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Aliases for PJA1 Gene

Aliases for PJA1 Gene

  • Praja Ring Finger Ubiquitin Ligase 1 2 3
  • Praja Ring Finger 1, E3 Ubiquitin Protein Ligase 2 3 5
  • RING Finger Protein 70 3 4
  • Praja 1 2 3
  • PRAJA1 3 4
  • RNF70 3 4
  • Praja Ring Finger 1 2
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for PJA1 Gene

Previous GeneCards Identifiers for PJA1 Gene

  • GC0XM064558
  • GC0XM065858
  • GC0XM066613
  • GC0XM067247
  • GC0XM068163
  • GC0XM068297
  • GC0XM062204

Summaries for PJA1 Gene

Entrez Gene Summary for PJA1 Gene

  • This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked mental retardation disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PJA1 Gene

PJA1 (Praja Ring Finger Ubiquitin Ligase 1) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF126.

UniProtKB/Swiss-Prot for PJA1 Gene

  • Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.

Gene Wiki entry for PJA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PJA1 Gene

Genomics for PJA1 Gene

Regulatory Elements for PJA1 Gene

Enhancers for PJA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PJA1 on UCSC Golden Path with GeneCards custom track

Promoters for PJA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PJA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PJA1 Gene

69,160,738 bp from pter
69,165,793 bp from pter
5,056 bases
Minus strand

Genomic View for PJA1 Gene

Genes around PJA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PJA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PJA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PJA1 Gene

Proteins for PJA1 Gene

  • Protein details for PJA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase Praja-1
    Protein Accession:
    Secondary Accessions:
    • A2A322
    • Q5JUT8
    • Q5JUT9
    • Q8NG28
    • Q9HAC1

    Protein attributes for PJA1 Gene

    643 amino acids
    Molecular mass:
    71002 Da
    Quaternary structure:
    • Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2.
    • Sequence=BAB13928.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PJA1 Gene

    Alternative splice isoforms for PJA1 Gene


neXtProt entry for PJA1 Gene

Proteomics data for PJA1 Gene at MOPED

Post-translational modifications for PJA1 Gene

Other Protein References for PJA1 Gene

Antibody Products

  • Abcam antibodies for RNF70

Domains & Families for PJA1 Gene

Gene Families for PJA1 Gene

Protein Domains for PJA1 Gene


Suggested Antigen Peptide Sequences for PJA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
  • Contains 1 RING-type zinc finger.
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with PJA1: view

Function for PJA1 Gene

Molecular function for PJA1 Gene

UniProtKB/Swiss-Prot Function:
Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.

Enzyme Numbers (IUBMB) for PJA1 Gene

Gene Ontology (GO) - Molecular Function for PJA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20864041
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with PJA1: view
genes like me logo Genes that share phenotypes with PJA1: view

Animal Model Products

miRNA for PJA1 Gene

miRTarBase miRNAs that target PJA1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PJA1 Gene

Localization for PJA1 Gene

Subcellular locations from

Jensen Localization Image for PJA1 Gene COMPARTMENTS Subcellular localization image for PJA1 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PJA1 Gene

Pathways & Interactions for PJA1 Gene

genes like me logo Genes that share pathways with PJA1: view

Interacting Proteins for PJA1 Gene

SIGNOR curated interactions for PJA1 Gene


Gene Ontology (GO) - Biological Process for PJA1 Gene


Drugs & Compounds for PJA1 Gene

(3) Drugs for PJA1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for PJA1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with PJA1: view

Transcripts for PJA1 Gene

Unigene Clusters for PJA1 Gene

Praja ring finger 1, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PJA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c
SP1: - - -
SP2: - -
SP4: -
SP5: -

Relevant External Links for PJA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PJA1 Gene

mRNA expression in normal human tissues for PJA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PJA1 Gene

This gene is overexpressed in Bone (47.9) and Testis (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PJA1 Gene

SOURCE GeneReport for Unigene cluster for PJA1 Gene Hs.522679

mRNA Expression by UniProt/SwissProt for PJA1 Gene

Tissue specificity: Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.
genes like me logo Genes that share expression patterns with PJA1: view

Protein tissue co-expression partners for PJA1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for PJA1 Gene

Orthologs for PJA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PJA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PJA1 35
  • 87.75 (n)
  • 87.07 (a)
PJA1 36
  • 87 (a)
(Mus musculus)
Mammalia Pja1 35
  • 81.9 (n)
  • 80.21 (a)
Pja1 16
Pja1 36
  • 81 (a)
(Rattus norvegicus)
Mammalia LOC683077 35
  • 82.34 (n)
  • 83.17 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
(Gallus gallus)
Aves -- 36
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
(Danio rerio)
Actinopterygii pja2 36
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 38
Species with no ortholog for PJA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PJA1 Gene

Gene Tree for PJA1 (if available)
Gene Tree for PJA1 (if available)

Paralogs for PJA1 Gene

Paralogs for PJA1 Gene

(2) SIMAP similar genes for PJA1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PJA1: view

Variants for PJA1 Gene

Sequence variations from dbSNP and Humsavar for PJA1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5937160 - 69,161,944(+) CAGCA(C/T)TGGCC reference, missense
rs11539157 - 69,161,421(+) GCCAC(A/C)TCCCC reference, missense
rs747979062 -- 69,165,764(+) AATGT(A/G)AGAGT upstream-variant-2KB
rs748086031 -- 69,162,184(+) TGTGC(A/G)TCCAG reference, missense
rs748245357 -- 69,166,539(+) AGAAG(A/C)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PJA1 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv829374 CNV Gain 20364138

Variation tolerance for PJA1 Gene

Residual Variation Intolerance Score: 65.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PJA1 Gene

Disorders for PJA1 Gene

Relevant External Links for PJA1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PJA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PJA1 Gene

Publications for PJA1 Gene

  1. PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. (PMID: 12036302) Yu P. … Cai T. (Genomics 2002) 2 3 4 67
  2. Contiguous gene deletions involving EFNB1, OPHN1, PJA1 and EDA in patients with craniofrontonasal syndrome. (PMID: 17941886) Wieland I. … Wieacker P. (Clin. Genet. 2007) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3

Products for PJA1 Gene

Sources for PJA1 Gene