PITX3 Gene
protein-coding GIFtS : 60 GCID: GC10 M103979
paired-like homeodomain 3 paired-like homeodomain transcription factor 3 )
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Aliasesfor PITX3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Paired-Like Homeodomain 3 1 2 Paired-Like Homeodomain Transcription Factor 31 3 Homeobox Protein PITX32 3 PTX32 3 CTPP42 5 Pituitary Homeobox 32
Export aliases for PITX3 gene to outside databases Previous GC identifers: GC10M102883 GC10M103223 GC10M104121 GC10M103654 GC10M097622
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Summariesfor PITX3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for PITX3 : This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: PITX3_HUMAN, O75364 Function : Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalicdopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity) Gene Wiki entry for PITX3
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Genomic Viewsfor PITX3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the PITX3 gene promoter:C/EBPbeta POU3F1 NF-AT NF-AT2 HOXA5 c-Myb Cart-1 Msx-1 NF-AT1 Other transcription factors Search SABiosciences Chromatin IP Primers for PITX3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q24.32 Ensembl cytogenetic band: 10q24.32 HGNC cytogenetic band: 10q24.32 PITX3 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10M103979: view genomic region
(about GC identifiers )
Start: 103,989,943 bp from pter End:
104,001,231 bp from pter
Size: 11,289 bases Orientation:
minus strand
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Proteinsfor PITX3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: PITX3_HUMAN, O75364 See
protein sequence )Recommended Name: Size : 302 amino acids; 31832 DaSubunit : Interacts with SFPQ (By similarity)Subcellular location : Nucleus (By similarity)Secondary accessions : Q5VZL2Explore the universe of human proteins at neXtProt for PITX3: NX_O75364 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O75364 PITX3 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_005020.1 ENSEMBL proteins: ENSP00000359019 ENSP00000439383 Human Recombinant Protein Products for PITX3: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
ISS --
About GeneDecksing PITX3 Antibody Products: Assay Products for PITX3:
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Protein
Domains /for PITX3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry O75364 ProtoNet protein and cluster: O75364
1 Blocks protein family : IPB003654 UniProtKB/Swiss-Prot: PITX3_HUMAN, O75364 Similarity : Belongs to the paired homeobox family. Bicoid subfamilySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor PITX3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: PITX3_HUMAN, O75364 Function : Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalicdopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity)
Genatlas biochemistry entry for PITX3 paired-like homeo domain transcription factor 3,expressed in lens with later expression extending to the midbrain,tongue,incisors,sternum,vertebrae and limbs Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0005515 protein binding
-- -- GO:0043565 sequence-specific DNA binding
IEA --
About GeneDecksing Phenotypes: 1 GenomeRNAi human phenotype for PITX3 :15/17 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Pitx3) (see all 17 ):About GeneDecksing Animal Models: Pitx3 tm1.1Jdr for PITX3Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PITX3 (NM_005029 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PITX3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PITX3
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PITX3
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Pathways & Interactionsfor PITX3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PITX3 STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)5 Interacting proteins for PITX3 (O75364 3 ENSP00000359019 4 via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0002088 lens development in camera-type eye
ISS -- GO:0002089 lens morphogenesis in camera-type eye
ISS -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0006355 regulation of transcription, DNA-dependent
ISS -- GO:0007626 locomotory behavior
IEA --
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Drugs & Compoundsfor PITX3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for PITX3 3 Novoseek chemical compound relationships for PITX3 gene About this table PITX3
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Transcriptsfor PITX3 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for PITX3 gene: NM_005029.3 Unigene Cluster for PITX3:
Paired-like homeodomain 3 Hs.137568 [show with all ESTs ] Unigene Representative Sequence: NM_005029 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000370002 (uc001kuu.1 ) ENST00000539804 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: PITX3 (NM_005029 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PITX3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PITX3
Additional cDNA sequence: AF041339.1 BC011642.2
2 DOTS entries : DT.95097058 DT.92046893
7 AceView cDNA sequences :
NM_005029 CD675151 BC011642 BX283382 AF041339 BI114852 BF308662 GeneLoc Exon Structure
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Expression for PITX3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section PITX3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTGCCCTCCGAbout this image PITX3 expression in embryonic tissues and stem cells About this table
See PITX3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for PITX3 SOURCE GeneReport for Unigene cluster: Hs.137568 UniProtKB/Swiss-Prot: PITX3_HUMAN, O75364 Tissue specificity : Highly expressed in developing eye lensSABiosciences Expression via Pathway-Focused PCR Arrays including PITX3 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PITX3
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Orthologsfor PITX3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for PITX3 gene from 3/17 species (see all 17 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia PITX36
