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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PKD2 Gene

protein-coding   GIFtS: 69
GCID: GC04P088929

Polycystic Kidney Disease 2 (Autosomal Dominant)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Polycystic Kidney Disease 2 (Autosomal Dominant)1 2     PKD42
Autosomal Dominant Polycystic Kidney Disease Type II Protein2 3     Pc-22
R483212 3     TRPP22
Member 21     polycystin-22
Subfamily P1     polycystwin2
Transient Receptor Potential Cation Channel1     Transient Receptor Potential Cation Channel, Subfamily P, Member 22
APKD22     Polycystwin3
PC22     Polycystic Kidney Disease 2 Protein3

External Ids:    HGNC: 90091   Entrez Gene: 53112   Ensembl: ENSG000001187627   OMIM: 1739105   UniProtKB: Q135633   

Export aliases for PKD2 gene to outside databases

Previous GC identifers: GC04P089086 GC04P089230 GC04P089387 GC04P089285 GC04P089147 GC04P084675


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PKD2 Gene:
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein
that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling
in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common
signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal
dominant polycystic kidney disease type 2. (provided by RefSeq, Mar 2011)

GeneCards Summary for PKD2 Gene: 
PKD2 (polycystic kidney disease 2 (autosomal dominant)) is a protein-coding gene. Diseases associated with PKD2 include kidney disease, and polycystic kidney disease. GO annotations related to this gene include identical protein binding and calcium ion binding. An important paralog of this gene is PKDREJ.

UniProtKB/Swiss-Prot: PKD2_HUMAN, Q13563
Function: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1
and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By
similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of
cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates
a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases
intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity).
Functions as a calcium permeable cation channel

Gene Wiki entry for PKD2 (Polycystic kidney disease 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PKD2 gene promoter:
         AML1a   AP-1   ATF-2   MyoD   NF-kappaB   HEN1   c-Jun   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPKD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PKD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PKD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1   Ensembl cytogenetic band:  4q22.1   HGNC cytogenetic band: 4q22.1

PKD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKD2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P088929:  view genomic region     (about GC identifiers)

Start:
88,928,799 bp from pter      End:
88,998,931 bp from pter
Size:
70,133 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PKD2_HUMAN, Q13563 (See protein sequence)
Recommended Name: Polycystin-2  
Size: 968 amino acids; 109691 Da
Subunit: Forms homooligomers. Isoform 1 interacts with PKD1 while isoform 3 does not (By similarity). PKD1
requires the presence of PKD2 for stable expression. Interacts with CD2AP. Interacts with HAX1. Interacts with
NEK8 (By similarity). Part of a complex containing AKAP5, ADCY5, ADCY6 and PDE4C (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum. Cell projection,
cilium (By similarity)
6 PDB 3D structures from and Proteopedia for PKD2:
2KLD (3D)        2KLE (3D)        2KQ6 (3D)        2Y4Q (3D)        3HRN (3D)        3HRO (3D)    
Secondary accessions: O60441 Q15764 Q2M1Q3 Q2M1Q5
Alternative splicing: 5 isoforms:  Q13563-1   Q13563-2   Q13563-3   Q13563-4   Q13563-5   (Minor isoform)

Explore the universe of human proteins at neXtProt for PKD2: NX_Q13563

Explore proteomics data for PKD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13563

  • PKD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PKD2 Protein Expression
    REFSEQ proteins: NP_000288.1  
    ENSEMBL proteins: 
     ENSP00000237596   ENSP00000427131   ENSP00000425289  

    Human Recombinant Protein Products for PKD2: 
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    Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002133polycystin complex ISS--
    GO:0005737cytoplasm IMP16311606
    GO:0005783endoplasmic reticulum IMP16223735
    GO:0005789endoplasmic reticulum membrane IDA11854751
    GO:0005886plasma membrane IDA15692563

    PKD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRP: Voltage-gated ion channels / Transient receptor potential cation channels
    EFHAND: EF-hand domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TRPP1 
    Transient Receptor Potential channels

    5 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR003915 PKD_2
     IPR027359 K_channel_four-helix_dom
     IPR013122 PKD1_2_channel

    Graphical View of Domain Structure for InterPro Entry Q13563

    ProtoNet protein and cluster: Q13563

    1 Blocks protein domain: IPB003915 Polycystic kidney disease type 2 protein (PKD2) signature

    UniProtKB/Swiss-Prot: PKD2_HUMAN, Q13563
    Domain: The C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is
    implicated in oligomerization and the interaction with PKD1
    Similarity: Belongs to the polycystin family
    Similarity: Contains 1 EF-hand domain


    PKD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PKD2_HUMAN, Q13563
    Function: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). PKD1
    and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis (By
    similarity). Acts as a regulator of cilium length, together with PKD1 (By similarity). The dynamic control of
    cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates
    a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases
    intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity).
    Functions as a calcium permeable cation channel

         Genatlas biochemistry entry for PKD2:
    polycystin 2,integral membrane protein,with some homology with PKD1 and TRPC1,C elegans ZK9459,and the family of
    voltage gated Ca+ channels,ubiquitously expressed,involved in regulating ion transport

         Gene Ontology (GO): 5/19 molecular function terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI16223735
    GO:0005216ion channel activity ----
    GO:0005244voltage-gated ion channel activity IDA11854751
    GO:0005245voltage-gated calcium channel activity IDA11252306
    GO:0005248voltage-gated sodium channel activity IDA11252306
         
    PKD2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PKD2:
     Decreased focal adhesion (FA)  

         14 MGI mutant phenotypes (inferred from 10 alleles(MGI details for Pkd2):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system 
     mortality/aging  normal  renal/urinary system  respiratory system 

    PKD2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for PKD2: Pkd2tm1Som Pkd2tm1.2Tjwt Pkd2tm2Som

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PKD2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Calcium channels
    Calcium channels
    2Selected targets of HNF1
    Selected targets of HNF1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for PKD2
        Selected targets of HNF1
    Calcium channels




    PKD2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PKD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/21 Interacting proteins for PKD2 (Q135632, 3 ENSP000002375964) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PKD1P981612, 3, ENSP000002623044MINT-7895347 MINT-7895311 MINT-7895557 MINT-7895283 MINT-7895327 MINT-7895498 MINT-7895375 I2D: score=7 STRING: ENSP00000262304
    BCAP31P515722, 3, ENSP000003923304MINT-7014632 I2D: score=1 STRING: ENSP00000392330
    PKD2Q135632MINT-7894978 MINT-7895056 MINT-7895235 MINT-7895259
    DIAPH1O606102, 3, ENSP000003815654MINT-6618320 I2D: score=3 STRING: ENSP00000381565
    CD2APQ9Y5K63, ENSP000003522644I2D: score=3 STRING: ENSP00000352264
    About this table

