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Aliases for PKIA Gene

Aliases for PKIA Gene

  • Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Alpha 2 3 5
  • CAMP-Dependent Protein Kinase Inhibitor, Muscle/Brain Isoform 3 4
  • PKI-Alpha 3 4
  • PRKACN1 3 4

External Ids for PKIA Gene

Previous HGNC Symbols for PKIA Gene

  • PRKACN1

Previous GeneCards Identifiers for PKIA Gene

  • GC08P079465
  • GC08P079152
  • GC08P079478
  • GC08P079590
  • GC08P074917

Summaries for PKIA Gene

Entrez Gene Summary for PKIA Gene

  • The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for PKIA Gene

PKIA (Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Alpha) is a Protein Coding gene. Among its related pathways are Myometrial Relaxation and Contraction Pathways and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include protein kinase A catalytic subunit binding and cAMP-dependent protein kinase inhibitor activity.

UniProtKB/Swiss-Prot for PKIA Gene

  • Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Gene Wiki entry for PKIA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKIA Gene

Genomics for PKIA Gene

Regulatory Elements for PKIA Gene

Enhancers for PKIA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PKIA on UCSC Golden Path with GeneCards custom track

Promoters for PKIA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PKIA on UCSC Golden Path with GeneCards custom track

Genomic Location for PKIA Gene

Chromosome:
8
Start:
78,516,101 bp from pter
End:
78,605,267 bp from pter
Size:
89,167 bases
Orientation:
Plus strand

Genomic View for PKIA Gene

Genes around PKIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKIA Gene

Proteins for PKIA Gene

  • Protein details for PKIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61925-IPKA_HUMAN
    Recommended name:
    cAMP-dependent protein kinase inhibitor alpha
    Protein Accession:
    P61925
    Secondary Accessions:
    • P04541
    • Q6IAV2

    Protein attributes for PKIA Gene

    Size:
    76 amino acids
    Molecular mass:
    7989 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.

    Three dimensional structures from OCA and Proteopedia for PKIA Gene

neXtProt entry for PKIA Gene

Proteomics data for PKIA Gene at MOPED

Post-translational modifications for PKIA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PKIA Gene

Antibody Products

No data available for DME Specific Peptides for PKIA Gene

Domains & Families for PKIA Gene

Protein Domains for PKIA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PKIA Gene

Graphical View of Domain Structure for InterPro Entry

P61925

UniProtKB/Swiss-Prot:

IPKA_HUMAN :
  • Belongs to the PKI family.
Family:
  • Belongs to the PKI family.
genes like me logo Genes that share domains with PKIA: view

No data available for Gene Families for PKIA Gene

Function for PKIA Gene

Molecular function for PKIA Gene

GENATLAS Biochemistry:
protein kinase (CAMP-dependent,catalytic) inhibitor alpha,widely expressed,downregulated by CYP27B1
UniProtKB/Swiss-Prot Function:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
genes like me logo Genes that share phenotypes with PKIA: view

Animal Models for PKIA Gene

MGI Knock Outs for PKIA:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKIA Gene

Localization for PKIA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PKIA Gene COMPARTMENTS Subcellular localization image for PKIA gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PKIA Gene

Pathways & Interactions for PKIA Gene

genes like me logo Genes that share pathways with PKIA: view

Pathways by source for PKIA Gene

1 GeneGo (Thomson Reuters) pathway for PKIA Gene
1 Qiagen pathway for PKIA Gene

SIGNOR curated interactions for PKIA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PKIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IEA --
GO:2000480 negative regulation of cAMP-dependent protein kinase activity IDA 7905001
genes like me logo Genes that share ontologies with PKIA: view

Drugs & Compounds for PKIA Gene

(31) Drugs for PKIA Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE Experimental Pharma Target 0
(1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE Experimental Pharma Target 0
(1S)-2-(1H-INDOL-3-YL)-1-{[(5-ISOQUINOLIN-6-YLPYRIDIN-3-YL)OXY]METHYL}ETHYLAMINE Experimental Pharma Target 0
(2R)-2-(4-CHLOROPHENYL)-2-[4-(1H-PYRAZOL-4-YL)PHENYL]ETHANAMINE Experimental Pharma Target 0
(2R)-2-(4-CHLOROPHENYL)-2-PHENYLETHANAMINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PKIA: view

Transcripts for PKIA Gene

mRNA/cDNA for PKIA Gene

Unigene Clusters for PKIA Gene

Protein kinase (cAMP-dependent, catalytic) inhibitor alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PKIA Gene

No ASD Table

Relevant External Links for PKIA Gene

GeneLoc Exon Structure for
PKIA
ECgene alternative splicing isoforms for
PKIA

Expression for PKIA Gene

mRNA expression in normal human tissues for PKIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKIA Gene

This gene is overexpressed in Muscle - Skeletal (x10.2), Brain - Nucleus accumbens (basal ganglia) (x4.2), and Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for PKIA Gene

This gene is overexpressed in Heart (48.3) and Fetal Brain (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PKIA Gene



SOURCE GeneReport for Unigene cluster for PKIA Gene Hs.433700

genes like me logo Genes that share expression patterns with PKIA: view

Protein tissue co-expression partners for PKIA Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PKIA Gene

Orthologs for PKIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for PKIA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PKIA 35
  • 97.37 (n)
  • 98.68 (a)
PKIA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PKIA 35
  • 99.12 (n)
  • 100 (a)
PKIA 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pkia 35
  • 93.42 (n)
  • 97.37 (a)
Pkia 16
Pkia 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PKIA 35
  • 100 (n)
  • 100 (a)
PKIA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pkia 35
  • 94.3 (n)
  • 97.37 (a)
oppossum
(Monodelphis domestica)
Mammalia PKIA 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PKIA 36
  • 25 (a)
OneToOne
chicken
(Gallus gallus)
Aves PKIA 35
  • 79.82 (n)
  • 81.58 (a)
PKIA 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PKIA 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pkia 35
  • 72.81 (n)
  • 64.47 (a)
Species with no ortholog for PKIA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PKIA Gene

ENSEMBL:
Gene Tree for PKIA (if available)
TreeFam:
Gene Tree for PKIA (if available)

Paralogs for PKIA Gene

(2) SIMAP similar genes for PKIA Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PKIA: view

No data available for Paralogs for PKIA Gene

Variants for PKIA Gene

Structural Variations from Database of Genomic Variants (DGV) for PKIA Gene

Variant ID Type Subtype PubMed ID
nsv891058 CNV Loss 21882294
esv1418655 CNV Insertion 17803354
nsv891059 CNV Loss 21882294

Variation tolerance for PKIA Gene

Residual Variation Intolerance Score: 52.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for PKIA Gene

Disorders for PKIA Gene

Relevant External Links for PKIA

Genetic Association Database (GAD)
PKIA
Human Genome Epidemiology (HuGE) Navigator
PKIA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKIA

No disorders were found for PKIA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKIA Gene

Publications for PKIA Gene

  1. Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor. (PMID: 1770951) Olsen S.R. … Uhler M.D. (Mol. Endocrinol. 1991) 2 3 4 67
  2. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. (PMID: 7836431) Wen W. … Meinkoth J.L. (J. Biol. Chem. 1995) 3 23
  3. Structural insights into how Yrb2p accelerates the assembly of the Xpo1p nuclear export complex. (PMID: 25437554) Koyama M. … Matsuura Y. (Cell Rep 2014) 3
  4. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3
  5. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K. … Rivadeneira F. (Nat. Genet. 2012) 3

Products for PKIA Gene

Sources for PKIA Gene

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