassen O.A. (J Affect Disord 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. (PMID: 7836431) Wen W. … Meinkoth J.L. (J. Biol. Chem. 1995) 3 22 64
  5. Structural insights into how Yrb2p accelerates the assembly of the Xpo1p nuclear export complex. (PMID: 25437554) Koyama M. … Matsuura Y. (Cell Rep 2014) 3 64

Products for PKIA Gene

Sources for PKIA Gene

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