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PIR Gene

protein-coding   GIFtS: 60
GCID: GC0XM015402

Pirin (Iron-Binding Nuclear Protein)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pirin (Iron-Binding Nuclear Protein)1 2
Probable Quercetin 2,3-Dioxygenase PIR2 3
Probable Quercetinase2 3
pirin2
EC 1.13.11.243

External Ids:    HGNC: 300481   Entrez Gene: 85442   Ensembl: ENSG000000878427   OMIM: 6033295   UniProtKB: O006253   

Export aliases for PIR gene to outside databases

Previous GC identifers: GC0XM015154 GC0XM014228 GC0XM014604 GC0XM014764 GC0XM015162 GC0XM015312 GC0XM013159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PIR Gene:
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein
expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with
nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the
encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and
replication. Alternatively spliced transcript variants have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for PIR Gene:
PIR (pirin (iron-binding nuclear protein)) is a protein-coding gene. Diseases associated with PIR include pleuropneumonia, and extratemporal epilepsy. GO annotations related to this gene include transcription cofactor activity and quercetin 2,3-dioxygenase activity.

UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
Function: Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target
kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of
hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro)

Gene Wiki entry for PIR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NC_018934.2  NT_167197.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIR gene promoter:
         HTF   NF-AT   YY1   POU2F1   COMP1   POU2F1a   POU2F1b   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIR promoter sequence
   Search Chromatin IP Primers for PIR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.2   Ensembl cytogenetic band:  Xp22.2   HGNC cytogenetic band: Xp22.31

PIR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIR gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM015402:  view genomic region     (about GC identifiers)

Start:
15,402,921 bp from pter      End:
15,511,711 bp from pter
Size:
108,791 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PIR_HUMAN, O00625 (See protein sequence)
Recommended Name: Pirin  
Size: 290 amino acids; 32113 Da
Cofactor: Binds 1 iron ion per subunit
Subunit: May interact with NF1/CTF1. Interacts with BCL3. Identified in a complex comprised of PIR, BLC3, NFKB1
and target DNA
Selected PDB 3D structures from and Proteopedia for PIR (see all 8):
1J1L (3D)        3ACL (3D)        4ERO (3D)        4EWA (3D)        4EWD (3D)        4EWE (3D)    
Secondary accessions: Q5U0G0 Q6FHD2

Explore the universe of human proteins at neXtProt for PIR: NX_O00625

Explore proteomics data for PIR at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See PIR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001018119.1  NP_003653.1  

    ENSEMBL proteins: 
     ENSP00000369785   ENSP00000369786  

    PIR Human Recombinant Protein Products:

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    Novus Biologicals PIR Proteins
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR012093 Pirin
     IPR008778 Pirin_C_dom
     IPR011051 RmlC_Cupin
     IPR003829 Pirin_N_dom
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry O00625

    ProtoNet protein and cluster: O00625

    1 Blocks protein domain: IPB003829 Protein of unknown function DUF209

    UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
    Similarity: Belongs to the pirin family


    PIR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIR_HUMAN, O00625
    Function: Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target
    kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal myeloid maturation of
    hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro)
    Catalytic activity: Quercetin + O(2) = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H(+)
    Enzyme regulation: Inhibited by kojic acid, sodium diethyldithiocarbamate and 1,10-phenanthroline
    monohydrochloride
    Induction: Up-regulated in CD34(+) cells upon myelomonocytic differentiation. Down-regulated in many acute myeloid
    leukemias. Up-regulated in primary bronchial epithelial cells exposed to cigarette smoke extract

         Enzyme Number (IUBMB): EC 1.13.11.241

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity IMP--
    GO:0005515protein binding IPI10362352
    GO:0008127quercetin 2,3-dioxygenase activity IDA15951572
    GO:0046872metal ion binding IDA--
         
    PIR for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pir):
     embryogenesis  growth/size/body 

    PIR for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIR
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIR

    miRNA
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    miRTarBase miRNAs that target PIR:
    hsa-mir-1 (MIRT023859)

    Block miRNA regulation of human, mouse, rat PIR using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PIR
    SwitchGear 3'UTR luciferase reporter plasmidPIR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PIR

