Aliases for PITPNM1 Gene
External Ids for PITPNM1 Gene
Previous HGNC Symbols for PITPNM1 Gene
Previous GeneCards Identifiers for PITPNM1 Gene
PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008]
GeneCards Summary for PITPNM1 Gene
PITPNM1 (Phosphatidylinositol Transfer Protein Membrane Associated 1) is a Protein Coding gene. Diseases associated with PITPNM1 include Retinal Degeneration and Hypopyon. Among its related pathways are Glycerophospholipid biosynthesis and Metabolism. GO annotations related to this gene include phosphatidylinositol transporter activity. An important paralog of this gene is PITPNM2.
UniProtKB/Swiss-Prot for PITPNM1 Gene
Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions.