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PKD1L1 Gene

protein-coding   GIFtS: 52
GCID: GC07M047780

Polycystic Kidney Disease 1 Like 1

  See PKD1L1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Polycystic Kidney Disease 1 Like 11 2
polycystin-1L11 2
PC1-Like 1 Protein2 3
PRO195632
Polycystic Kidney Disease Protein 1-Like 12
Polycystin-1L13

External Ids:    HGNC: 180531   Entrez Gene: 1685072   Ensembl: ENSG000001586837   OMIM: 6097215   UniProtKB: Q8TDX93   

Export aliases for PKD1L1 gene to outside databases

Previous GC identifers: GC07M047461 GC07M047555 GC07M047587 GC07M047698


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PKD1L1 Gene:
This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for
egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play
a role in the male reproductive system. Alternative splice variants have been described but their biological
nature has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for PKD1L1 Gene:
PKD1L1 (polycystic kidney disease 1 like 1) is a protein-coding gene. Diseases associated with PKD1L1 include diaphanospondylodysostosis, and polycystic kidney disease. GO annotations related to this gene include calcium channel activity. An important paralog of this gene is PKD2.

UniProtKB/Swiss-Prot: PK1L1_HUMAN, Q8TDX9
Function: Component of a ciliary calcium channel that controls calcium concentration within primary cilia without
affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a
calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not
constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow:
forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PKD1L1 gene promoter:
         ATF-2   Nkx2-5   CBF-C   CRE-BP1   CBF-A   CBF-B   CP1C   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPKD1L1 promoter sequence
   Search Chromatin IP Primers for PKD1L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PKD1L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.3   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p12.3

PKD1L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PKD1L1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M047780:  view genomic region     (about GC identifiers)

Start:
47,814,250 bp from pter      End:
47,988,088 bp from pter
Size:
173,839 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 47,854,508-48,027,995     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PK1L1_HUMAN, Q8TDX9 (See protein sequence)
Recommended Name: Polycystic kidney disease protein 1-like 1  
Size: 2849 amino acids; 315435 Da
Subunit: Heterodimer; heterodimerizes with PKD2 proteins to form a calcium channel. Interacts with PKD2L1; to form
ciliary calcium channel. Interacts with PKD2
Sequence caution: Sequence=AAQ89117.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6UWK1
Alternative splicing: 2 isoforms:  Q8TDX9-1   Q8TDX9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PKD1L1: NX_Q8TDX9

Explore proteomics data for PKD1L1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8, Asn295, Asn338, Asn376, Asn447, Asn482, Asn514, Asn605, Asn657, Asn751,
                                 Asn875, Asn926, Asn937, Asn1233, Asn1301, Asn1306, Asn1572, Asn1681, Asn1716, Asn2426
  • Modification sites at PhosphoSitePlus

  • See PKD1L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612152.1  
    ENSEMBL proteins: 
     ENSP00000289672   ENSP00000393466  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR002859 PKD/REJ-like
     IPR000601 PKD_dom
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR014010 REJ-like

    Graphical View of Domain Structure for InterPro Entry Q8TDX9

    ProtoNet protein and cluster: Q8TDX9

    3 Blocks protein domains:
    IPB000601 PKD
    IPB001024 Lipoxygenase
    IPB002859 PKD/REJ-like protein


    UniProtKB/Swiss-Prot: PK1L1_HUMAN, Q8TDX9
    Similarity: Belongs to the polycystin family
    Similarity: Contains 1 GPS domain
    Similarity: Contains 2 PKD domains
    Similarity: Contains 1 PLAT domain
    Similarity: Contains 1 REJ domain


    Find genes that share domains with PKD1L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PK1L1_HUMAN, Q8TDX9
    Function: Component of a ciliary calcium channel that controls calcium concentration within primary cilia without
    affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a
    calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not
    constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow:
    forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005262calcium channel activity IBA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with PKD1L1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PKD1L1:
     Increased S DNA content 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Pkd1l1):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size/body  homeostasis/metabolism 
     mortality/aging  nervous system  normal  renal/urinary system  reproductive system 
     respiratory system 

    Find genes that share phenotypes with PKD1L1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pkd1l1tm1Lex for PKD1L1

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    hsa-miR-3128
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PK1L1_HUMAN, Q8TDX9: Cell projection, cilium membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    golgi apparatus2
    nucleus2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005929cilium ISS--
    GO:0016020membrane TAS11863367
    GO:0016021integral component of membrane IEA--
    GO:0060170ciliary membrane IEA--

    Find genes that share ontologies with PKD1L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PKD1L1 About    
    See pathways by source

    SuperPathContained pathways About
    1Neuropeptides signaling through G protein alpha i and G protein alpha q
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    2Adenylate cyclase activating neuropeptides
    Adenylate cyclase activating neuropeptides



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PKD1L1
    Interactions:

        Search GeneGlobe Interaction Network for PKD1L1

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003127detection of nodal flow ISS--
    GO:0016337cell-cell adhesion NAS11863367
    GO:0050982detection of mechanical stimulus IBA--
    GO:0070588calcium ion transmembrane transport ----
    GO:0070986left/right axis specification ISS--

    Find genes that share ontologies with PKD1L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for PKD1L1 (PK1L1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PKD1L1 gene: 
    NM_138295.3  

