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Aliases for PIWIL3 Gene

Aliases for PIWIL3 Gene

  • Piwi Like RNA-Mediated Gene Silencing 3 2 3 5
  • Piwi-Like 3 (Drosophila) 2
  • Piwi-Like Protein 3 3
  • Piwi-Like 3 3
  • HIWI3 3

External Ids for PIWIL3 Gene

Previous GeneCards Identifiers for PIWIL3 Gene

  • GC00U991200
  • GC22M023442
  • GC22M025115
  • GC22M008063
  • GC22M024759
  • GC22M025071
  • GC22M025304
  • GC22M025453

Summaries for PIWIL3 Gene

Entrez Gene Summary for PIWIL3 Gene

  • This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for PIWIL3 Gene

PIWIL3 (Piwi Like RNA-Mediated Gene Silencing 3) is a Protein Coding gene. Among its related pathways are Dorso-ventral axis formation. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PIWIL1.

UniProtKB/Swiss-Prot for PIWIL3 Gene

  • May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIWIL3 Gene

Genomics for PIWIL3 Gene

Regulatory Elements for PIWIL3 Gene

Enhancers for PIWIL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F024775 0.2 ENCODE 12.1 -1.2 -1239 0.2 GATA3 CTBP1 RCOR1 DPF2 PIWIL3 SGSM1
GH22F024844 1.2 Ensembl ENCODE 12.1 -70.5 -70541 1.4 ZNF366 PIWIL3 PIR59021 PIR47227
GH22F024809 0.7 ENCODE 11.4 -35.7 -35651 1.6 RFX1 MAX FEZF1 REST ZNF664 ZFHX2 SMARCA4 MYNN EGR2 PIWIL3 SGSM1 PIR59021
GH22F024789 0.5 ENCODE 10.9 -14.9 -14919 0.6 BCL6 NR2F6 PIWIL3 SGSM1
GH22F024772 0.2 ENCODE 10.7 +2.0 2032 0.2 CTCF ZNF654 REST RAD21 ATF3 IKZF1 ZNF143 SMC3 ZBTB33 PIWIL3 TOP1P2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PIWIL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIWIL3 Gene

Chromosome:
22
Start:
24,719,034 bp from pter
End:
24,774,720 bp from pter
Size:
55,687 bases
Orientation:
Minus strand

Genomic View for PIWIL3 Gene

Genes around PIWIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIWIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIWIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIWIL3 Gene

Proteins for PIWIL3 Gene

  • Protein details for PIWIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Z3-PIWL3_HUMAN
    Recommended name:
    Piwi-like protein 3
    Protein Accession:
    Q7Z3Z3

    Protein attributes for PIWIL3 Gene

    Size:
    882 amino acids
    Molecular mass:
    101089 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIWIL3 Gene

Post-translational modifications for PIWIL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIWIL3 Gene

Antibody Products

  • Abcam antibodies for PIWIL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PIWIL3

No data available for DME Specific Peptides for PIWIL3 Gene

Domains & Families for PIWIL3 Gene

Gene Families for PIWIL3 Gene

Suggested Antigen Peptide Sequences for PIWIL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3Z3

UniProtKB/Swiss-Prot:

PIWL3_HUMAN :
  • Contains 1 PAZ domain.
  • Belongs to the argonaute family. Piwi subfamily.
Domain:
  • Contains 1 PAZ domain.
  • Contains 1 Piwi domain.
Family:
  • Belongs to the argonaute family. Piwi subfamily.
genes like me logo Genes that share domains with PIWIL3: view

Function for PIWIL3 Gene

Molecular function for PIWIL3 Gene

UniProtKB/Swiss-Prot Function:
May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

Gene Ontology (GO) - Molecular Function for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PIWIL3: view
genes like me logo Genes that share phenotypes with PIWIL3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PIWIL3 Gene

Localization for PIWIL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIWIL3 Gene

Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIWIL3 Gene COMPARTMENTS Subcellular localization image for PIWIL3 gene
Compartment Confidence
nucleus 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PIWIL3: view

Pathways & Interactions for PIWIL3 Gene

SuperPathways for PIWIL3 Gene

SuperPathway Contained pathways
1 Dorso-ventral axis formation
genes like me logo Genes that share pathways with PIWIL3: view

