Aliases for PITX1 Gene
Aliases for PITX1 Gene
External Ids for PITX1 Gene
- HGNC: 9004
- Entrez Gene: 5307
- Ensembl: ENSG00000069011
- OMIM: 602149
- UniProtKB: P78337
Previous HGNC Symbols for PITX1 Gene
- BFT
Previous GeneCards Identifiers for PITX1 Gene
- GC05M134015
- GC05M134930
- GC05M134394
- GC05M134439
- GC05M134391
- GC05M129551
- GC05M134363
Summaries for PITX1 Gene
-
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
GeneCards Summary for PITX1 Gene
PITX1 (Paired Like Homeodomain 1) is a Protein Coding gene. Diseases associated with PITX1 include Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/Or Mirror-Image Polydactyly and Liebenberg Syndrome. Among its related pathways are DAG and IP3 signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is PITX2.
UniProtKB/Swiss-Prot for PITX1 Gene
-
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PITX1 Gene
Genomics for PITX1 Gene
Regulatory Elements for PITX1 Gene
Enhancers for PITX1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH05G135137 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 16.1 | -105.2 | -105229 | 5.9 | FOXA2 PKNOX1 ARNT BRCA1 GLIS2 FOS DEK SP5 SMARCB1 SSRP1 | PITX1 CATSPER3 LOC105379188 C5orf66-AS2 |
| GH05G135026 | 1.7 | Ensembl ENCODE dbSUPER | 13.2 | +3.8 | 3806 | 9.3 | CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 | C5orf66-AS1 PITX1 C5orf66 CATSPER3 |
| GH05G135035 | 1 | dbSUPER | 12.6 | -3.8 | -3763 | 5.3 | ATF1 AGO1 SIN3A ZNF48 GLIS2 ELK1 REST TSHZ1 CBX8 MIER3 | C5orf66-AS1 PITX1 C5orf66 ENSG00000270021 |
| GH05G135024 | 1 | ENCODE dbSUPER | 12 | +9.4 | 9385 | 1.5 | TFAP4 PKNOX1 ATF1 NFIB JUN RAD21 ZIC2 THRB FOSL1 GATA3 | C5orf66-AS1 PITX1 C5orf66 CATSPER3 |
| GH05G135014 | 0.8 | ENCODE dbSUPER | 12.6 | +20.4 | 20408 | 0.2 | JUND NFIA HNF4A RAD21 | PITX1 C5orf66-AS1 C5orf66 CATSPER3 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PITX1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PITX1 gene promoter:
Regulatory Element Products
Genomic Location for PITX1 Gene
- Chromosome:
- 5
- Start:
- 135,027,734 bp from pter
- End:
- 135,034,813 bp from pter
- Size:
- 7,080 bases
- Orientation:
- Minus strand
Genomic View for PITX1 Gene
Genes around PITX1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by Ensembl
- 5q31.1 by Entrez Gene
- 5q31.1 by HGNC
PITX1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PITX1 Gene
Proteins for PITX1 Gene
-
Protein details for PITX1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78337-PITX1_HUMAN
- Recommended name:
- Pituitary homeobox 1
- Protein Accession:
- P78337
- A8K3M0
- D3DQB0
- O14677
- O60425
- Q9BTI5
Protein attributes for PITX1 Gene
- Size:
- 314 amino acids
- Molecular mass:
- 34128 Da
- Quaternary structure:
-
- Interacts with POU1F1 (PubMed:26612202).
Protein Expression for PITX1 Gene
Post-translational modifications for PITX1 Gene
Other Protein References for PITX1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for PITX1
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- antibodies-online Antibodies for PITX1: See all 49
- GeneTex PITX1 antibody for PITX1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PITX1
Protein Products
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OriGene Purified Proteins for PITX1
- Search Origene for MassSpec and Protein Over-expression Lysates for PITX1
- Origene Custom Protein Services for PITX1
- antibodies-online Proteins for PITX1: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PITX1
Assay Products
- antibodies-online Kits for PITX1: See all 6
No data available for DME Specific Peptides for PITX1 Gene
Domains & Families for PITX1 Gene
Gene Families for PITX1 Gene
Protein Domains for PITX1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PITX1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P78337- Family:
-
- Belongs to the paired homeobox family. Bicoid subfamily.
