Aliases for PKIA Gene
External Ids for PKIA Gene
Previous HGNC Symbols for PKIA Gene
Previous GeneCards Identifiers for PKIA Gene
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PKIA Gene
PKIA (Protein Kinase (CAMP-Dependent, Catalytic) Inhibitor Alpha) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein kinase A catalytic subunit binding and cAMP-dependent protein kinase inhibitor activity.
UniProtKB/Swiss-Prot for PKIA Gene
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.