Aliases for PITRM1 Gene
External Ids for PITRM1 Gene
Previous GeneCards Identifiers for PITRM1 Gene
GeneCards Summary for PITRM1 Gene
PITRM1 (Pitrilysin Metallopeptidase 1) is a Protein Coding gene. GO annotations related to this gene include metalloendopeptidase activity and enzyme activator activity.
UniProtKB/Swiss-Prot for PITRM1 Gene
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.