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Aliases for PIR Gene

Aliases for PIR Gene

  • Pirin (Iron-Binding Nuclear Protein) 2 3
  • Probable Quercetin 2,3-Dioxygenase PIR 3 4
  • Probable Quercetinase 3 4
  • EC 4
  • Pirin 3

External Ids for PIR Gene

Summaries for PIR Gene

Entrez Gene Summary for PIR Gene

  • This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIR Gene

PIR (Pirin (Iron-Binding Nuclear Protein)) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and NF-kappaB Signaling. GO annotations related to this gene include transcription cofactor activity and quercetin 2,3-dioxygenase activity.

UniProtKB/Swiss-Prot for PIR Gene

  • Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).

Gene Wiki entry for PIR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIR Gene

Genomics for PIR Gene

Genomic Location for PIR Gene

15,384,799 bp from pter
15,493,588 bp from pter
108,790 bases
Minus strand

Genomic View for PIR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIR Gene

Regulatory Elements for PIR Gene

Proteins for PIR Gene

  • Protein details for PIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5U0G0
    • Q6FHD2

    Protein attributes for PIR Gene

    290 amino acids
    Molecular mass:
    32113 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
    Quaternary structure:
    • May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 and target DNA.

    Three dimensional structures from OCA and Proteopedia for PIR Gene

neXtProt entry for PIR Gene

Proteomics data for PIR Gene at MOPED

Post-translational modifications for PIR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIR Gene

Domains for PIR Gene

Protein Domains for PIR Gene


  • Belongs to the pirin family.:
    • O00625
genes like me logo Genes that share domains with PIR: view

No data available for Gene Families for PIR Gene

Function for PIR Gene

Molecular function for PIR Gene

UniProtKB/Swiss-Prot CatalyticActivity: Quercetin + O(2) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+).
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochloride.
UniProtKB/Swiss-Prot Function: Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).
UniProtKB/Swiss-Prot Induction: Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract.

Enzyme Numbers (IUBMB) for PIR Gene

Gene Ontology (GO) - Molecular Function for PIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity IMP 23716661
GO:0005515 protein binding IPI 10362352
GO:0008127 quercetin 2,3-dioxygenase activity IDA 15951572
GO:0046872 metal ion binding IDA 20711196
genes like me logo Genes that share ontologies with PIR: view

Phenotypes for PIR Gene

genes like me logo Genes that share phenotypes with PIR: view

miRNA for PIR Gene

miRTarBase miRNAs that target PIR

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PIR Gene

Localization for PIR Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIR Gene

Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression.

Subcellular locations from

Jensen Localization Image for PIR Gene COMPARTMENTS Subcellular localization image for PIR gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9079676
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PIR: view

Pathways for PIR Gene

genes like me logo Genes that share pathways with PIR: view

Pathways by source for PIR Gene

2 Cell Signaling Technology pathways for PIR Gene

UniProtKB/Swiss-Prot O00625-PIR_HUMAN

  • Pathway: Flavonoid metabolism; quercetin degradation

Gene Ontology (GO) - Biological Process for PIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9079676
GO:0030099 myeloid cell differentiation --
GO:0030224 monocyte differentiation IMP 20010624
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with PIR: view

Transcripts for PIR Gene

Unigene Clusters for PIR Gene

Pirin (iron-binding nuclear protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
SP1: -

Relevant External Links for PIR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIR Gene

mRNA expression in normal human tissues for PIR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIR Gene

SOURCE GeneReport for Unigene cluster for PIR Gene Hs.495728

mRNA Expression by UniProt/SwissProt for PIR Gene

Tissue specificity: Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at protein level). Expressed in all tissues, with highest level of expression in heart and liver.
genes like me logo Genes that share expressions with PIR: view

Orthologs for PIR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIR 36
  • 95.24 (n)
  • 93.93 (a)
PIR 37
  • 99 (a)
(Bos Taurus)
Mammalia PIR 36
  • 90.74 (n)
  • 92.36 (a)
PIR 37
  • 92 (a)
(Canis familiaris)
Mammalia PIR 36
  • 92.3 (n)
  • 96.21 (a)
PIR 37
  • 96 (a)
(Mus musculus)
Mammalia Pir 36
  • 89.66 (n)
  • 95.86 (a)
Pir 16
Pir 37
  • 96 (a)
(Monodelphis domestica)
Mammalia PIR 37
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PIR 37
  • 89 (a)
(Rattus norvegicus)
Mammalia Pir 36
  • 89.08 (n)
  • 95.52 (a)
(Anolis carolinensis)
Reptilia PIR 37
  • 82 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53094 36
tropical clawed frog
(Silurana tropicalis)
Amphibia pir 36
  • 72.41 (n)
  • 76.9 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.395 36
(Danio rerio)
Actinopterygii pir 36
  • 67.49 (n)
  • 72.28 (a)
pir 37
  • 69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D01243g 36
  • 50 (n)
  • 41.79 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43120 36
  • 57.74 (n)
  • 56.79 (a)
(Hordeum vulgare)
Liliopsida Hv.6878 36
(Oryza sativa)
Liliopsida Os.7536 36
Os03g0845000 36
  • 56.31 (n)
  • 55.36 (a)
(Triticum aestivum)
Liliopsida Ta.25447 36
bread mold
(Neurospora crassa)
Ascomycetes NCU03369 36
  • 51.33 (n)
  • 51.09 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1684 37
  • 56 (a)
Species with no ortholog for PIR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for PIR Gene

Gene Tree for PIR (if available)
Gene Tree for PIR (if available)

Paralogs for PIR Gene

No data available for Paralogs for PIR Gene

Variants for PIR Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PIR Gene

Genetic variations in PIR might have a sex-specific influence on bone mineral density differences in some populations, as reported by PubMed:19766747. In a cohort of 4000 Chinese, a significant statistical association has been identified, in women but not in men, between the intronic SNP rs5935970 and lumbar spine bone mineral density, and between a haplotype composed of three SNPs with bone mineral density at other sites

Sequence variations from dbSNP and Humsavar for PIR Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs908004 -- 15,494,752(-) GAAAC(C/G)TTCAC upstream-variant-2KB
rs3788932 -- 15,494,172(+) AAAAC(C/T)TTGTC upstream-variant-2KB
rs3827466 -- 15,494,611(+) TAGGC(A/G)GTTCA upstream-variant-2KB
rs3827467 -- 15,495,090(+) aatat(A/G)tgagt upstream-variant-2KB
rs4830963 -- 15,493,948(+) ATTGG(C/T)TAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PIR Gene

Variant ID Type Subtype PubMed ID
nsv528343 CNV Gain 19592680
nsv515969 CNV Gain 19592680
nsv521301 CNV Gain 19592680
esv2669590 CNV Deletion 23128226
nsv518666 CNV Loss 19592680
esv2739977 CNV Deletion 23290073

Relevant External Links for PIR Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for PIR Gene

(4) Novoseek inferred disease relationships for PIR Gene

Disease -log(P) Hits PubMed IDs
necrosis 6.06 1
metastasis 5.35 1
tumors 0 2
cancer 0 1

Relevant External Links for PIR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PIR: view

No data available for UniProtKB/Swiss-Prot for PIR Gene

Publications for PIR Gene

  1. Identification of pirin, a novel highly conserved nuclear protein. (PMID: 9079676) Wendler W.M.F. … Winnacker E.-L. (J. Biol. Chem. 1997) 2 3 4 23
  2. Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese. (PMID: 19766747) Tang N.L. … Leung P.C. (Bone 2010) 3 4 23 49
  3. Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches. (PMID: 20089166) Licciulli S. … Alcalay M. (BMC Cell Biol. 2010) 3 4 23
  4. Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. (PMID: 14573596) Pang H. … Rao Z. (J. Biol. Chem. 2004) 3 4 23
  5. Structural and biochemical analysis reveal pirins to possess quercetinase activity. (PMID: 15951572) Adams M. … Jia Z. (J. Biol. Chem. 2005) 3 4 23

Products for PIR Gene

  • Addgene plasmids for PIR

Sources for PIR Gene

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