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Aliases for PJA1 Gene

Aliases for PJA1 Gene

  • Praja Ring Finger 1, E3 Ubiquitin Protein Ligase 2 3
  • RING Finger Protein 70 3 4
  • Praja 1 2 3
  • PRAJA1 3 4
  • RNF70 3 4
  • E3 Ubiquitin-Protein Ligase Praja-1 3
  • Praja Ring Finger 1 2
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for PJA1 Gene

Previous GeneCards Identifiers for PJA1 Gene

  • GC0XM064558
  • GC0XM065858
  • GC0XM066613
  • GC0XM067247
  • GC0XM068163
  • GC0XM068297
  • GC0XM062204

Summaries for PJA1 Gene

Entrez Gene Summary for PJA1 Gene

  • This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PJA1 Gene

PJA1 (Praja Ring Finger 1, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is RNF126.

UniProtKB/Swiss-Prot for PJA1 Gene

  • Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.

Gene Wiki entry for PJA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PJA1 Gene

Genomics for PJA1 Gene

Regulatory Elements for PJA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PJA1 Gene

Start:
69,160,738 bp from pter
End:
69,165,793 bp from pter
Size:
5,056 bases
Orientation:
Minus strand

Genomic View for PJA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PJA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PJA1 Gene

Proteins for PJA1 Gene

  • Protein details for PJA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG27-PJA1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase Praja-1
    Protein Accession:
    Q8NG27
    Secondary Accessions:
    • A2A322
    • Q5JUT8
    • Q5JUT9
    • Q8NG28
    • Q9HAC1

    Protein attributes for PJA1 Gene

    Size:
    643 amino acids
    Molecular mass:
    71002 Da
    Quaternary structure:
    • Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2.
    SequenceCaution:
    • Sequence=BAB13928.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PJA1 Gene

    Alternative splice isoforms for PJA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PJA1 Gene

Proteomics data for PJA1 Gene at MOPED

Post-translational modifications for PJA1 Gene

Other Protein References for PJA1 Gene

Domains for PJA1 Gene

Gene Families for PJA1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for PJA1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for PJA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG27

UniProtKB/Swiss-Prot:

PJA1_HUMAN :
  • Q8NG27
Domain:
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PJA1: view

Function for PJA1 Gene

Molecular function for PJA1 Gene

UniProtKB/Swiss-Prot Function: Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.

Enzyme Numbers (IUBMB) for PJA1 Gene

Gene Ontology (GO) - Molecular Function for PJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 20864041
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with PJA1: view
genes like me logo Genes that share phenotypes with PJA1: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PJA1 Gene

Localization for PJA1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PJA1 Gene COMPARTMENTS Subcellular localization image for PJA1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PJA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PJA1 Gene

Pathways for PJA1 Gene

genes like me logo Genes that share pathways with PJA1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for PJA1 Gene

Gene Ontology (GO) - Biological Process for PJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0030163 protein catabolic process IEA --
genes like me logo Genes that share ontologies with PJA1: view

Compounds for PJA1 Gene

(4) HMDB Compounds for PJA1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with PJA1: view

Transcripts for PJA1 Gene

Unigene Clusters for PJA1 Gene

Praja ring finger 1, E3 ubiquitin protein ligase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PJA1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PJA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -

Relevant External Links for PJA1 Gene

GeneLoc Exon Structure for
PJA1
ECgene alternative splicing isoforms for
PJA1

Expression for PJA1 Gene

mRNA expression in normal human tissues for PJA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PJA1 Gene

SOURCE GeneReport for Unigene cluster for PJA1 Gene Hs.522679

mRNA Expression by UniProt/SwissProt for PJA1 Gene

Q8NG27-PJA1_HUMAN
Tissue specificity: Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.
genes like me logo Genes that share expressions with PJA1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PJA1 Gene

Orthologs for PJA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PJA1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PJA1 35
  • 87.75 (n)
  • 87.07 (a)
PJA1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pja1 35
  • 81.9 (n)
  • 80.21 (a)
Pja1 16
Pja1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC683077 35
  • 82.34 (n)
  • 83.17 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pja2 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
Species with no ortholog for PJA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PJA1 Gene

ENSEMBL:
Gene Tree for PJA1 (if available)
TreeFam:
Gene Tree for PJA1 (if available)

Paralogs for PJA1 Gene

Paralogs for PJA1 Gene

Selected SIMAP similar genes for PJA1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PJA1: view

Variants for PJA1 Gene

Sequence variations from dbSNP and Humsavar for PJA1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3210690 -- 69,160,877(-) TAAAG(C/T)TGTTC utr-variant-3-prime
rs3761645 -- 69,162,155(-) ACTGC(A/G)ACGAA missense, reference
rs3761646 -- 69,162,069(-) AGTGG(C/T)GAAAG reference, synonymous-codon
rs4844165 -- 69,164,384(+) TGAGC(A/G)CATGT intron-variant
rs5937160 - 69,161,944(+) CAGCA(C/T)TGGCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PJA1 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv829374 CNV Gain 20364138

Relevant External Links for PJA1 Gene

HapMap Linkage Disequilibrium report
PJA1
Locus Specific Mutation Databases (LSDB)
PJA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PJA1 Gene

Disorders for PJA1 Gene

(1) University of Copenhagen DISEASES for PJA1 Gene

Relevant External Links for PJA1

Genetic Association Database (GAD)
PJA1
genes like me logo Genes that share disorders with PJA1: view

No data available for UniProtKB/Swiss-Prot for PJA1 Gene

Publications for PJA1 Gene

  1. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. (PMID: 12036302) Yu P. … Cai T. (Genomics 2002) 2 3 4
  2. Contiguous gene deletions involving EFNB1, OPHN1, PJA1 and EDA in patients with craniofrontonasal syndrome. (PMID: 17941886) Wieland I. … Wieacker P. (Clin. Genet. 2007) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for PJA1 Gene

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