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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PKD2L1 Gene

protein-coding   GIFtS: 59
GCID: GC10M102037

polycystic kidney disease 2-like 1


(Previous symbols: PKD2L, PKDL)
 Explore 15 diseases affiliated with
PKD2L1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PKD2L1    

Aliases
for PKD2L1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Polycystic Kidney Disease 2-Like 11 2     Polycystin-2L13
PKD2L1 2 3 5     Polycystin-L3
PKDL1 2 3 5     Polycystin-L13
PCL1 2     Transient Receptor Potential Cation Channel, Subfamily P, Member 32
TRPP31 2     Polycystin-2L13
Polycystin-2 Homolog2 3     Polycystin-L3
Polycystic Kidney Disease 2-Like 1 Protein2     Polycystin-L13

External Ids:    HGNC: 90111   Entrez Gene: 90332   Ensembl: ENSG000001075937   OMIM: 6045325   UniProtKB: Q9P0L93   

Export aliases for PKD2L1 gene to outside databases

Previous GC identifers: GC10M100941 GC10M101281 GC10M102179 GC10M101712 GC10M095676


Summaries
for PKD2L1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PKD2L1:
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane
domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in
cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2011)

UniProtKB/Swiss-Prot: PK2L1_HUMAN, Q9P0L9
Function: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling

Gene Wiki entry for PKD2L1


Genomic Views
for PKD2L1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PKD2L1 gene promoter:
         GR   C/EBPbeta   Pbx1a   GR-beta   NRSF form 1   NRSF form 2   GATA-1   PPAR-gamma1   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PKD2L1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PKD2L1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKD2L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.31

PKD2L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKD2L1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102037:  view genomic region     (about GC identifiers)

Start:
 102,047,903 bp from pter      End:
 102,090,243 bp from pter
Size:
 42,341 bases      Orientation:
 minus strand

Proteins
for PKD2L1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PK2L1_HUMAN, Q9P0L9 (See protein sequence)
Recommended Name: Polycystic kidney disease 2-like 1 protein  
Size: 805 amino acids; 91982 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
2 PDB 3D structures from and Proteopedia for PKD2L1:
3TE3 (3D)        4GIF (3D)    
Secondary accessions: O75972 Q5W039 Q9UP35 Q9UPA2
Alternative splicing: 4 isoforms:  Q9P0L9-1   Q9P0L9-2   Q9P0L9-3   Q9P0L9-4   (Unusual intron exon spliced junction)

Explore the universe of human proteins at neXtProt for PKD2L1: NX_Q9P0L9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P0L9

    • PKD2L1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001240766.1  NP_057196.2  

    ENSEMBL proteins: 
     ENSP00000434019   ENSP00000325296   ENSP00000436514   ENSP00000434224   ENSP00000345068  
     ENSP00000266049  

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    Uscn Proteins for PKD2L1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ISS--
    GO:0005886plasma membrane IMP17944866
    GO:0009986colocalizes with cell surface ISS--
    GO:0016021integral to membrane NAS9748274
    GO:0043231intracellular membrane-bounded organelle IDA17944866


    PKD2L1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for PKD2L1

    Protein Domains /
    Families
    for PKD2L1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PKD2L1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR003915 PKD_2
     IPR013122 PKD1_2_channel

    Graphical View of Domain Structure for InterPro Entry Q9P0L9

    ProtoNet protein and cluster: Q9P0L9

    1 Blocks protein family: IPB003915 Polycystic kidney disease type 2 protein (PKD2) signature

    UniProtKB/Swiss-Prot: PK2L1_HUMAN, Q9P0L9
    Similarity: Belongs to the polycystin family


    Function
    for PKD2L1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PK2L1_HUMAN, Q9P0L9
    Function: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling

         Genatlas biochemistry entry for PKD2L1:
    polycystic kidney disease 2 (polycystin)-like 1,expressed at high level in fetal tissues,including kidney and
    liver,down-regulated in adult,deleted in mice with kidney and retinal defects,calcium modulated non selective cation
    channel permeable to Na+,K+,Ca++ ions,highly homolog to PKD2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005227calcium activated cation channel activity IDA11959145
    GO:0005261cation channel activity IDA17944866
    GO:0005272sodium channel activity IDA10517637
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding IPI12525172


    PKD2L1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PKD2L1:
     Synthetic lethal with Ras 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pkd2l1):
     nervous system  taste/olfaction 

    PKD2L1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PKD2L1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sodium channels and transporters: inward current
    		Sodium channels and transporters: inward current1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for PKD2L1
        Sodium channels and transporters- inward current




    PKD2L1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PKD2L1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for PKD2L1 (Q9P0L92, 3 ENSP000003252964) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKD1L3Q7Z4432, 3MINT-6743439 I2D: score=1 
    TNNI1P192373, ENSP000003370224I2D: score=1 STRING: ENSP00000337022
    TNNI2P487883, ENSP000002528984I2D: score=1 STRING: ENSP00000252898
    TNNI3P194293, ENSP000003418384I2D: score=2 STRING: ENSP00000341838
    --ENSP000003352724STRING: ENSP00000335272
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001581detection of chemical stimulus involved in sensory perception of sour taste ISS--
    GO:0006812cation transport ISS--
    GO:0035725sodium ion transmembrane transport IDA10517637
    GO:0051925regulation of calcium ion transport via voltage-gated calcium channel activity ----
    GO:0071468cellular response to acidity ISS--


    PKD2L1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for PKD2L1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PKD2L1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PKD2L1

    1 HMDB Compound for PKD2L1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for PKD2L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 26.8 9 11959145 (3), 9748274 (1), 10602992 (1), 17111037 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about PKD2L1 / PK2L1 

    Transcripts
    for PKD2L1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PKD2L1 gene (2 alternative transcripts): 
    NM_001253837.1  NM_016112.2  

    Unigene Cluster for PKD2L1:

    Polycystic kidney disease 2-like 1
    Hs.159241  [show with all ESTs]
    Unigene Representative Sequence: NM_001253837
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465680 ENST00000318222(uc009xwm.1 uc001kqx.1) ENST00000528248
    ENST00000532547 ENST00000338519 ENST00000353274

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate PKD2L1:
    hsa-miR-146a* hsa-miR-3156-5p
    SwitchGear 3'UTR luciferase reporter plasmid: PKD2L1 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKD2L1
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    Additional cDNA sequence: 

    AF053316.1 AF073481.1 AF092170.1 AF094827.1 BC025665.1 DQ084244.1 

    5 DOTS entries:

    DT.92417930  DT.102820728  DT.97767910  DT.75125894  DT.92003376 

    12 AceView cDNA sequences:

    BU728803 AF073481 NM_016112 AF094827 BC025665 AF092170 AF053316 CB529429 
    AI953740 AI217982 BI755892 CD627520 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PKD2L1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                  
    SP2:              -                                                                                                   


    ECgene alternative splicing isoforms for PKD2L1

    Expression
    for PKD2L1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PKD2L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCACAAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PKD2L1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PKD2L1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PKD2L1

    SOURCE GeneReport for Unigene cluster: Hs.159241

    UniProtKB/Swiss-Prot: PK2L1_HUMAN, Q9P0L9
    Tissue specificity: Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to
    PubMed:9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult
    tissues. According to PubMed:10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney.
    Isoform 4 appears to be expressed only in transformed lymphoblasts

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    In Situ
    Assay Products:     
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    Orthologs
    for PKD2L1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PKD2L1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PKD2L11 polycystic kidney disease 2-like 1 72.01(n)
    76.03(a)    		   428954  XM_426509.3  XP_426509.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PKD2L16
    		 --
    		 70(a)
    		 1 ↔ 1
    		 GL343388.1(52514-80863)
    zebrafish
    (Danio rerio)    		 Actinopterygii pkd2l11 polycystic kidney disease 2-like 1 63.49(n)
    62.13(a)    		   567026  XM_690312.4  XP_695404.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pkd23   -- 39(a)   33E3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea pkd-23 Expression: CEM neurons, male sensory rays,
    nerve more    		 37(a)   IV(15228104-15236176)   --


    ENSEMBL Gene Tree for PKD2L1 (if available)
    TreeFam Gene Tree for PKD2L1 (if available) 

    Paralogs
    for PKD2L1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PKD2L1 gene
    PKD22  NPIPP12  PKDREJ2  PKD12  PKD2L22  PKD1L12  
    2 SIMAP similar genes for PKD2L1 using alignment to 5 protein entries:     PK2L1_HUMAN (see all proteins):
    PKD2    PKD2L2

