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Aliases for PIRT Gene

Aliases for PIRT Gene

  • Phosphoinositide-Interacting Regulator Of Transient Receptor Potential Channels 2 3
  • Phosphoinositide-Interacting Regulator Of TRPV1 2

External Ids for PIRT Gene

Previous GeneCards Identifiers for PIRT Gene

  • GC17M010725
  • GC17M010626

Summaries for PIRT Gene

GeneCards Summary for PIRT Gene

PIRT (Phosphoinositide-Interacting Regulator Of Transient Receptor Potential Channels) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PIRT Gene

  • Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIRT Gene

Genomics for PIRT Gene

Regulatory Elements for PIRT Gene

Genomic Location for PIRT Gene

Start:
10,822,475 bp from pter
End:
10,838,445 bp from pter
Size:
15,971 bases
Orientation:
Minus strand

Genomic View for PIRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIRT Gene

Proteins for PIRT Gene

  • Protein details for PIRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C851-PIRT_HUMAN
    Recommended name:
    Phosphoinositide-interacting protein
    Protein Accession:
    P0C851
    Secondary Accessions:
    • B7Z648

    Protein attributes for PIRT Gene

    Size:
    137 amino acids
    Molecular mass:
    15334 Da
    Quaternary structure:
    • Interacts with TRPV1.

neXtProt entry for PIRT Gene

Proteomics data for PIRT Gene at MOPED

Post-translational modifications for PIRT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIRT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIRT Gene

Domains for PIRT Gene

Protein Domains for PIRT Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIRT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIRT: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIRT Gene

Function for PIRT Gene

Molecular function for PIRT Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol 4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI) (By similarity).
genes like me logo Genes that share phenotypes with PIRT: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PIRT Gene

Localization for PIRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIRT Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIRT Gene COMPARTMENTS Subcellular localization image for PIRT gene
Compartment Confidence
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PIRT: view

Pathways for PIRT Gene

SuperPathways for PIRT Gene

No Data Available

Interacting Proteins for PIRT Gene

Gene Ontology (GO) - Biological Process for PIRT Gene

None

No data available for Pathways by source for PIRT Gene

Transcripts for PIRT Gene

mRNA/cDNA for PIRT Gene

(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIRT Gene

Phosphoinositide-interacting regulator of transient receptor potential channels:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIRT

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PIRT
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIRT Gene

No ASD Table

Relevant External Links for PIRT Gene

GeneLoc Exon Structure for
PIRT
ECgene alternative splicing isoforms for
PIRT

Expression for PIRT Gene

mRNA expression in normal human tissues for PIRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIRT Gene

This gene is overexpressed in Brain - Hypothalamus (7.3), Brain - Substantia nigra (6.5), Brain - Spinal cord (cervical c-1) (6.0), and Colon - Sigmoid (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PIRT Gene

SOURCE GeneReport for Unigene cluster for PIRT Gene Hs.553909

genes like me logo Genes that share expressions with PIRT: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PIRT Gene

Orthologs for PIRT Gene

This gene was present in the common ancestor of chordates.

Orthologs for PIRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIRT 35
  • 99.76 (n)
  • 100 (a)
PIRT 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIRT 35
  • 84.91 (n)
  • 83.94 (a)
PIRT 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIRT 35
  • 89.05 (n)
  • 89.05 (a)
PIRT 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pirt 35
  • 83.21 (n)
  • 79.26 (a)
Pirt 16
Pirt 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIRT 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pirt 35
  • 82.22 (n)
  • 80.74 (a)
chicken
(Gallus gallus)
Aves LOC100857238 35
  • 73.22 (n)
  • 67.21 (a)
PIRT 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIRT 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pirt 35
  • 64.41 (n)
  • 52.54 (a)
Species with no ortholog for PIRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIRT Gene

ENSEMBL:
Gene Tree for PIRT (if available)
TreeFam:
Gene Tree for PIRT (if available)

Paralogs for PIRT Gene

No data available for Paralogs for PIRT Gene

Variants for PIRT Gene

Sequence variations from dbSNP and Humsavar for PIRT Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2165875 -- 10,831,373(-) atctt(A/G)attgt intron-variant
rs2840173 -- 10,823,841(+) ACTTG(A/G)TGAAG utr-variant-3-prime
rs3744572 -- 10,822,832(+) ATTTC(C/G)TCATA utr-variant-3-prime
rs4299188 -- 10,826,998(+) gtaga(A/G)atggg intron-variant
rs4791425 -- 10,827,578(+) CAAGC(C/G)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIRT Gene

Variant ID Type Subtype PubMed ID
nsv833367 CNV Loss 17160897
nsv907683 CNV Gain 21882294

Relevant External Links for PIRT Gene

HapMap Linkage Disequilibrium report
PIRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIRT Gene

Disorders for PIRT Gene

No disorders were found for PIRT Gene.

No data available for UniProtKB/Swiss-Prot for PIRT Gene

Publications for PIRT Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. (PMID: 18455988) Kim A.Y. … Dong X. (Cell 2008) 2 3
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3

Products for PIRT Gene

Sources for PIRT Gene

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