Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PJA2 Gene

protein-coding   GIFtS: 54
GCID: GC05M108698

praja ring finger 2, E3 ubiquitin protein ligase

(Previous names: ring finger protein 131, praja ring finger 2 )
(Previous symbol: RNF131)
 Explore 2 diseases affiliated with
PJA2 via our new
 Human Malady Compendium 
Biological research products
for PJA2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Praja Ring Finger 2, E3 Ubiquitin Protein Ligase1 2     E3 Ubiquitin-Protein Ligase Praja-22
RING Finger Protein 1311 2 3     Praja 2, RING-H2 Motif Containing2
RNF1311 2 3     Praja23
Neurodap11 2     EC 6.3.2.-3
KIAA04381 3     Praja23
Praja Ring Finger 21     EC 6.3.28

External Ids:    HGNC: 174811   Entrez Gene: 98672   Ensembl: ENSG000001989617   UniProtKB: O431643   

Export aliases for PJA2 gene to outside databases

Previous GC identifers: GC05M108701 GC05M108746 GC05M108733 GC05M103843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PJA2_HUMAN, O43164
Function: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent
protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation.
Essential for PKA-mediated long-term memory processes

Gene Wiki entry for PJA2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PJA2 gene promoter:
         c-Fos   C/EBPbeta   AP-1   Sp1   JunB   Fra-1   FosB   YY1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPJA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for PJA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PJA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.3   Ensembl cytogenetic band:  5q21.3   HGNC cytogenetic band: 5q22.1

PJA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PJA2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M108698:  view genomic region     (about GC identifiers)

Start:
108,670,410 bp from pter      End:
108,745,695 bp from pter
Size:
75,286 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PJA2_HUMAN, O43164 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase Praja-2  
Size: 708 amino acids; 78214 Da
Subunit: Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2.
The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent
protein kinase
Subcellular location: Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi
apparatus membrane; Peripheral membrane protein. Cell junction, synapse (By similarity). Cell junction, synapse,
postsynaptic cell membrane, postsynaptic density (By similarity). Note=Localizes at the cytoplasmic side of
endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity).
Co-localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane
Sequence caution: Sequence=BAA23710.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6U4 D3DSZ5 Q68D49 Q8N1G5
Alternative splicing: 2 isoforms:  O43164-1   O43164-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PJA2: NX_O43164

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43164

  • 4/5 DME Specific Peptides for PJA2 (O43164) (see all 5)
     ATELPCHH  TGRRYGRRHAYVSF  FMLDGNNNLEDDSSVSEDL  FHKPCVSIWLQKSGTCPVCR 

    PJA2 Protein expression data from MOPED and PaxDb:    About this image 
    PJA2 Protein Expression
    REFSEQ proteins: NP_055634.3  
    ENSEMBL proteins: 
     ENSP00000354775   ENSP00000355284  
    Reactome Protein details: O43164
    Human Recombinant Protein Products for PJA2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PJA2
    OriGene Custom Protein Services for PJA2 
    GenScript Custom Purified and Recombinant Proteins Services for PJA2
    Novus Biologicals PJA2 Proteins
    Novus Biologicals PJA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PJA2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005737cytoplasm IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density IEA--

    PJA2 for ontologies           About GeneDecksing



    PJA2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for PJA2 
    GenScript Custom Superior Antibodies Services for PJA2
    Novus Biologicals PJA2 Antibodies
    Abcam antibodies for PJA2 
    Uscn Antibodies for PJA2
    Search ThermoFisher Antibodies for PJA2

    Assay Products for PJA2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PJA2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PJA2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PJA2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry O43164

    ProtoNet protein and cluster: O43164

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB002052 N-6 Adenine-specific DNA methylase


    UniProtKB/Swiss-Prot: PJA2_HUMAN, O43164
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PJA2_HUMAN, O43164
    Function: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent
    protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation.
    Essential for PKA-mediated long-term memory processes

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0034236protein kinase A catalytic subunit binding IMP--
    GO:0034237protein kinase A regulatory subunit binding IMP--
         