Function for PITX1 Gene
Molecular function for PITX1 Gene
- GENATLAS Biochemistry:
- POU domain,class 1,transcription factor 3,mammalian homeo box backfoot,Drosophila bicoid related,mapping in TCOF1 region and possibly involved in the syndrome,expressed in Rathke pouch at an early stage of pituitary development in a subset of adult anterior pituitary cells that express POMC,and in craniofacial development
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IEA | -- |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI | 26612202 |
| GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for PITX1 Gene
- MGI mutant phenotypes for PITX1:
-
inferred from 2 alleles
- mortality/aging
- growth/size/body region phenotype
- muscle phenotype
- nervous system phenotype
- cardiovascular system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- hearing/vestibular/ear phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for PITX1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PITX1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PITX1 gene
- Search ViGene Biosciences for PITX1
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for PITX1
- GenScript: Design CRISPR guide RNA sequences for PITX1
miRNA for PITX1 Gene
- miRTarBase miRNAs that target PITX1
-
- hsa-mir-331-3p (MIRT043542)
- hsa-mir-320a (MIRT044749)
- hsa-mir-149-5p (MIRT045636)
- hsa-mir-92a-3p (MIRT049789)
- hsa-mir-6836-3p (MIRT614511)
- hsa-mir-6749-3p (MIRT614512)
- hsa-mir-1908-3p (MIRT614513)
- hsa-mir-6850-3p (MIRT614514)
- hsa-mir-4707-5p (MIRT614515)
- hsa-mir-6840-5p (MIRT614516)
- hsa-mir-431-3p (MIRT614517)
Targeted motifs for PITX1 Gene
HOMER Transcription Factor Regulatory Elements motif PITX1
- Consensus sequence: TAATCCCN Submotif: canonical Cell Type: Chicken GEO ID: GSE38910
miRNA Products
- Search ViGene Biosciences for PITX1
Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PITX1
-
ViGene Biosciences adenoviral particle packaged cDNA for PITX1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PITX1 gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for PITX1 Gene
Localization for PITX1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PITX1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 17984056 |
| GO:0005667 | transcription factor complex | IEA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for PITX1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling | ||
Pathways by source for PITX1 Gene
1 GeneGo (Thomson Reuters) pathway for PITX1 Gene
Interacting Proteins for PITX1 Gene
Selected Interacting proteins:
ENSP00000265340
P78337-PITX1_HUMAN
for PITX1 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | TAS | 9070926 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for PITX1 Gene
Transcripts for PITX1 Gene
mRNA/cDNA for PITX1 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (162) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PITX1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PITX1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PITX1
- GenScript: Design CRISPR guide RNA sequences for PITX1
miRNA Products
- Search ViGene Biosciences for PITX1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for PITX1
- Browse OriGene Inhibitory RNA Products For PITX1
-
ViGene Biosciences ready-to-package AAV shRNAs for PITX1 gene
Clone Products
-
OriGene ORF clones in human for PITX1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PITX1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PITX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PITX1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for PITX1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Neural Crest (Gastrulation Derivatives)
- Mesencephalic Neural Crest Cells Prechordal Mesenchyme
- Diencephalic Neural Crest Cells Prechordal Mesenchyme
- Cranial Neural Crest Cells Branchial Arch 1
- PureStem SK11, NCr-fac & Meso-prx Progenitor
- PureStem SM30, NCr-fac & Meso-latp Progenitor
-
Head Mesenchyme (Muscoskeletal System)
- Mesencephalic Neural Crest Cells Prechordal Mesenchyme
- Diencephalic Neural Crest Cells Prechordal Mesenchyme
- Cranial Neural Crest Cells Branchial Arch 1
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Skeletal Muscle (Muscoskeletal System)
- Muscle satellite Cells Extraocular Muscles
- Paraxial Mesoderm (Gastrulation Derivatives)
- Lateral Plate Mesoderm (Gastrulation Derivatives)
mRNA differential expression in normal tissues according to GTEx for PITX1 Gene
This gene is overexpressed in Esophagus - Mucosa (x23.8), Pituitary (x6.5), Vagina (x5.9), and Minor Salivary Gland (x4.7).
