Aliases for PKD2 Gene
- Polycystin 2, Transient Receptor Potential Cation Channel 2 3 5
- Transient Receptor Potential Cation Channel Subfamily P Member 2 3 4
- Autosomal Dominant Polycystic Kidney Disease Type II Protein 3 4
- Polycystic Kidney Disease 2 (Autosomal Dominant) 2 3
- Polycystwin 3 4
- R48321 3 4
- TRPP2 3 4
- Transient Receptor Potential Cation Channel, Subfamily P, Member 2 2
External Ids for PKD2 Gene
Previous GeneCards Identifiers for PKD2 Gene
This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
GeneCards Summary for PKD2 Gene
PKD2 (Polycystin 2, Transient Receptor Potential Cation Channel) is a Protein Coding gene. Diseases associated with PKD2 include Polycystic Kidney Disease 2 and Polycystic Kidney Disease, Autosomal Dominant. Among its related pathways are Organelle biogenesis and maintenance and Cargo trafficking to the periciliary membrane. GO annotations related to this gene include calcium ion binding and identical protein binding. An important paralog of this gene is PKD2L1.
UniProtKB/Swiss-Prot for PKD2 Gene
Functions as a calcium permeable cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Together with TRPV4, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD1L1 in cilia to facilitate flow detection in left/right patterning (By similarity).