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Aliases for PITPNB Gene

Aliases for PITPNB Gene

  • Phosphatidylinositol Transfer Protein Beta 2 3 5
  • PtdIns Transfer Protein Beta 3 4
  • PI-TP-Beta 3 4
  • Phosphatidylinositol Transfer Protein Beta Isoform 3
  • Phosphotidylinositol Transfer Protein, Beta 3
  • PtdInsTP Beta 4
  • PtdInsTP 3
  • VIB1B 3

External Ids for PITPNB Gene

Previous GeneCards Identifiers for PITPNB Gene

  • GC22M024943
  • GC22M026572
  • GC22M028202
  • GC22M011211

Summaries for PITPNB Gene

Entrez Gene Summary for PITPNB Gene

  • This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PITPNB Gene

PITPNB (Phosphatidylinositol Transfer Protein Beta) is a Protein Coding gene. Among its related pathways are Metabolism and PI Metabolism. GO annotations related to this gene include lipid binding. An important paralog of this gene is PITPNA.

UniProtKB/Swiss-Prot for PITPNB Gene

  • Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Gene Wiki entry for PITPNB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PITPNB Gene

Genomics for PITPNB Gene

Regulatory Elements for PITPNB Gene

Enhancers for PITPNB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F027863 1.2 FANTOM5 Ensembl ENCODE 19 +52.3 52305 9.6 ELF3 INSM2 FEZF1 BRCA1 RAD21 ZNF2 YY1 ZNF366 FOS MIXL1 PITPNB TTC28-AS1 MN1 TTC28 GC22M027880
GH22F027892 0.4 ENCODE 12.1 +27.8 27787 0.2 ATF3 HLF CEBPA CEBPB RAD21 YY1 PITPNB TTC28-AS1 GC22M027880
GH22F027986 0.2 ENCODE 12 -67.5 -67482 1.6 GLIS1 BHLHE40 SCRT2 FOS NR2F2 NFE2L2 TTC28-AS1 PITPNB ENSG00000274342 GC22P027932
GH22F027881 0.9 Ensembl ENCODE 11.8 +37.6 37615 4.2 HDGF CTCF ZNF654 TRIM22 REST RAD21 RFX5 CEBPA SMC3 TTC28-AS1 PITPNB GC22M027880
GH22F027885 0.6 ENCODE 11.8 +33.8 33757 2.4 CTCF PKNOX1 JUN RAD21 ZEB1 HIC1 ZFHX2 ZNF366 SMC3 FOS TTC28-AS1 PITPNB ENSG00000272858 GC22M027880
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PITPNB on UCSC Golden Path with GeneCards custom track

Promoters for PITPNB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for PITPNB Gene

27,851,669 bp from pter
27,920,134 bp from pter
68,466 bases
Minus strand

Genomic View for PITPNB Gene

Genes around PITPNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PITPNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PITPNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PITPNB Gene

Proteins for PITPNB Gene

  • Protein details for PITPNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol transfer protein beta isoform
    Protein Accession:
    Secondary Accessions:
    • B3KYB8
    • B7Z7Q0
    • Q8N5W1

    Protein attributes for PITPNB Gene

    271 amino acids
    Molecular mass:
    31540 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PITPNB Gene


neXtProt entry for PITPNB Gene

Post-translational modifications for PITPNB Gene

  • Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting.
  • Ubiquitination at Lys 5, Lys 86, Lys 104, Lys 110, Lys 179, Lys 201, Lys 208, Lys 215, and Lys 252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PITPNB Gene

Domains & Families for PITPNB Gene

Gene Families for PITPNB Gene

Protein Domains for PITPNB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
  • Belongs to the PtdIns transfer protein family. PI transfer class I subfamily.
genes like me logo Genes that share domains with PITPNB: view

Function for PITPNB Gene

Molecular function for PITPNB Gene

GENATLAS Biochemistry:
phosphotidylinositol transfer protein, beta
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes.

Gene Ontology (GO) - Molecular Function for PITPNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with PITPNB: view
genes like me logo Genes that share phenotypes with PITPNB: view

Animal Models for PITPNB Gene

MGI Knock Outs for PITPNB:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PITPNB Gene

Localization for PITPNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PITPNB Gene

Cytoplasm. Golgi apparatus.