This gene is overexpressed in Pancreatic juice (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PITX1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PITX1 Gene:
PITX1SOURCE GeneReport for Unigene cluster for PITX1 Gene:
Hs.84136Evidence on tissue expression from TISSUES for PITX1 Gene
- Pancreas(4.1)
- Muscle(2.6)
- Intestine(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PITX1 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeleton
Organs:
Head and neck:
- brain
- head
- skull
Limb:
- ankle
- arm
- digit
- elbow
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- shoulder
- toe
- ulna
- upper limb
- wrist
General:
- skin
Primer Products
-
OriGene qPCR primer pairs and template standards for PITX1
-
OriGene qPCR primer pairs for PITX1
No data available for mRNA Expression by UniProt/SwissProt for PITX1 Gene
Orthologs for PITX1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PITX1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PITX1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | PITX1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Pitx1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Pitx1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PITX1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PITX1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PITX1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PITX1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | pitx1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | pitx1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | pitx1 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5257 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ptx1 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | unc-30 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for PITX1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PITX1 Gene
Paralogs for PITX1 Gene
(14) SIMAP similar genes for PITX1 Gene using alignment to 4 proteins:
Variants for PITX1 Gene
| SNP ID | Clin | Chr 05 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121909109 | Pathogenic, Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly (CCF) [MIM:119800] | 135,031,290(-) | TCACC(A/G)AGCCG | upstream-variant-2KB, reference, missense | |
| rs730882191 | Pathogenic | 135,028,925(-) | AACTC(-/GGCCATGTCGCCGGGCGCTTGCCCGTACGGCACTC)CCGCC | reference, frameshift-variant | |
| rs200888898 | Uncertain significance | 135,031,416(+) | CTGCT(G/T)CTTCT | upstream-variant-2KB, reference, missense | |
| rs201133610 | Uncertain significance | 135,031,427(+) | TCTTG(G/T)CTGGG | upstream-variant-2KB, reference, missense | |
| rs794727495 | Uncertain significance | 135,029,308(-) | CAAGA(A/C)CCGGC | reference, missense |
Residual Variation Intolerance Score:
36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.64;
91.36% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PITX1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PITX1 Gene
Disorders for PITX1 Gene
(14) MalaCards diseases for PITX1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly |
|
|
| liebenberg syndrome |
|
|
| pitx1-related congenital clubfoot |
|
|
| acute diarrhea |
|
|
| inflammatory diarrhea |
|
|
Search PITX1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PITX1_HUMAN- Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly (CCF) [MIM:119800]: A congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e., inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Some patients present tibial hemimelia, bilateral patellar hypoplasia, and preaxial mirror-image polydactyly. {ECO:0000269 PubMed:18950742, ECO:0000269 PubMed:22258522}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Liebenberg syndrome (LBNBG) [MIM:186550]: An upper limb-malformation syndrome characterized by the combination of dysplastic elbow joints and the fusion of wrist bones with consequent radial deviation. {ECO:0000269 PubMed:23022097}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving the PITX1 locus results in LBNBG. Translocation t(5;18)(q31.1;q12.3). Additionally, two chromosome 5 deletions located 5of PITX1 have been found in LBNBG patients. These structural variations cause altered expression of PITX1 in the forelimb via the activation of ectopic enhancers (PubMed:23022097). {ECO:0000269 PubMed:23022097}.
Relevant External Links for PITX1
No data available for Genatlas for PITX1 Gene
Publications for PITX1 Gene
- Human and murine PTX1/Ptx1 gene maps to the region for Treacher Collins syndrome. (PMID: 9337397) Crawford M.J. … Drouin J. (Mamm. Genome 1997) 2 3 4 22 64
- Backfoot, a novel homeobox gene, maps to human chromosome 5 (BFT) and mouse chromosome 13 (Bft). (PMID: 9070926) Shang J. … Francke U. (Genomics 1997) 2 3 4 64
- Functional characterization of a human POU1F1 mutation associated with isolated growth hormone deficiency: a novel etiology for IGHD. (PMID: 26612202) Sobrier M.L. … Amselem S. (Hum. Mol. Genet. 2015) 3 4 64
- Deletions in PITX1 cause a spectrum of lower-limb malformations including mirror-image polydactyly. (PMID: 22258522) Klopocki E. … Kurth I. (Eur. J. Hum. Genet. 2012) 3 4 64
- Homeotic arm-to-leg transformation associated with genomic rearrangements at the PITX1 locus. (PMID: 23022097) Spielmann M. … Mundlos S. (Am. J. Hum. Genet. 2012) 3 4 64
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- Search GeneTex for Proteins for PITX1
- ViGene Biosciences adenoviral particle packaged cDNA for PITX1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PITX1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PITX1 gene
- Search ViGene Biosciences for PITX1
- Santa Cruz Biotechnology (SCBT) Antibodies for PITX1
- Search Santa Cruz Biotechnology (SCBT) for PITX1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PITX1
- Horizon Cell Lines for PITX1
- Cyagen custom Knockout/knockin (KOKI) mouse models for PITX1
- VectorBuilder custom plasmid, inducible vectors for PITX1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PITX1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PITX1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer