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Aliases for PIPOX Gene

Aliases for PIPOX Gene

  • Pipecolic Acid Oxidase 2 3
  • L-Pipecolic Acid Oxidase 2 3 4
  • L-Pipecolate Oxidase 3 4
  • LPIPOX 3 4
  • PSO 3 4
  • EC 1.5.3.1 4
  • EC 1.5.3.7 4

External Ids for PIPOX Gene

Previous GeneCards Identifiers for PIPOX Gene

  • GC17U990195
  • GC17P029269
  • GC17P027221
  • GC17P027515
  • GC17P024394
  • GC17P027369
  • GC17P023579
  • GC17P027277

Summaries for PIPOX Gene

GeneCards Summary for PIPOX Gene

PIPOX (Pipecolic Acid Oxidase) is a Protein Coding gene. Diseases associated with PIPOX include peroxisome biogenesis disorder 1b. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include receptor binding and sarcosine oxidase activity.

UniProtKB/Swiss-Prot for PIPOX Gene

  • Metabolizes sarcosine, L-pipecolic acid and L-proline

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIPOX Gene

Genomics for PIPOX Gene

Regulatory Elements for PIPOX Gene

Genomic Location for PIPOX Gene

Chromosome:
17
Start:
28,950,513 bp from pter
End:
29,057,220 bp from pter
Size:
106,708 bases
Orientation:
Plus strand

Genomic View for PIPOX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIPOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIPOX Gene

Proteins for PIPOX Gene

  • Protein details for PIPOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0Z9-SOX_HUMAN
    Recommended name:
    Peroxisomal sarcosine oxidase
    Protein Accession:
    Q9P0Z9
    Secondary Accessions:
    • B3KNH0
    • Q96H28
    • Q9C070

    Protein attributes for PIPOX Gene

    Size:
    390 amino acids
    Molecular mass:
    44066 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    • Monomer.

neXtProt entry for PIPOX Gene

Proteomics data for PIPOX Gene at MOPED

Post-translational modifications for PIPOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIPOX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PIPOX Gene

Domains & Families for PIPOX Gene

Protein Domains for PIPOX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIPOX Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0Z9

UniProtKB/Swiss-Prot:

SOX_HUMAN :
  • Belongs to the MSOX/MTOX family.
Family:
  • Belongs to the MSOX/MTOX family.
genes like me logo Genes that share domains with PIPOX: view

No data available for Gene Families for PIPOX Gene

Function for PIPOX Gene

Molecular function for PIPOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Sarcosine + H(2)O + O(2) = glycine + formaldehyde + H(2)O(2)
UniProtKB/Swiss-Prot CatalyticActivity:
L-pipecolate + O(2) = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Metabolizes sarcosine, L-pipecolic acid and L-proline

Enzyme Numbers (IUBMB) for PIPOX Gene

Gene Ontology (GO) - Molecular Function for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0008115 sarcosine oxidase activity IDA 10642506
GO:0016491 oxidoreductase activity --
GO:0050031 L-pipecolate oxidase activity NAS 10772957
genes like me logo Genes that share ontologies with PIPOX: view

Phenotypes for PIPOX Gene

GenomeRNAi human phenotypes for PIPOX:
genes like me logo Genes that share phenotypes with PIPOX: view

Animal Model Products

miRNA for PIPOX Gene

miRTarBase miRNAs that target PIPOX

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIPOX

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PIPOX Gene

Localization for PIPOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIPOX Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIPOX Gene COMPARTMENTS Subcellular localization image for PIPOX gene
Compartment Confidence
peroxisome 5

Gene Ontology (GO) - Cellular Components for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IDA 10642506
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with PIPOX: view

Pathways & Interactions for PIPOX Gene

genes like me logo Genes that share pathways with PIPOX: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0033514 L-lysine catabolic process to acetyl-CoA via L-pipecolate IDA 10642506
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046653 tetrahydrofolate metabolic process IEA --
genes like me logo Genes that share ontologies with PIPOX: view

No data available for SIGNOR curated interactions for PIPOX Gene

Drugs & Compounds for PIPOX Gene

(5) Drugs for PIPOX Gene - From: HMDB, NovoSeek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Agonist, Target Endogenous potentiator, co-transmitter 102
FAD Approved Pharma 0
Formaldehyde Experimental Pharma 65
Hydrogen peroxide Pharma 42
proline Nutra 20

(7) Additional Compounds for PIPOX Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pipecolic acid
  • ()-Piperidine-2-carboxylic acid
  • (+/-)-2-Piperidinecarboxylate
  • (+/-)-2-Piperidinecarboxylic acid
  • (+/-)-Pipecolate
  • (+/-)-Pipecolic acid
535-75-1
Sarcosine
  • (methylamino)-Acetate
  • (methylamino)-Acetic acid
  • (Methylamino)acetate
  • (Methylamino)acetic acid
  • (Methylamino)ethanoate
107-97-1
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate
D-1-Piperideine-2-carboxylic acid
  • 1,2-Didehydropiperidine-2-carboxylate
  • delta(1)-Piperideine-2-carboxylate
  • Delta1-piperideine-2-carboxylate
2756-89-0
L-Pipecolic acid
  • (-)-Pipecolate
  • (-)-Pipecolic acid
  • (S)-(-)-2-Piperidinecarboxylate
  • (S)-(-)-2-Piperidinecarboxylic acid
  • (S)-(-)-Pipecolate
3105-95-1
genes like me logo Genes that share compounds with PIPOX: view

Transcripts for PIPOX Gene

Unigene Clusters for PIPOX Gene

Pipecolic acid oxidase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIPOX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIPOX Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - -
SP7:

Relevant External Links for PIPOX Gene

GeneLoc Exon Structure for
PIPOX
ECgene alternative splicing isoforms for
PIPOX

Expression for PIPOX Gene

mRNA expression in normal human tissues for PIPOX Gene

mRNA differential expression in normal tissues according to GTEx for PIPOX Gene

This gene is overexpressed in Liver (x31.3) and Kidney - Cortex (x7.0).

Protein differential expression in normal tissues from HIPED for PIPOX Gene

This gene is overexpressed in Gallbladder (34.3), Liver, secretome (19.1), Liver (8.1), and Kidney (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIPOX Gene



SOURCE GeneReport for Unigene cluster for PIPOX Gene Hs.462585

genes like me logo Genes that share expression patterns with PIPOX: view

Protein tissue co-expression partners for PIPOX Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PIPOX Gene

Orthologs for PIPOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIPOX Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIPOX 35
  • 87.61 (n)
  • 85.64 (a)
PIPOX 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIPOX 35
  • 86.75 (n)
  • 83.85 (a)
PIPOX 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pipox 35
  • 81.79 (n)
  • 81.03 (a)
Pipox 16
Pipox 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIPOX 35
  • 99.66 (n)
  • 99.49 (a)
PIPOX 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pipox 35
  • 82.31 (n)
  • 79.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PIPOX 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIPOX 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIPOX 35
  • 62.69 (n)
  • 59.68 (a)
PIPOX 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIPOX 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pipox 35
  • 62.32 (n)
  • 61.1 (a)
zebrafish
(Danio rerio)
Actinopterygii pipox 35
  • 59.76 (n)
  • 53.54 (a)
pipox 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C15B12.1 37
  • 34 (a)
C15B12.8 37
  • 30 (a)
C15B12.1 35
  • 46.54 (n)
  • 36.34 (a)
C15B12.1 36
  • 33 (a)
OneToMany
C15B12.8 36
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G24580 35
  • 48.05 (n)
  • 36.51 (a)
rice
(Oryza sativa)
Liliopsida Os01g0316100 35
  • 48.68 (n)
  • 37.81 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04771 35
  • 41.72 (n)
  • 28.7 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fap1 35
  • 40.52 (n)
  • 28.74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for PIPOX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIPOX Gene

ENSEMBL:
Gene Tree for PIPOX (if available)
TreeFam:
Gene Tree for PIPOX (if available)

Paralogs for PIPOX Gene

No data available for Paralogs for PIPOX Gene

Variants for PIPOX Gene

Sequence variations from dbSNP and Humsavar for PIPOX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3736253 -- 29,054,945(-) CACTC(A/C)TGGCA intron-variant
rs3884011 -- 29,050,983(-) cacca(C/T)acccg intron-variant
rs4794849 -- 29,041,983(+) gagga(C/T)gaggt upstream-variant-2KB
rs4795491 -- 29,052,103(+) AACAG(A/G)CAGCC intron-variant
rs5819860 -- 29,047,690(+) GGATT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIPOX Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV Loss 17160897
esv2672779 CNV Deletion 23128226

Variation tolerance for PIPOX Gene

Residual Variation Intolerance Score: 85.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIPOX Gene

HapMap Linkage Disequilibrium report
PIPOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIPOX Gene

Disorders for PIPOX Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIPOX Gene - From: NovoSeek

Disorder Aliases PubMed IDs
peroxisome biogenesis disorder 1b
  • infantile refsum disease
- elite association
Search PIPOX in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIPOX

Genetic Association Database (GAD)
PIPOX
Human Genome Epidemiology (HuGE) Navigator
PIPOX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIPOX
genes like me logo Genes that share disorders with PIPOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIPOX Gene

Publications for PIPOX Gene

  1. Molecular cloning and expression of human L-pipecolate oxidase. (PMID: 10772957) Ijlst L. … Wanders R.J.A. (Biochem. Biophys. Res. Commun. 2000) 2 23 67
  2. L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. (PMID: 10642506) Dodt G. … Mihalik S.J. (Biochem. J. 2000) 2 23 67
  3. Characterization of a 7.6-Mb germline deletion encompassing the NF1 locus and about a hundred genes in an NF1 contiguous gene syndrome patient. (PMID: 18648396) Pasmant E. … BiA"che I. (Eur. J. Hum. Genet. 2008) 23 67
  4. Investigational methods for peroxisomal disorders. (PMID: 18633975) Steinberg S. … Moser A. (Curr Protoc Hum Genet 2008) 23 67
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for PIPOX Gene

Sources for PIPOX Gene

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