Aliases for PKD2 Gene
- Polycystic Kidney Disease 2 (Autosomal Dominant) 2 3
- Autosomal Dominant Polycystic Kidney Disease Type II Protein 3 4
- Polycystwin 3 4
- R48321 3 4
- Transient Receptor Potential Cation Channel, Subfamily P, Member 2 3
- Transient Receptor Potential Cation Channel 2
- Polycystic Kidney Disease 2 Protein 4
- Polycystin-2 3
External Ids for PKD2 Gene
Previous GeneCards Identifiers for PKD2 Gene
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
GeneCards Summary for PKD2 Gene
PKD2 (Polycystic Kidney Disease 2 (Autosomal Dominant)) is a Protein Coding gene. Diseases associated with PKD2 include polycystic kidney disease 2 and polycystic kidney disease, autosomal dominant. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is PKD1L1.
UniProtKB/Swiss-Prot for PKD2 Gene
Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning (By similarity).