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Aliases for PKD2L2 Gene

Aliases for PKD2L2 Gene

  • Polycystin 2 Like 2, Transient Receptor Potential Cation Channel 2 3
  • Transient Receptor Potential Cation Channel Subfamily P Member 5 2 3
  • Polycystic Kidney Disease 2-Like 2 2 5
  • Polycystin-2L2 3 4
  • Polycystin-L2 3 4
  • TRPP5 3

External Ids for PKD2L2 Gene

Previous GeneCards Identifiers for PKD2L2 Gene

  • GC05P137100
  • GC05P137256
  • GC05P137301
  • GC05P137253
  • GC05P137225
  • GC05P132416

Summaries for PKD2L2 Gene

GeneCards Summary for PKD2L2 Gene

PKD2L2 (Polycystin 2 Like 2, Transient Receptor Potential Cation Channel) is a Protein Coding gene. Diseases associated with PKD2L2 include Polycystic Kidney Disease and Polycystic Kidney Disease 2. GO annotations related to this gene include calcium ion binding and calcium channel activity. An important paralog of this gene is ENSG00000279362.

UniProtKB/Swiss-Prot for PKD2L2 Gene

  • May function as a subunit of a cation channel and play a role in fertilization.

Gene Wiki entry for PKD2L2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKD2L2 Gene

Genomics for PKD2L2 Gene

Regulatory Elements for PKD2L2 Gene

Enhancers for PKD2L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PKD2L2 on UCSC Golden Path with GeneCards custom track

Promoters for PKD2L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PKD2L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for PKD2L2 Gene

137,887,968 bp from pter
137,942,747 bp from pter
54,780 bases
Plus strand

Genomic View for PKD2L2 Gene

Genes around PKD2L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKD2L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKD2L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKD2L2 Gene

Proteins for PKD2L2 Gene

  • Protein details for PKD2L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Polycystic kidney disease 2-like 2 protein
    Protein Accession:
    Secondary Accessions:
    • A6NK98
    • B4DXD2
    • E9PC91
    • E9PDG4
    • Q86YB4
    • Q9UNJ0

    Protein attributes for PKD2L2 Gene

    624 amino acids
    Molecular mass:
    73790 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD46478.1; Type=Frameshift; Positions=595; Evidence={ECO:0000305};

    Alternative splice isoforms for PKD2L2 Gene

neXtProt entry for PKD2L2 Gene

Proteomics data for PKD2L2 Gene at MOPED

Post-translational modifications for PKD2L2 Gene

  • Glycosylation at Asn 115 and Asn 138
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PKD2L2 Gene

Domains & Families for PKD2L2 Gene

Gene Families for PKD2L2 Gene

Protein Domains for PKD2L2 Gene


Suggested Antigen Peptide Sequences for PKD2L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the polycystin family.
  • Belongs to the polycystin family.
genes like me logo Genes that share domains with PKD2L2: view

Function for PKD2L2 Gene

Molecular function for PKD2L2 Gene

GENATLAS Biochemistry:
polycystic kidney disease 2(polycystin)-like 2,restrictively expressed in testis
UniProtKB/Swiss-Prot Function:
May function as a subunit of a cation channel and play a role in fertilization.
genes like me logo Genes that share phenotypes with PKD2L2: view

Animal Models for PKD2L2 Gene

MGI Knock Outs for PKD2L2:

Animal Model Products

  • Taconic Biosciences Mouse Models for PKD2L2

miRNA for PKD2L2 Gene

miRTarBase miRNAs that target PKD2L2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKD2L2 Gene

Localization for PKD2L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKD2L2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for PKD2L2 Gene COMPARTMENTS Subcellular localization image for PKD2L2 gene
Compartment Confidence
plasma membrane 4
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for PKD2L2 Gene

Pathways & Interactions for PKD2L2 Gene

SuperPathways for PKD2L2 Gene

No Data Available

Interacting Proteins for PKD2L2 Gene

Gene Ontology (GO) - Biological Process for PKD2L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050982 detection of mechanical stimulus IBA --
genes like me logo Genes that share ontologies with PKD2L2: view

No data available for Pathways by source and SIGNOR curated interactions for PKD2L2 Gene

Drugs & Compounds for PKD2L2 Gene

No Compound Related Data Available

Transcripts for PKD2L2 Gene

Unigene Clusters for PKD2L2 Gene

Polycystic kidney disease 2-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PKD2L2 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14
SP2: - -
SP3: -

Relevant External Links for PKD2L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PKD2L2 Gene

mRNA expression in normal human tissues for PKD2L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PKD2L2 Gene

This gene is overexpressed in Testis (x14.2).

