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PIRT Gene

protein-coding   GIFtS: 35
GCID: GC17M010725

Phosphoinositide-Interacting Regulator Of Transient Receptor...

  Search for PIRT
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphoinositide-Interacting Regulator Of Transient Receptor Potential
Channels1 2
Phosphoinositide-Interacting Regulator Of TRPV11 2
Phosphoinositide-Interacting Protein2

External Ids:    HGNC: 372391   Entrez Gene: 6441392   Ensembl: ENSG000002336707   OMIM: 6120685   UniProtKB: P0C8513   

Export aliases for PIRT gene to outside databases

Previous GC identifer: GC17M010626


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PIRT Gene:
PIRT (phosphoinositide-interacting regulator of transient receptor potential channels) is a protein-coding gene.

UniProtKB/Swiss-Prot: PIRT_HUMAN, P0C851
Function: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates
TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide,
including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIRT gene promoter:
         ER-alpha   AP-4   LCR-F1   Cdc5   RORalpha1   POU2F1   FOXO4   POU2F1a   c-Myb   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12   Ensembl cytogenetic band:  17p12   HGNC cytogenetic band: 17p12

PIRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIRT gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M010725:  view genomic region     (about GC identifiers)

Start:
10,725,792 bp from pter      End:
10,741,762 bp from pter
Size:
15,971 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIRT_HUMAN, P0C851 (See protein sequence)
Recommended Name: Phosphoinositide-interacting protein  
Size: 137 amino acids; 15334 Da
Subunit: Interacts with TRPV1 (By similarity)
Caution: It is uncertain whether Met-1 or Met-3 is the initiator
Secondary accessions: B7Z648

Explore the universe of human proteins at neXtProt for PIRT: NX_P0C851

Explore proteomics data for PIRT at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PIRT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001094857.1  
    ENSEMBL proteins: 
     ENSP00000462046  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028068 PIRT

    Graphical View of Domain Structure for InterPro Entry P0C851

    ProtoNet protein and cluster: P0C851


    Find genes that share domains with PIRT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIRT_HUMAN, P0C851
    Function: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates
    TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide,
    including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity)

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pirt):

     behavior/neurological  integument  nervous system 

    Find genes that share phenotypes with PIRT           About GenesLikeMe

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIRT_HUMAN, P0C851: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with PIRT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIRT
    Interactions:

        Search GeneGlobe Interaction Network for PIRT

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIRT



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIRT gene: 
    NM_001101387.1  

    Unigene Cluster for PIRT:

    Phosphoinositide-interacting regulator of transient receptor potential channels
    Hs.553909  [show with all ESTs]
    Unigene Representative Sequence: NM_001101387
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000580256(uc010col.3)
    miRNA
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    Additional mRNA sequence: 

    AK021549.1 AK299808.1 AK300493.1 

    2 DOTS entries:

    DT.92066052  DT.100749643 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    PIRT Expression
    About this image


    PIRT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Brain (Nervous System)
             Cerebellum
     
     Heart (Cardiovascular System)
     
     Lung (Respiratory System)
    PIRT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIRT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553909
        Custom PCR Arrays for PIRT
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for PIRT gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pirt1 , 5 phosphoinositide-interacting regulator of transient more1, 5 83.21(n)1
    79.26(a)1
      11 (40.59 cM)5
    1930031  NM_178656.31  NP_848771.11 
     669119815 
    chicken
    (Gallus gallus)
    Aves LOC1008572381 phosphoinositide-interacting protein-like 73.22(n)
    67.21(a)
      100857238  XM_004946070.1  XP_004946127.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIRT6
    phosphoinositide-interacting regulator of transien...
    57(a)
    1 ↔ 1
    2(104784412-104784858)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia pirt1 phosphoinositide-interacting regulator of transient more 64.41(n)
    52.54(a)
      101730299  XM_004918406.1  XP_004918463.1 


    ENSEMBL Gene Tree for PIRT (if available)
    TreeFam Gene Tree for PIRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIRT (see all 392)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs98955021,2
    C,F,A,H--10725356(+) GGAGAC/TGAGGA 1 -- ds500113Minor allele frequency- T:0.50NA WA CSA EA 378
    rs1827058521,2
    --10725402(+) AACTGC/TACCTG 1 -- ds50010--------
    rs1881236401,2
    --10725860(+) CCAAAC/GAGAAT 1 -- ut310--------
    rs110788661,2
    C,F,A,H--10725883(+) CATGAG/TACAAT 1 -- ut3116Minor allele frequency- T:0.30NA EA WA CSA 739
    rs1912666311,2
    --10725947(+) AAAGAA/GTCATT 1 -- ut310--------
    rs1504139771,2
    C--10726057(+) GGCAAA/GAAATG 1 -- ut310--------
    rs1382817761,2
    C--10726107(+) CTCATA/GTGGAG 1 -- ut310--------
    rs1172605101,2
    C,F--10726108(+) TCATGT/CGGAGG 1 -- ut311Minor allele frequency- C:0.02NA 120
    rs37445721,2
    C,F,H--10726149(+) ATTTCC/GTCATA 1 -- ut3112Minor allele frequency- G:0.18EA NS WA NA CSA 2276
    rs1827263201,2
    --10726222(+) GCAAAA/GTGAGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for PIRT (10725792 - 10741762 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for PIRT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833367CNV Loss17160897
    nsv907683CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612068    OMIM disorders: --


    Find genes that share disorders with PIRT           About GenesLikeMe


    Export disorders for PIRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIRT gene integrated from 10 sources:
    (articles sorted by number of sources associating them with PIRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. (PubMed id 18455988)1, 3 Kim A.Y....Dong X. (Cell 2008)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    4. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 644139 HGNC: 37239 Ensembl:ENSG00000233670 euGenes: HUgn644139 ECgene: PIRT
    H-InvDB: PIRT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIRT gene:
    Search GeneIP for patents involving PIRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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