    PJA2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PJA2:
     Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PJA2 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: PJA2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PJA2
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate PJA2 (see all 79):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-3607-3p hsa-miR-631 hsa-miR-3146 hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidPJA2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PJA2 (see all 7)
    OriGene shRNA RFP: PJA2
    OriGene siRNA: PJA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PJA2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PJA2 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PJA2
    Sirion Biotech Customized adenovirus for overexpression of PJA2 
    Sirion Biotech Customized adenovirus for potent knockdown of PJA2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PJA2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PJA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PJA2 (NM_014819)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PJA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PJA2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PJA2
    Search LifeMap BioReagents cell lines for PJA2
    Sirion Biotech Customized stable knockdown cell line services for PJA2 
    Sirion Biotech Customized inducible knockdown cell line services for PJA2
    Sirion Biotech Customized stable overexpressing cell line services for PJA2
    Sirion Biotech Customized inducible overexpressing cell line services for PJA2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PJA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Polyubiquitination of substrate0.75
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System1.00
    Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for PJA2
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: PJA2_HUMAN, O43164
    Pathway: Protein modification; protein ubiquitination


    PJA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PJA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for PJA2 (O431643 ENSP000003547754) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=4 STRING: ENSP00000364847
    UBE2D2P628373, ENSP000003817174I2D: score=4 STRING: ENSP00000381717
    FAF1Q9UNN53, ENSP000003794574I2D: score=2 STRING: ENSP00000379457
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007616long-term memory ISS--
    GO:0010738regulation of protein kinase A signaling cascade IMP--
    GO:0016567protein ubiquitination IDA--

    PJA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PJA2

    4 HMDB Compounds for PJA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about PJA2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PJA2 gene: 
    NM_014819.4  

    Unigene Cluster for PJA2:

    Praja ring finger 2, E3 ubiquitin protein ligase
    Hs.483036  [show with all ESTs]
    Unigene Representative Sequence: NM_014819
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361189(uc003kos.4) ENST00000511624 ENST00000512822 ENST00000361557


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: PJA2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PJA2
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate PJA2 (see all 79):
    hsa-miR-323-3p hsa-miR-100* hsa-miR-3607-3p hsa-miR-631 hsa-miR-3146 hsa-miR-4272 hsa-miR-605 hsa-miR-3074-3p
    SwitchGear 3'UTR luciferase reporter plasmidPJA2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PJA2 (see all 7)
    OriGene shRNA RFP: PJA2
    OriGene siRNA: PJA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PJA2
    Sirion Biotech Custom design and validation of potent shRNA sequences against PJA2 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PJA2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PJA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PJA2 (NM_014819)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PJA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PJA2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PJA2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PJA2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PJA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PJA2

    Additional cDNA sequence: 

    AB007898.1 AK291759.1 BC030826.1 CR749579.1 

    13 DOTS entries:

    DT.91822946  DT.217678  DT.101967888  DT.75188144  DT.92055932  DT.120796232  DT.95300444  DT.120796233 
    DT.120796272  DT.91792494  DT.91886327  DT.92055589  DT.92466593 

    24/307 AceView cDNA sequences (see all 307):

    AW469273 AI051748 AW028955 AA296527 CN483613 BQ228553 BG251012 AI753214 
    AW028472 BU177299 AL705617 AA348485 AI263414 AW469281 AV725853 BU618442 
    AV727328 BF515699 BM930051 BM983712 AI003389 AL040792 AI874307 AU125178 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PJA2    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                                          
    SP2:        -     -     -                                                                     
    SP3:                    -                                                                     
    SP4:                                                                                          


    ECgene alternative splicing isoforms for PJA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PJA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTAACAAGCT
    PJA2 Expression
    About this image
    See PJA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PJA2

    SOURCE GeneReport for Unigene cluster: Hs.483036
        SABiosciences Expression via Pathway-Focused PCR Array including PJA2: 

              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PJA2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PJA2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PJA2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PJA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PJA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PJA2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pja21 , 5 praja 2, RING-H2 motif containing1, 5 85.27(n)1
    83.66(a)1
      17 (33.24 cM)5
    2249381  NM_001025309.11  NP_001020480.11 
     642810055 
    chicken
    (Gallus gallus)
    Aves PJA21 praja ring finger 2, E3 ubiquitin protein ligase 63.18(n)
    50.52(a)
      415612  XM_413980.3  XP_413980.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    40(a)
    1 → many
    GL343193.1(5359057-5404720)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.134592 Xenopus laevis transcribed sequence with moderate similarity to protein pirT00064 (H.sapiens) T00064 hypothetical protein KIAA0438 - human less 76.81(n)    BJ073601.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.61142 Transcribed sequence with weak similarity to protein pirT00064 (H.sapiens) T00064 hypothetical protein KIAA0438 - human less 74.06(n)    BM403772.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E10BR.36
    Protein Y54E10BR.3
    14(a)
    1 → many
    I(3021651-3028386)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G681806
    RING/U-box domain-containing protein
    14(a)
    1 → many
    1(25554721-25555661)


    ENSEMBL Gene Tree for PJA2 (if available)
    TreeFam Gene Tree for PJA2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PJA2 gene
    RNF1812  RNF1152  RNF1262  PJA12  
    2 SIMAP similar genes for PJA2 using alignment to 1 protein entry:     PJA2_HUMAN:
    RNF181    PJA1

    PJA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1546 NCBI SNPs in PJA2 are shown (see all 1546    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113339231,2
    C--103873561(+) AAAAA-/ACTGTA 1 -- int1 trp32Minor allele frequency- A:0.00NA CSA 4
    rs1489167611,2
    --108669985(+) AATTGC/TGTAAT 1 -- int10--------
    rs171617301,2
    C,F,H--108670000(+) CAGCAC/GCCAAT 1 -- int19Minor allele frequency- G:0.07NA NS EA WA 678
    rs752485971,2
    --108670238(+) CTCAGA/CGACCC 1 -- int10--------
    rs1482657031,2
    --108670306(+) GATTAC/TAGTTC 1 -- int10--------
    rs1121046741,2
    --108670320(+) GACTTC/TTAACA 1 -- int12Minor allele frequency- T:0.08CSA NA 122
    rs1412737881,2
    --108670396(+) ATACAA/GTTACA 1 -- int10--------
    rs4147241,2
    C,F,H--108670421(+) AAATGA/GCCACC 1 -- ut31 ese320Minor allele frequency- G:0.41NS EA NA WA 3868
    rs1147349581,2
    F--108670476(+) GGCTGG/CGGTTA 1 -- ut311Minor allele frequency- C:0.07NA 120
    rs794529991,2
    C,F--108670552(+) AATTCG/ATATGT 1 -- ut311Minor allele frequency- A:0.06NA 120

    HapMap Linkage Disequilibrium report for PJA2 (108670410 - 108745695 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for PJA2
         4 CNVs: 93177 64271 93176 81002
         1 Indel: 12731

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PJA2
    DNA2.0 Custom Variant and Variant Library Synthesis for PJA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PJA2 for disorders           About GeneDecksing

    2 diseases for PJA2:    About MalaCards
    sideroblastic anemia    anemia


    Export disorders for PJA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PJA2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with PJA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Control of PKA stability and signalling by the RING ligase praja2. (PubMed id 21423175)1, 2 Lignitto L.... Feliciello A. (2011)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. (PubMed id 12036302)1, 2 Yu P.... Cai T. (2002)
    5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K....Ohara O. (1997)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Expression of the ring ligase PRAJA2 in thyroid cancer . (PubMed id 22948757)1 Cantara S....Pacini F. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9867 HGNC: 17481 AceView: PJA2 Ensembl:ENSG00000198961 euGenes: HUgn9867
    ECgene: PJA2 H-InvDB: PJA2

    (According to HUGE)
    About This Section
    HUGE: KIAA0438

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PJA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PJA2 gene:
    Search GeneIP for patents involving PJA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for PJA2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PJA2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PJA2  
     OriGene Protein Over-expression Lysate for PJA2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for PJA2   OriGene 3'-UTR Clone for PJA2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PJA2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PJA2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PJA2   OriGene Custom Protein Services for PJA2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PJA2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PJA2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PJA2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PJA2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PJA2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PJA2
     GenScript Custom Purified and Recombinant Proteins Services for PJA2 GenScript cDNA clones with any tag delivered in your preferred vector for PJA2
     GenScript Custom Assay Services for PJA2 GenScript Custom Superior Antibodies Services for PJA2
     GenScript Custom overexpressing Cell Line Services for PJA2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PJA2 promoter
     Search Chromatin IP Primers for PJA2
     RT2 qPCR Primer Assay in human, mouse, rat PJA2
     Search GNC Networks for PJA2
     SABiosciences PCR Arrays including human, mouse, rat PJA2
     Search Tocris compounds for PJA2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PJA2 antibodies
     PJA2 proteins
     PJA2 lysates
     Antibodies for PJA2
     See all of Abcam's Antibodies, Kits and Proteins for PJA2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     PJA2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for PJA2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PJA2
     SwitchGear 3'UTR luciferase reporter plasmids for PJA2
     SwitchGear Promoter luciferase reporter plasmids for PJA2
     Search ThermoFisher Antibodies for PJA2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PJA2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PJA2
    Sirion Biotech Customized:
     stable knockdown cell line services for PJA2
     inducible knockdown cell line services for PJA2
     design and validation of potent shRNA sequences against PJA2
     adenovirus for potent knockdown of PJA2
     adenovirus for overexpression of PJA2
     stable overexpressing cell line services for PJA2
     inducible overexpressing cell line services for PJA2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PJA2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4