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Aliases for PIWIL2 Gene

Aliases for PIWIL2 Gene

  • Piwi-Like RNA-Mediated Gene Silencing 2 2 3
  • Cancer/Testis Antigen 80 2 3 4
  • CT80 3 4
  • HILI 3 4
  • 80kDa PIWIL2 Short Isoform 3
  • Piwi-Like 2 (Drosophila) 2
  • Piwil2-Like Protein 3
  • Piwi-Like 2 3
  • Hiwi-Like 2
  • Miwi Like 3
  • PIWIL1L 3
  • Mili 3

External Ids for PIWIL2 Gene

Previous GeneCards Identifiers for PIWIL2 Gene

  • GC08P021891
  • GC08P022485
  • GC08P021953
  • GC08P022154
  • GC08P022188
  • GC08P022132
  • GC08P020675

Summaries for PIWIL2 Gene

Entrez Gene Summary for PIWIL2 Gene

  • PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PIWIL2 Gene

PIWIL2 (Piwi-Like RNA-Mediated Gene Silencing 2) is a Protein Coding gene. Diseases associated with PIWIL2 include acute cor pulmonale and acute pulmonary heart disease. Among its related pathways are Gene Expression and Mitotic Prophase. GO annotations related to this gene include nucleic acid binding and piRNA binding. An important paralog of this gene is PIWIL4.

UniProtKB/Swiss-Prot for PIWIL2 Gene

  • Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIWIL2 Gene

Genomics for PIWIL2 Gene

Regulatory Elements for PIWIL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIWIL2 Gene

Chromosome:
8
Start:
22,275,297 bp from pter
End:
22,357,568 bp from pter
Size:
82,272 bases
Orientation:
Plus strand

Genomic View for PIWIL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIWIL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIWIL2 Gene

Proteins for PIWIL2 Gene

  • Protein details for PIWIL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC59-PIWL2_HUMAN
    Recommended name:
    Piwi-like protein 2
    Protein Accession:
    Q8TC59
    Secondary Accessions:
    • A8K4S3
    • A8K8S5
    • B0AZN9
    • B0AZP2
    • B4DR22
    • E7ECA4
    • Q96SW6
    • Q9NW28

    Protein attributes for PIWIL2 Gene

    Size:
    973 amino acids
    Molecular mass:
    109849 Da
    Quaternary structure:
    • Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77. Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes. Interacts (when methylated on arginine residues) with TDRD1 and TDRKH/TDRD2. Interacts with TDRD12 (By similarity).
    SequenceCaution:
    • Sequence=BAA91558.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55155.1; Type=Erroneous termination; Positions=421; Note=Translated as Arg.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIWIL2 Gene

    Alternative splice isoforms for PIWIL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIWIL2 Gene

Proteomics data for PIWIL2 Gene at MOPED

Post-translational modifications for PIWIL2 Gene

  • Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIWIL2 Gene

Antibody Products

No data available for DME Specific Peptides for PIWIL2 Gene

Domains & Families for PIWIL2 Gene

Gene Families for PIWIL2 Gene

Suggested Antigen Peptide Sequences for PIWIL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TC59

UniProtKB/Swiss-Prot:

PIWL2_HUMAN :
  • Contains 1 PAZ domain.
  • Belongs to the argonaute family. Piwi subfamily.
Domain:
  • Contains 1 PAZ domain.
  • Contains 1 Piwi domain.
Family:
  • Belongs to the argonaute family. Piwi subfamily.
genes like me logo Genes that share domains with PIWIL2: view

Function for PIWIL2 Gene

Molecular function for PIWIL2 Gene

UniProtKB/Swiss-Prot Function:
Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with primary piRNAs in the cytoplasm and is required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense. The piRNA process acts upstream of known mediators of DNA methylation. Participates in a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Indirectly modulate expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8. Inhibits tumor cell growth when repressed. When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (By similarity).

