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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIP5KL1 Gene

protein-coding   GIFtS: 50
GCID: GC09M130683

Phosphatidylinositol-4-Phosphate 5-Kinase-Like 1

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Phosphatidylinositol-4-Phosphate 5-Kinase-Like 11 2     Phosphatidylinositol 4-Phosphate 5-Kinase-Like Protein 12
PtdIns(4)P-5-Kinase-Like Protein 12 3     Phosphatidylinositol Phosphate Kinase Homolog2
PI(4)P 5-Kinase-Like Protein 12 3     Phosphatidylinositol-4-Phosphate 5-Kinase-Like Protein 12
PIPKH2 5     EC 2.7.1.683
bA203J24.52     

External Ids:    HGNC: 287111   Entrez Gene: 1384292   Ensembl: ENSG000001671037   OMIM: 6128655   UniProtKB: Q5T9C93   

Export aliases for PIP5KL1 gene to outside databases

Previous GC identifers: GC09M126060 GC09M127763 GC09M129723 GC09M100300


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PIP5KL1 Gene:
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with
type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004
(PubMed 14701839)).(supplied by OMIM, Jun 2009)

GeneCards Summary for PIP5KL1 Gene: 
PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase-like 1) is a protein-coding gene. Diseases associated with PIP5KL1 include alzheimer's disease, and hypoxia, and among its related super-pathways are Phosphatidylinositol signaling system and Regulation of actin cytoskeleton. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 5-kinase activity and ATP binding. An important paralog of this gene is PIP4K2A.

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9
Function: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within
the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and
conversion to PI(3,4,5)P3 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIP5KL1 gene promoter:
         MEF-2A   MEF-2   aMEF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIP5KL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for PIP5KL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIP5KL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.13

PIP5KL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP5KL1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M130683:  view genomic region     (about GC identifiers)

Start:
130,683,158 bp from pter      End:
130,693,076 bp from pter
Size:
9,919 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-phosphate 5-kinase-like protein 1  
Size: 394 amino acids; 44572 Da
Subunit: Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase (By similarity)
Subcellular location: Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures (By
similarity)
Caution: It is unsure if the enzyme has intrinsic kinase activity
Secondary accessions: Q8IVS3
Alternative splicing: 2 isoforms:  Q5T9C9-1   Q5T9C9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIP5KL1: NX_Q5T9C9

Explore proteomics data for PIP5KL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T9C9

  • PIP5KL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIP5KL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_775763.1  NP_001128691.1  

    ENSEMBL proteins: 
     ENSP00000373399   ENSP00000300432  

    Human Recombinant Protein Products for PIP5KL1: 
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    Novus Biologicals PIP5KL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIP5KL1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0042995cell projection IEA--

    PIP5KL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR027484 PInositol-4-P-5-kinase_N
     IPR002498 PInositol-4-P-5-kinase_core
     IPR027483 PInositol-4-P-5-kinase_C
     IPR023610 PInositol-4-P-5-kinase

    Graphical View of Domain Structure for InterPro Entry Q5T9C9

    ProtoNet protein and cluster: Q5T9C9

    1 Blocks protein domain: IPB002498 Phosphatidylinositol-4-phosphate 5-kinase

    UniProtKB/Swiss-Prot: PI5L1_HUMAN, Q5T9C9
    Similarity: Contains 1 PIPK domain


    PIP5KL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI5L1_HUMAN, Q5T9C9
    Function: May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within
    the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and
    conversion to PI(3,4,5)P3 (By similarity)
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    4,5-bisphosphate

         Enzyme Number (IUBMB): EC 2.7.1.681

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016307phosphatidylinositol phosphate kinase activity ----
    GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activity IEA--
         
    PIP5KL1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIP5KL1 
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    hsa-miR-125a-5p hsa-miR-136 hsa-miR-3607-3p hsa-miR-4311 hsa-miR-610 hsa-miR-137 hsa-miR-1304 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidPIP5KL1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP5KL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIP5KL1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    2Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    3Anandamide biosynthesis and metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.50
    4PI Metabolism
    3-phosphoinositide biosynthesis0.48
    5Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for PIP5KL1
        Regulation of Actin Cytoskeleton
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    3-phosphoinositide biosynthesis
    superpathway of inositol phosphate compounds


    3         Kegg Pathways  (Kegg details for PIP5KL1):
        Inositol phosphate metabolism
    Metabolic pathways
    Endocytosis


    PIP5KL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PIP5KL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for PIP5KL1 (Q5T9C93 ENSP000003733994) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIP5K1AQ997553, ENSP000003578834I2D: score=2 STRING: ENSP00000357883
    PIP5K1BO149863, ENSP000002653824I2D: score=1 STRING: ENSP00000265382
    PIP5K1CO603313, ENSP000003353334I2D: score=1 STRING: ENSP00000335333
    PIK3CAENSP000002639674STRING: ENSP00000263967
    PIK3CBENSP000002891534STRING: ENSP00000289153
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046488phosphatidylinositol metabolic process ----

    PIP5KL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIP5KL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIP5KL1 (PI5L1)

    8 Novoseek inferred chemical compound relationships for PIP5KL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol phosphate 98.9 46 15728183 (2), 14691141 (2), 16616931 (2), 15623515 (2) (see all 35)
    pip2 74 2 16616931 (1)
    phosphatidylinositol 69.3 7 8395284 (1), 9879681 (1), 1655800 (1), 7928021 (1) (see all 6)
    phosphoinositide 66.1 4 11134066 (1), 19638643 (1)
    phosphotyrosine 37 1 16616931 (1)
    choline 21.4 1 9879681 (1)
    tyrosine 18.4 3 14691141 (1), 14701839 (1), 12422220 (1)
    phospholipid 8.89 1 11134066 (1)

    Search CenterWatch for drugs/clinical trials and news about PIP5KL1 / PI5L1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIP5KL1 gene (2 alternative transcripts): 
    NM_173492.1  NM_001135219.1  

    Unigene Cluster for PIP5KL1:

    Phosphatidylinositol-4-phosphate 5-kinase-like 1
    Hs.734928  [show with all ESTs]
    Unigene Representative Sequence: NM_001135219
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388747(uc011mao.2) ENST00000477191 ENST00000485562 ENST00000300432(uc004bsu.3)
    ENST00000464759 ENST00000495448 ENST00000464108 ENST00000498783 ENST00000490773
    ENST00000497234 ENST00000476624 ENST00000492296

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate PIP5KL1 (see all 12):
    hsa-miR-125a-5p hsa-miR-136 hsa-miR-3607-3p hsa-miR-4311 hsa-miR-610 hsa-miR-137 hsa-miR-1304 hsa-miR-125b
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    Additional mRNA sequence: BC042184.1 

    6 DOTS entries:

    DT.100022493  DT.91899619  DT.91812678  DT.91837732  DT.97777253  DT.95362824 

    24/33 AceView cDNA sequences (see all 33):

    BM714700 BM786675 NM_173492 BM726577 BE019642 BF817093 CA425729 BQ014508 
    BI520079 BM980218 BC042184 BU739350 Z38321 BG697332 BM476476 BQ774376 
    BX112998 BQ574658 AW135807 AI923090 BU621382 BE881330 BE787282 BI085535 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PIP5KL1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b
    SP1:                                      -     -     -                 -     -                                       
    SP2:              -                       -     -     -                                                               
    SP3:                                                                          -                                       
    SP4:                                                              -           -                                       
    SP5:                                                                    -     -                                       


    ECgene alternative splicing isoforms for PIP5KL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIP5KL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGGAGGC
    PIP5KL1 Expression
    About this image


    See PIP5KL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIP5KL1

    SOURCE GeneReport for Unigene cluster: Hs.734928
        SABiosciences Custom PCR Arrays for PIP5KL1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP5KL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIP5KL1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pip5kl11 , 5 phosphatidylinositol-4-phosphate 5-kinase-like 11, 5 78.8(n)1
    73.28(a)1
      2 (22.09 cM)5
    2277331  NM_198191.21  NP_937834.11 
     325747975 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001498431 phosphatidylinositol-4-phosphate 5-kinase, type I, more 61.17(n)
    57.59(a)
      100149843  XM_001923957.2  XP_001923992.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSS46
    Phosphatidylinositol-4-phosphate 5-kinase, involve...
    11(a)
    1 → many
    IV(868224-870563)


    ENSEMBL Gene Tree for PIP5KL1 (if available)
    TreeFam Gene Tree for PIP5KL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIP5KL1 gene
    PIP4K2A2  PIP5K1B2  PIP4K2B2  PIP4K2C2  PIP5K1C2  PIP5K1A2  

    PIP5KL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/239 SNPs in PIP5KL1 are shown (see all 239)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1905990291,2
    --130683375(+) AGGAGA/GAGGAG 2 -- int10--------
    rs1142112401,2
    C,F--130683424(+) GCCAAG/AACCTT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs756498751,2
    C,F--130683501(+) CTCACC/TTGAGA 2 -- int12Minor allele frequency- T:0.07WA EA 238
    rs1842374481,2
    --130683574(+) TCTCCC/TACCTG 2 -- int10--------
    rs1887425491,2
    --130683790(+) GCTCCA/GGAATC 2 -- int10--------
    rs1995092961,2
    --130684189(+) ACAGTA/GGAGAA 4 S syn10--------
    rs1120652571,2
    C--130684270(+) AGATCC/TACGAC 4 V syn11Minor allele frequency- T:0.50CSA 2
    rs2014951451,2
    C--130684332(+) GGCGTC/TGGGCA 4 N D mis10--------
    rs799888891,2
    C--130684349(+) GGCGGG/TTTTGG 4 N T mis10--------
    rs1450226581,2
    C--130684397(+) ACCTGA/GGGGCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for PIP5KL1 (130683158 - 130693076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for PIP5KL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6722CNV Insertion18451855
    dgv8291n71CNV Loss21882294
    nsv893865CNV Loss21882294
    nsv466577CNV Loss19166990
    dgv8287n71CNV Loss21882294
    dgv8293n71CNV Loss21882294
    nsv831727CNV Loss17160897
    nsv893859CNV Loss21882294
    nsv893860CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612865    OMIM disorders: --

    6 diseases for PIP5KL1:    About MalaCards
    alzheimer's disease    hypoxia    cervical cancer    cervicitis
    gastric cancer    endotheliitis


    PIP5KL1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for PIP5KL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 8.86 1 8395284 (1)


    Export disorders for PIP5KL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIP5KL1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with PIP5KL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Identification and characterization of a phosphoinositide phosphate kinase homolog. (PubMed id 14701839)1, 9 Chang J.D....Cantley L.C. (2004)
    3. Overexpression of PIP5KL1 suppresses cell proliferati on and migration in human gastric cancer cells. (PubMed id 19680787)1 Shi L....Huang C.Z. (2010)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Overexpression of PIP5KL1 suppresses the growth of hu man cervical cancer cells in vitro and in vivo. (PubMed id 19947914)9 Shi L....Huang C. (2010)
    8. Structural basis for the phosphorylation-regulated focal adhesion targeting of type Igamma phosphatidylinositol phosphate kinase (PIPKIgamma) by talin. (PubMed id 16616931)9 Kong X....Qin J. (2006)
    9. Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. (PubMed id 15623515)9 de Pereda J.M....Liddington R.C. (2005)
    10. Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place. (PubMed id 14502432)9 Doughman R.L....Anderson R.A. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 138429 HGNC: 28711 AceView: PIP5KL1 Ensembl:ENSG00000167103 euGenes: HUgn138429
    ECgene: PIP5KL1 Kegg: 138429 H-InvDB: PIP5KL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIP5KL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIP5KL1 gene:
    Search GeneIP for patents involving PIP5KL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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