    Gene Ontology (GO): 5/55 biological process terms (GO ID links to tree view) (see all 55):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001658branching involved in ureteric bud morphogenesis IEP11891195
    GO:0001822kidney development ----
    GO:0001889liver development IEP11891195
    GO:0001892embryonic placenta development ISS--
    GO:0001947heart looping IMP--

    PKD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PKD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PKD2

    1 HMDB Compound for PKD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    7 IUPHAR Ligands for PKD2 (TRPP1)    About this table 
    LigandTypeActionAffinityPubmed IDs
    Cai2+
    ActivatorNone611854751
    SKF96365
    Pore BlockerNone616396967
    amiloride
    Channel blockerNone6--
    La3+
    Pore BlockerNone616396967
    Gd3+
    Pore BlockerNone616396967
    Ni2+
    Pore BlockerNone616396967
    Cd2+
    Pore BlockerNone616396967

    6 Novoseek inferred chemical compound relationships for PKD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    trp-p-2 81.5 9 18037411 (2), 19812035 (2), 17233617 (1), 17217069 (1) (see all 7)
    calcium 29.6 11 10097141 (3), 15001556 (2), 9192675 (1), 10435671 (1) (see all 7)
    ryanodine 2.73 3 14732716 (3)
    polyacrylamide 0 1 16215947 (1)
    sodium 0 1 17233617 (1)
    silver 0 1 11007674 (1)

    Search CenterWatch for drugs/clinical trials and news about PKD2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PKD2 gene: 
    NM_000297.3  

    Unigene Cluster for PKD2:

    Polycystic kidney disease 2 (autosomal dominant)
    Hs.181272  [show with all ESTs]
    Unigene Representative Sequence: NM_000297
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000237596(uc003hre.3 uc011cdf.2 uc011cdg.2 uc011cdh.2)
    ENST00000506727 ENST00000506367 ENST00000508588 ENST00000511337 ENST00000512858
    ENST00000502363
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    Additional mRNA sequence: 

    AF054992.1 AF113693.1 AK293461.1 AK294173.1 BC112261.1 BC112263.1 U50928.1 U56813.1 

    4 DOTS entries:

    DT.216427  DT.100676422  DT.102828651  DT.91683947 

    24/141 AceView cDNA sequences (see all 141):

    NM_000297 AI090067 CA417804 AA749414 CA446398 BE645879 BU683371 BP372674 
    AA233186 AF054992 AI093570 BG897537 CA413959 BE645590 AW338910 BQ574566 
    AI349570 AW069616 BG402881 BQ959129 CD251213 BM760937 AI091028 AA232888 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PKD2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -     -                                                                             -                           
    SP2:                    -                                                                                                               
    SP3:                                                                                      -                                             
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for PKD2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PKD2 expression in normal human tissues (normalized intensities)      PKD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAACTCCC
    PKD2 Expression
    About this image


    PKD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Pons+Medulla   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion   
     
     Nose (Sensory Organs)
             sensory organ/nose   
     
     Endothelium (Cardiovascular System)
             pulmonary artery   
     
     Spinal Cord (Nervous System)
             spinal/ganglion   

    See PKD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PKD2

    SOURCE GeneReport for Unigene cluster: Hs.181272

    UniProtKB/Swiss-Prot: PKD2_HUMAN, Q13563
    Tissue specificity: Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected
    in peripheral leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including PKD2: 
              Primary Cilia in human mouse rat
              T Helper Cell Differentiation in human mouse rat

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    OriGene qSTAR qPCR primer pairs in human, mouse for PKD2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PKD2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PKD2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PKD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PKD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PKD2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkd21 , 5 polycystic kidney disease 21, 5 86.22(n)1
    90.65(a)1
      5 (50.68 cM)5
    187641  NM_008861.31  NP_032887.31 
     1044594505 
    chicken
    (Gallus gallus)
    Aves PKD21 polycystic kidney disease 2 (autosomal dominant) 77.29(n)
    81.65(a)
      422585  NM_001031140.1  NP_001026311.1 
    lizard
    (Anolis carolinensis)
    Reptilia PKD26
    polycystic kidney disease 2 (autosomal dominant)
    77(a)
    1 ↔ 1
    5(45599248-45617326)
    zebrafish
    (Danio rerio)
    Actinopterygii pkd21 polycystic kidney disease 2 66.22(n)
    68.16(a)
      432387  NM_001002310.1  NP_001002310.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71253 protein amino acid phosphorylation
    protein serine/threonine more
    50(a)
    (best of 2)
      91A2   --
    worm
    (Caenorhabditis elegans)
    Secernentea W09C5.53
    pkd-21
    Phorbol esters/diacylglycerol binding
    domain (C1 more3
    Protein PKD-21
    38(a)
    (best of 2)3
    50.16(n)1
    39.1(a)1
      I(13648484-13656446)3
    1784241  NM_070437.31  NP_502838.31 


    ENSEMBL Gene Tree for PKD2 (if available)
    TreeFam Gene Tree for PKD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PKD2 gene
    PKDREJ2  PKD12  PKD2L22  PKD2L12  PKD1L22  PKD1L12  
    2 SIMAP similar genes for PKD2 using alignment to 3 protein entries:     PKD2_HUMAN (see all proteins):
    PKD2L1    PKD2L2

    PKD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1653 SNPs in PKD2 are shown (see all 1653)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0588284
    Polycystic kidney disease 2 (PKD2)4--see VAR_0588282 C R mis40--------
    VAR_0588254
    Polycystic kidney disease 2 (PKD2)4--see VAR_0588252 R G mis40--------
    VAR_0588244
    Polycystic kidney disease 2 (PKD2)4--see VAR_0588242 R W mis40--------
    VAR_0588234
    Polycystic kidney disease 2 (PKD2)4--see VAR_0588232 R Q mis40--------
    VAR_0110734
    Polycystic kidney disease 2 (PKD2)4--see VAR_0110732 A P mis40--------
    VAR_0643944
    Polycystic kidney disease 2 (PKD2)4--see VAR_0643942 A P mis40--------
    VAR_0588274
    Polycystic kidney disease 2 (PKD2)4--see VAR_0588272 D V mis40--------
    VAR_0091954
    Polycystic kidney disease 2 (PKD2)4--see VAR_0091952 W G mis40--------
    VAR_0588224
    Polycystic kidney disease 2 (PKD2)4--see VAR_0588222 R Q mis40--------
    rs1476542631,2,4
    C,FPolycystic kidney disease 2 (PKD2)4 --88797695(+) CCCTCG/AAAGCC 2 /Q /R mis12Minor allele frequency- A:0.00NA EU 5875

    HapMap Linkage Disequilibrium report for PKD2 (88928799 - 88998931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PKD2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2668876CNV Deletion23128226
    esv2658797CNV Deletion23128226
    esv2665331CNV Deletion23128226
    esv25882CNV Loss19812545
    essv19863CNV CNV17122850
    dgv1651e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): PKD2

    Locus Specific Mutation Databases (LSDB): PKD2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PKD2
    DNA2.0 Custom Variant and Variant Library Synthesis for PKD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 173910   
    OMIM disorders: 613095  
    UniProtKB/Swiss-Prot: PKD2_HUMAN, Q13563
  • Polycystic kidney disease 2 (PKD2) [MIM:613095]: A disorder characterized by progressive formation and
    enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also
    occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant
    polycystic kidney disease. PKD2 is clinically milder than PKD1 but it has a deleterious impact on overall life
    expectancy. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/23 diseases for PKD2 (see all 23):    About MalaCards
    kidney disease    polycystic kidney disease    polycystic kidney disease, type 2    polycystic kidney disease, autosomal dominant
    cystic kidney    polycystic kidney disease, type 1    polycystic liver disease    autosomal dominant disease
    intracranial aneurysm    mucolipidosis    situs inversus    liver disease
    gout    retinal degeneration    cystic fibrosis    retinitis
    ischemia    gastric cancer    squamous cell carcinoma    endotheliitis

    4 diseases from the University of Copenhagen DISEASES database for PKD2:
    Polycystic kidney disease     Cystic kidney     Polycystic liver disease     Situs inversus

    PKD2 for disorders           About GeneDecksing

    10/18 Novoseek inferred disease relationships for PKD2 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adpkd 97.6 215 17100995 (5), 11007674 (5), 19098310 (3), 10411676 (3) (see all 99)
    polycystic kidney diseases 93.4 34 15300626 (2), 11195048 (2), 9175744 (2), 10541293 (1) (see all 27)
    polycystic kidney type 2 autosomal dominant disease 90.9 3 15300626 (2), 16135816 (1)
    renal cyst 88.4 20 9568711 (2), 12140187 (2), 10417277 (2), 10655555 (1) (see all 15)
    arpkd 88.2 13 15029248 (2), 10200981 (1), 11981261 (1), 18235088 (1) (see all 9)
    polycystic liver disease 82.5 2 16294159 (1), 19766642 (1)
    medullary cystic kidney 79.8 1 16207829 (1)
    cystic kidney disease 77.8 5 16207829 (2), 15029248 (1), 10362797 (1), 17217069 (1)
    cysts 76.9 40 12140187 (3), 19098310 (3), 10362797 (3), 16720597 (3) (see all 23)
    somatic mutations 62.7 13 10655555 (2), 10835625 (2), 9949210 (2), 12028433 (1) (see all 8)

    Genatlas disease: PKD2
    polycystic kidney disease 2,adult type,autosomal dominant,similar to PKD1 with cen average better
    prognosis,occuring by a cellular recessive mechanism supporting a two-hit model for cyst formation (somatic
    mutation in the cysts)

    GeneTests: PKD2
    GeneReviews: PKD2
    Genetic Association Database (GAD): PKD2
    Human Genome Epidemiology (HuGE) Navigator: PKD2 (17 documents)

