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PKD1L2 Gene

protein-coding   GIFtS: 54
GCID: GC16M081135

Polycystic Kidney Disease 1-Like 2

  See PKD1L2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polycystic Kidney Disease 1-Like 21 2     polycystin-1L22
PC1L22 3     KIAA18793
PC1-Like 2 Protein2 3     Polycystin-1L23
Polycystic Kidney Disease Protein 1-Like 22     

External Ids:    HGNC: 217151   Entrez Gene: 1147802   Ensembl: ENSG000001664737   OMIM: 6078945   UniProtKB: Q7Z4423   

Export aliases for PKD1L2 gene to outside databases

Previous GC identifers: GC16M080885 GC16M080914 GC16M079691 GC16M066891


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PKD1L2 Gene:
This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane
domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase,
alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jun 2013)

GeneCards Summary for PKD1L2 Gene:
PKD1L2 (polycystic kidney disease 1-like 2) is a protein-coding gene. Diseases associated with PKD1L2 include polycystic kidney disease, and kidney disease. GO annotations related to this gene include carbohydrate binding and calcium ion binding. An important paralog of this gene is PKD2.

UniProtKB/Swiss-Prot: PK1L2_HUMAN, Q7Z442
Function: May function as an ion-channel regulator. May function as a G-protein-coupled receptor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PKD1L2 gene promoter:
         Max1   LHX3b/Lhx3b   HTF   MyoD   LCR-F1   S8   GATA-6   LHX3a/Lhx3a   Sox9   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPKD1L2 promoter sequence
   Search Chromatin IP Primers for PKD1L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PKD1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.2   Ensembl cytogenetic band:  16q23.2   HGNC cytogenetic band: 16q23.2

PKD1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKD1L2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M081135:  view genomic region     (about GC identifiers)

Start:
81,134,480 bp from pter      End:
81,253,975 bp from pter
Size:
119,496 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PK1L2_HUMAN, Q7Z442 (See protein sequence)
Recommended Name: Polycystic kidney disease protein 1-like 2 precursor  
Size: 2459 amino acids; 272575 Da
Subunit: May interact via its C-terminus with GNAS and GNAI1
Developmental stage: Expressed in fetal heart
Sequence caution: Sequence=AAQ73173.1; Type=Frameshift; Positions=2113, 2117; Sequence=AAQ73173.1;
Type=Frameshift; Positions=2114, 2218; Sequence=BAB67772.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened; Sequence=BAC05222.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6UEE1 Q6ZN46 Q6ZSP2 Q8N1H9 Q96CL2 Q96Q08
Alternative splicing: 7 isoforms:  Q7Z442-1   Q7Z442-2   Q7Z442-3   Q7Z442-4   Q7Z442-5   Q7Z442-6   Q7Z442-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PKD1L2: NX_Q7Z442

Explore proteomics data for PKD1L2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn96, Asn110, Asn268, Asn307, Asn441, Asn536, Asn1176, Asn1186

  • See PKD1L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001070248.1  NP_001265352.1  NP_001265354.1  NP_443124.3  

    ENSEMBL proteins: 
     ENSP00000434644   ENSP00000434417   ENSP00000436309   ENSP00000436389   ENSP00000432818  
     ENSP00000337397  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 11):
     IPR002859 PKD/REJ-like
     IPR000922 Lectin_gal-bd_dom
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR003915 PKD_2

    Graphical View of Domain Structure for InterPro Entry Q7Z442

    ProtoNet protein and cluster: Q7Z442

    1 Blocks protein domain: IPB000922 D-galactoside/L-rhamnose binding SUEL lectin domain

    UniProtKB/Swiss-Prot: PK1L2_HUMAN, Q7Z442
    Similarity: Belongs to the polycystin family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 1 GPS domain
    Similarity: Contains 1 PLAT domain
    Similarity: Contains 1 REJ domain
    Similarity: Contains 1 SUEL-type lectin domain


    Find genes that share domains with PKD1L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK1L2_HUMAN, Q7Z442
    Function: May function as an ion-channel regulator. May function as a G-protein-coupled receptor

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005261cation channel activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0008324cation transmembrane transporter activity ----
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with PKD1L2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PKD1L2:
     Decreased p24 protein expressi 