Pathways by source for PIWIL3 Gene

1 KEGG pathway for PIWIL3 Gene

Interacting Proteins for PIWIL3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000330031%0d%0a9606.ENSP00000343745%0d%0a9606.ENSP00000350028%0d%0a9606.ENSP00000262794%0d%0a9606.ENSP00000351524%0d%0a9606.ENSP00000417401%0d%0a
Selected Interacting proteins: ENSP00000330031 Q7Z3Z3-PIWL3_HUMAN for PIWIL3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with PIWIL3: view

No data available for SIGNOR curated interactions for PIWIL3 Gene

Transcripts for PIWIL3 Gene

mRNA/cDNA for PIWIL3 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIWIL3 Gene

Piwi-like RNA-mediated gene silencing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIWIL3 Gene

No ASD Table

Relevant External Links for PIWIL3 Gene

GeneLoc Exon Structure for
PIWIL3
ECgene alternative splicing isoforms for
PIWIL3

Expression for PIWIL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIWIL3 Gene

mRNA differential expression in normal tissues according to GTEx for PIWIL3 Gene

This gene is overexpressed in Testis (x31.1) and Ovary (x8.0).

Protein differential expression in normal tissues from HIPED for PIWIL3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIWIL3 Gene



Protein tissue co-expression partners for PIWIL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIWIL3 Gene:

PIWIL3

SOURCE GeneReport for Unigene cluster for PIWIL3 Gene:

Hs.448343

mRNA Expression by UniProt/SwissProt for PIWIL3 Gene:

Q7Z3Z3-PIWL3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with PIWIL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PIWIL3 Gene

Orthologs for PIWIL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIWIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIWIL3 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia LOC486307 34
  • 70.92 (n)
PIWIL3 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 57 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PIWIL3 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIWIL1 35
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii piwil1 35
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta piwi 34
  • 47.29 (n)
AGO3 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rde-1 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for PIWIL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIWIL3 Gene

ENSEMBL:
Gene Tree for PIWIL3 (if available)
TreeFam:
Gene Tree for PIWIL3 (if available)

Paralogs for PIWIL3 Gene

Paralogs for PIWIL3 Gene

(3) SIMAP similar genes for PIWIL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIWIL3: view

Variants for PIWIL3 Gene

Sequence variations from dbSNP and Humsavar for PIWIL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1001445 -- 24,772,430(-) tcagg(G/T)tcaca intron-variant
rs10427616 -- 24,774,639(+) tatct(A/C)tacta nc-transcript-variant, utr-variant-5-prime
rs10427641 -- 24,774,713(+) gaggc(A/G)gcaaa nc-transcript-variant, utr-variant-5-prime
rs10427667 -- 24,775,249(+) ataaa(A/T)ttctt upstream-variant-2KB
rs10427740 -- 24,774,636(+) cccta(C/T)ctcta nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PIWIL3 Gene

Variant ID Type Subtype PubMed ID
esv2611432 CNV deletion 19546169
esv3568313 CNV loss 25503493
esv3893464 CNV gain 25118596
nsv1064902 CNV loss 25217958
nsv1109460 CNV deletion 24896259
nsv1110863 OTHER inversion 24896259
nsv1114315 CNV deletion 24896259
nsv3579 CNV insertion 18451855
nsv522434 CNV gain 19592680
nsv7350 OTHER inversion 18451855
nsv962778 CNV duplication 23825009

Variation tolerance for PIWIL3 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIWIL3 Gene

Human Gene Mutation Database (HGMD)
PIWIL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIWIL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIWIL3 Gene

Disorders for PIWIL3 Gene

Relevant External Links for PIWIL3

Genetic Association Database (GAD)
PIWIL3
Human Genome Epidemiology (HuGE) Navigator
PIWIL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIWIL3

No disorders were found for PIWIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIWIL3 Gene

Publications for PIWIL3 Gene

  1. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T. … Shimizu N. (Genomics 2003) 2 3 4 64
  2. Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. (PMID: 20940137) Gu A. … Wang X. (Hum. Reprod. 2010) 3 46 64
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
  4. [Preparation and distribution of polyclonal antibodies against human PIWIL3 protein in tumor tissues]. (PMID: 18616918) Wang X.L. … Huang Z.G. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for PIWIL3 Gene

Sources for PIWIL3 Gene

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