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PITPNM2 Gene

protein-coding   GIFtS: 51
GCID: GC12M123468

Phosphatidylinositol Transfer Protein, Membrane-Associated...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol Transfer Protein, Membrane-Associated 21 2 3     RDGB22
Pyk2 N-Terminal Domain-Interacting Receptor 32 3     RDGBA22
NIR-32 3     Membrane-Associated Phosphatidylinositol Transfer Protein 22
NIR32 3     Retinal Degeneration B Alpha 22
PITPnm 22 3     KIAA14573

External Ids:    HGNC: 210441   Entrez Gene: 576052   Ensembl: ENSG000000909757   OMIM: 6089205   UniProtKB: Q9BZ723   

Export aliases for PITPNM2 gene to outside databases

Previous GC identifers: GC12M123276 GC12M121905 GC12M121907 GC12M121992 GC12M120429


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PITPNM2 Gene:
PITPNM2 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that
share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 (PubMed
15627748)).(supplied by OMIM, Mar 2008)

GeneCards Summary for PITPNM2 Gene:
PITPNM2 (phosphatidylinositol transfer protein, membrane-associated 2) is a protein-coding gene. GO annotations related to this gene include lipid binding and calcium ion binding. An important paralog of this gene is PITPNC1.

UniProtKB/Swiss-Prot: PITM2_HUMAN, Q9BZ72
Function: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro).
Binds calcium ions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PITPNM2 gene promoter:
         Max1   USF1   SRY   POU2F1   FOXJ2 (long isoform)   POU2F1a   USF-1   FOXJ2   TGIF   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPITPNM2 promoter sequence
   Search Chromatin IP Primers for PITPNM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PITPNM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

PITPNM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PITPNM2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M123468:  view genomic region     (about GC identifiers)

Start:
123,468,027 bp from pter      End:
123,634,562 bp from pter
Size:
166,536 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PITM2_HUMAN, Q9BZ72 (See protein sequence)
Recommended Name: Membrane-associated phosphatidylinositol transfer protein 2  
Size: 1349 amino acids; 148933 Da
Subunit: Interacts with PTK2B via its C-terminus
Sequence caution: Sequence=BAA95981.2; Type=Erroneous initiation;
Secondary accessions: Q9P271
Alternative splicing: 3 isoforms:  Q9BZ72-1   Q9BZ72-2   Q9BZ72-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PITPNM2: NX_Q9BZ72

Explore proteomics data for PITPNM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PITPNM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065896.1  
    ENSEMBL proteins: 
     ENSP00000280562   ENSP00000437611   ENSP00000474962   ENSP00000437869   ENSP00000445399  
     ENSP00000322218   ENSP00000376223  

    PITPNM2 Human Recombinant Protein Products:

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    antibodies-online peptides for PITPNM2

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    antibodies-online antibodies for PITPNM2 (9 products) 

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    antibodies-online kits for PITPNM2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR013209 LNS2
     IPR023214 HAD-like_dom
     IPR004177 DDHD
     IPR023393 START-like_dom
     IPR001666 PI_transfer

    Graphical View of Domain Structure for InterPro Entry Q9BZ72

    ProtoNet protein and cluster: Q9BZ72

    1 Blocks protein domain: IPB001666 Phosphatidylinositol transfer protein signature

    UniProtKB/Swiss-Prot: PITM2_HUMAN, Q9BZ72
    Similarity: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily
    Similarity: Contains 1 DDHD domain


    Find genes that share domains with PITPNM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PITM2_HUMAN, Q9BZ72
    Function: Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro).
    Binds calcium ions

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding NAS10022914
    GO:0008289lipid binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with PITPNM2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Pitpnm2):
     normal 

    Find genes that share phenotypes with PITPNM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Pitpnm2tm1Tili for PITPNM2

       genOway: Develop your customized and physiologically relevant rodent model for PITPNM2

    miRNA
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    miRTarBase miRNAs that target PITPNM2:
    hsa-mir-296-3p (MIRT038447), hsa-mir-324-3p (MIRT042927), hsa-mir-335-5p (MIRT018089)

    Block miRNA regulation of human, mouse, rat PITPNM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PITPNM2 (see all 84):
    hsa-miR-376b hsa-miR-128 hsa-miR-30d hsa-miR-219-5p hsa-miR-3653 hsa-miR-342-3p hsa-miR-30a hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidPITPNM2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PITPNM2

