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Aliases for PIWIL3 Gene

Aliases for PIWIL3 Gene

  • Piwi-Like RNA-Mediated Gene Silencing 3 2 3
  • Piwi-Like 3 (Drosophila) 2
  • Piwi-Like Protein 3 3
  • Piwi-Like 3 3
  • HIWI3 3

External Ids for PIWIL3 Gene

Previous GeneCards Identifiers for PIWIL3 Gene

  • GC00U991200
  • GC22M023442
  • GC22M025115
  • GC22M008063

Summaries for PIWIL3 Gene

Entrez Gene Summary for PIWIL3 Gene

  • This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

GeneCards Summary for PIWIL3 Gene

PIWIL3 (Piwi-Like RNA-Mediated Gene Silencing 3) is a Protein Coding gene. Among its related pathways are Dorso-ventral axis formation. GO annotations related to this gene include RNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot for PIWIL3 Gene

  • May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIWIL3 Gene

Genomics for PIWIL3 Gene

Regulatory Elements for PIWIL3 Gene

Genomic Location for PIWIL3 Gene

Start:
24,719,034 bp from pter
End:
24,774,720 bp from pter
Size:
55,687 bases
Orientation:
Minus strand

Genomic View for PIWIL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIWIL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIWIL3 Gene

Proteins for PIWIL3 Gene

  • Protein details for PIWIL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3Z3-PIWL3_HUMAN
    Recommended name:
    Piwi-like protein 3
    Protein Accession:
    Q7Z3Z3
    Secondary Accessions:

    Protein attributes for PIWIL3 Gene

    Size:
    882 amino acids
    Molecular mass:
    101089 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIWIL3 Gene

Proteomics data for PIWIL3 Gene at MOPED

Post-translational modifications for PIWIL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIWIL3 Gene

No data available for DME Specific Peptides for PIWIL3 Gene

Domains for PIWIL3 Gene

Gene Families for PIWIL3 Gene

HGNC:
  • AGO :Argonaute/PIWI family

Protein Domains for PIWIL3 Gene

Suggested Antigen Peptide Sequences for PIWIL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z3Z3

UniProtKB/Swiss-Prot:

PIWL3_HUMAN :
  • Q7Z3Z3
Domain:
  • Contains 1 PAZ domain.
  • Contains 1 Piwi domain.
Family:
  • Belongs to the argonaute family. Piwi subfamily.
genes like me logo Genes that share domains with PIWIL3: view

Function for PIWIL3 Gene

Molecular function for PIWIL3 Gene

UniProtKB/Swiss-Prot Function: May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity).

Gene Ontology (GO) - Molecular Function for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PIWIL3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIWIL3 Gene

Localization for PIWIL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIWIL3 Gene

Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIWIL3 Gene COMPARTMENTS Subcellular localization image for PIWIL3 gene
Compartment Confidence
nucleus 3
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PIWIL3: view

Pathways for PIWIL3 Gene

SuperPathways for PIWIL3 Gene

genes like me logo Genes that share pathways with PIWIL3: view

Pathways by source for PIWIL3 Gene

1 KEGG pathway for PIWIL3 Gene

Gene Ontology (GO) - Biological Process for PIWIL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006417 regulation of translation IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0031047 gene silencing by RNA IEA --
genes like me logo Genes that share ontologies with PIWIL3: view

Transcripts for PIWIL3 Gene

mRNA/cDNA for PIWIL3 Gene

(7) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIWIL3 Gene

Piwi-like RNA-mediated gene silencing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIWIL3 Gene

No ASD Table

Relevant External Links for PIWIL3 Gene

GeneLoc Exon Structure for
PIWIL3
ECgene alternative splicing isoforms for
PIWIL3

Expression for PIWIL3 Gene

mRNA expression in normal human tissues for PIWIL3 Gene

mRNA differential expression in normal tissues according to GTEx for PIWIL3 Gene

This gene is overexpressed in Testis (31.1) and Ovary (8.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PIWIL3 Gene

SOURCE GeneReport for Unigene cluster for PIWIL3 Gene Hs.448343

mRNA Expression by UniProt/SwissProt for PIWIL3 Gene

Q7Z3Z3-PIWL3_HUMAN
Tissue specificity: Expressed in testis.
genes like me logo Genes that share expressions with PIWIL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PIWIL3 Gene

Orthologs for PIWIL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIWIL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIWIL3 35
  • 99.42 (n)
  • 99.42 (a)
PIWIL3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIWIL3 36
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC486307 35
  • 70.92 (n)
  • 57.28 (a)
PIWIL3 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PIWIL1 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 35 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii piwil1 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AGO3 36
  • 32 (a)
OneToMany
piwi 35
  • 47.29 (n)
  • 35.7 (a)
worm
(Caenorhabditis elegans)
Secernentea rde-1 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for PIWIL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PIWIL3 Gene

ENSEMBL:
Gene Tree for PIWIL3 (if available)
TreeFam:
Gene Tree for PIWIL3 (if available)

Paralogs for PIWIL3 Gene

Paralogs for PIWIL3 Gene

Selected SIMAP similar genes for PIWIL3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIWIL3: view

Variants for PIWIL3 Gene

Sequence variations from dbSNP and Humsavar for PIWIL3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs131472 -- 24,723,317(+) ACAGT(A/G)TATTG intron-variant
rs131473 -- 24,722,722(+) AAATA(A/G)ATAGA intron-variant
rs131474 -- 24,722,084(+) GTTTT(A/G)TTTTT intron-variant
rs131475 -- 24,721,996(+) ACACA(C/T)CATTT intron-variant
rs131476 -- 24,721,953(+) CTATA(C/T)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIWIL3 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv3579 CNV Insertion 18451855
esv2611432 CNV Deletion 19546169
nsv522434 CNV Gain 19592680
nsv914637 CNV Loss 21882294

Relevant External Links for PIWIL3 Gene

HapMap Linkage Disequilibrium report
PIWIL3
Human Gene Mutation Database (HGMD)
PIWIL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIWIL3 Gene

Disorders for PIWIL3 Gene

Relevant External Links for PIWIL3

Genetic Association Database (GAD)
PIWIL3
Human Genome Epidemiology (HuGE) Navigator
PIWIL3
genes like me logo Genes that share disorders with PIWIL3: view

No data available for UniProtKB/Swiss-Prot for PIWIL3 Gene

Publications for PIWIL3 Gene

  1. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T. … Shimizu N. (Genomics 2003) 2 3 4
  2. Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. (PMID: 20940137) Gu A. … Wang X. (Hum. Reprod. 2010) 3 48
  3. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3
  4. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4
  5. [Preparation and distribution of polyclonal antibodies against human PIWIL3 protein in tumor tissues]. (PMID: 18616918) Wang X.L. … Huang Z.G. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008) 3

Products for PIWIL3 Gene

Sources for PIWIL3 Gene

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