Subcellular locations from

Jensen Localization Image for PITPNB Gene COMPARTMENTS Subcellular localization image for PITPNB gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
cytosol 4
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PITPNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with PITPNB: view

Pathways & Interactions for PITPNB Gene

genes like me logo Genes that share pathways with PITPNB: view

Interacting Proteins for PITPNB Gene

Gene Ontology (GO) - Biological Process for PITPNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process NAS 8541325
GO:0006810 transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS 22822086
GO:0006997 nucleus organization TAS 22822086
GO:0015914 phospholipid transport TAS --
genes like me logo Genes that share ontologies with PITPNB: view

No data available for SIGNOR curated interactions for PITPNB Gene

Drugs & Compounds for PITPNB Gene

(385) Additional Compounds for PITPNB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
genes like me logo Genes that share compounds with PITPNB: view

Transcripts for PITPNB Gene


Unigene Clusters for PITPNB Gene

Phosphatidylinositol transfer protein, beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PITPNB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -

Relevant External Links for PITPNB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PITPNB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PITPNB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PITPNB Gene

Protein tissue co-expression partners for PITPNB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PITPNB Gene:


SOURCE GeneReport for Unigene cluster for PITPNB Gene:


mRNA Expression by UniProt/SwissProt for PITPNB Gene:

Tissue specificity: Widely expressed in various tissues including brain.
genes like me logo Genes that share expression patterns with PITPNB: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for PITPNB Gene

Orthologs for PITPNB Gene

This gene was present in the common ancestor of animals.

Orthologs for PITPNB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PITPNB 34 35
  • 99.88 (n)
(Canis familiaris)
Mammalia PITPNB 34 35
  • 95.94 (n)
(Bos Taurus)
Mammalia PITPNB 34 35
  • 94.46 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
-- 35
  • 82 (a)
-- 35
  • 75 (a)
(Rattus norvegicus)
Mammalia Pitpnb 34
  • 92.5 (n)
(Mus musculus)
Mammalia Pitpnb 34 16 35
  • 91.88 (n)
(Ornithorhynchus anatinus)
Mammalia PITPNB 35
  • 89 (a)
(Gallus gallus)
Aves PITPNB 34 35
  • 81.6 (n)
(Anolis carolinensis)
Reptilia PITPNB 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pitpnb.2 34
  • 79.43 (n)
MGC75853 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8543 34
(Danio rerio)
Actinopterygii pitpnb 34 35
  • 75.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta vib 36 34 35
  • 61.78 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001957 34
  • 59 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y54F10AR.1 34
  • 61.07 (n)
Y54F10AR.1 36 35
  • 59 (a)
Y71G12B.17 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9844 35
  • 57 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12029 34
Species where no ortholog for PITPNB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PITPNB Gene

Gene Tree for PITPNB (if available)
Gene Tree for PITPNB (if available)

Paralogs for PITPNB Gene

Paralogs for PITPNB Gene

(4) SIMAP similar genes for PITPNB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PITPNB: view

Variants for PITPNB Gene

Sequence variations from dbSNP and Humsavar for PITPNB Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000112 -- 27,877,351(+) ATTCG(C/G)ATTAG intron-variant
rs1016495 -- 27,892,148(+) TGCAG(C/T)GCCTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1028363 -- 27,892,058(+) CACTT(A/G)GGCTC intron-variant
rs10483137 -- 27,857,237(+) CAAAC(A/C)ATCAA intron-variant
rs10483138 -- 27,868,389(+) GTTTC(A/C)TTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PITPNB Gene

Variant ID Type Subtype PubMed ID
dgv2452n106 CNV deletion 24896259
nsv1071787 CNV deletion 25765185
nsv588878 CNV loss 21841781

Variation tolerance for PITPNB Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.04; 0.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PITPNB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PITPNB Gene

Disorders for PITPNB Gene

Relevant External Links for PITPNB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PITPNB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PITPNB Gene

Publications for PITPNB Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 64
  2. Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta. (PMID: 8541325) Tanaka S. … Hosaka K. (Biochim. Biophys. Acta 1995) 3 4 22 64
  3. Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum. (PMID: 20332109) Carvou N. … Cockcroft S. (J. Cell. Sci. 2010) 3 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64

Products for PITPNB Gene

Sources for PITPNB Gene

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