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PJA1 Gene

protein-coding   GIFtS: 63
GCID: GC0XM068297

Praja Ring Finger 1, E3 Ubiquitin Protein Ligase

(Previous names: praja 1, praja ring finger 1)
  See PJA1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Praja Ring Finger 1, E3 Ubiquitin Protein Ligase1 2     PRAJA12
Praja 11 2     E3 Ubiquitin-Protein Ligase Praja-12
RNF702 3     EC 6.3.2.-3
RING Finger Protein 702 3     Praja13
Praja Ring Finger 11     EC 6.3.28

External Ids:    HGNC: 166481   Entrez Gene: 642192   Ensembl: ENSG000001811917   OMIM: 3004205   UniProtKB: Q8NG273   

Export aliases for PJA1 gene to outside databases

Previous GC identifers: GC0XM064558 GC0XM065858 GC0XM066613 GC0XM067247 GC0XM068163 GC0XM062204


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PJA1 Gene:
This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a
class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2
ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked
mental retardation disorders have been associated, and it has also been found as part of a contiguous gene
deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be
demonstrated. Alternative splicing results in multiple transcript variants. (provided by RefSeq, May 2010)

GeneCards Summary for PJA1 Gene:
PJA1 (praja ring finger 1, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with PJA1 include craniofrontonasal syndrome. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is PJA2.

UniProtKB/Swiss-Prot: PJA1_HUMAN, Q8NG27
Function: Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its
subsequent degradation by proteasome (By similarity). May be involved in protein sorting

Gene Wiki entry for PJA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PJA1 gene promoter:
         HOXA3   FOXO4   FOXD3   XBP-1   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPJA1 promoter sequence
   Search Chromatin IP Primers for PJA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PJA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.1   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13.1

PJA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PJA1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM068297:  view genomic region     (about GC identifiers)

Start:
68,380,581 bp from pter      End:
68,385,636 bp from pter
Size:
5,056 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PJA1_HUMAN, Q8NG27 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase Praja-1  
Size: 643 amino acids; 71002 Da
Subunit: Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme,
UBE2D2
Sequence caution: Sequence=BAB13928.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for PJA1:
2L0B (3D)    
Secondary accessions: A2A322 Q5JUT8 Q5JUT9 Q8NG28 Q9HAC1
Alternative splicing: 3 isoforms:  Q8NG27-1   Q8NG27-2   Q8NG27-3   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for PJA1: NX_Q8NG27

Explore proteomics data for PJA1 at MOPED

Post-translational modifications: 

  • Substrate for E2-dependent ubiquitination1
  • Ubiquitination2 at Lys337, Lys628
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PJA1 (Q8NG27) (see all 5)
     ATELPCHH  TGRRYGRRHAYVSF  FMLDGNNNLEDDSSVSEDL  FHKPCVSIWLQKSGTCPVCR 


    See PJA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001027568.1  NP_071763.2  NP_660095.1  

    ENSEMBL proteins: 
     ENSP00000467564   ENSP00000363711   ENSP00000363712   ENSP00000355014   ENSP00000363699  
     ENSP00000467404  
    Reactome Protein details: Q8NG27

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8NG27

    ProtoNet protein and cluster: Q8NG27

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: PJA1_HUMAN, Q8NG27
    Domain: The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates
    ubiquitination (By similarity)
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with PJA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PJA1_HUMAN, Q8NG27
    Function: Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its
    subsequent degradation by proteasome (By similarity). May be involved in protein sorting

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with PJA1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PJA1:
     Decreased viability of wild-ty  Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PJA1
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    hsa-miR-2110 hsa-miR-3120-3p hsa-miR-876-5p hsa-miR-548aa hsa-miR-4275 hsa-miR-3167 hsa-miR-873 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidPJA1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with PJA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PJA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with PJA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for PJA1
        Antigen processing: Ubiquitination & Proteasome degradation


        Pathway & Disease-focused RT2 Profiler PCR Array including PJA1: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PJA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PJA1 (Q8NG271, 2, 3 ENSP000003550144) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSRP003902, 3, ENSP000002211304MINT-63334 I2D: score=6 STRING: ENSP00000221130
    KIF22Q148072, 3, ENSP000001608274MINT-64332 I2D: score=5 STRING: ENSP00000160827
    MAGED1Q9Y5V31, 3, ENSP000003648474EBI-714606,EBI-716006 I2D: score=4 STRING: ENSP00000364847
    ASCC2Q9H1I82, 3MINT-65475 I2D: score=5 
    ATP5C1P365422, 3MINT-63708 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination ----
    GO:0030163protein catabolic process IEA--

    Find genes that share ontologies with PJA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PJA1

    4 HMDB Compounds for PJA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PJA1 gene (3 alternative transcripts): 
    NM_001032396.2  NM_022368.4  NM_145119.3  

    Unigene Cluster for PJA1:

    Praja ring finger 1, E3 ubiquitin protein ligase
    Hs.522679  [show with all ESTs]
    Unigene Representative Sequence: NM_145119
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471141 ENST00000374583(uc022byl.1) ENST00000374584 ENST00000361478(uc004dxg.3 uc004dxh.3 uc004dxi.3 uc011mpi.2)
    ENST00000374571 ENST00000477231 ENST00000590146
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate PJA1:
    hsa-miR-2110 hsa-miR-3120-3p hsa-miR-876-5p hsa-miR-548aa hsa-miR-4275 hsa-miR-3167 hsa-miR-873 hsa-miR-1976
    SwitchGear 3'UTR luciferase reporter plasmidPJA1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PJA1
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    GenScript: all cDNA clones in your preferred vector (see all 3): PJA1 (NM_001032396)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PJA1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PJA1
      QuantiTect SYBR Green Assays in human, mouse, rat PJA1
      QuantiFast Probe-based Assays in human, mouse, rat PJA1

    Additional mRNA sequence: 

    AF262024.1 AF264620.1 AK021892.1 AK096611.1 AK226171.1 AK290543.1 AK294632.1 BC039149.1 
    BC048323.1 BC058327.1 BC075803.1 BC105051.1 BC105053.1 BC113035.1 

    9 DOTS entries:

    DT.414300  DT.92429044  DT.100795547  DT.101983245  DT.121643606  DT.100024631  DT.100795546  DT.100024628 
    DT.121318399 

    Selected AceView cDNA sequences (see all 156):

    AA338366 BG818926 BG740254 BQ638725 AI197904 CD671816 NM_022368 CF140611 
    CA309809 BU173270 BP372063 AI498701 W86389 AL538620 BG055851 BC075803 
    BE045333 AA992514 BX118642 CK906058 NM_145119 AI912734 AF264620 BE889906 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for PJA1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c
    SP1:                    -           -     -                     
    SP2:                                -     -                     
    SP3:                                                            
    SP4:                    -                                       
    SP5:                    -                                       


    ECgene alternative splicing isoforms for PJA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PJA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGGGTCG
    PJA1 Expression
    About this image


    PJA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Kidney (Urinary System)
             Metanephros
    PJA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PJA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.522679

    UniProtKB/Swiss-Prot: PJA1_HUMAN, Q8NG27
    Tissue specificity: Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla,
    occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex

        Pathway & Disease-focused RT2 Profiler PCR Array including PJA1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PJA1
    QuantiTect SYBR Green Assays in human, mouse, rat PJA1
    QuantiFast Probe-based Assays in human, mouse, rat PJA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PJA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PJA1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pja11 , 5 praja1, RING-H2 motif containing1, 5 81.9(n)1
    80.21(a)1
      X (43.38 cM)5
    187441  NM_001083110.11  NP_001076579.11 
     994657345 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    38(a)
    1 → many
    Z(47205112-47225715)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    1 → many
    GL343193.1(5356791-5421072)
    zebrafish
    (Danio rerio)
    Actinopterygii pja26
    praja ring finger 2
    32(a)
    1 → many
    5(58617347-58676442) ENSDARG00000022893


    ENSEMBL Gene Tree for PJA1 (if available)
    TreeFam Gene Tree for PJA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PJA1 gene
    PJA22  RNF1812  RNF1152  RNF1262  
    2 SIMAP similar genes for PJA1 using alignment to 4 protein entries:     PJA1_HUMAN (see all proteins):
    PJA2    RNF181

    Find genes that share paralogs with PJA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PJA1 (see all 163)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753878471,2
    C--68380167(+) CAGACA/GGACAG 3 -- ds50010--------
    rs796253091,2
    C--68380173(+) GACAGA/GCAGAG 3 -- ds50010--------
    rs1449679271,2
    C--68380564(+) CTTCA-/TTTTTTT 3 -- ds50010--------
    rs1813350801,2
    --68387774(+) TTCAAC/TTCCTA 3 -- ds50010--------
    rs1418125481,2
    --68387915(+) CCTACA/CATTGT 3 -- ds50010--------
    rs128450391,2
    C,H--68387920(+) CATTGT/GTTTGT 3 -- ds50014Minor allele frequency- G:0.00NS EA 410
    rs172175841,2
    C,F,H--68388099(+) TTTCCA/GGTGAA 3 -- ut3114Minor allele frequency- G:0.05NA NS EA 1665
    rs1396026301,2
    --68388247(+) TACAGC/GAACAT 3 -- ut310--------
    rs1427698361,2
    C,F--68388658(+) GGAGGG/CAACAT 6 /F /L mis11Minor allele frequency- C:0.00NA 4286
    rs1499695401,2
    C--68388682(+) GGGCAG/CGTGCC 6 /T syn11Minor allele frequency- C:0.00NA 4502

    HapMap Linkage Disequilibrium report for PJA1 (68380581 - 68385636 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PJA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829374CNV Gain20364138
    esv1584074OTHER Inversion17803354

    Locus Specific Mutation Databases (LSDB): PJA1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300420    OMIM disorders: --

    1 disease for PJA1:    
    About MalaCards
    craniofrontonasal syndrome

    1 disease from the University of Copenhagen DISEASES database for PJA1:
    Craniofrontonasal syndrome

    Find genes that share disorders with PJA1           About GenesLikeMe

    Genetic Association Database (GAD): PJA1

    Export disorders for PJA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PJA1 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PJA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. (PubMed id 12036302)1, 2, 3 Yu P.... Cai T. (Genomics 2002)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Contiguous gene deletions involving EFNB1, OPHN1, PJA1 and EDA in patients with craniofrontonasal syndrome. (PubMed id 17941886)1, 9 Wieland I....Wieacker P. (Clin. Genet. 2007)
    6. Downregulation of Ezh2 methyltransferase by FOXP3: new insight of FOXP3 into chromatin remodeling? (PubMed id 23688634)1 Shen Z....Xiong Y. (Biochim. Biophys. Acta 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (Biochim. Biophys. Acta 2012)
    9. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    10. Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR). (PubMed id 22544753)1 Agrawal P....Hughes R.E. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64219 HGNC: 16648 AceView: PJA1 Ensembl:ENSG00000181191 euGenes: HUgn64219
    ECgene: PJA1 H-InvDB: PJA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PJA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PJA1 gene:
    Search GeneIP for patents involving PJA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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