         1 MGI phenotypic allele for Pkd1l2 (no phenotypes)

    Find genes that share phenotypes with PKD1L2           About GenesLikeMe

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PK1L2_HUMAN, Q7Z442: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PKD1L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PKD1L2 About    
    See pathways by source

    SuperPathContained pathways About
    1Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    2Adenylate cyclase activating neuropeptides
    Adenylate cyclase activating neuropeptides




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    Interactions:

        Search GeneGlobe Interaction Network for PKD1L2

    1 Interacting protein for PKD1L2 (Q7Z4423) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SHC1P293533I2D: score=2 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001581detection of chemical stimulus involved in sensory perception of sour taste ----
    GO:0006811ion transport ----
    GO:0006812cation transport ----
    GO:0007218neuropeptide signaling pathway IEA--
    GO:0071468cellular response to acidity IEA--

    Find genes that share ontologies with PKD1L2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for PKD1L2 (PK1L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PKD1L2 gene (5 alternative transcripts): 
    NM_001076780.1  NM_001278423.1  NM_001278425.1  NM_052892.3  NM_182740.1  

    Unigene Cluster for PKD1L2:

    Polycystic kidney disease 1-like 2
    Hs.413525  [show with all ESTs]
    Unigene Representative Sequence: NM_052892
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534447 ENST00000534142(uc002fgf.1) ENST00000533478(uc002fgg.1)
    ENST00000525539(uc002fgh.1) ENST00000530363 ENST00000299598 ENST00000529079
    ENST00000531391(uc002fgi.3) ENST00000526632 ENST00000527937(uc002fgk.1 uc002fgl.1)
    ENST00000529791 ENST00000337114(uc002fgj.3)
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    Additional mRNA sequence: 

    AK098052.1 AK127266.1 AK131378.1 AL832135.1 AY164483.1 AY371495.1 BC004562.2 BC014157.2 
    CR627341.1 

    8 DOTS entries:

    DT.100649542  DT.92028011  DT.100740302  DT.102822899  DT.99930336  DT.97836505  DT.100001488  DT.95291811 

    Selected AceView cDNA sequences (see all 37):

    BX115637 BC014157 BM841886 BE503919 BC004562 BM840998 AA669315 AB067466 
    BX481943 AK131378 BM841509 BG104257 AA157971 BG718223 NM_182740 NM_052892 
    BI861303 CA438401 CA397713 BV172285 CR627341 BC014120 CB266350 AY164483 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PKD1L2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^
    SP1:                                                                    -           -                                   -                                       
    SP2:                                -                                   -                                                                                       
    SP3:                                                                                                                                                            
    SP4:                                                                    -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41a · 41b
    SP1:                                            -     -                       -                       -                 -                                 
    SP2:                                                                                                                                                      
    SP3:                                                  -                       -                       -                 -                                 
    SP4:                                                                                                                                                      
    SP5:                                -           -     -                       -     -                                                                     


    ECgene alternative splicing isoforms for PKD1L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PKD1L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAATAAA
    PKD1L2 Expression
    About this image

    PKD1L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PKD1L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.413525

    UniProtKB/Swiss-Prot: PK1L2_HUMAN, Q7Z442
    Tissue specificity: Expressed in all tissues tested including brain, placenta, mammary gland, testis, lung and
    liver. Highest expression in skeletal muscle. Isoform 2 is expressed in heart and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PKD1L2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkd1l21 , 5 polycystic kidney disease 1 like 21, 5 80.01(n)1
    74.36(a)1
      8 (63.45 cM)5
    766451  NM_029686.41  NP_083962.41 
     1169956795 
    chicken
    (Gallus gallus)
    Aves LOC1008584371 polycystic kidney disease protein 1-like 2-like 63.64(n)
    58.3(a)
      100858437  XM_004944313.1  XP_004944370.1 
    lizard
    (Anolis carolinensis)
    Reptilia PKD1L26
    polycystic kidney disease 1-like 2
    1(a)
    1 ↔ 1
    GL343483.1(336740-346755)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.326802 Xenopus laevis transcribed sequence with weak similarity more 77.66(n)    BJ068659.1 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71384751 im:7138475 56.14(n)
    49.83(a)
      497373  XM_002662913.2  XP_002662959.2 
    worm
    (Caenorhabditis elegans)
    Secernentea lov-16
    Protein LOV-1 (lov-1) mRNA, complete cds
    1(a)
    1 ↔ 1
    II(10109279-10121825) WBGene00003058