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    GenScript: all cDNA clones in your preferred vector (see all 2): PIR (NM_003662)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIR_HUMAN, O00625: Nucleus. Cytoplasm. Note=Predominantly localized in dot-like subnuclear structures.
    Cytoplasmic localization of PIR seems to positively correlate with melanoma progression
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9079676
    GO:0005737cytoplasm IDA--

    PIR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIR About    
    See pathways by source

    SuperPathContained pathways About
    1NF-kappaB Signaling
    NF-kappaB Signaling
    2Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for PIR
        Apoptosis and Autophagy
    NF-kappaB Signaling


    UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
    Pathway: Flavonoid metabolism; quercetin degradation


    PIR for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIR
    Interactions:

        GeneGlobe Interaction Network for PIR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for PIR (O006252, 3 ENSP000003697854) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62077 I2D: score=3 
    BCL3P207493, ENSP000001642274I2D: score=1 STRING: ENSP00000164227
    NFIXQ149383, ENSP000003532194I2D: score=2 STRING: ENSP00000353219
    NFKBIAP259633, ENSP000002167974I2D: score=1 STRING: ENSP00000216797
    HDAC2ENSP000003813314STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS9079676
    GO:0030099myeloid cell differentiation ----
    GO:0030224monocyte differentiation IMP--

    PIR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PIR gene (2 alternative transcripts): 
    NM_001018109.2  NM_003662.3  

    Unigene Cluster for PIR:

    Pirin (iron-binding nuclear protein)
    Hs.495728  [show with all ESTs]
    Unigene Representative Sequence: BX537579
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492432 ENST00000380420 ENST00000380421(uc004cwu.3 uc004cwv.3)
    ENST00000484433 ENST00000476381 ENST00000471725
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidPIR 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat PIR
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    GenScript: all cDNA clones in your preferred vector (see all 2): PIR (NM_003662)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIR
    Primer
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    OriGene qPCR primer pairs and template standards for PIR
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIR
      QuantiTect SYBR Green Assays in human, mouse, rat PIR
      QuantiFast Probe-based Assays in human, mouse, rat PIR

    Additional mRNA sequence: 

    AK309656.1 BC002517.2 BT019583.1 BT019584.1 BX537579.1 CR541822.1 NR_037859.2 Y07867.1 
    Y07868.1 

    11 DOTS entries:

    DT.453697  DT.97844513  DT.100792998  DT.100695245  DT.100793001  DT.100793005  DT.121322643  DT.86852506 
    DT.92443154  DT.97779725  DT.95319940 

    Selected AceView cDNA sequences (see all 219):

    AI250638 BX537579 BG683055 BQ675556 CR596849 BM549371 BQ278073 Y07867 
    BI855912 CA314654 BQ431545 CR615023 BE877308 AA682279 CR590557 NM_003662 
    BG742867 BU156094 CB113596 AL530875 BI257932 BQ229118 BQ935706 BG764928 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for PIR    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10
    SP1:              -                                                               
    SP2:                                                                              


    ECgene alternative splicing isoforms for PIR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATAAACC
    PIR Expression
    About this image


    PIR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    PIR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.495728

    UniProtKB/Swiss-Prot: PIR_HUMAN, O00625
    Tissue specificity: Highly expressed in a subset of melanomas. Detected at very low levels in most tissues (at
    protein level). Expressed in all tissues, with highest level of expression in heart and liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PIR gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pir1 , 5 pirin1, 5 89.66(n)1
    95.86(a)1
      X (76.12 cM)5
    696561  NM_027153.31  NP_081429.11 
     1642693715 
    lizard
    (Anolis carolinensis)
    Reptilia PIR6
    pirin (iron-binding nuclear protein)
    82(a)
    1 ↔ 1
    3(121455956-121470375)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC530942 hypothetical protein MGC53094 74.87(n)    BC045224.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pir1 pirin 67.49(n)
    72.28(a)
      436823  NM_001002550.1  NP_001002550.1 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0D01243g1 KLLA0D01243g 50(n)
    41.79(a)
      2893016  XM_453124.1  XP_453124.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G431201 AT2G43120 57.74(n)
    56.79(a)
      818914  NM_180054.1  NP_850385.1 
    rice
    (Oryza sativa)
    Liliopsida Os.75362 Oryza sativa (japonica cultivar-group) cDNA clone0 more 78.47(n)    AK105971.1 


    ENSEMBL Gene Tree for PIR (if available)
    TreeFam Gene Tree for PIR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    PIR_HUMAN, O00625: Genetic variations in PIR might have a sex-specific influence on bone mineral density differences in
    some populations, as reported by PubMed:19766747. In a cohort of 4000 Chinese, a significant statistical
    association has been identified, in women but not in men, between the intronic SNP rs5935970 and lumbar spine
    bone mineral density, and between a haplotype composed of three SNPs with bone mineral density at other sites


    Selected SNPs for PIR (see all 1591)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894929671,2
    --13270610(+) TGTCCA/GCAACT 2 -- us2k10--------
    rs1395034091,2
    C--13270761(+) CCAGAC/TGGTGG 2 -- us2k10--------
    rs1820427691,2
    --13270827(+) ACAATC/TTTAGG 2 -- us2k10--------
    rs1898949321,2
    --15317688(+) AACCTA/GTAACA 2 -- ds50010--------
    rs413118331,2
    C--15317780(+) GCCAAG/TGACAC 2 -- ds50010--------
    rs1403354481,2
    C--15317879(+) ATACAC/TAAAAC 2 -- ds50010--------
    rs131151,2
    F--15318029(+) GTGTGG/CAATTC 2 -- ut31 ese31Minor allele frequency- C:0.04MN 184
    rs66325321,2
    C,F,H--15318047(+) GCACCC/G/TGCTAA 4 -- ut31 ese320NS EA NA CSA 2097
    rs1807087541,2
    --15318070(+) AATGGA/GATGCC 2 -- ut310--------
    rs1860892711,2
    C--15318100(+) AAATGA/GCAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for PIR (15402921 - 15511711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PIR:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739977CNV Deletion23290073
    esv2669590CNV Deletion23128226
    nsv518666CNV Loss19592680
    nsv515969CNV Gain19592680
    nsv521301CNV Gain19592680
    nsv528343CNV Gain19592680

    Human Gene Mutation Database (HGMD): PIR
    Locus Specific Mutation Databases (LSDB): PIR

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603329    OMIM disorders: --

    11 diseases for PIR:    
    About MalaCards
    pleuropneumonia    extratemporal epilepsy    b-cell lymphomas    agoraphobia
    adenoid cystic carcinoma    adenoiditis    acute myeloid leukemia    parkinson's disease
    myeloid leukemia    melanoma    leukemia


    PIR for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PIR gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 6.06 1 14969819 (1)
    metastasis 5.35 1 14969819 (1)
    tumors 0 7 14969819 (1), 20089166 (1)
    cancer 0 1 15547752 (1)

    Genetic Association Database (GAD): PIR
    Human Genome Epidemiology (HuGE) Navigator: PIR (1 document)

    Export disorders for PIR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIR gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with PIR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of pirin, a novel highly conserved nuclear protein. (PubMed id 9079676)1, 2, 3, 9 Wendler W.M.F.... Winnacker E.-L. (J. Biol. Chem. 1997)
    2. Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese. (PubMed id 19766747)1, 2, 4, 9 Tang N.L.... Leung P.C. (Bone 2010)
    3. Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches. (PubMed id 20089166)1, 2, 9 Licciulli S.... Alcalay M. (BMC Cell Biol. 2010)
    4. Structural and biochemical analysis reveal pirins to possess quercetinase activity. (PubMed id 15951572)1, 2, 9 Adams M. and Jia Z. (J. Biol. Chem. 2005)
    5. Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. (PubMed id 14573596)1, 2, 9 Pang H.... Rao Z. (J. Biol. Chem. 2004)
    6. Pirin is an iron-dependent redox regulator of NF-I_B. (PubMed id 23716661)1, 2 Liu F....Liu A. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    7. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. (PubMed id 20010624)1, 2 Licciulli S.... Alcalay M. (Leukemia 2010)
    8. A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. (PubMed id 20711196)1, 2 Miyazaki I.... Osada H. (Nat. Chem. Biol. 2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. (PubMed id 10362352)1, 2 Dechend R.... Leutz A. (Oncogene 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8544 HGNC: 30048 AceView: PIR Ensembl:ENSG00000087842 euGenes: HUgn8544
    ECgene: PIR H-InvDB: PIR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PIR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIR gene:
    Search GeneIP for patents involving PIR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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