Gene Ontology (GO) - Molecular Function for PIWIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding --
GO:0034584 piRNA binding ISS --
genes like me logo Genes that share ontologies with PIWIL2: view
genes like me logo Genes that share phenotypes with PIWIL2: view

Animal Models for PIWIL2 Gene

MGI Knock Outs for PIWIL2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIWIL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PIWIL2 Gene

Localization for PIWIL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIWIL2 Gene

Cytoplasm. Note=Present in chromatoid body. Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIWIL2 Gene COMPARTMENTS Subcellular localization image for PIWIL2 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for PIWIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005844 polysome IEA --
GO:0010370 perinucleolar chromocenter IEA --
GO:0033391 chromatoid body ISS --
GO:0043186 P granule ISS --
genes like me logo Genes that share ontologies with PIWIL2: view

Pathways & Interactions for PIWIL2 Gene

genes like me logo Genes that share pathways with PIWIL2: view

Pathways by source for PIWIL2 Gene

1 KEGG pathway for PIWIL2 Gene

Gene Ontology (GO) - Biological Process for PIWIL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000966 RNA 5-end processing ISS --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0010467 gene expression TAS --
GO:0030718 germ-line stem cell population maintenance ISS --
genes like me logo Genes that share ontologies with PIWIL2: view

No data available for SIGNOR curated interactions for PIWIL2 Gene

Drugs & Compounds for PIWIL2 Gene

No Compound Related Data Available

Transcripts for PIWIL2 Gene

Unigene Clusters for PIWIL2 Gene

Piwi-like RNA-mediated gene silencing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIWIL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIWIL2 Gene

No ASD Table

Relevant External Links for PIWIL2 Gene

GeneLoc Exon Structure for
PIWIL2
ECgene alternative splicing isoforms for
PIWIL2

Expression for PIWIL2 Gene

mRNA expression in normal human tissues for PIWIL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIWIL2 Gene

This gene is overexpressed in Testis (x15.7).

Protein differential expression in normal tissues from HIPED for PIWIL2 Gene

This gene is overexpressed in Ovary (43.1) and Testis (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIWIL2 Gene



SOURCE GeneReport for Unigene cluster for PIWIL2 Gene Hs.614809

mRNA Expression by UniProt/SwissProt for PIWIL2 Gene

Q8TC59-PIWL2_HUMAN
Tissue specificity: Expressed in adult testis and in most tumors.
genes like me logo Genes that share expression patterns with PIWIL2: view

Protein tissue co-expression partners for PIWIL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PIWIL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIWIL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIWIL2 35
  • 89.16 (n)
  • 88.85 (a)
PIWIL2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIWIL2 35
  • 89.85 (n)
  • 90.71 (a)
PIWIL2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Piwil2 35
  • 85.68 (n)
  • 88.16 (a)
Piwil2 16
Piwil2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIWIL2 35
  • 99.52 (n)
  • 98.97 (a)
PIWIL2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Piwil2 35
  • 85.89 (n)
  • 88.77 (a)
oppossum
(Monodelphis domestica)
Mammalia PIWIL2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIWIL2 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIWIL2 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIWIL2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia piwil2 35
  • 63.87 (n)
  • 66.45 (a)
zebrafish
(Danio rerio)
Actinopterygii piwil2 35
  • 62.36 (n)
  • 62.02 (a)
piwil2 36
  • 49 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008862 35
  • 46.31 (n)
  • 35.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta AGO3 35
  • 48.35 (n)
  • 38.7 (a)
AGO3 36
  • 34 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea alg-1 36
  • 17 (a)
ManyToMany
alg-2 36
  • 18 (a)
ManyToMany
C04F12.1 36
  • 15 (a)
ManyToMany
C14B1.7 36
  • 14 (a)
ManyToMany
csr-1 36
  • 13 (a)
ManyToMany
hpo-24 36
  • 17 (a)
ManyToMany
hrde-1 36
  • 13 (a)
ManyToMany
M03D4.6 36
  • 19 (a)
ManyToMany
nrde-3 36
  • 13 (a)
ManyToMany
ppw-1 36
  • 16 (a)
ManyToMany
ppw-2 36
  • 13 (a)
ManyToMany
prg-2 36
  • 30 (a)
ManyToMany
sago-1 36
  • 15 (a)
ManyToMany
sago-2 36
  • 16 (a)
ManyToMany
T22B3.2 36
  • 17 (a)
ManyToMany
tag-76 36
  • 17 (a)
ManyToMany
wago-1 36
  • 15 (a)
ManyToMany
wago-10 36
  • 14 (a)
ManyToMany
wago-11 36
  • 13 (a)
ManyToMany
wago-2 36
  • 15 (a)
ManyToMany
wago-4 36
  • 14 (a)
ManyToMany
wago-5 36
  • 14 (a)
ManyToMany
ZK218.8 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToOne
Species with no ortholog for PIWIL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIWIL2 Gene