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PITM2_HUMAN, Q9BZ72: Endomembrane system; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0012505endomembrane system IEA--
    GO:0016021integral component of membrane NAS10022914
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with PITPNM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PITPNM2
    Interactions:

        GeneGlobe Interaction Network for PITPNM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PITPNM2 (Q9BZ723 ENSP000003222184) via UniProtKB, MINT, STRING, and/or I2D (see all 55)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTK2BQ142893, ENSP000003328164I2D: score=2 STRING: ENSP00000332816
    CPNE1Q998293, ENSP000003172574I2D: score=1 STRING: ENSP00000317257
    PLCB4Q151473, ENSP000003341054I2D: score=1 STRING: ENSP00000334105
    ARRB1P494073, ENSP000003771414I2D: score=1 STRING: ENSP00000377141
    CPNE4Q96A233I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0008152metabolic process NAS10022914

    Find genes that share ontologies with PITPNM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PITPNM2 (PITM2)

    Selected HMDB Compounds for PITPNM2 (see all 1455)    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PC(14:0/14:0)Phosphatidylcholine(14:0/14:0) (see all 8)----
    PC(14:0/14:1(9Z))Phosphatidylcholine(14:0/14:1) (see all 14)----
    PC(14:0/15:0)GPCho(14:0/15:0) (see all 8)----
    PC(14:0/16:0)GPCho(30:0) (see all 8)----
    PC(14:0/16:1(9Z))1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine (see all 14)----
    PC(14:0/18:0)1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine (see all 8)----
    PC(14:0/18:1(11Z))Phosphatidylcholine(14:0/18:1w7) (see all 14)----
    PC(14:0/18:1(9Z))1-myristoyl-2-oleoyl-sn-glycero-3-phosphocholine (see all 14)----
    PC(14:0/18:2(9Z,12Z))Phosphatidylcholine(32:2) (see all 14)----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PITPNM2 gene: 
    NM_020845.2  

    Unigene Cluster for PITPNM2:

    Phosphatidylinositol transfer protein, membrane-associated 2
    Hs.272759  [show with all ESTs]
    Unigene Representative Sequence: AB040890
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280562(uc001uek.1) ENST00000542749 ENST00000436074 ENST00000546049
    ENST00000451868(uc009zxu.1) ENST00000542210 ENST00000535289 ENST00000541244
    ENST00000320201(uc001uej.1) ENST00000392428
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PITPNM2 (see all 84):
    hsa-miR-376b hsa-miR-128 hsa-miR-30d hsa-miR-219-5p hsa-miR-3653 hsa-miR-342-3p hsa-miR-30a hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidPITPNM2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat PITPNM2

    Additional mRNA sequence: 

    AB040890.2 AF334585.1 AK026156.1 AL133612.1 BC025360.1 BC040063.1 BC050567.1 BC141813.1 

    6 DOTS entries:

    DT.100742290  DT.439502  DT.121149386  DT.121149342  DT.121149363  DT.121149375 

    Selected AceView cDNA sequences (see all 80):

    AL549956 BC025360 BU732093 BM703287 R19190 BM717063 AI650815 BM757394 
    AI611064 AB040890 AW590553 AI673017 AI652082 BM792645 BU731117 AI989918 
    BC050567 BC040063 AL133612 AI207141 BI753330 BF353740 BU541008 BI042456 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PITPNM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGTTACAC
    PITPNM2 Expression
    About this image


    PITPNM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PITPNM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PITPNM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.272759

