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Aliases for PIPOX Gene

Aliases for PIPOX Gene

  • Pipecolic Acid And Sarcosine Oxidase 2 3
  • L-Pipecolic Acid Oxidase 2 3 4
  • Pipecolic Acid Oxidase 2 3 5
  • L-Pipecolate Oxidase 3 4
  • LPIPOX 3 4
  • PSO 3 4
  • EC 4
  • EC 4

External Ids for PIPOX Gene

Previous GeneCards Identifiers for PIPOX Gene

  • GC17U990195
  • GC17P029269
  • GC17P027221
  • GC17P027515
  • GC17P024394
  • GC17P027369
  • GC17P023579
  • GC17P027277

Summaries for PIPOX Gene

GeneCards Summary for PIPOX Gene

PIPOX (Pipecolic Acid And Sarcosine Oxidase) is a Protein Coding gene. Diseases associated with PIPOX include Peroxisomal Biogenesis Disorders. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Metabolism. GO annotations related to this gene include receptor binding and sarcosine oxidase activity.

UniProtKB/Swiss-Prot for PIPOX Gene

  • Metabolizes sarcosine, L-pipecolic acid and L-proline.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIPOX Gene

Genomics for PIPOX Gene

Regulatory Elements for PIPOX Gene

Enhancers for PIPOX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIPOX on UCSC Golden Path with GeneCards custom track

Promoters for PIPOX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIPOX on UCSC Golden Path with GeneCards custom track

Genomic Location for PIPOX Gene

28,950,513 bp from pter
29,057,220 bp from pter
106,708 bases
Plus strand

Genomic View for PIPOX Gene

Genes around PIPOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIPOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIPOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIPOX Gene

Proteins for PIPOX Gene

  • Protein details for PIPOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peroxisomal sarcosine oxidase
    Protein Accession:
    Secondary Accessions:
    • B3KNH0
    • Q96H28
    • Q9C070

    Protein attributes for PIPOX Gene

    390 amino acids
    Molecular mass:
    44066 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer.

neXtProt entry for PIPOX Gene

Proteomics data for PIPOX Gene at MOPED

Post-translational modifications for PIPOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIPOX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIPOX Gene

Domains & Families for PIPOX Gene

Protein Domains for PIPOX Gene

Suggested Antigen Peptide Sequences for PIPOX Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MSOX/MTOX family.
  • Belongs to the MSOX/MTOX family.
genes like me logo Genes that share domains with PIPOX: view

No data available for Gene Families for PIPOX Gene

Function for PIPOX Gene

Molecular function for PIPOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Sarcosine + H(2)O + O(2) = glycine + formaldehyde + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
L-pipecolate + O(2) = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Metabolizes sarcosine, L-pipecolic acid and L-proline.

Enzyme Numbers (IUBMB) for PIPOX Gene

Gene Ontology (GO) - Molecular Function for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with PIPOX: view
genes like me logo Genes that share phenotypes with PIPOX: view

Animal Models for PIPOX Gene

MGI Knock Outs for PIPOX:

Animal Model Products

miRNA for PIPOX Gene

miRTarBase miRNAs that target PIPOX

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIPOX Gene

Localization for PIPOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIPOX Gene


Subcellular locations from

Jensen Localization Image for PIPOX Gene COMPARTMENTS Subcellular localization image for PIPOX gene
Compartment Confidence
peroxisome 5
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for PIPOX Gene

Pathways & Interactions for PIPOX Gene

genes like me logo Genes that share pathways with PIPOX: view

Gene Ontology (GO) - Biological Process for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046653 tetrahydrofolate metabolic process IEA --
genes like me logo Genes that share ontologies with PIPOX: view

No data available for SIGNOR curated interactions for PIPOX Gene

Drugs & Compounds for PIPOX Gene

(5) Drugs for PIPOX Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist, Target Endogenous potentiator, co-transmitter 197
FAD Approved Pharma 0
Formaldehyde Experimental Pharma 78
Hydrogen peroxide Pharma 47

(7) Additional Compounds for PIPOX Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pipecolic acid
  • ()-Piperidine-2-carboxylic acid
  • (+/-)-2-Piperidinecarboxylate
  • (+/-)-2-Piperidinecarboxylic acid
  • (+/-)-Pipecolate
  • (+/-)-Pipecolic acid
  • (methylamino)-Acetate
  • (methylamino)-Acetic acid
  • (Methylamino)acetate
  • (Methylamino)acetic acid
  • (Methylamino)ethanoate
D-1-Piperideine-2-carboxylic acid
  • 1,2-Didehydropiperidine-2-carboxylate
  • delta(1)-Piperideine-2-carboxylate
  • Delta1-piperideine-2-carboxylate
L-Pipecolic acid
  • (-)-Pipecolate
  • (-)-Pipecolic acid
  • (S)-(-)-2-Piperidinecarboxylate
  • (S)-(-)-2-Piperidinecarboxylic acid
  • (S)-(-)-Pipecolate
genes like me logo Genes that share compounds with PIPOX: view

Transcripts for PIPOX Gene

Unigene Clusters for PIPOX Gene

Pipecolic acid oxidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIPOX Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - -

Relevant External Links for PIPOX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIPOX Gene

mRNA expression in normal human tissues for PIPOX Gene

mRNA differential expression in normal tissues according to GTEx for PIPOX Gene

This gene is overexpressed in Liver (x31.3) and Kidney - Cortex (x7.0).

Protein differential expression in normal tissues from HIPED for PIPOX Gene

This gene is overexpressed in Gallbladder (34.3), Liver, secretome (19.1), Liver (8.1), and Kidney (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIPOX Gene

SOURCE GeneReport for Unigene cluster for PIPOX Gene Hs.462585

genes like me logo Genes that share expression patterns with PIPOX: view

Protein tissue co-expression partners for PIPOX Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PIPOX Gene

Orthologs for PIPOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIPOX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIPOX 35
  • 87.61 (n)
  • 85.64 (a)
  • 85 (a)
(Canis familiaris)
Mammalia PIPOX 35
  • 86.75 (n)
  • 83.85 (a)
  • 83 (a)
(Mus musculus)
Mammalia Pipox 35
  • 81.79 (n)
  • 81.03 (a)
Pipox 16
Pipox 36
  • 81 (a)
(Pan troglodytes)
Mammalia PIPOX 35
  • 99.66 (n)
  • 99.49 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Pipox 35
  • 82.31 (n)
  • 79.74 (a)
(Monodelphis domestica)
Mammalia PIPOX 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia PIPOX 36
  • 68 (a)
(Gallus gallus)
Aves PIPOX 35
  • 62.69 (n)
  • 59.68 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia PIPOX 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pipox 35
  • 62.32 (n)
  • 61.1 (a)
(Danio rerio)
Actinopterygii pipox 35
  • 59.76 (n)
  • 53.54 (a)
pipox 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea C15B12.1 37
  • 34 (a)
C15B12.8 37
  • 30 (a)
C15B12.1 35
  • 46.54 (n)
  • 36.34 (a)
C15B12.1 36
  • 33 (a)
C15B12.8 36
  • 31 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G24580 35
  • 48.05 (n)
  • 36.51 (a)
(Oryza sativa)
Liliopsida Os01g0316100 35
  • 48.68 (n)
  • 37.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04771 35
  • 41.72 (n)
  • 28.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fap1 35
  • 40.52 (n)
  • 28.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for PIPOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIPOX Gene

Gene Tree for PIPOX (if available)
Gene Tree for PIPOX (if available)

Paralogs for PIPOX Gene

No data available for Paralogs for PIPOX Gene

Variants for PIPOX Gene

Sequence variations from dbSNP and Humsavar for PIPOX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3736253 -- 29,054,945(-) CACTC(A/C)TGGCA intron-variant
rs3884011 -- 29,050,983(-) cacca(C/T)acccg intron-variant
rs5819860 -- 29,047,690(+) GGATT(-/A)AAAAA intron-variant
rs4794849 -- 29,041,983(+) gagga(C/T)gaggt upstream-variant-2KB
rs4795491 -- 29,052,103(+) AACAG(A/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIPOX Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV Loss 17160897
esv2672779 CNV Deletion 23128226

Variation tolerance for PIPOX Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PIPOX Gene

Disorders for PIPOX Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIPOX Gene - From: Novoseek

Disorder Aliases PubMed IDs
peroxisomal biogenesis disorders
  • disorders of peroxisome biogenesis
- elite association - COSMIC cancer census association via MalaCards
Search PIPOX in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIPOX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PIPOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIPOX Gene

Publications for PIPOX Gene

  1. L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. (PMID: 10642506) Dodt G. … Mihalik S.J. (Biochem. J. 2000) 2 3 4 23 67
  2. Molecular cloning and expression of human L-pipecolate oxidase. (PMID: 10772957) Ijlst L. … Wanders R.J.A. (Biochem. Biophys. Res. Commun. 2000) 2 3 23
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  5. The human L-pipecolic acid oxidase is similar to bacterial monomeric sarcosine oxidases rather than D-amino acid oxidases. (PMID: 11330064) Dodt G. … Mihalik S.J. (Cell Biochem. Biophys. 2000) 3 23

Products for PIPOX Gene

Sources for PIPOX Gene