--
53(a)
possible ortholog
GL343858.1(88457-89742)
fruit fly Insecta Ptx13
specific RNA polymerase II transcription
41(a)
--
worm Secernentea unc-306
Homeobox protein unc-30
20(a)
1 → many
IV(13119072-13124363)
ENSEMBL Gene Tree for PITX3 (if available)TreeFam Gene Tree for PITX3 (if available)
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Paralogsfor PITX3 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for PITX3 gene ALX1 2 PHOX2B 2 RAX 2 VSX1 2 DRGX 2 PITX2 2 PRRX2 2 PITX1 2 ARX 2 PRRX1 2 PHOX2A 2 ISX 2 ALX4 2 VSX2 2 RAX2 2 ALX3 2 5 SIMAP similar genes for PITX3 using alignment to 2 protein entries: PITX3_HUMAN (see all proteins ):PITX1 PITX2 POU6F1 ARX DRGX About GeneDecksing
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Genomic Variantsfor PITX3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 10 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for PITX3 (103989943 - 104001231 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for PITX3: -- Human Gene Mutation Database (HGMD) : PITX3 Locus Specific Mutation Databases (LSDB): PITX3 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor PITX3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 602669 OMIM disorders : 107250 610623 UniProtKB/Swiss-Prot: PITX3_HUMAN, O75364 Defects in PITX3 are a cause of cataract autosomal dominant (ADC) [MIM:604219]. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood Defects in PITX3 are a cause of anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]; also known as anterior segment ocular dysgenesis (ASOD). ASMD consists of a range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Mature anterior segment anomalies are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis Defects in PITX3 are the cause of cataract posterior polar type 4 (CTPP4) [MIM:610623]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity. Some patients affected by cataract posterior polar type 4 can present a severe phenotype including microphthalmia and neurological dysfunction 20/23 (see all 23 ): About MalaCards anterior segment mesenchymal dysgenesis cataract, posterior polar, 4 cataract, posterior polar, 4, syndromic congenital cataracts cataract anophthalmia/microphthalmia posterior polar cataract peters plus syndrome peters anomaly cataracts, autosomal dominant anophthalmia autism spectrum disorder microphthalmia iridogoniodysgenesis aniridia pituitary adenoma parkinson's disease glaucoma adenoma blindness 3 diseases from the University of Copenhagen DISEASES database for PITX3 :Posterior polar cataract Parkinson's disease Microphthalmia 7 Novoseek disease relationships for PITX3 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
anterior segment mesenchymal dysgenesis
94.9
4
18989383 (2), 16565358 (1), 9620774 (1)
rieg
83.9
3
9620774 (2)
congenital cataract
70.7
2
17888164 (1), 9620774 (1)
aphakia
70.4
4
9328475 (2), 19007884 (1), 10861284 (1)
microphthalmia
68.8
8
20084168 (3), 20033184 (2), 16565358 (1), 17888164 (1)
parkinson disease
64.5
3
17350004 (1), 18049867 (1), 19144721 (1)
cataract
52.8
8
16565358 (3), 18989383 (2), 15665340 (2), 9620774 (1)
GeneTests: PITX3 Anophthalmia/Microphthalmia Human Genome Epidemiology (HuGE) Navigator: PITX3 (9 documents) Export disorders for PITX3 gene to outside databases
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Publicationsfor PITX3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for PITX3 gene, integrated from 9 sources (see all 80 ):(articles sorted by number of sources associating them with PITX3) Utopia : connect your pdf to the dynamic
A novel homeobox gene PITX3 is mutated in families with autosomal- dominant cataracts and ASMD. (PubMed id 9620774) 1 , 2 , 3, 9(1998) Recurrent 17 bp duplication in PITX3 is primarily associated with posterior polar cataract (CPP4). (PubMed id 15286169) 1 , 2 (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Heterozygous and homozygous mutations in PITX3 in a large Lebanese family with posterior polar cataracts and neurodevelopmental abnormalities. (PubMed id 16565358) 1 , 9(2006) Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. (PubMed id 19144721) 1 , 9(2009) Anterior segment mesenchymal dysgenesis in a large Australian family is associated with the recurrent 17 bp duplication in PITX3. (PubMed id 18989383) 1 , 9(2008) Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. (PubMed id 16477036) 1 , 9(2006) Functional analysis of human mutations in homeodomain transcription factor PITX3. (PubMed id 17888164) 1 , 9(2007) Posterior polar cataract: genetic analysis of a large family. (PubMed id 16272057) 1 , 9(2005) Meta-analysis of association between PITX3 gene polymo rphism and Parkinson's disease. (PubMed id 22429667) 1 (2012)
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Specialized Databases showing PITX3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for PITX3 Pharmacogenomics, SNPs, Pathways GeneReviews http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/PITX3
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About This Section Patent Information for PITX3 gene: PITX3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor PITX3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for PITX3 OriGene shRNA RFP for PITX3 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for PITX3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for PITX3 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for PITX3 OriGene Custom Protein Services for PITX3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PITX3 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Search Tocris compounds for PITX3
PITX3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PITX3
ThermoFisher Antibodies for PITX3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat PITX3
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Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
In-situ hybridization