    UniProtKB/Swiss-Prot: PITM2_HUMAN, Q9BZ72
    Tissue specificity: Highly expressed in brain, heart, ovary, testis and thymus. Detected in small intestine,
    prostate, pancreas, skeletal muscle, liver, colon and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PITPNM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PITPNM2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pitpnm21 , 5 phosphatidylinositol transfer protein, membrane-associated 2 less1, 5 86.86(n)1
    90.79(a)1
      5 (63.39 cM)5
    196791  NM_011256.21  NP_035386.11 
     1241186905 
    chicken
    (Gallus gallus)
    Aves PITPNM21 phosphatidylinositol transfer protein, membrane-associated 2 less 73.33(n)
    79.77(a)
      416830  XM_004945545.1  XP_004945602.1 
    lizard
    (Anolis carolinensis)
    Reptilia PITPNM26
    phosphatidylinositol transfer protein, membrane-as...
    71(a)
    1 ↔ 1
    LGb(1909930-2010003)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pitpnm21 phosphatidylinositol transfer protein, membrane-associated 2 less 70.91(n)
    79.62(a)
      100216221  NM_001142189.1  NP_001135661.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003339011 membrane-associated phosphatidylinositol transfer protein 2-like less 66.94(n)
    64.5(a)
      100333901  XM_002663669.3  XP_002663715.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta rdgB1 retinal degeneration B 58.32(n)
    53.23(a)
      32340  NM_001014740.2  NP_001014740.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pitp-11 pitp-1 51.79(n)
    48.02(a)
      175459  NM_065325.3  NP_497726.2 


    ENSEMBL Gene Tree for PITPNM2 (if available)
    TreeFam Gene Tree for PITPNM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PITPNM2 gene
    PITPNC12  PITPNB2  PITPNM32  PITPNM12  PITPNA2  
    6 SIMAP similar genes for PITPNM2 using alignment to 7 protein entries:     PITM2_HUMAN (see all proteins):
    DKFZp434P0917    PITPNM1    PITPNM3    PITPNA    PITPNC1    PITPNB

    Find genes that share paralogs with PITPNM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PITPNM2 (see all 1915)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1854938561,2
    --123467988(+) CCACCA/GTGCCC 1 -- int10--------
    rs1498506391,2
    C--123468546(+) GGAGGC/TGGAAA 1 -- ut310--------
    rs1157436901,2
    --123468557(+) GCAGAC/TCTGGA 1 -- ut310--------
    rs1458868451,2
    --123468572(+) GAAGAA/GACTTC 1 -- ut310--------
    rs1490222841,2
    --123468657(+) GTTGTC/TCTTGG 1 -- ut310--------
    rs673060851,2
    C--123468733(+) GAGGCT/CGAGCC 1 -- ut312Minor allele frequency- C:0.03NA 122
    rs1907942741,2
    --123469081(+) TTTTTC/TCTCTG 1 -- ut310--------
    rs15689181,2
    C--123469141(+) TTACAC/G/TGACCC 2 -- ut31 ese35MN NA CSA WA EA 425
    rs1466853651,2
    C--123469170(+) CACACA/GGGAAA 1 -- ut310--------
    rs1402804771,2
    --123469240(+) AGGTCA/GGCCGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PITPNM2 (123468027 - 123634562 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for PITPNM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2646329CNV Deletion19546169
    nsv914CNV Insertion18451855
    dgv1497n71CNV Loss21882294
    nsv455732CNV Loss19166990
    dgv22n68CNV Loss17160897
    nsv899577CNV Loss21882294
    nsv517200CNV Loss19592680
    nsv899578CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608920    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for PITPNM2:
    Retinal degeneration

    Find genes that share disorders with PITPNM2           About GenesLikeMe

    Genetic Association Database (GAD): PITPNM2

    Export disorders for PITPNM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PITPNM2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PITPNM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. (PubMed id 10022914)1, 2, 3, 9 Lev S....Schlessinger J. (Mol. Cell. Biol. 1999)
    2. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1, 4 Ramsuran V....Ndung'u T. (Clin. Infect. Dis. 2011)
    3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)
    5. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. (PubMed id 22361696)2 Stadler C.... Lundberg E. (J. Proteomics 2012)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    7. Chromosomal localization, genomic organization and evolution of the genes encoding human phosphatidylinositol transfer protein membrane- associated (PITPNM) 1, 2 and 3. (PubMed id 15627748)1 Ocaka L.... Halford S. (Cytogenet. Genome Res. 2005)
    8. Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif. (PubMed id 12522145)1 Tomsig J.L....Creutz C.E. (J. Biol. Chem. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57605 HGNC: 21044 AceView: PITPNM2 Ensembl:ENSG00000090975 euGenes: HUgn57605
    ECgene: PITPNM2 H-InvDB: PITPNM2

    (According to HUGE)
    About This Section

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    HUGE: KIAA1457

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PITPNM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PITPNM2 gene:
    Search GeneIP for patents involving PITPNM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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