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Aliases for PIWIL3 Gene

Aliases for PIWIL3 Gene

  • Piwi Like RNA-Mediated Gene Silencing 3 2 3 5
  • Piwi-Like 3 (Drosophila) 2
  • Piwi-Like Protein 3 3
  • Piwi-Like 3 3
  • HIWI3 3

External Ids for PIWIL3 Gene

Previous GeneCards Identifiers for PIWIL3 Gene

  • GC00U991200
  • GC22M023442
  • GC22M025115
  • GC22M008063
  • GC22M024759
  • GC22M025071
  • GC22M025304
  • GC22M025453
  • GC22M025634
  • GC22M025820
  • GC22M026005

Summaries for PIWIL3 Gene

Entrez Gene Summary for PIWIL3 Gene

  • This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for PIWIL3 Gene

PIWIL3 (Piwi Like RNA-Mediated Gene Silencing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is PIWIL1.

UniProtKB/Swiss-Prot for PIWIL3 Gene

  • May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

Additional gene information for PIWIL3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIWIL3 Gene

Genomics for PIWIL3 Gene

GeneHancer (GH) Regulatory Elements for PIWIL3 Gene

Promoters and enhancers for PIWIL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I024775 Enhancer 0.6 ENCODE 562.1 -1.2 -1239 0.2 SMARCE1 GATAD2B DPF2 ELF1 ZNF217 GATA3 CTBP1 RCOR1 PIWIL3 SGSM1
GH22I024774 Promoter 0.5 EPDnew 550.8 +0.2 237 0.1 PIWIL3 TOP1P2
GH22I024776 Enhancer 0.3 ENCODE 557.3 -1.5 -1549 0.2 GATA3 PIWIL3 SGSM1
GH22I024809 Enhancer 0.6 ENCODE 11.5 -35.7 -35651 1.6 MXI1 USF1 RFX1 MAX ZNF398 FEZF1 REST BMI1 ZFHX2 POLR2A RN7SL268P PIWIL3 SGSM1 ENSG00000272973 GSTT2 PIR59021
GH22I024772 Enhancer 0.6 ENCODE 10.7 +2.0 2031 0.2 CTCF ZNF654 IKZF1 ZNF143 SMC3 SIN3A REST RAD21 PIWIL3 TOP1P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PIWIL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIWIL3 gene promoter:

Genomic Locations for PIWIL3 Gene

Genomic Locations for PIWIL3 Gene
chr22:24,719,034-24,774,720
(GRCh38/hg38)
Size:
55,687 bases
Orientation:
Minus strand
chr22:25,115,001-25,170,687
(GRCh37/hg19)

Genomic View for PIWIL3 Gene

Genes around PIWIL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIWIL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIWIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIWIL3 Gene

Proteins for PIWIL3 Gene

  • Protein details for PIWIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Z3-PIWL3_HUMAN
    Recommended name:
    Piwi-like protein 3
    Protein Accession:
    Q7Z3Z3

    Protein attributes for PIWIL3 Gene

    Size:
    882 amino acids
    Molecular mass:
    101089 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIWIL3 Gene

Post-translational modifications for PIWIL3 Gene

No Post-translational modifications

Other Protein References for PIWIL3 Gene

Antibody Products

  • Abcam antibodies for PIWIL3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PIWIL3

No data available for DME Specific Peptides for PIWIL3 Gene

Domains & Families for PIWIL3 Gene

Gene Families for PIWIL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PIWIL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3Z3

UniProtKB/Swiss-Prot:

PIWL3_HUMAN :
  • Belongs to the argonaute family. Piwi subfamily.
Family:
  • Belongs to the argonaute family. Piwi subfamily.
genes like me logo Genes that share domains with PIWIL3: view

Function for PIWIL3 Gene

Molecular function for PIWIL3 Gene

UniProtKB/Swiss-Prot Function:
May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

Phenotypes From GWAS Catalog for PIWIL3 Gene

Gene Ontology (GO) - Molecular Function for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PIWIL3: view
genes like me logo Genes that share phenotypes with PIWIL3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PIWIL3 Gene

Localization for PIWIL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIWIL3 Gene

Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250 UniProtKB:Q9JMB7}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIWIL3 gene
Compartment Confidence
nucleus 3
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PIWIL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIWIL3 Gene

Pathways & Interactions for PIWIL3 Gene

SuperPathways for PIWIL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with PIWIL3: view

No data available for Pathways by source and SIGNOR curated interactions for PIWIL3 Gene

Drugs & Compounds for PIWIL3 Gene

No Compound Related Data Available

Transcripts for PIWIL3 Gene

mRNA/cDNA for PIWIL3 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIWIL3 Gene

Piwi-like RNA-mediated gene silencing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIWIL3 Gene

No ASD Table

Relevant External Links for PIWIL3 Gene

GeneLoc Exon Structure for
PIWIL3
ECgene alternative splicing isoforms for
PIWIL3

Expression for PIWIL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIWIL3 Gene

mRNA differential expression in normal tissues according to GTEx for PIWIL3 Gene

This gene is overexpressed in Testis (x31.1) and Ovary (x8.0).

Protein differential expression in normal tissues from HIPED for PIWIL3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIWIL3 Gene



Protein tissue co-expression partners for PIWIL3 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIWIL3 Gene:

PIWIL3

SOURCE GeneReport for Unigene cluster for PIWIL3 Gene:

Hs.448343

mRNA Expression by UniProt/SwissProt for PIWIL3 Gene:

Q7Z3Z3-PIWL3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expression patterns with PIWIL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIWIL3 Gene

Orthologs for PIWIL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIWIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIWIL3 34 33
  • 99.42 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC486307 33
  • 70.92 (n)
PIWIL3 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
ManyToMany
-- 34
  • 51 (a)
ManyToMany
-- 34
  • 46 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia PIWIL3 34
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIWIL1 34
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
ManyToMany
-- 34
  • 47 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii piwil1 34
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta piwi 33
  • 47.29 (n)
AGO3 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rde-1 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for PIWIL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIWIL3 Gene

ENSEMBL:
Gene Tree for PIWIL3 (if available)
TreeFam:
Gene Tree for PIWIL3 (if available)

Paralogs for PIWIL3 Gene

Paralogs for PIWIL3 Gene

(3) SIMAP similar genes for PIWIL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIWIL3: view

Variants for PIWIL3 Gene

Sequence variations from dbSNP and Humsavar for PIWIL3 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000066715 -- 24,720,045(-) AAACAA/AA intron_variant
rs1000094730 -- 24,742,917(-) C/G intron_variant
rs1000100426 -- 24,773,300(-) C/T intron_variant
rs1000162250 -- 24,761,783(-) T/C intron_variant
rs1000226429 -- 24,762,136(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PIWIL3 Gene

Variant ID Type Subtype PubMed ID
esv2611432 CNV deletion 19546169
esv3568313 CNV loss 25503493
esv3893464 CNV gain 25118596
nsv1064902 CNV loss 25217958
nsv1109460 CNV deletion 24896259
nsv1110863 OTHER inversion 24896259
nsv1114315 CNV deletion 24896259
nsv3579 CNV insertion 18451855
nsv522434 CNV gain 19592680
nsv7350 OTHER inversion 18451855
nsv962778 CNV duplication 23825009

Variation tolerance for PIWIL3 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.12; 69.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIWIL3 Gene

Human Gene Mutation Database (HGMD)
PIWIL3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIWIL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIWIL3 Gene

Disorders for PIWIL3 Gene

Additional Disease Information for PIWIL3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PIWIL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIWIL3 Gene

Publications for PIWIL3 Gene

  1. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T … Shimizu N (Genomics 2003) 2 3 4 58
  2. Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. (PMID: 20940137) Gu A … Wang X (Human reproduction (Oxford, England) 2010) 3 44 58
  3. Expression of PIWIL3 in primary and metastatic melanoma. (PMID: 27858163) Gambichler T … Sand M (Journal of cancer research and clinical oncology 2017) 3 58
  4. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  5. [Preparation and distribution of polyclonal antibodies against human PIWIL3 protein in tumor tissues]. (PMID: 18616918) Wang XL … Huang ZG (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2008) 3 58

Products for PIWIL3 Gene

Sources for PIWIL3 Gene

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