Aliases for PIWIL2 Gene
External Ids for PIWIL2 Gene
Previous GeneCards Identifiers for PIWIL2 Gene
PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PIWIL2 Gene
PIWIL2 (Piwi Like RNA-Mediated Gene Silencing 2) is a Protein Coding gene. Diseases associated with PIWIL2 include Caplan's Syndrome and Acute Cor Pulmonale. Among its related pathways are Dorso-ventral axis formation and Gene Expression. GO annotations related to this gene include nucleic acid binding and piRNA binding. An important paralog of this gene is PIWIL1.
UniProtKB/Swiss-Prot for PIWIL2 Gene
Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (By similarity). Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a slicer-competent piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto slicer-incompetent PIWIL4 (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). Inhibits tumor cell growth when repressed (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660).