Aliases for PIR Gene
External Ids for PIR Gene
Previous GeneCards Identifiers for PIR Gene
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for PIR Gene
PIR (Pirin) is a Protein Coding gene. Diseases associated with PIR include Chilblain Lupus and Acrocallosal Syndrome. Among its related pathways are Apoptosis and Autophagy and NF-kappaB Signaling. GO annotations related to this gene include transcription cofactor activity and quercetin 2,3-dioxygenase activity.
UniProtKB/Swiss-Prot for PIR Gene
Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro).