PIR Gene
protein-coding GIFtS: 57
GCID: GC0XM015402
|
|
pirin (iron-binding nuclear protein)
| |
Aliases
for PIR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pirin (Iron-Binding Nuclear Protein)1 2 | | Probable Quercetin 2,3-Dioxygenase PIR2 3 | | Probable Quercetinase2 3 | | Pirin1 | | EC 1.13.11.243 |
Export aliases for PIR gene to outside databasesPrevious GC identifers: GC0XM015154 GC0XM014228 GC0XM014604 GC0XM014764 GC0XM015162 GC0XM015312 GC0XM013159 |
Summaries
for PIR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PIR:
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear proteinexpressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclearfactor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded proteinmay act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication.Alternatively spliced transcript variants have been described. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PIR_HUMAN, O00625Function: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via itsinteraction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play arole in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenaseactivity (in vitro)
Gene Wiki entry for PIR
|
Genomic Views
for PIR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PIR gene promoter:
HTF NF-AT YY1 POU2F1 COMP1 POU2F1a POU2F1b STAT3 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for PIR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp22.2 Ensembl cytogenetic band: Xp22.2 HGNC cytogenetic band: Xp22.31PIR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM015402: view genomic region
(about GC identifiers)
Start:
|
15,402,921 bp from pter |
End:
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15,511,687 bp from pter |
Size:
|
108,767 bases |
Orientation:
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minus strand |
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Proteins
for PIR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PIR_HUMAN, O00625 (See
protein sequence)Recommended Name: Pirin Size: 290 amino acids; 32113 Da
Cofactor: Binds 1 iron ion per subunit
Subunit: May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1 andtarget DNA
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmiclocalization of PIR seems to positively correlate with melanoma progression
2 PDB 3D structures from  and Proteopedia  for PIR:1J1L (3D)
3ACL (3D)
Secondary accessions: Q5U0G0 Q6FHD2Explore the universe of human proteins at neXtProt for PIR: NX_O00625
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00625
PIR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001018119.1 NP_003653.1
ENSEMBL proteins: ENSP00000369785 ENSP00000369786
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
PIR for ontologies About GeneDecksing
PIR Antibody Products:
Assay Products for PIR: |
Protein
Domains /
Families
for PIR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PIR for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00625ProtoNet protein and cluster: O00625 1 Blocks protein family: IPB003829 Protein of unknown function DUF209
UniProtKB/Swiss-Prot: PIR_HUMAN, O00625Similarity: Belongs to the pirin family |
Function
for PIR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PIR_HUMAN, O00625Function: Possible transcriptional coregulator. May contribute to the regulation of cellular processes via itsinteraction with BCL3. May be required for efficient terminal myeloid maturation of hematopoietic cells. May play arole in the regulation of cell migration. May promote apoptosis when overexpressed. Has quercetin 2,3-dioxygenaseactivity (in vitro)Catalytic activity: Quercetin + O(2) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+)Enzyme regulation: Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline monohydrochlorideInduction: Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloidleukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extractEnzyme Number (IUBMB): EC 1.13.11.241
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIR (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PIR (NM_003662) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIR |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PIR for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Pir):
PIR for phenotypes About GeneDecksing
|
Pathways & Interactions
for PIR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Apoptosis and Autophagy | | | 2 | NF-kappaB Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for PIR
UniProtKB/Swiss-Prot: PIR_HUMAN, O00625Pathway: Flavonoid metabolism; quercetin degradation
PIR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIR
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for PIR (O006252, 3 ENSP000003697854) via UniProtKB, MINT, STRING, and/or I2D
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 9079676 | | GO:0030099 | myeloid cell differentiation |
-- | -- | | GO:0030224 | monocyte differentiation |
IMP | -- |
PIR for ontologies About GeneDecksing
|
Drugs & Compounds
for PIR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PIR
Search CenterWatch for drugs/clinical trials and news about PIR
|
Transcripts
for PIR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PIR gene (2 alternative transcripts): NM_001018109.2 NM_003662.3 Unigene Cluster for PIR: Pirin (iron-binding nuclear protein) Hs.495728 [show with all ESTs]Unigene Representative Sequence: BX5375796 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380420 ENST00000380421(uc004cwu.3 uc004cwv.3) ENST00000492432
ENST00000484433 ENST00000476381 ENST00000471725
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIR (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIR (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PIR (NM_003662) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PIR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIR |
Additional cDNA sequence: AK309656.1 BC002517.2 BT019583.1 BT019584.1 BX537579.1 CR541822.1 Y07867.1 Y07868.1 11 DOTS entries: DT.453697 DT.97844513 DT.100792998 DT.100695245 DT.100793001 DT.100793005 DT.121322643 DT.86852506 DT.92443154 DT.97779725 DT.95319940 24/219 AceView cDNA sequences (see all 219): BQ944919 BQ278073 CR615023 BU156094 BI334584 Y07868 BP340889 BQ230288 CR590557 AL555050 BG683055 BQ431545 BQ935706 BI257932 CD673032 NM_003662 BQ675556 BM549371 BQ668994 CR596849 BG764928 CB116431 Y07867 CA314654
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for PIR About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for PIR
|
Expression
for PIR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PIR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAATAAACC
About this image
See PIR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIR
SOURCE GeneReport for Unigene cluster: Hs.495728
UniProtKB/Swiss-Prot: PIR_HUMAN, O00625Tissue specificity: Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at proteinlevel). Expressed in all tissues, with highest level of expression in heart and liver
SABiosciences Custom PCR Arrays for PIR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIR |
Orthologs
for PIR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PIR gene from 7/26 species (see all 26) About this table
ENSEMBL Gene Tree for PIR (if available)
TreeFam Gene Tree for PIR (if available) |
Paralogs
for PIR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for PIR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: PIR_HUMAN, O00625Polymorphism: Genetic variations in PIR might have a sex-specific influence on bone mineral density differences in somepopulations, as reported by PubMed:19766747. In a cohort of 4000 Chinese, a significant statistical association hasbeen identified, in women but not in men, between the intronic SNP rs5935970 and lumbar spine bone mineral density,and between a haplotype composed of three SNPs with bone mineral density at other sites
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PIR (15402921 - 15511687 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PIR
1 CNV: 52962
Human Gene Mutation Database (HGMD): PIR
Locus Specific Mutation Databases (LSDB): PIR
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIR |
|
Disorders
/ Diseases
for PIR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PIR for disorders About GeneDecksing
OMIM gene information: 603329
OMIM disorders: --
12  diseases for PIR: About MalaCardsb-cell lymphomas extratemporal epilepsy pleuropneumonia adenoid cystic carcinoma
agoraphobia acute myeloid leukemia myeloid leukemia adenoiditis
parkinson's disease leukemia melanoma carcinoma
4 Novoseek disease relationships for PIR gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
6.06 |
1 |
14969819 (1) |
| metastasis |
5.35 |
1 |
14969819 (1) |
| tumors |
0 |
7 |
14969819 (1), 20089166 (1) |
| cancer |
0 |
1 |
15547752 (1) |
Human Genome Epidemiology (HuGE) Navigator: PIR (1 document)
Export disorders for PIR gene to outside databases
|
Publications
for PIR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PIR gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with PIR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of pirin, a novel highly conserved nuclear protein. (PubMed id 9079676)1, 2, 3, 9 Wendler W.M.F.... Winnacker E.-L. (1997)
- Pirin delocalization in melanoma progression identifi ed by high content immuno-detection based approaches. (PubMed id 20089166)1, 2, 9 Licciulli S....Alcalay M. (2010)
- Structural and biochemical analysis reveal pirins to possess quercetinase activity. (PubMed id 15951572)1, 2, 9 Adams M. and Jia Z. (2005)
- Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. (PubMed id 14573596)1, 2, 9 Pang H.... Rao Z. (2004)
- Sex-specific effect of Pirin gene on bone mineral den sity in a cohort of 4000 Chinese. (PubMed id 19766747)1, 2, 9 Tang N.L....Leung P.C. (2010)
- Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. (PubMed id 20010624)1, 2 Licciulli S....Alcalay M. (2010)
- A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. (PubMed id 20711196)1, 2 Miyazaki I....Osada H. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. (PubMed id 10362352)1, 2 Dechend R.... Leutz A. (1999)
- Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. (PubMed id 17288615)2, 9 Gelbman B.D....Crystal R.G. (2007)
|
External Searches for PIR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PIR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PIR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PIR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PIR gene:
Search GeneIP for patents involving PIR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PIR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for PIR | | OriGene shRNA RFP for PIR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIR | | | OriGene Protein Over-expression Lysate for PIR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PIR | | OriGene 3'-UTR Clone for PIR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PIR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PIR | | OriGene Custom Protein Services for PIR | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIR |
| |
 |  |  |  | |
| | Antibodies & Assays for PIR |
| | | | Search Tocris compounds for PIR |
| |  |  |  |  | | | | | | Recombinant Protein for PIR |
|
 |
 |
 |
 | | | PIR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIR |
|  |  |  | | | | ThermoFisher Antibodies for PIR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIR |
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