    Export disorders for PKD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PKD2 gene, integrated from 9 sources (see all 275) (see top 10):
    (articles sorted by number of sources associating them with PKD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PKD2 mutations in a Czech population with autosomal dominant polycystic kidney disease. (PubMed id 14993477)1, 2, 4, 9 Stekrova J.... Kohoutova M. (2004)
    2. The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. (PubMed id 10760273)1, 2, 9 Gallagher A.R.... Witzgall R. (2000)
    3. [Genetic analysis (PKD2) of autosomal dominant polycy stic kidney disease] (PubMed id 19936001)1, 4, 9 GA^mez P.F....Romo J.M. (2009)
    4. Mutations of the PKD2 gene in Taiwanese patients with autosomal dominant polycystic kidney disease. (PubMed id 15717641)1, 4, 9 Chang M.Y....Wu Chou Y.H. (2005)
    5. Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2). (PubMed id 9286709)1, 2, 9 Hayashi T.... Somlo S. (1997)
    6. A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1. (PubMed id 16192288)1, 2, 9 Hackmann K....Gerke V. (2005)
    7. Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease. (PubMed id 10411676)1, 2, 9 Torra R.... San Millan J.L. (1999)
    8. Genotype-renal function correlation in type 2 autosomal dominant polycystic kidney disease. (PubMed id 12707387)1, 2, 9 Magistroni R....Pei Y. (2003)
    9. Aberrant splicing in the PKD2 gene as a cause of polycystic kidney disease. (PubMed id 10541293)1, 2, 9 Reynolds D.M.... Somlo S. (1999)
    10. Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations. (PubMed id 10835625)1, 2, 9 Watnick T.J.... Pei Y. (2000)
    11. A gene similar to PKD1 maps to chromosome 4q22: a candidate gene for PKD2. (PubMed id 8954772)1, 2, 9 Schneider M.C.... Weremowicz S. (1996)
    12. Study of candidate genes affecting the progression of renal disease in autosomal dominant polycystic kidney disease type 1. (PubMed id 17303584)1, 4, 9 Tazon-Vega B....Torra R. (2007)
    13. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    14. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    15. Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease. (PubMed id 19194729)1, 4 Fencl F....Seeman T. (2009)
    16. Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis. (PubMed id 18694932)1, 2 Celic A.... Boggon T.J. (2008)
    17. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    18. Polycystin channels and kidney disease. (PubMed id 11698076)1, 2 Stayner C. and Zhou J. (2001)
    19. In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. (PubMed id 10913159)1, 2 Lehtonen S....Lehtonen E. (2000)
    20. A spectrum of mutations in the second gene for autosomal dominant polycystic kidney disease (PKD2). (PubMed id 9326320)1, 2 Veldhuisen B.... Peters D.J.M. (1997)
    21. PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. (PubMed id 8650545)1, 2 Mochizuki T.... Somlo S. (1996)
    22. Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease. (PubMed id 8298643)1, 3 Peters D.J....Constantinou-Deltas C.D. (1993)
    23. Specific association of the gene product of PKD2 with the TRPC1 channel. (PubMed id 10097141)1, 9 Tsiokas L.... Sukhatme V.P. (1999)
    24. Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice. (PubMed id 19098310)1, 9 Park E.Y....Park J.H. (2009)
    25. Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development. (PubMed id 11891195)1, 9 Chauvet V....Gubler M.C. (2002)
    26. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. (PubMed id 9192675)1, 9 Tsiokas L....Walz G. (1997)
    27. NCAM as a cystogenesis marker gene of PKD2 overexpression. (PubMed id 18755075)1, 9 Yoo K.H....Park J.H. (2008)
    28. [A Chinese autosomal dominant polycystic kidney disease family probably related to PKD2 gene] (PubMed id 16215947)1, 9 Sun Y....Zhang S.Z. (2005)
    29. Overexpression of PKD2 in the mouse is associated with renal tubulopathy. (PubMed id 18048422)1, 9 Burtey S....Fontes M. (2008)
    30. Four novel mutations of the PKD2 gene in Czech families with autosomal dominant polycystic kidney disease. (PubMed id 11968093)2, 9 Reiterova J.... Zidovska J. (2002)
    31. Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease. (PubMed id 9949210)1, 9 Koptides M....Constantinou Deltas C. (1999)
    32. PKD1 interacts with PKD2 through a probable coiled-coil domain. (PubMed id 9171830)1, 9 Qian F....Germino G.G. (1997)
    33. A translation frameshift mutation induced by a cytosine insertion in the polycystic kidney disease 2 gene (PDK2). (PubMed id 9175744)1, 9 Xenophontos S....Deltas C.C. (1997)
    34. Molecular advances in autosomal dominant polycystic k idney disease. (PubMed id 20219615)1, 9 Gallagher A.R....Somlo S. (2010)
    35. Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells. (PubMed id 15001556)1, 9 Aguiari G....Del Senno L. (2004)
    36. Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. (PubMed id 10770959)1, 9 Foggensteiner L....Sandford R. (2000)
    37. Family history of renal disease severity predicts the mutated gene in ADPKD. (PubMed id 19443633)1, 9 Barua M....Pei Y. (2009)
    38. A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. (PubMed id 19812035)1, 9 Miyagi K....Mori Y. (2009)
    39. Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro. (PubMed id 16551655)1, 9 Streets A.J....Ong A.C. (2006)
    40. [Gene diagnosis of autosomal dominant polycystic kidney disease type 2 using microsatellite DNA tightly linked to polycystic kidney disease gene 2] (PubMed id 15300626)1, 9 Zhang W.L....Mei C.L. (2004)
    41. Polycystic disease of the liver. (PubMed id 15382167)1, 9 Everson G.T....Doctor R.B. (2004)
    42. New insights into polycystic kidney disease and its treatment. (PubMed id 9529618)1, 9 Torres V.E. (1998)
    43. Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2. (PubMed id 19546223)1, 9 Schumann F....Kalbitzer H.R. (2009)
    44. TRPP2 channel regulation. (PubMed id 17217069)1, 9 Witzgall R. (2007)
    45. Kidney injury molecule 1 (Kim1) is a novel ciliary molecule and interactor of polycystin 2. (PubMed id 18273441)1, 9 Kuehn E.W....Walz G. (2007)
    46. Polycystin-2 regulates proliferation and branching morphogenesis in kidney epithelial cells. (PubMed id 16278216)1, 9 Grimm D.H....Caplan M.J. (2006)
    47. Kinesin-2 mediates physical and functional interactions between polycystin-2 and fibrocystin. (PubMed id 17008358)1, 9 Wu Y....Chen X.Z. (2006)
    48. Genetics and phenotypic characteristics of autosomal dominant polycystic kidney disease in Finns. (PubMed id 15772804)2, 9 Peltola P....Laakso M. (2005)
    49. Molecular pathogenesis of ADPKD: the polycystin complex gets complex. (PubMed id 15780076)1, 9 Ong A.C. and Harris P.C. (2005)
    50. Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling. (PubMed id 16223735)1, 9 Li Y....Guggino W.B. (2005)
    51. Alpha-actinin associates with polycystin-2 and regulates its channel activity. (PubMed id 15843396)1, 9 Li Q....Chen X.Z. (2005)
    52. Regulation of calcium signaling by polycystin-2. (PubMed id 15130895)1, 9 Cantiello H.F. (2004)
    53. Polycystin-2 associates with tropomyosin-1, an actin microfilament component. (PubMed id 12527301)1, 9 Li Q....Chen X.Z. (2003)
    54. Polycystin-2 interacts with troponin I, an angiogenesis inhibitor. (PubMed id 12525172)1, 9 Li Q....Chen X.Z. (2003)
    55. GWAS of dental caries patterns in the permanent dentit ion. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (2013)
    56. N-myc downstream-regulated gene 1 is involved in the r egulation of cystogenesis in transgenic mice overexpressing human PKD2 gene. (PubMed id 23212942)1 Kim B.H....Park J.H. (2013)
    57. Adult patients with sporadic polycystic kidney disease : the importance of screening for mutations in the PKD1 and PKD2 genes. (PubMed id 22367170)1 Neumann H.P....Jilg C. (2012)
    58. Clinical utility of PKD2 mutation testing in a polycys tic kidney disease cohort attending a specialist nephrology out-patient clinic. (PubMed id 22863349)1 Robinson C....Sandford R.N. (2012)
    59. PKD2 and PKD3 promote prostate cancer cell invasion by modulating NF-kB- and HDAC1-mediated expression and activation of uPA. (PubMed id 22797919)1 Zou Z....Deng F. (2012)
    60. Autosomal dominant polycystic kidney disease: Comprehensive mutation analysis of PKD1 and PKD2 in 700 unrelated patients. (PubMed id 22508176)1 Audrezet M.P.... Ferec C. (2012)
    61. Structural interaction and functional regulation of po lycystin-2 by filamin. (PubMed id 22802962)1 Wang Q....Chen X.Z. (2012)
    62. Polycystin-1 and polycystin-2 are both required to amp lify inositol-trisphosphate-induced Ca2+ release. (PubMed id 22456092)1 Mekahli D....Missiaen L. (2012)
    63. Neonatal onset autosomal dominant polycystic kidney di sease (ADPKD) in a patient homozygous for a PKD2 missense mutation due to unipar ental disomy. (PubMed id 22114106)1 Losekoot M....Peters D.J. (2012)
    64. Interferon-g-induced PD-L1 surface expression on human oral squamous carcinoma via PKD2 signal pathway. (PubMed id 22204817)1 Chen J....Zhang P. (2012)
    65. Calcium-induced conformational changes in C-terminal t ail of polycystin-2 are necessary for channel gating. (PubMed id 22474326)1 Celic A.S....Boggon T.J. (2012)
    66. Pathway analysis of genome-wide association studies on uric acid concentrations. (PubMed id 22609445)1 Lee Y.H. and Song G.G. (2012)
    67. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (2012)
    68. Protein kinase D2 is a novel regulator of glioblastom a growth and tumor formation. (PubMed id 21727210)1 Azoitei N....Seufferlein T. (2011)
    69. PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression. (PubMed id 20934246)1 Chen J....Zhang P. (2011)
    70. A single amino acid residue constitutes the third dim erization domain essential for the assembly and function of the tetrameric poly cystin-2 (TRPP2) channel. (PubMed id 21474446)1 Feng S....Ong A.C. (2011)
    71. [Identification of mutations in PKD1 and PKD2 genes i n two Chinese families with autosomal dominant polycystic kidney disease]. (PubMed id 21983717)1 Yu C.W....Zhang S.Z. (2011)
    72. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    73. Association of PKD2 (polycystin 2) mutations with lef t-right laterality defects. (PubMed id 21719175)1 Bataille S....Burtey S. (2011)
    74. Macromolecular assembly of polycystin-2 intracytosoli c C-terminal domain. (PubMed id 21622852)1 Ferreira F.M....Onuchic L.F. (2011)
    75. The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes. (PubMed id 21490950)1 Fogelgren B....Lipschutz J.H. (2011)
    76. Protein kinase C mediates platelet secretion and thro mbus formation through protein kinase D2. (PubMed id 21527521)1 Konopatskaya O....Poole A.W. (2011)
    77. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    78. Mutations in multiple PKD genes may explain early and severe polycystic kidney disease. (PubMed id 22034641)1 Bergmann C....Zerres K. (2011)
    79. Novel PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease (ADPKD). (PubMed id 21115670)2 Hoefele J.... Klein H.G. (2010)
    80. Identification of the structural motif responsible fo r trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2. (PubMed id 20408813)1 Molland K.L....Yernool D.A. (2010)
    81. Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma. (PubMed id 19569180)1 Yamano Y....Tanzawa H. (2010)
    82. Polycystin-2 activity is controlled by transcriptiona l coactivator with PDZ binding motif and PALS1-associated tight junction protei n. (PubMed id 20833712)1 Duning K....Weide T. (2010)
    83. Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site. (PubMed id 20980620)1 Chapin H.C.... Caplan M.J. (2010)
    84. Structure of the EF-hand domain of polycystin-2 sugge sts a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. (PubMed id 20439752)1 Petri E.T....Hodsdon M.E. (2010)
    85. Protein kinase D1 and D2 are involved in chemokine re lease induced by toll-like receptors 2, 4, and 5. (PubMed id 20557879)1 Steiner T.S....Kifayet A. (2010)
    86. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. (PubMed id 20168298)1 Giamarchi A....Delmas P. (2010)
    87. PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. (PubMed id 19801576)1 Gao H....Walz G. (2010)
    88. Protein kinase D-mediated phosphorylation of polycyst in-2 (TRPP2) is essential for its effects on cell growth and calcium channel ac tivity. (PubMed id 20881056)1 Streets A.J....Ong A.C. (2010)
    89. Role of the second cysteine-rich domain and Pro275 in protein kinase D2 interaction with ADP-ribosylation factor 1, trans-Golgi netw ork recruitment, and protein transport. (PubMed id 20089835)1 Pusapati G.V....Seufferlein T. (2010)
    90. MicroRNA-17 post-transcriptionally regulates polycyst ic kidney disease-2 gene and promotes cell proliferation. (PubMed id 19821056)1 Sun H....Zhou Q. (2010)
    91. Atomic force microscopy reveals the alternating subun it arrangement of the TRPP2-TRPV4 heterotetramer. (PubMed id 20682256)1 Stewart A.P....Edwardson J.M. (2010)
    92. The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C -termini. (PubMed id 21044049)1 Hoffmeister H....Witzgall R. (2010)
    93. Inhibition of CtBP1 activity by Akt-mediated phosphor ylation. (PubMed id 20361981)1 Merrill J.C....Wotton D. (2010)
    94. Quantifying the interaction of the C-terminal regions of polycystin-2 and polycystin-1 attached to a lipid bilayer by means of QCM. (PubMed id 20206434)1 Behn D....Steinem C. (2010)
    95. Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades. (PubMed id 19265036)1 AbouAlaiwi W.A....Nauli S.M. (2009)
    96. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    97. Polycystin-1 C-terminal cleavage is modulated by poly cystin-2 expression. (PubMed id 19491093)1 Bertuccio C.A....Caplan M.J. (2009)
    98. Novel method for genomic analysis of PKD1 and PKD2 mutations in autosomal dominant polycystic kidney disease. (PubMed id 18837007)2 Tan Y.-C.... Rennert H. (2009)
    99. The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1. (PubMed id 19193631)1 Zhang P....Cantiello H.F. (2009)
    100. Evidence for pathogenicity of atypical splice mutatio ns in autosomal dominant polycystic kidney disease. (PubMed id 19158373)1 Wang K....Pei Y. (2009)
    101. Characterization of PKD protein-positive exosome-like vesicles. (PubMed id 19158352)1 Hogan M.C....Ward C.J. (2009)
    102. The transient receptor potential channels TRPP2 and T RPC1 form a heterotetramer with a 2:2 stoichiometry and an alternating subunit arrangement. (PubMed id 19850920)1 Kobori T....Edwardson J.M. (2009)
    103. Helicobacter pylori infection of gastric cancer cells elevates the level of expression and activation of protein kinase D2. (PubMed id 19783969)1 Shabelnik M.Y....Sidorenko S.P. (2009)
    104. Polycystin-1 interacts with inositol 1,4,5-trisphosph ate receptor to modulate intracellular Ca2+ signaling with implications for pol ycystic kidney disease. (PubMed id 19854836)1 Li Y....Guggino W.B. (2009)