    Unigene Cluster for PKD1L1:

    Polycystic kidney disease 1 like 1
    Hs.195979  [show with all ESTs]
    Unigene Representative Sequence: NM_138295
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289672(uc003tny.2) ENST00000483616(uc003tob.3) ENST00000462350
    ENST00000433506
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate PKD1L1:
    hsa-miR-3128
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    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat PKD1L1

    Additional mRNA sequence: 

    AB061683.1 AY358757.1 

    2 DOTS entries:

    DT.100017125  DT.75111827 

    5 AceView cDNA sequences:

    AX747337 CA420605 AK092057 AK024728 NM_025031 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PKD1L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCACACGA
    PKD1L1 Expression
    About this image


    PKD1L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    PKD1L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PKD1L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.195979

    UniProtKB/Swiss-Prot: PK1L1_HUMAN, Q8TDX9
    Tissue specificity: Detected in testis and in fetal and adult heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PKD1L1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pkd1l11 , 5 polycystic kidney disease 1 like 11, 5 72.73(n)1
    61.85(a)1
      11 (5.57 cM)5
    1713951  XM_006514925.11  XP_006514988.11 
     88267085 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    16(a)
    many ↔ many
    LGc(5744709-5791782)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004920561 polycystic kidney disease protein 1-like 1-like 50.97(n)
    38.62(a)
      100492056  XM_002933413.2  XP_002933459.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018871301 polycystic kidney disease protein 1-like 1-like 46.82(n)
    35.43(a)
      101887130  XM_005162630.1  XP_005162687.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta brv36
    brv16
    (see all 3)
    brivido-1
    (see all 3)
    13(a)
    13(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    X(2516102-2518608)
    3L(19476926-19479598)


    ENSEMBL Gene Tree for PKD1L1 (if available)
    TreeFam Gene Tree for PKD1L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PKD1L1 gene
    PKD22  PKDREJ2  PKD12  PKD2L22  PKD1L22  PKD2L12  

    Find genes that share paralogs with PKD1L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PKD1L1 (see all 3564)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126695191,2
    C,H--47813816(+) TGAGGC/AAGGTT 1 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1500328021,2
    C--47813819(+) GGCAGA/GTTCCA 1 -- ds50010--------
    rs1867165771,2
    --47813858(+) TTGTGG/TATTAA 1 -- ds50010--------
    rs1453699921,2
    --47814048(+) ACTTCC/TACCCA 1 -- ds50010--------
    rs1895482901,2
    --47814086(+) GCATAC/TTGAAA 1 -- ds50010--------
    rs1491578871,2
    C--47814088(+) ATATTG/TAAACT 1 -- ds50010--------
    rs1811319281,2
    --47814155(+) TCTGAC/TCTGAG 1 -- ds50010--------
    rs1173918621,2
    C,F--47814164(+) AGCACG/ATAGGT 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1432988831,2
    --47814343(+) GAATGC/TTATCC 1 -- ut310--------
    rs1467751721,2
    --47814506(+) AGAATC/TTTGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PKD1L1 (47814250 - 47988088 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for PKD1L1 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734359CNV Deletion23290073
    esv2734360CNV Deletion23290073
    esv272374CNV Insertion20981092
    esv269639CNV Insertion20981092
    nsv365291CNV Loss16902084
    nsv830990CNV Loss17160897
    nsv824090CNV Loss20364138
    nsv830991CNV Loss17160897
    nsv888003CNV Gain21882294
    nsv470221CNV Gain18288195

    Human Gene Mutation Database (HGMD): PKD1L1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609721    OMIM disorders: --

    3 diseases for PKD1L1:    
    About MalaCards
    diaphanospondylodysostosis    polycystic kidney disease    kidney disease

    1 disease from the University of Copenhagen DISEASES database for PKD1L1:
    Primary ciliary dyskinesia

    Find genes that share disorders with PKD1L1           About GenesLikeMe

    Genetic Association Database (GAD): PKD1L1
    Human Genome Epidemiology (HuGE) Navigator: PKD1L1 (1 document)

    Export disorders for PKD1L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PKD1L1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PKD1L1)
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    1. The sequence, expression, and chromosomal localization of a novel polycystic kidney disease 1-like gene, PKD1L1, in human. (PubMed id 11863367)1, 2, 3, 9 Yuasa T.... Zhou J. (Genomics 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Polycystin-1L2 is a novel G-protein-binding protein. (PubMed id 15203210)1, 9 Yuasa T.... Zhou J. (Genomics 2004)
    5. Direct recording and molecular identification of the calcium channel of primary cilia. (PubMed id 24336289)2 DeCaen P.G.... Clapham D.E. (Nature 2013)
    6. Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. (PubMed id 22841784)1 Patin E.... . (Gastroenterology 2012)
    7. BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing. (PubMed id 20869035)2 Funari V.A.... Cohn D.H. (Am. J. Hum. Genet. 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    10. Molecular complexes formed with polycystins. (PubMed id 12411743)1 Lakkis M. and Zhou J. (Nephron Exp. Nephrol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 168507 HGNC: 18053 AceView: FLJ21075 Ensembl:ENSG00000158683 euGenes: HUgn168507
    ECgene: PKD1L1 H-InvDB: PKD1L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PKD1L1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PKD1L1 gene:
    Search GeneIP for patents involving PKD1L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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