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Aliases for PIRT Gene

Aliases for PIRT Gene

  • Phosphoinositide Interacting Regulator Of Transient Receptor Potential Channels 2 3 5
  • Phosphoinositide-Interacting Regulator Of Transient Receptor Potential Channels 2
  • Phosphoinositide-Interacting Regulator Of TRPV1 2

External Ids for PIRT Gene

Previous GeneCards Identifiers for PIRT Gene

  • GC17M010725
  • GC17M010626

Summaries for PIRT Gene

GeneCards Summary for PIRT Gene

PIRT (Phosphoinositide Interacting Regulator Of Transient Receptor Potential Channels) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PIRT Gene

  • Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIRT Gene

Genomics for PIRT Gene

Regulatory Elements for PIRT Gene

Enhancers for PIRT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G010793 1.6 Ensembl ENCODE dbSUPER 12.4 +39.3 39313 11.7 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS SP3 ADPRM SCO1 PIRT MYH3 TMEM220-AS1 ENSG00000263508 LINC00675 ENSG00000266114
GH17G010058 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5 +776.8 776830 6.2 TBP TBL1XR1 WRNIP1 BMI1 RAD21 RELB ETV6 IKZF2 CREM ZNF654 GAS7 PIRT GC17M010055 GC17M010087 PIR48956
GH17G010024 0.8 dbSUPER 5.9 +811.5 811539 5.7 CTCF PKNOX1 KLF1 ZSCAN4 ZNF384 RAD21 ZIC2 ZFHX2 SCRT2 SMC3 GAS7 PIRT GC17P010023 GC17M010055
GH17G010069 0.8 ENCODE dbSUPER 4.8 +769.0 769023 0.5 SCRT1 GATA3 SCRT2 KLF9 FEZF1 PIRT GC17M010055 GC17M010087 PIR48956
GH17G010836 0.5 ENCODE dbSUPER 6.3 +1.1 1059 1.2 PIRT TMEM220 GC17M010823
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIRT on UCSC Golden Path with GeneCards custom track

Genomic Location for PIRT Gene

Chromosome:
17
Start:
10,822,475 bp from pter
End:
10,838,445 bp from pter
Size:
15,971 bases
Orientation:
Minus strand

Genomic View for PIRT Gene

Genes around PIRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIRT Gene

Proteins for PIRT Gene

  • Protein details for PIRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C851-PIRT_HUMAN
    Recommended name:
    Phosphoinositide-interacting protein
    Protein Accession:
    P0C851
    Secondary Accessions:
    • B7Z648

    Protein attributes for PIRT Gene

    Size:
    137 amino acids
    Molecular mass:
    15334 Da
    Quaternary structure:
    • Interacts with TRPV1.

neXtProt entry for PIRT Gene

Post-translational modifications for PIRT Gene

No Post-translational modifications

Other Protein References for PIRT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIRT Gene

Domains & Families for PIRT Gene

Protein Domains for PIRT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIRT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIRT Gene

Function for PIRT Gene

Molecular function for PIRT Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity).

Gene Ontology (GO) - Molecular Function for PIRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA --
GO:0044325 ion channel binding IEA --
GO:1902936 phosphatidylinositol bisphosphate binding IEA --
genes like me logo Genes that share ontologies with PIRT: view

Phenotypes for PIRT Gene

genes like me logo Genes that share phenotypes with PIRT: view

Animal Models for PIRT Gene

MGI Knock Outs for PIRT:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIRT Gene

Localization for PIRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIRT Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIRT gene
Compartment Confidence
plasma membrane 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIRT: view

Pathways & Interactions for PIRT Gene

No Data Available

Interacting Proteins for PIRT Gene

Gene Ontology (GO) - Biological Process for PIRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009408 response to heat IEA --
GO:0048015 phosphatidylinositol-mediated signaling IEA --
GO:0048266 behavioral response to pain IEA --
GO:2001259 positive regulation of cation channel activity IEA --
genes like me logo Genes that share ontologies with PIRT: view

No data available for Pathways by source and SIGNOR curated interactions for PIRT Gene

Drugs & Compounds for PIRT Gene

No Compound Related Data Available

Transcripts for PIRT Gene

mRNA/cDNA for PIRT Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIRT Gene

Phosphoinositide-interacting regulator of transient receptor potential channels:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIRT Gene

No ASD Table

Relevant External Links for PIRT Gene

GeneLoc Exon Structure for
PIRT
ECgene alternative splicing isoforms for
PIRT

Expression for PIRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIRT Gene

This gene is overexpressed in Brain - Hypothalamus (x7.3), Brain - Substantia nigra (x6.5), Brain - Spinal cord (cervical c-1) (x6.0), and Colon - Sigmoid (x4.3).

Protein differential expression in normal tissues from HIPED for PIRT Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PIRT Gene



Protein tissue co-expression partners for PIRT Gene

NURSA nuclear receptor signaling pathways regulating expression of PIRT Gene:

PIRT

SOURCE GeneReport for Unigene cluster for PIRT Gene:

Hs.553909

Evidence on tissue expression from TISSUES for PIRT Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with PIRT: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIRT Gene

Orthologs for PIRT Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIRT 34 35
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia PIRT 34 35
  • 89.05 (n)
cow
(Bos Taurus)
Mammalia PIRT 34 35
  • 84.91 (n)
mouse
(Mus musculus)
Mammalia Pirt 34 16 35
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Pirt 34
  • 82.22 (n)
oppossum
(Monodelphis domestica)
Mammalia PIRT 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857783 34
  • 73.22 (n)
PIRT 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIRT 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pirt 34
  • 64.41 (n)
Species where no ortholog for PIRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIRT Gene

ENSEMBL:
Gene Tree for PIRT (if available)
TreeFam:
Gene Tree for PIRT (if available)

Paralogs for PIRT Gene

No data available for Paralogs for PIRT Gene

Variants for PIRT Gene

Sequence variations from dbSNP and Humsavar for PIRT Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000230573 -- 10,837,312(+) TGCCT(A/G)ACTGA intron-variant
rs1000520329 -- 10,828,118(+) TTATA(C/T)AGAAA intron-variant
rs1000552834 -- 10,825,740(+) CATCC(A/T)TCTCT utr-variant-5-prime
rs1000699519 -- 10,834,374(+) ACCTA(C/T)ATGGC intron-variant
rs1000824894 -- 10,822,600(+) CTGGT(C/T)CTGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PIRT Gene

Variant ID Type Subtype PubMed ID
nsv1058835 CNV loss 25217958
nsv833367 CNV loss 17160897

Variation tolerance for PIRT Gene

Residual Variation Intolerance Score: 78.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIRT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIRT Gene

Disorders for PIRT Gene

Relevant External Links for PIRT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIRT

No disorders were found for PIRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIRT Gene

Publications for PIRT Gene

  1. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. (PMID: 18455988) Kim A.Y. … Dong X. (Cell 2008) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for PIRT Gene

Sources for PIRT Gene

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