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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIRT Gene

protein-coding GIFtS: 33
GCID: GC17M010725

phosphoinositide-interacting regulator of transient receptor...

Search for PIRT
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphoinositide-Interacting Regulator Of Transient Receptor Potential Channels¹ ²
Phosphoinositide-Interacting Protein²
Phosphoinositide-Interacting Regulator Of TRPV1²

External Ids:	HGNC: 37239¹	Entrez Gene: 644139²	Ensembl: ENSG00000233670⁷	OMIM: 612068⁵	UniProtKB: P0C851³

Export aliases for PIRT gene to outside databases

Previous GC identifer: GC17M010626

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PIRT_HUMAN, P0C851

Function: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1

channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including

phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIRT gene promoter:
ER-alpha AP-4 LCR-F1 Cdc5 RORalpha1 POU2F1 FOXO4 POU2F1a c-Myb RSRFC4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIRT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12 Ensembl cytogenetic band: 17p12 HGNC cytogenetic band: 17p12

PIRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIRT gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M010725: view genomic region (about GC identifiers)

Start:	10,725,792 bp from pter	End:	10,741,762 bp from pter
Size:	15,971 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PIRT_HUMAN, P0C851 (See protein sequence)

Recommended Name: Phosphoinositide-interacting protein

Size: 137 amino acids; 15334 Da

Subunit: Interacts with TRPV1 (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Caution: It is uncertain whether Met-1 or Met-3 is the initiator

Secondary accessions: B7Z648

Explore the universe of human proteins at neXtProt for PIRT: NX_P0C851

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P0C851

PIRT Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001094857.1

ENSEMBL proteins:

ENSP00000462046

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

PIRT for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P0C851

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PIRT_HUMAN, P0C851

Function: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1

channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including

phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity)

Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pirt):

behavior/neurological

integument

nervous system

PIRT for phenotypes About GeneDecksing

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PIRT

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about PIRT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for PIRT gene:

NM_001101387.1

Unigene Cluster for PIRT:

Phosphoinositide-interacting regulator of transient receptor potential channels

Hs.553909 [show with all ESTs]

Unigene Representative Sequence: NM_001101387

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000441732 ENST00000580256(uc010col.3)

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Additional cDNA sequence:

AK021549.1 AK299808.1 AK300493.1

2 DOTS entries:

DT.92066052 DT.100749643

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PIRT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

PIRT expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for PIRT

SOURCE GeneReport for Unigene cluster: Hs.553909

SABiosciences Custom PCR Arrays for PIRT

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for PIRT gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Pirt^{1 , 5}	phosphoinositide-interacting regulator of transient more^{1, 5}	83.21(n)¹ 79.26(a)¹		11 (40.59 cM)⁵ 193003¹ NM_178656.3¹ NP_848771.1¹ 66911981⁵
chicken (Gallus gallus)	Aves	PIRT⁶	Uncharacterized protein	64(a)	1 ↔ 1	18(1635934-1636332)
lizard (Anolis carolinensis)	Reptilia	PIRT⁶	--	57(a)	1 ↔ 1	2(104784412-104784858)

ENSEMBL Gene Tree for PIRT (if available)
TreeFam Gene Tree for PIRT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9895502^1,2	C,F,A,H	--	10725356(+)	`GGAGAC/TGAGGA`	1	--	ds500¹		13		NA WA CSA EA	378
rs182705852^1,2		--	10725402(+)	`AACTGC/TACCTG`	1	--	ds500¹		0	--	--	--	--
rs188123640^1,2		--	10725860(+)	`CCAAAC/GAGAAT`	1	--	ut3¹		0	--	--	--	--
rs11078866^1,2	C,F,A,H	--	10725883(+)	`CATGAG/TACAAT`	1	--	ut3¹		16		NA EA WA CSA	739
rs191266631^1,2		--	10725947(+)	`AAAGAA/GTCATT`	1	--	ut3¹		0	--	--	--	--
rs150413977^1,2		--	10726057(+)	`GGCAAA/GAAATG`	1	--	ut3¹		0	--	--	--	--
rs138281776^1,2		--	10726107(+)	`CTCATA/GTGGAG`	1	--	ut3¹		0	--	--	--	--
rs117260510^1,2	C,F	--	10726108(+)	`TCATGT/CGGAGG`	1	--	ut3¹		1		NA	120
rs3744572^1,2	C,F,H	--	10726149(+)	`ATTTCC/GTCATA`	1	--	ut3¹		12		EA NS WA NA CSA	2276
rs182726320^1,2		--	10726222(+)	`GCAAAA/GTGAGT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PIRT (10725792 - 10741762 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PIRT: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PIRT for disorders About MalaCards

PIRT for disorders About GeneDecksing

OMIM gene information: 612068 OMIM disorders: --

Export disorders for PIRT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for PIRT gene integrated from 9 sources:
(articles sorted by number of sources associating them with PIRT)

Utopia: connect your pdf to the dynamic
world of online information

Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. (PubMed id 18455988)^{1, 3} Kim A.Y....Dong X. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 644139	HGNC: 37239	Ensembl:ENSG00000233670	euGenes: HUgn644139	ECgene: PIRT
H-InvDB: PIRT

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for PIRT	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PIRT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for PIRT gene:
Search GeneIP for patents involving PIRT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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Search ThermoFisher Antibodies for PIRT

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PIRT

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PIRT

Sirion Biotech Customized:

	stable knockdown cell line services for PIRT
	inducible knockdown cell line services for PIRT
	design and validation of potent shRNA sequences against PIRT
	adenovirus for potent knockdown of PIRT
	adenovirus for overexpression of PIRT
	stable overexpressing cell line services for PIRT
	inducible overexpressing cell line services for PIRT

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes PIRT gene at Home site.

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PIRT Gene

phosphoinositide-interacting regulator of transient receptor...

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PIRT Gene

phosphoinositide-interacting regulator of transient receptor...

Aliasesfor PIRT gene

Summariesfor PIRT gene

Genomic Viewsfor PIRT gene

Proteinsfor PIRT gene

Protein Domains /Familiesfor PIRT gene

Functionfor PIRT gene

Pathways & Interactionsfor PIRT gene

Drugs & Compoundsfor PIRT gene

Transcriptsfor PIRT gene

Expression for PIRT gene

Orthologsfor PIRT gene

Paralogsfor PIRT gene

Genomic Variantsfor PIRT gene

Disorders / Diseasesfor PIRT gene

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External Searches for PIRT gene

Genome Databases showing PIRT gene

Other Databases showing PIRT gene

Specialized Databases showing PIRT gene

Intellectual Propertyfor PIRT gene

Productsfor PIRT gene

View Random Gene

Aliases
for PIRT gene

Summaries
for PIRT gene

Genomic Views
for PIRT gene

Proteins
for PIRT gene

Protein Domains /
Families
for PIRT gene

Function
for PIRT gene

Pathways & Interactions
for PIRT gene

Drugs & Compounds
for PIRT gene

Transcripts
for PIRT gene

Expression
for PIRT gene

Orthologs
for PIRT gene

Paralogs
for PIRT gene

Genomic Variants
for PIRT gene

Disorders / Diseases
for PIRT gene

Publications
for PIRT gene

Intellectual Property
for PIRT gene

Products
for PIRT gene