Aliases for PIWIL4 Gene
External Ids for PIWIL4 Gene
Previous GeneCards Identifiers for PIWIL4 Gene
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PIWIL4 Gene
PIWIL4 (Piwi Like RNA-Mediated Gene Silencing 4) is a Protein Coding gene. Diseases associated with PIWIL4 include klatskin's tumor. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include nucleic acid binding and piRNA binding. An important paralog of this gene is AGO3.
UniProtKB/Swiss-Prot for PIWIL4 Gene
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing Lys-9 methylation of histone H3 at some loci (PubMed:12906857).