Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIR Gene

protein-coding   GIFtS: 59
GCID: GC0XM015402

Pirin (Iron-Binding Nuclear Protein)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pirin (Iron-Binding Nuclear Protein)1 2
Probable Quercetin 2,3-Dioxygenase PIR2 3
Probable Quercetinase2 3
pirin2
EC 1.13.11.243

External Ids:    HGNC: 300481   Entrez Gene: 85442   Ensembl: ENSG000000878427   OMIM: 6033295   UniProtKB: O006253   

Export aliases for PIR gene to outside databases

Previous GC identifers: GC0XM015154 GC0XM014228 GC0XM014604 GC0XM014764 GC0XM015162 GC0XM015312 GC0XM013159


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIR Gene:
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein
expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with
nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the
encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and
replication. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIR Gene: 
PIR (pirin (iron-binding nuclear protein)) is a protein-coding gene. Diseases associated with PIR include pleuropneumonia, and extratemporal epilepsy. GO annotations related to this gene include transcription cofactor activity and quercetin 2,3-dioxygenase activity.

UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
Function: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its
interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play
a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin
2,3-dioxygenase activity (in vitro)

Gene Wiki entry for PIR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167197.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIR gene promoter:
         HTF   NF-AT   YY1   POU2F1   COMP1   POU2F1a   POU2F1b   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIR promoter sequence
   Search SABiosciences Chromatin IP Primers for PIR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.31

PIR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIR gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM015402:  view genomic region     (about GC identifiers)

Start:
15,402,921 bp from pter      End:
15,511,711 bp from pter
Size:
108,791 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIR_HUMAN, O00625 (See protein sequence)
Recommended Name: Pirin  
Size: 290 amino acids; 32113 Da
Cofactor: Binds 1 iron ion per subunit
Subunit: May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1
and target DNA
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures.
Cytoplasmic localization of PIR seems to positively correlate with melanoma progression
6/8 PDB 3D structures from and Proteopedia for PIR (see all 8):
1J1L (3D)        3ACL (3D)        4ERO (3D)        4EWA (3D)        4EWD (3D)        4EWE (3D)    
Secondary accessions: Q5U0G0 Q6FHD2

Explore the universe of human proteins at neXtProt for PIR: NX_O00625

Explore proteomics data for PIR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00625

  • PIR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIR Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001018119.1  NP_003653.1  

    ENSEMBL proteins: 
     ENSP00000369785   ENSP00000369786  

    Human Recombinant Protein Products for PIR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for PIR
    OriGene Protein Over-expression Lysate for PIR
    OriGene MassSpec for PIR 
    OriGene Custom Protein Services for PIR
    GenScript Custom Purified and Recombinant Proteins Services for PIR
    Novus Biologicals PIR Proteins
    Novus Biologicals PIR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for PIR
    Cloud-Clone Corp. Proteins for PIR 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9079676
    GO:0005737cytoplasm IDA--

    PIR for ontologies           About GeneDecksing



    PIR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PIR 
    OriGene Antibodies for PIR
    OriGene Custom Antibody Services for PIR
    GenScript Superior Antibodies for PIR
    Novus Biologicals PIR Antibodies
    Abcam antibodies for PIR
    Cloud-Clone Corp. Antibodies for PIR 
    ThermoFisher Antibody for PIR
    LSBio Antibodies in human, mouse, rat for PIR 

    Assay Products for PIR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PIR 
    Cloud-Clone Corp. CLIAs for PIR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR012093 Pirin
     IPR008778 Pirin_C_dom
     IPR011051 RmlC_Cupin
     IPR003829 Pirin_N_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry O00625

    ProtoNet protein and cluster: O00625

    1 Blocks protein domain: IPB003829 Protein of unknown function DUF209

    UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
    Similarity: Belongs to the pirin family