    ENSEMBL Gene Tree for PKD1L2 (if available)
    TreeFam Gene Tree for PKD1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PKD1L2 gene
    PKD22  PKDREJ2  PKD12  PKD2L22  PKD2L12  PKD1L12  
    3 SIMAP similar genes for PKD1L2 using alignment to 5 protein entries:     PK1L2_HUMAN (see all proteins):
    DKFZp686J19100    PKD2L2    PKD1L3

    Find genes that share paralogs with PKD1L2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for PKD1L2
    PGOHUM00000258025


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PKD1L2 (see all 5222)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1119486631,2
    C--81137974(+) CTATTA/-AAAAA 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs356566991,2
    C--81137975(+) AAAAAA/-GAAGG 1 -- int11Minor allele frequency- -:0.00NA 2
    rs30602411,2
    C--81138753(+) ttttt-/TT    
       
    /TTTT
    agaca
    1 -- int11NA 2
    rs340992801,2
    C--81140412(+) TGTTC-/TGTGTTA 1 -- int10--------
    rs711436741,2
    C--81140413(-) TTAAC-/ACAGAAC 1 -- int11Minor allele frequency- AC:0.00NA 2
    rs2005025231,2
    C--81140413(-) TAACAC/GAGAAC 1 -- int10--------
    rs576757571,2
    C--81140415(+) TCTGT-/G/GT  
            
    TAAGT
    1 -- int10--------
    rs357890541,2
    C--81140432(+) TTAGTA/-GAAAT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs673237051,2
    C--81140433(+) TAGTG-/AAAATA 1 -- int10--------
    rs105512261,2
    C--81143613(+) GTATA-/TTTG  
            
    TTTGT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for PKD1L2 (81134480 - 81253975 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PKD1L2 (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714776CNV Deletion23290073
    esv2672172CNV Deletion23128226
    esv2714777CNV Deletion23290073
    dgv510e199CNV Deletion23128226
    esv2668114CNV Deletion23128226
    esv2664656CNV Deletion23128226
    esv2714775CNV Deletion23290073
    esv2672468CNV Deletion23128226
    esv1317764CNV Deletion17803354
    esv2662178CNV Deletion23128226

    Human Gene Mutation Database (HGMD): PKD1L2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PKD1L2
    DNA2.0 Custom Variant and Variant Library Synthesis for PKD1L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607894    OMIM disorders: --

    2 diseases for PKD1L2:    
    About MalaCards
    polycystic kidney disease    kidney disease

    1 disease from the University of Copenhagen DISEASES database for PKD1L2:
    Polycystic kidney disease

    Find genes that share disorders with PKD1L2           About GenesLikeMe

    Genetic Association Database (GAD): PKD1L2
    Human Genome Epidemiology (HuGE) Navigator: PKD1L2 (3 documents)

    Export disorders for PKD1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PKD1L2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with PKD1L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes. (PubMed id 12782129)1, 2, 3 Li A.... Somlo S. (Genomics 2003)
    2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    3. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PubMed id 18951430)1, 4 Anney R.J....Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    4. Polycystin-1L2 is a novel G-protein-binding protein. (PubMed id 15203210)1, 2 Yuasa T.... Zhou J. (Genomics 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    7. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    8. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    9. Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. (PubMed id 19185284)4 Ferrucci L....Frayling T.M. (Am. J. Hum. Genet. 2009)
    10. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. (PubMed id 19729612)4 Paterson A.D....Bull S.B. (Arterioscler. Thromb. Vasc. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114780 HGNC: 21715 AceView: PKD1L2 Ensembl:ENSG00000166473 euGenes: HUgn114780
    ECgene: PKD1L2 H-InvDB: PKD1L2

    (According to HUGE)
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    HUGE: KIAA1879

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PKD1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PKD1L2 gene:
    Search GeneIP for patents involving PKD1L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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