ENSEMBL:
Gene Tree for PIWIL2 (if available)
TreeFam:
Gene Tree for PIWIL2 (if available)

Paralogs for PIWIL2 Gene

Paralogs for PIWIL2 Gene

(3) SIMAP similar genes for PIWIL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIWIL2: view

Variants for PIWIL2 Gene

Sequence variations from dbSNP and Humsavar for PIWIL2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2290274 -- 22,356,861(-) GGGGG(A/G)AAAAA utr-variant-3-prime
rs2404331 -- 22,328,465(+) tctgc(A/G)aaaaa intron-variant
rs2404332 -- 22,330,817(+) ttttt(C/T)cccca intron-variant
rs2404336 -- 22,345,921(+) gagtc(A/G)aagga intron-variant
rs3923432 -- 22,312,434(-) ttttt(A/T)aatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIWIL2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv831264 CNV Gain+Loss 17160897
nsv831265 CNV Loss 17160897
nsv6115 CNV Insertion 18451855
nsv518646 CNV Gain 19592680
nsv831266 CNV Loss 17160897
essv1932 CNV CNV 17122850
esv22246 CNV Loss 19812545
esv2669515 CNV Deletion 23128226

Variation tolerance for PIWIL2 Gene

Residual Variation Intolerance Score: 13.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIWIL2 Gene

HapMap Linkage Disequilibrium report
PIWIL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIWIL2 Gene

Disorders for PIWIL2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PIWIL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
acute cor pulmonale
acute pulmonary heart disease
  • acute pulmonary heart disease nos
- elite association

Relevant External Links for PIWIL2

Genetic Association Database (GAD)
PIWIL2
Human Genome Epidemiology (HuGE) Navigator
PIWIL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIWIL2
genes like me logo Genes that share disorders with PIWIL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIWIL2 Gene

Publications for PIWIL2 Gene

  1. Absence of PIWIL2 (HILI) expression in human bladder cancer cell lines and tissues. (PMID: 19683485) Nikpour P. … Mowla S.J. (Cancer Epidemiol 2009) 23 67
  2. Small RNA silencing pathways in germ and stem cells. (PMID: 19270082) Aravin A.A. … Hannon G.J. (Cold Spring Harb. Symp. Quant. Biol. 2008) 23 67
  3. Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes. (PMID: 16261612) Lee J.H. … Nayernia K. (Mol. Reprod. Dev. 2006) 23 67
  4. A novel class of small RNAs bind to MILI protein in mouse testes. (PMID: 16751777) Aravin A. … Tuschl T. (Nature 2006) 23 67
  5. Identification of eight members of the Argonaute family in the human genome. (PMID: 12906857) Sasaki T. … Shimizu N. (Genomics 2003) 2 67

Products for PIWIL2 Gene

Sources for PIWIL2 Gene

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