    PIR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIR_HUMAN, O00625
    Function: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via its
    interaction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play
    a role in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin
    2,3-dioxygenase activity (in vitro)
    Catalytic activity: Quercetin + O(2) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+)
    Enzyme regulation: Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline
    monohydrochloride
    Induction: Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid
    leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract

         Enzyme Number (IUBMB): EC 1.13.11.241

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity IMP--
    GO:0005515protein binding IPI10362352
    GO:0008127quercetin 2,3-dioxygenase activity IDA15951572
    GO:0046872metal ion binding IDA--
         
    PIR for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pir):
     embryogenesis  growth/size 

    PIR for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIR
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PIR
    SwitchGear 3'UTR luciferase reporter plasmidPIR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIR
    Sirion Biotech Customized adenovirus for overexpression of PIR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PIR (see all 13)
    OriGene ORF clones in mouse, rat for PIR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PIR (NM_003662)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIR
    Sirion Biotech Customized lentivirus for stable overexpression of PIR 
                         Customized lentivirus expression plasmids for stable overexpression of PIR 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIR
    Search LifeMap BioReagents cell lines for PIR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptosis and Autophagy
    Apoptosis and Autophagy
    2NF-kappaB Signaling
    NF-kappaB Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PIR
        Apoptosis and Autophagy
    NF-kappaB Signaling


    UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
    Pathway: Flavonoid metabolism; quercetin degradation


    PIR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIR

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for PIR (O006252, 3 ENSP000003697854) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62077 I2D: score=3 
    BCL3P207493, ENSP000001642274I2D: score=1 STRING: ENSP00000164227
    NFIXQ149383, ENSP000003532194I2D: score=2 STRING: ENSP00000353219
    NFKBIAP259633, ENSP000002167974I2D: score=1 STRING: ENSP00000216797
    HDAC2ENSP000003813314STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS9079676
    GO:0030099myeloid cell differentiation ----
    GO:0030224monocyte differentiation IMP--

    PIR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIR

    Search CenterWatch for drugs/clinical trials and news about PIR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIR gene (2 alternative transcripts): 
    NM_001018109.2  NM_003662.3  

    Unigene Cluster for PIR:

    Pirin (iron-binding nuclear protein)
    Hs.495728  [show with all ESTs]
    Unigene Representative Sequence: BX537579
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492432 ENST00000380420 ENST00000380421(uc004cwu.3 uc004cwv.3)
    ENST00000484433 ENST00000476381 ENST00000471725

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIR
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PIR
    SwitchGear 3'UTR luciferase reporter plasmidPIR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIR
    Clone
    Products:
         
    OriGene clones in human, mouse for PIR (see all 13)
    OriGene ORF clones in mouse, rat for PIR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): PIR (NM_003662)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIR
    Sirion Biotech Customized lentivirus for stable overexpression of PIR 
                         Customized lentivirus expression plasmids for stable overexpression of PIR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PIR
    OriGene qSTAR qPCR primer pairs in human, mouse for PIR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIR

    Additional mRNA sequence: 

    AK309656.1 BC002517.2 BT019583.1 BT019584.1 BX537579.1 CR541822.1 NR_037859.2 Y07867.1 
    Y07868.1 

    11 DOTS entries:

    DT.453697  DT.97844513  DT.100792998  DT.100695245  DT.100793001  DT.100793005  DT.121322643  DT.86852506 
    DT.92443154  DT.97779725  DT.95319940 

    24/219 AceView cDNA sequences (see all 219):

    CB113596 BQ011465 CR599849 AI697271 BQ668994 BI855912 BU158495 BG742867 
    CR608851 CR590557 BM549371 BQ935706 BQ944919 Y07867 NM_003662 CR605821 
    BX537579 CD673032 AI701540 AL530875 BI257932 BQ675556 BC002517 BQ230288 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PIR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:              -                                                               
    SP2:                                                                              