    PKD2L1 for paralogs           About GeneDecksing



    Genomic Variants
    for PKD2L1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/911 NCBI SNPs in PKD2L1 are shown (see all 911)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2022109781,2
    		C--102047418(-) GGCTAA/CTNNNN 6 -- us2k1 ds50010--------
    rs1808360151,2
    		--102047670(+) GGCTTG/TTCTGG 6 -- ds5001 us2k10--------
    rs1872718761,2
    		--102047701(+) CCACCC/TAACAT 6 -- ds5001 us2k10--------
    rs1142175701,2
    		--102047795(+) GCACCT/CACTCT 6 -- us2k1 ds50011Minor allele frequency- C:0.01WA 118
    rs1921812001,2
    		--102047813(+) CTAGAC/GAGCAT 6 -- us2k1 ds50010--------
    rs749418611,2
    		F,--102047876(+) CCTCTA/GTAATA 6 -- us2k1 ds50011Minor allele frequency- G:0.04WA 118
    rs746329281,2
    		C,--102047896(+) AATGCA/GAAGTC 6 -- us2k1 ds50013Minor allele frequency- G:0.07CSA EA 124
    rs1816135131,2
    		--102048078(+) CAGTTG/TCCAGG 6 -- us2k1 ut310--------
    rs1997897441,2
    		--102048164(+) CCTCTA/GCAACG 7 Q * stg1 us2k10--------
    rs1424391361,2
    		C,F--102048184(+) CACCAC/TGGGAG 7 H R us2k1 mis11Minor allele frequency- T:0.00NA 4552

    HapMap Linkage Disequilibrium report for PKD2L1 (102047903 - 102090243 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PKD2L1: --

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    Disorders / Diseases
    for PKD2L1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PKD2L1 for disorders           About GeneDecksing

    OMIM gene information: 604532    OMIM disorders: --

    15 diseases for PKD2L1:    About MalaCards
    polycystic kidney disease    polycystic kidney disease 2    kidney disease    miliaria rubra
    pityriasis rosea    miliaria    mucocutaneous leishmaniasis    visceral leishmaniasis
    blastomycosis    leishmaniasis    cutaneous leishmaniasis    leprosy
    alzheimer's disease    retinitis    neuronitis

    3 diseases from the University of Copenhagen DISEASES database for PKD2L1:
    Visceral leishmaniasis     Polycystic kidney disease     Mucocutaneous leishmaniasis

    2 Novoseek disease relationships for PKD2L1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpkd 88.8 10 11805156 (2), 9748274 (1), 16564495 (1), 12809519 (1) (see all 5)
    polycystic kidney diseases 80.7 5 11805156 (2), 9748274 (1), 11959145 (1)

    Human Genome Epidemiology (HuGE) Navigator: PKD2L1 (1 document)

    Export disorders for PKD2L1 gene to outside databases

    Publications
    for PKD2L1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PKD2L1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PKD2L1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. (PubMed id 9748274)1, 2, 3, 9 Nomura H.... Zhou J. (1998)
    2. Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25. (PubMed id 9878261)1, 2, 3 Wu G.... Somlo S. (1998)
    3. Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). (PubMed id 10602361)1, 2, 9 Veldhuisen B.... Peters D.J.M. (1999)
    4. The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism. (PubMed id 10602992)1, 2, 9 Guo L.... Zhou J. (2000)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Polycystin channels and kidney disease. (PubMed id 11698076)1, 2 Stayner C. and Zhou J. (2001)
    7. Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. (PubMed id 10517637)1, 2 Chen X.-Z.... Zhou J. (1999)
    8. Tissue and cellular localization of a novel polycystic kidney disease-like gene product, polycystin-L. (PubMed id 11805156)1, 9 Basora N....Zhou J. (2002)
    9. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. (PubMed id 11959145)1, 9 Li Q....Chen X.Z. (2002)
    10. Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. (PubMed id 12809519)1, 9 Li Q....Chen X.Z. (2003)

    External Searches for PKD2L1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PKD2L1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9033 HGNC: 9011 AceView: PKD2L1 Ensembl:ENSG00000107593 euGenes: HUgn9033
    ECgene: PKD2L1 H-InvDB: PKD2L1

    Other Databases showing PKD2L1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PKD2L1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PKD2L1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PKD2L1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PKD2L1 gene:
    Search GeneIP for patents involving PKD2L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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