    105. Reactive oxygen species inhibit polycystin-2 (TRPP2) cation channel activity in term human syncytiotrophoblast. (PubMed id 18417208)1 Montalbetti N....Cantiello H.F. (2008)
    106. Mediation of angiotensin II-induced Ca2+ signaling by polycystin 2 in glomerular mesangial cells. (PubMed id 18256307)1 Du J....Ma R. (2008)
    107. Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. (PubMed id 18701462)1 Feng S....Ong A.C. (2008)
    108. Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2. (PubMed id 18721488)1 Felekkis K.N....Deltas C. (2008)
    109. Centrosome overduplication and mitotic instability in PKD2 transgenic lines. (PubMed id 18725310)1 Burtey S....Fontes M. (2008)
    110. Submembraneous microtubule cytoskeleton: interaction of TRPP2 with the cell cytoskeleton. (PubMed id 18754774)1 Chen X.Z....Cantiello H.F. (2008)
    111. Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha. (PubMed id 18664456)1 Liang G....Chen X.Z. (2008)
    112. A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. (PubMed id 18552856)1 Li X....Li R. (2008)
    113. Polycystin-2 cation channel function in the human syncytiotrophoblast is regulated by microtubular structures. (PubMed id 17204494)1 Montalbetti N....Cantiello H.F. (2007)
    114. TRPP2 and autosomal dominant polycystic kidney disease. (PubMed id 17292589)1 Kottgen M. (2007)
    115. Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia. (PubMed id 17283055)1 Wang S....Zhou J. (2007)
    116. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    117. Polycystins: inhibiting the inhibitors. (PubMed id 16319969)1 Benezra R. (2005)
    118. Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation. (PubMed id 15692563)1 Koettgen M.... Walz G. (2005)
    119. A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia. (PubMed id 16038619)1 Roitbak T....Wandinger-Ness A. (2005)
    120. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. (PubMed id 16311606)1 Li X....Zhou J. (2005)
    121. Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast. (PubMed id 16025301)1 Montalbetti N....Cantiello H.F. (2005)
    122. PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. (PubMed id 15123714)1 Rundle D.R....Tsiokas L. (2004)
    123. Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. (PubMed id 15337773)1 Jurczyk A....Doxsey S. (2004)
    124. PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2. (PubMed id 15194699)1 Hidaka S....Witzgall R. (2004)
    125. Polycystin-2 as a signal transducer. (PubMed id 18727244)1 Cantiello H.F....Gonzalez-Perrett S. (2004)
    126. Troponin I binds polycystin-L and inhibits its calcium-induced channel activation. (PubMed id 12809519)1 Li Q....Chen X.Z. (2003)
    127. Role of polycystins in renal tubulogenesis. (PubMed id 12946628)1 Boletta A. and Germino G.G. (2003)
    128. Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. (PubMed id 11901144)1 Newby L.J....Ong A.C. (2002)
    129. Voltage dependence and pH regulation of human polycystin-2-mediated cation channel activity. (PubMed id 11991947)1 Gonzalez-Perrett S....Cantiello H.F. (2002)
    130. Polycystin-2 is an intracellular calcium release channel. (PubMed id 11854751)1 Koulen P....Somlo S. (2002)
    131. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    132. Mutations of the human polycystic kidney disease 2 (PKD2) gene. (PubMed id 11438989)1 Deltas C.C. (2001)
    133. Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. (PubMed id 11252306)1 Gonzalez-Perrett S....Cantiello H.F. (2001)
    134. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
    135. A novel frameshift mutation induced by an adenosine insertion in the polycystic kidney disease 2 (PKD2) gene. (PubMed id 9573526)1 Pei Y....St George-Hyslop P. (1998)
    136. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
    137. Novel stop and frameshifting mutations in the autosomal dominant polycystic kidney disease 2 (PKD2) gene. (PubMed id 9402976)1 Viribay M....San Millan J.L. (1997)
    138. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)
    139. PKD2 gene mutation analysis in Korean autosomal dominant polycystic kidney disease patients using two-dimensional gene scanning. (PubMed id 17100995)9 Chung W....Ahn C. (2006)
    140. Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility. (PubMed id 14732716)9 Gao Z....Lu X. (2004)
    141. PKD2 functions as an epidermal growth factor-activated plasma membrane channel. (PubMed id 16135816)9 Ma R....Tsiokas L. (2005)
    142. Cloning and characterization of the murine pkd2 promoter. (PubMed id 10873385)9 Park J.H....Wu G. (2000)
    143. Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes. (PubMed id 10781953)9 Guillaume R. and Trudel M. (2000)
    144. The rat pkd2 protein assumes distinct subcellular distributions in different organs. (PubMed id 10600939)9 Obermuller N....Witzgall R. (1999)
    145. PKD1 and PKD2 mutations in Slovenian families with autosomal dominant polycystic kidney disease. (PubMed id 16430766)9 Vouk K....Komel R. (2006)
    146. Current advances in molecular genetics of autosomal-dominant polycystic kidney disease. (PubMed id 11195048)9 Wu G. (2001)
    147. Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2. (PubMed id 18037411)9 Knobel K.M....Barr M.M. (2008)
    148. Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models. (PubMed id 16720597)9 Chang M.Y....Ong A.C. (2006)
    149. Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese. (PubMed id 15775720)9 Zhang S....Song J. (2005)
    150. Increased prevalence of polycystic kidney disease type 2 among elderly polycystic patients. (PubMed id 11007674)9 Torra R....Darnell A. (2000)
    151. A spectrum of mutations in the polycystic kidney disease-2 (PKD2) gene from eight Canadian kindreds. (PubMed id 9773786)9 Pei Y....St George-Hyslop P. (1998)
    152. [Expression of PKD1 and PKD2 transcripts and proteins and its significance in different types of kidney tissues and kidney lines] (PubMed id 16536277)9 Zhao H.D....Li L. (2005)
    153. Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease. (PubMed id 12140187)9 Wu G....Somlo S. (2002)
    154. Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease. (PubMed id 11156533)9 Pei Y....St George-Hyslop P. (2001)
    155. The role of the polycystins in kidney development. (PubMed id 10412869)9 van Adelsberg J.S. (1999)
    156. Identification of genes involved in the ciliary trafficking of C. elegans PKD-2. (PubMed id 18407554)9 Bae Y.K....Knobel K.M. (2008)
    157. Common regulatory elements in the polycystic kidney disease 1 and 2 promoter regions. (PubMed id 15770226)9 Lantinga-van Leeuwen I.S....Peters D.J. (2005)
    158. Vascular expression of polycystin-2. (PubMed id 11134244)9 Torres V.E....Somlo S. (2001)
    159. Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2). (PubMed id 10602361)9 Veldhuisen B.... Peters D.J.M. (1999)
    160. Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. (PubMed id 10207066)9 Arnould T....Walz G. (1999)
    161. Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue. (PubMed id 10362797)9 Ong A.C....Harris P.C. (1999)
    162. A loss-of-function model for cystogenesis in human autosomal dominant polycystic kidney disease type 2. (PubMed id 10417277)9 Torra R....Darnell A. (1999)
    163. Somatic inactivation of Pkd2 results in polycystic kidney disease. (PubMed id 9568711)9 Wu G....Somlo S. (1998)
    164. DNA diagnosis and clinical manifestations of autosomal dominant polycystic kidney disease. (PubMed id 9595261)9 Merta M....Rysava R. (1997)
    165. Genetic heterogeneity in adult dominant polycystic kidney disease in Cypriot families. (PubMed id 7705838)9 Constantinou-Deltas C.D....Pierides A. (1995)
    166. Molecular diagnostics for autosomal dominant polycyst ic kidney disease. (PubMed id 20177400)9 Harris P.C. and Rossetti S. (2010)
    167. The RNA-binding protein bicaudal C regulates polycyst in 2 in the kidney by antagonizing miR-17 activity. (PubMed id 20215348)9 Tran U....Wessely O. (2010)
    168. Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease. (PubMed id 19165178)9 Rossetti S....Harris P.C. (2009)
    169. PKDB: Polycystic Kidney Disease Mutation Database--a gene variant database for autosomal dominant polycystic kidney disease. (PubMed id 17370309)9 Gout A.M....Ravine D. (2007)
    170. The C-terminal tail of protein kinase D2 and protein kinase D3 regulates their intracellular distribution. (PubMed id 16494840)9 Papazyan R....Rey O. (2006)
    171. DNA microsatellite analysis in families with autosomal dominant polycystic kidney disease (ADPKD): the first Polish study. (PubMed id 17132904)9 Binczak-Kuleta A....Ciechanowicz A. (2006)
    172. Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat. (PubMed id 16207829)9 Brown J.H.... Gauguier D. (2005)
    173. Association of mutation position in polycystic kidney disease 1 (PKD1) gene and development of a vascular phenotype. (PubMed id 12842373)9 Rossetti S.... Harris P.C. (2003)
    174. A tale of two tails: ciliary mechanotransduction in ADPKD. (PubMed id 12829010)9 Cantiello H.F. (2003)
    175. Immortalized epithelial cells from human autosomal dominant polycystic kidney cysts. (PubMed id 12734101)9 Loghman-Adham M....Zhou J. (2003)
    176. Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells. (PubMed id 12840011)9 Grimm D.H....Caplan M.J. (2003)
    177. Glomerulocystic kidney disease in a family. (PubMed id 11981068)9 Gusmano R....Seri M. (2002)
    178. The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. (PubMed id 11854320)9 Nickel C....Walz G. (2002)
    179. Genetic heterogeneity in Korean families with autosomal-dominant polycystic kidney disease (ADPKD): the first Asian report. (PubMed id 11553048)9 Lee J.G....Lee J.S. (2001)
    180. Molecular genetics and mechanism of autosomal dominant polycystic kidney disease. (PubMed id 10655152)9 Wu G. and Somlo S. (2000)
    181. An ever-expanding story of cyst formation. (PubMed id 10928266)9 Gallagher A.R....Witzgall R. (2000)
    182. Genetic evidence for a trans-heterozygous model for cystogenesis in autosomal dominant polycystic kidney disease. (PubMed id 10655555)9 Koptides M....Deltas C.C. (2000)
    183. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. (PubMed id 11140688)9 Hanaoka K....Germino G.G. (2000)
    184. Identification and characterization of polycystin-2, the PKD2 gene product. (PubMed id 10497221)9 Cai Y....Somlo S. (1999)
    185. Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25. (PubMed id 9878261)9 Wu G.... Somlo S. (1998)
    186. Presymptomatic molecular diagnosis of autosomal dominant polycystic kidney disease using PKD1- and PKD2-linked markers in Cypriot families. (PubMed id 8891380)9 Deltas C.C....Pierides A. (1996)
    187. ERK1/2-dependent vascular endothelial growth factor s ignaling sustains cyst growth in polycystin-2 defective mice. (PubMed id 19766642)9 Spirli C....Strazzabosco M. (2010)
    188. Diagnosis and screening of autosomal dominant polycys tic kidney disease. (PubMed id 20219617)9 Pei Y. and Watnick T. (2010)
    189. Molecular evolution of PKD2 gene family in mammals. (PubMed id 19184643)9 Ye C....Zhou Q. (2009)
    190. Unified criteria for ultrasonographic diagnosis of AD PKD. (PubMed id 18945943)9 Pei Y....Ravine D. (2009)
    191. Usefulness of combined genetic data in Hungarian families affected by autosomal dominant polycystic kidney disease. (PubMed id 19056484)9 Endreffy E....TA_ri S. (2009)
    192. Presence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history. (PubMed id 18640754)9 Reed B....Schrier R.W. (2008)
    193. Diagnostic approach in autosomal dominant polycystic kidney disease. (PubMed id 17699332)9 Pei Y. (2006)
    194. Molecular basis of autosomal dominant polycystic kidney disease. (PubMed id 15900113)9 Al-Bhalal L. and Akhtar M. (2005)
    195. [Mutation detection of PKD2 gene in Chinese by denaturing high-performance liquid chromatograph] (PubMed id 15192819)9 Zhang D.Y....Mei C.L. (2004)
    196. Autosomal recessive and dominant polycystic kidney diseases. (PubMed id 15785425)9 Sessa A....Battini G. (2004)
    197. Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2). (PubMed id 14872199)9 Boucher C. and Sandford R. (2004)
    198. Characterization of microsatellite markers to diagnose ADPKD. (PubMed id 15135448)9 Bae Y....Kang S. (2004)
    199. Molecular genetics of autosomal dominant polycystic kidney disease. (PubMed id 14596487)9 Pei Y. (2003)
    200. Towards understanding the polycystins. (PubMed id 12411744)9 Kaletta T....Wilson P. (2003)
    201. Molecular basis of autosomal dominant polycystic kidney disease. (PubMed id 10435671)9 Watnick T. and Germino G.G. (1999)
    202. The polycystins: a novel class of membrane-associated proteins involved in renal cystic disease. (PubMed id 11212307)9 Sandford R....Foggensteiner L. (1999)
    203. Autosomal dominant polycystic kidney disease: clinical and genetic aspects. (PubMed id 9442442)9 Sessa A....Turco A.E. (1997)
    204. An Italian family with autosomal dominant polycystic kidney disease unlinked to either the PKD1 or PKD2 gene. (PubMed id 9158217)9 Turco A.E....Pignatti P.F. (1996)
    205. [Clinical analysis of a population with autosomal dom inant polycystic kidney disease] (PubMed id 20098473)9 GA^mez P.F....Romo J.M. (2010)
    206. Colchicine treatment in autosomal dominant polycystic kidney disease: many points in common. (PubMed id 19765912)9 Solak Y....Biyik Z. (2010)
    207. Carboxy terminal tail of polycystin-1 regulates local ization of TSC2 to repress mTOR. (PubMed id 20169078)9 Dere R....Walker C.L. (2010)
    208. A novel dephosphorylation-activated conductance in a mouse renal collecting duct cell line. (PubMed id 19429644)9 Laycock S....Robson L. (2009)
    209. Polycystic kidney disease. (PubMed id 18947299)9 Harris P.C. and Torres V.E. (2009)
    210. Might there be an association between polycystic kidn ey disease and noncompaction of the ventricular myocardium? (PubMed id 19762607)9 Lubrano R....Elli M. (2009)
    211. Kidney function and volume progression in unilateral autosomal dominant polycystic kidney disease with contralateral renal agenesis or hypoplasia: a case series. (PubMed id 19515475)9 Poster D....Serra A.L. (2009)
    212. Polycystin-1 and -2 dosage regulates pressure sensing . (PubMed id 19879844)9 Sharif-Naeini R....HonorAc E. (2009)
    213. Emerging evidence of a link between the polycystins a nd the mTOR pathways. (PubMed id 19863783)9 Boletta A. (2009)
    214. Linkage confirms canine pkd1 orthologue as a candidat e for bull terrier polycystic kidney disease. (PubMed id 19397527)9 O'Leary C.A....Corley S. (2009)
    215. Pkd2 dosage influences cellular repair responses foll owing ischemia-reperfusion injury. (PubMed id 19729489)9 Prasad S....Ong A.C. (2009)
    216. Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. (PubMed id 18235088)9 Kim I....Wu G. (2008)
    217. Characterization of large rearrangements in autosomal dominant polycystic kidney disease and the PKD1/TSC2 contiguous gene syndrome. (PubMed id 18818683)9 Consugar M.B....Harris P.C. (2008)
    218. Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions. (PubMed id 18505769)9 Chu T.J. and Peters D.G. (2008)
    219. Kidney cysts, pancreatic cysts, and biliary disease in a mouse model of autosomal recessive polycystic kidney disease. (PubMed id 18286309)9 Williams S.S....Igarashi P. (2008)
    220. Mouse models of polycystic kidney disease. (PubMed id 19186247)9 Wilson P.D. (2008)
    221. [Autosomal dominant polycystic kidney disease: from g enes to cilium] (PubMed id 18350498)9 Magistroni R....Albertazzi A. (2008)
    222. Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease. (PubMed id 17429049)9 Rossetti S. and Harris P.C. (2007)
    223. TRP channels and kidney disease: lessons from polycystic kidney disease. (PubMed id 17233617)9 Qamar S....Sandford R. (2007)
    224. Cardiovascular characterization of Pkd2(+/LacZ) mice, an animal model for the autosomal dominant polycystic kidney disease type 2 (ADPKD2). (PubMed id 17182135)9 Stypmann J....Pennekamp P. (2007)
    225. Molecular pathogenesis of autosomal dominant polycystic kidney disease. (PubMed id 16515728)9 Yoder B.K....Sandford R. (2006)
    226. Nonspecific cation current associated with native polycystin-2 in HEK-293 cells. (PubMed id 16396967)9 Pelucchi B....Belluzzi O. (2006)
    227. [Molecular diagnosis of adult dominant polycystic kidney disease in the Canary Islands] (PubMed id 17227243)9 Torres M.J....Palop L. (2006)
    228. Research on autosomal dominant polycystic kidney disease in China. (PubMed id 17134592)9 Dai B. and Mei C.L. (2006)
    229. A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats. (PubMed id 16943309)9 Gallagher A.R....Witzgall R. (2006)
    230. A regulatory role of polycystin-1 on cystic fibrosis transmembrane conductance regulator plasma membrane expression. (PubMed id 16914886)9 Ikeda M....Guggino W.B. (2006)
    231. Polycystins: polymodal receptor/ion-channel cellular sensors. (PubMed id 15889307)9 Delmas P. (2005)
    232. Polycystic liver and kidney diseases. (PubMed id 16338757)9 Tahvanainen E....Hockerstedt K. (2005)
    233. Polycystic kidney disease. (PubMed id 16227765)9 Fall P.J. and Prisant L.M. (2005)
    234. Feline polycystic kidney disease is linked to the PKD1 region. (PubMed id 15674734)9 Young A.E....Lyons L.A. (2005)
    235. [Cystic liver diseases. Genetics and cell biology] (PubMed id 16294159)9 Housset C. (2005)
    236. The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans. (PubMed id 15753033)9 Peden E.M. and Barr M.M. (2005)
    237. Management of polycystic liver disease. (PubMed id 15701294)9 Everson G.T. and Taylor M.R. (2005)
    238. Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease. (PubMed id 16049073)9 Le N.H....Peters D.J. (2005)
    239. Polycystins: what polycystic kidney disease tells us about sperm. (PubMed id 14991728)9 Kierszenbaum A.L. (2004)
    240. New insights into ADPKD molecular pathways using combination of SAGE and microarray technologies. (PubMed id 15498457)9 Husson H....Ibraghimov-Beskrovnaya O. (2004)
    241. The genetic role in autosomal dominant polycystic kidney disease and nephrology clinical practice. (PubMed id 15673153)9 Avery-Lynch M. (2004)
    242. Calcium signaling and polycystin-2. (PubMed id 15336985)9 Anyatonwu G.I. and Ehrlich B.E. (2004)
    243. A transcriptional network in polycystic kidney disease. (PubMed id 15029248)9 Gresh L....Pontoglio M. (2004)
    244. Evolutionary conservation of Drosophila polycystin-2 as a calcium-activated cation channel. (PubMed id 15100357)9 Venglarik C.J....Lu X. (2004)
    245. Siah-1 interacts with the intracellular region of polycystin-1 and affects its stability via the ubiquitin-proteasome pathway. (PubMed id 15284290)9 Kim H....Kang S. (2004)
    246. Molecular cytogenetic aberrations in autosomal dominant polycystic kidney disease tissue. (PubMed id 12538736)9 Gogusev J....Droz D. (2003)
    247. Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease. (PubMed id 12529853)9 Li A.... Somlo S. (2003)
    248. Polycystin-1 activates and stabilizes the polycystin-2 channel. (PubMed id 12407099)9 Xu G.M....Cantiello H.F. (2003)
    249. Molecular basis of autosomal-dominant polycystic kidney disease. (PubMed id 12022474)9 Gallagher A.R....Witzgall R. (2002)
    250. Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1. (PubMed id 11981261)9 Harris P.C. (2002)
    251. The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation. (PubMed id 11959145)9 Li Q....Chen X.Z. (2002)
    252. A complete mutation screen of the ADPKD genes by DHPLC. (PubMed id 11967008)9 Rossetti S.... Harris P.C. (2002)
    253. [Polymorphisms of four microsatellite markers tightly linked with polycystic kidney disease 2 gene in Chinese] (PubMed id 11836683)9 Ding L....Peng Y. (2002)
    254. Polycystin-2 expression is increased following experimental ischaemic renal injury. (PubMed id 12454224)9 Zhao Y....Ong A.C. (2002)
    255. The genes and proteins associated with poly-cystic kidney diseases. (PubMed id 12536190)9 Wilson P.D. (2002)
    256. Clinical and genetic epidemiology of inherited renal disease in Newfoundland. (PubMed id 12028433)9 Parfrey P.S....Green J.S. (2002)
    257. Polycystin: new aspects of structure, function, and regulation. (PubMed id 11274246)9 Wilson P.D. (2001)
    258. Autosomal dominant polycystic kidney disease: modification of disease progression. (PubMed id 11705510)9 Peters D.J. and Breuning M.H. (2001)
    259. Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease. (PubMed id 11160770)9 Arnaout M.A. (2001)
    260. The genetics and physiology of polycystic kidney disease. (PubMed id 11245774)9 Calvet J.P. and Grantham J.J. (2001)
    261. Mutations of the PKD1 gene among Japanese autosomal dominant polycystic kidney disease patients, including one heterozygous mutation identified in members of the same family. (PubMed id 11558899)9 Mizoguchi M.... Shimizu Y. (2001)
    262. Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X. (PubMed id 11302751)9 Chen X.Z....Zhou J. (2001)
    263. Cloning of the gene encoding a novel integral membrane protein, mucolipidin, and identification of the two major founder mutations causing mucolipidosis type IV. (PubMed id 11013137)9 Bassi M.T.... Borsani G. (2000)
    264. Loss of heterozygosity in renal and hepatic epithelial cystic cells from ADPKD1 patients. (PubMed id 10909847)9 Badenas C....Darnell A. (2000)
    265. New insights into the molecular pathophysiology of polycystic kidney disease. (PubMed id 10200981)9 Murcia N.S....Avner E.D. (1999)
    266. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. (PubMed id 10517638)9 Barr M.M. and Sternberg P.W. (1999)
    267. Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects. (PubMed id 9748274)9 Nomura H.... Zhou J. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5311 HGNC: 9009 AceView: PKD2 Ensembl:ENSG00000118762 euGenes: HUgn5311
    ECgene: PKD2 H-InvDB: PKD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PKD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PKD2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PKD2
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_205

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PKD2 gene:
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