    ECgene alternative splicing isoforms for PIR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIR expression in normal human tissues (normalized intensities)      PIR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATAAACC
    PIR Expression
    About this image


    PIR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Endothelium (Cardiovascular System)
             blood vessel   
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow

    See PIR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIR

    SOURCE GeneReport for Unigene cluster: Hs.495728

    UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
    Tissue specificity: Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at
    protein level). Expressed in all tissues, with highest level of expression in heart and liver

        SABiosciences Custom PCR Arrays for PIR
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PIR
    OriGene qSTAR qPCR primer pairs in human, mouse for PIR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIR
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIR
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIR gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pir1 , 5 pirin1, 5 89.66(n)1
    95.86(a)1
      X (76.12 cM)5
    696561  NM_027153.31  NP_081429.11 
     1642693715 
    lizard
    (Anolis carolinensis)
    Reptilia PIR6
    Uncharacterized protein
    82(a)
    1 ↔ 1
    3(121455956-121470375)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC530942 hypothetical protein MGC53094 74.87(n)    BC045224.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pir1 pirin 67.61(n)
    72.54(a)
      436823  NM_001002550.1  NP_001002550.1 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0D01243g1 hypothetical protein 51.36(n)
    42.96(a)
      2893016  XM_453124.1  XP_453124.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G431201 pirin-like protein 57.74(n)
    56.79(a)
      818914  NM_180054.1  NP_850385.1 
    rice
    (Oryza sativa)
    Liliopsida Os.75362 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.47(n)    AK105971.1 


    ENSEMBL Gene Tree for PIR (if available)
    TreeFam Gene Tree for PIR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
    Polymorphism: Genetic variations in PIR might have a sex-specific influence on bone mineral density differences in
    some populations, as reported by PubMed:19766747. In a cohort of 4000 Chinese, a significant statistical
    association has been identified, in women but not in men, between the intronic SNP rs5935970 and lumbar spine
    bone mineral density, and between a haplotype composed of three SNPs with bone mineral density at other sites


    10/1591 SNPs in PIR are shown (see all 1591)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894929671,2
    --13270610(+) TGTCCA/GCAACT 2 -- us2k10--------
    rs1395034091,2
    C--13270761(+) CCAGAC/TGGTGG 2 -- us2k10--------
    rs1820427691,2
    --13270827(+) ACAATC/TTTAGG 2 -- us2k10--------
    rs1898949321,2
    --15317688(+) AACCTA/GTAACA 2 -- ds50010--------
    rs413118331,2
    C--15317780(+) GCCAAG/TGACAC 2 -- ds50010--------
    rs1403354481,2
    C--15317879(+) ATACAC/TAAAAC 2 -- ds50010--------
    rs131151,2
    F--15318029(+) GTGTGG/CAATTC 2 -- ut31 ese31Minor allele frequency- C:0.04MN 184
    rs66325321,2
    C,F,H--15318047(+) GCACCC/G/TGCTAA 4 -- ut31 ese320NS EA NA CSA 2097
    rs1807087541,2
    --15318070(+) AATGGA/GATGCC 2 -- ut310--------
    rs1860892711,2
    C--15318100(+) AAATGA/GCAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PIR (15402921 - 15511711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PIR:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739977CNV Deletion23290073
    esv2669590CNV Deletion23128226
    nsv518666CNV Loss19592680
    nsv515969CNV Gain19592680
    nsv521301CNV Gain19592680
    nsv528343CNV Gain19592680


    Human Gene Mutation Database (HGMD): PIR

    Locus Specific Mutation Databases (LSDB): PIR
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PIR
    DNA2.0 Custom Variant and Variant Library Synthesis for PIR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603329    OMIM disorders: --

    11 diseases for PIR:    About MalaCards
    pleuropneumonia    extratemporal epilepsy    b-cell lymphomas    agoraphobia
    adenoid cystic carcinoma    adenoiditis    acute myeloid leukemia    parkinson's disease
    myeloid leukemia    melanoma    leukemia


    PIR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for PIR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 6.06 1 14969819 (1)
    metastasis 5.35 1 14969819 (1)
    tumors 0 7 14969819 (1), 20089166 (1)
    cancer 0 1 15547752 (1)

    Genetic Association Database (GAD): PIR
    Human Genome Epidemiology (HuGE) Navigator: PIR (1 document)

    Export disorders for PIR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIR gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with PIR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of pirin, a novel highly conserved nuclear protein. (PubMed id 9079676)1, 2, 3, 9 Wendler W.M.F.... Winnacker E.-L. (1997)
    2. Sex-specific effect of Pirin gene on bone mineral den sity in a cohort of 4000 Chinese. (PubMed id 19766747)1, 2, 4, 9 Tang N.L....Leung P.C. (2010)
    3. Pirin delocalization in melanoma progression identifi ed by high content immuno-detection based approaches. (PubMed id 20089166)1, 2, 9 Licciulli S....Alcalay M. (2010)
    4. Structural and biochemical analysis reveal pirins to possess quercetinase activity. (PubMed id 15951572)1, 2, 9 Adams M. and Jia Z. (2005)
    5. Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. (PubMed id 14573596)1, 2, 9 Pang H.... Rao Z. (2004)
    6. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. (PubMed id 20010624)1, 2 Licciulli S....Alcalay M. (2010)
    7. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. (PubMed id 20711196)1, 2 Miyazaki I....Osada H. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. (PubMed id 10362352)1, 2 Dechend R.... Leutz A. (1999)
    10. Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. (PubMed id 17288615)2, 9 Gelbman B.D....Crystal R.G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8544 HGNC: 30048 AceView: PIR Ensembl:ENSG00000087842 euGenes: HUgn8544
    ECgene: PIR H-InvDB: PIR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIR gene:
    Search GeneIP for patents involving PIR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PIR   OriGene RNAi products in human, mouse, rat for PIR  
     OriGene qPCR primer pairs and template standards for PIR   OriGene Protein Over-expression Lysate for PIR  
     OriGene MassSpec something-or-other for PIR   OriGene clones in human, mouse for PIR  
     OriGene qSTAR qPCR primer pairs in human, mouse for PIR   OriGene Purified Protein for PIR  
     OriGene ORF clones in mouse, rat for PIR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIR   OriGene Custom Protein Services for PIR  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIR
     QIAGEN SeqTarget long-range PCR primers for resequencing PIR
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIR
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIR
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIR
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIR
     GenScript Custom Purified and Recombinant Proteins Services for PIR GenScript cDNA clones with any tag delivered in your preferred vector for PIR
     GenScript Custom Assay Services for PIR GenScript Superior Antibodies for PIR
     GenScript Custom overexpressing Cell Line Services for PIR CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for PIR 

     Regulatory tfbs in PIR promoter
     Search Chromatin IP Primers for PIR
     RT2 qPCR Primer Assay in human, mouse, rat PIR
     GNC Network for PIR
     SABiosciences Custom PCR Arrays for PIR
     Search Tocris compounds for PIR
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIR antibodies
     PIR proteins
     PIR lysates
     Antibodies for PIR
     See all of Abcam's Antibodies, Kits and Proteins for PIR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for PIR




     Proteins for PIR
     Antibodies for PIR
     ELISAs for PIR
     CLIAs for PIR
     Search LifeMap BioReagents cell lines for PIR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIR
     SwitchGear 3'UTR luciferase reporter plasmids for PIR
     SwitchGear Promoter luciferase reporter plasmids for PIR
     ThermoFisher Antibody for PIR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIR
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PIR
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIR
    Customized:
     lentivirus for stable overexpression of PIR
     lentivirus expression plasmids for stable overexpression of PIR
     adenovirus for overexpression of PIR
     LSBio Antibodies in human, mouse, rat for PIR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIR gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4