Protein differential expression in normal tissues from HIPED for PKD2L2 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PKD2L2 Gene

SOURCE GeneReport for Unigene cluster for PKD2L2 Gene Hs.716884

mRNA Expression by UniProt/SwissProt for PKD2L2 Gene

Tissue specificity: According to PubMed:10602361, expressed only in testis. According to PubMed:10756092, expressed also in brain and kidney. Isoform 2 is found only in transformed lymphoblasts. Isoform 3 is found in all tissues tested.
genes like me logo Genes that share expression patterns with PKD2L2: view

Protein tissue co-expression partners for PKD2L2 Gene

Primer Products

Orthologs for PKD2L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PKD2L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PKD2L2 35
  • 89.35 (n)
  • 85.76 (a)
PKD2L2 36
  • 81 (a)
(Canis familiaris)
Mammalia PKD2L2 35
  • 90.72 (n)
  • 88.17 (a)
PKD2L2 36
  • 85 (a)
(Mus musculus)
Mammalia Pkd2l2 35
  • 80.82 (n)
  • 81.94 (a)
Pkd2l2 16
Pkd2l2 36
  • 78 (a)
(Pan troglodytes)
Mammalia PKD2L2 35
  • 99.39 (n)
  • 98.67 (a)
PKD2L2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Pkd2l2 35
  • 80.43 (n)
  • 81.94 (a)
(Monodelphis domestica)
Mammalia PKD2L2 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia PKD2L2 36
  • 60 (a)
(Gallus gallus)
Aves PKD2L2 35
  • 61.57 (n)
  • 54.79 (a)
PKD2L2 36
  • 50 (a)
(Anolis carolinensis)
Reptilia PKD2L2 36
  • 54 (a)
(Danio rerio)
Actinopterygii pkd1l3 36
fruit fly
(Drosophila melanogaster)
Insecta Pkd2 37
  • 38 (a)
Pkd2 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea pkd-2 36
  • 28 (a)
Species with no ortholog for PKD2L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PKD2L2 Gene

Gene Tree for PKD2L2 (if available)
Gene Tree for PKD2L2 (if available)

Paralogs for PKD2L2 Gene

Paralogs for PKD2L2 Gene

(4) SIMAP similar genes for PKD2L2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PKD2L2: view

Variants for PKD2L2 Gene

Sequence variations from dbSNP and Humsavar for PKD2L2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1880458 - 137,908,828(+) GTTGT(A/G)TTAAA intron-variant, reference, missense
rs12187140 - 137,923,490(+) AAGGC(C/T)AGATT reference, missense
rs722883 -- 137,926,179(-) TGATA(C/T)TCACA intron-variant
rs722884 -- 137,926,385(-) GAGCA(A/G)TGGTT intron-variant
rs732900 -- 137,908,007(-) TAATA(A/G)TTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PKD2L2 Gene

Variant ID Type Subtype PubMed ID
nsv830501 CNV Gain 17160897
dgv6339n71 CNV Loss 21882294
nsv882936 CNV Loss 21882294
nsv830502 CNV Gain 17160897

Variation tolerance for PKD2L2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PKD2L2 Gene

Disorders for PKD2L2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PKD2L2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
polycystic kidney disease
  • congenital biliary ectasias
polycystic kidney disease 2
  • polycystic kidney disease, type 2
kidney disease
  • nephropathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PKD2L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PKD2L2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PKD2L2 Gene

Publications for PKD2L2 Gene

  1. Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). (PMID: 10602361) Veldhuisen B. … Peters D.J.M. (Eur. J. Hum. Genet. 1999) 2 3 4 67
  2. Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization. (PMID: 10756092) Guo L. … Zhou J. (Genomics 2000) 3 23
  3. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. (PMID: 11959145) Li Q. … Chen X.Z. (FEBS Lett. 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Polycystin channels and kidney disease. (PMID: 11698076) Stayner C. … Zhou J. (Trends Pharmacol. Sci. 2001) 3

Products for PKD2L2 Gene

Sources for PKD2L2 Gene