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Aliases for PIPOX Gene

Aliases for PIPOX Gene

  • Pipecolic Acid And Sarcosine Oxidase 2 3 5
  • L-Pipecolic Acid Oxidase 2 3 4
  • Pipecolic Acid Oxidase 2 3
  • L-Pipecolate Oxidase 3 4
  • LPIPOX 3 4
  • PSO 3 4
  • Peroxisomal Sarcosine Oxidase 3
  • EC 1.5.3.1 4
  • EC 1.5.3.7 4

External Ids for PIPOX Gene

Previous GeneCards Identifiers for PIPOX Gene

  • GC17U990195
  • GC17P029269
  • GC17P027221
  • GC17P027515
  • GC17P024394
  • GC17P027369
  • GC17P023579
  • GC17P027277

Summaries for PIPOX Gene

GeneCards Summary for PIPOX Gene

PIPOX (Pipecolic Acid And Sarcosine Oxidase) is a Protein Coding gene. Diseases associated with PIPOX include Peroxisomal Biogenesis Disorders. Among its related pathways are Glycine, serine and threonine metabolism and Metabolism. GO annotations related to this gene include receptor binding and sarcosine oxidase activity.

UniProtKB/Swiss-Prot for PIPOX Gene

  • Metabolizes sarcosine, L-pipecolic acid and L-proline.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIPOX Gene

Genomics for PIPOX Gene

Regulatory Elements for PIPOX Gene

Enhancers for PIPOX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F028944 1.5 FANTOM5 ENCODE 0.8 -1.2 -1175 8.9 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000264577 SDF2 MIR4723 NUFIP2 ENSG00000264290 PHF12 RPL23A ANKRD13B ENSG00000258472 TAOK1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIPOX on UCSC Golden Path with GeneCards custom track

Genomic Location for PIPOX Gene

Chromosome:
17
Start:
28,950,513 bp from pter
End:
29,057,220 bp from pter
Size:
106,708 bases
Orientation:
Plus strand

Genomic View for PIPOX Gene

Genes around PIPOX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIPOX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIPOX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIPOX Gene

Proteins for PIPOX Gene

  • Protein details for PIPOX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0Z9-SOX_HUMAN
    Recommended name:
    Peroxisomal sarcosine oxidase
    Protein Accession:
    Q9P0Z9
    Secondary Accessions:
    • B3KNH0
    • Q96H28
    • Q9C070

    Protein attributes for PIPOX Gene

    Size:
    390 amino acids
    Molecular mass:
    44066 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Monomer.

neXtProt entry for PIPOX Gene

Post-translational modifications for PIPOX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIPOX Gene

No data available for DME Specific Peptides for PIPOX Gene

Domains & Families for PIPOX Gene

Protein Domains for PIPOX Gene

Suggested Antigen Peptide Sequences for PIPOX Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0Z9

UniProtKB/Swiss-Prot:

SOX_HUMAN :
  • Belongs to the MSOX/MTOX family.
Family:
  • Belongs to the MSOX/MTOX family.
genes like me logo Genes that share domains with PIPOX: view

No data available for Gene Families for PIPOX Gene

Function for PIPOX Gene

Molecular function for PIPOX Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Sarcosine + H(2)O + O(2) = glycine + formaldehyde + H(2)O(2).
UniProtKB/Swiss-Prot CatalyticActivity:
L-pipecolate + O(2) = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Metabolizes sarcosine, L-pipecolic acid and L-proline.

Enzyme Numbers (IUBMB) for PIPOX Gene

Gene Ontology (GO) - Molecular Function for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 21044950
GO:0008115 sarcosine oxidase activity IDA 10642506
GO:0016491 oxidoreductase activity IEA --
GO:0050031 L-pipecolate oxidase activity TAS --
genes like me logo Genes that share ontologies with PIPOX: view
genes like me logo Genes that share phenotypes with PIPOX: view

Animal Models for PIPOX Gene

MGI Knock Outs for PIPOX:

Animal Model Products

miRNA for PIPOX Gene

miRTarBase miRNAs that target PIPOX

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PIPOX Gene

Localization for PIPOX Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIPOX Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIPOX gene
Compartment Confidence
peroxisome 5
extracellular 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IEA,IDA 10642506
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with PIPOX: view

Pathways & Interactions for PIPOX Gene

genes like me logo Genes that share pathways with PIPOX: view

Gene Ontology (GO) - Biological Process for PIPOX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006554 lysine catabolic process TAS --
GO:0033514 L-lysine catabolic process to acetyl-CoA via L-pipecolate IDA 10642506
GO:0046653 tetrahydrofolate metabolic process IEA --
GO:0055114 oxidation-reduction process IEA,IDA 10642506
genes like me logo Genes that share ontologies with PIPOX: view

No data available for SIGNOR curated interactions for PIPOX Gene

Drugs & Compounds for PIPOX Gene

(8) Drugs for PIPOX Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 226
FAD Approved Pharma 0
Formaldehyde Approved, Vet_approved Pharma 84
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(4) Additional Compounds for PIPOX Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pipecolic acid
  • ()-Piperidine-2-carboxylic acid
  • (+/-)-2-Piperidinecarboxylate
  • (+/-)-2-Piperidinecarboxylic acid
  • (+/-)-Pipecolate
  • (+/-)-Pipecolic acid
535-75-1
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate
D-1-Piperideine-2-carboxylic acid
  • 1,2-Didehydropiperidine-2-carboxylate
  • delta(1)-Piperideine-2-carboxylate
  • Delta1-piperideine-2-carboxylate
2756-89-0
L-Pipecolic acid
  • (-)-Pipecolate
  • (-)-Pipecolic acid
  • (S)-(-)-2-Piperidinecarboxylate
  • (S)-(-)-2-Piperidinecarboxylic acid
  • (S)-(-)-Pipecolate
3105-95-1
genes like me logo Genes that share compounds with PIPOX: view

Transcripts for PIPOX Gene

Unigene Clusters for PIPOX Gene

Pipecolic acid oxidase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIPOX Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - -
SP6: - - - - - -
SP7:

Relevant External Links for PIPOX Gene

GeneLoc Exon Structure for
PIPOX
ECgene alternative splicing isoforms for
PIPOX

Expression for PIPOX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PIPOX Gene

mRNA differential expression in normal tissues according to GTEx for PIPOX Gene

This gene is overexpressed in Liver (x31.3) and Kidney - Cortex (x7.0).

Protein differential expression in normal tissues from HIPED for PIPOX Gene

This gene is overexpressed in Gallbladder (34.3), Liver, secretome (19.1), Liver (8.1), and Kidney (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIPOX Gene



Protein tissue co-expression partners for PIPOX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIPOX Gene:

PIPOX

SOURCE GeneReport for Unigene cluster for PIPOX Gene:

Hs.462585
genes like me logo Genes that share expression patterns with PIPOX: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PIPOX Gene

Orthologs for PIPOX Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIPOX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIPOX 34 35
  • 99.66 (n)
cow
(Bos Taurus)
Mammalia PIPOX 34 35
  • 87.61 (n)
dog
(Canis familiaris)
Mammalia PIPOX 34 35
  • 86.75 (n)
rat
(Rattus norvegicus)
Mammalia Pipox 34
  • 82.31 (n)
mouse
(Mus musculus)
Mammalia Pipox 34 16 35
  • 81.79 (n)
oppossum
(Monodelphis domestica)
Mammalia PIPOX 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIPOX 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIPOX 34 35
  • 62.69 (n)
lizard
(Anolis carolinensis)
Reptilia PIPOX 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pipox 34
  • 62.32 (n)
zebrafish
(Danio rerio)
Actinopterygii pipox 34 35
  • 59.76 (n)
worm
(Caenorhabditis elegans)
Secernentea C15B12.1 36 34 35
  • 46.54 (n)
C15B12.8 36 35
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G24580 34
  • 48.05 (n)
rice
(Oryza sativa)
Liliopsida Os01g0316100 34
  • 48.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04771 34
  • 41.72 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes fap1 34
  • 40.52 (n)
Species where no ortholog for PIPOX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIPOX Gene

ENSEMBL:
Gene Tree for PIPOX (if available)
TreeFam:
Gene Tree for PIPOX (if available)

Paralogs for PIPOX Gene

No data available for Paralogs for PIPOX Gene

Variants for PIPOX Gene

Sequence variations from dbSNP and Humsavar for PIPOX Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111262357 -- 29,057,572(+) ACAGC(A/G)TTAGC downstream-variant-500B
rs111436134 -- 29,045,102(+) GAATG(A/C/T)AATGG intron-variant, upstream-variant-2KB
rs111439910 -- 29,056,075(+) ATGTG(A/G)CCAGG intron-variant
rs111784387 -- 29,043,814(+) TTTTT(A/T)TTTTT intron-variant
rs111837721 -- 29,056,533(+) TTCTT(C/T)TCTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PIPOX Gene

Variant ID Type Subtype PubMed ID
nsv833408 CNV loss 17160897
esv2672779 CNV deletion 23128226

Variation tolerance for PIPOX Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIPOX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIPOX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIPOX Gene

Disorders for PIPOX Gene

MalaCards: The human disease database

(1) MalaCards diseases for PIPOX Gene - From: Novoseek

Disorder Aliases PubMed IDs
peroxisomal biogenesis disorders
  • disorders of peroxisome biogenesis
- elite association - COSMIC cancer census association via MalaCards
Search PIPOX in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIPOX

Genetic Association Database (GAD)
PIPOX
Human Genome Epidemiology (HuGE) Navigator
PIPOX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIPOX
genes like me logo Genes that share disorders with PIPOX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIPOX Gene

Publications for PIPOX Gene

  1. L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases. (PMID: 10642506) Dodt G. … Mihalik S.J. (Biochem. J. 2000) 2 3 4 22 64
  2. Molecular cloning and expression of human L-pipecolate oxidase. (PMID: 10772957) Ijlst L. … Wanders R.J.A. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PIPOX Gene

Sources for PIPOX Gene

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