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Aliases for PIP5KL1 Gene

Aliases for PIP5KL1 Gene

  • Phosphatidylinositol-4-Phosphate 5-Kinase Like 1 2 3 5
  • PtdIns(4)P-5-Kinase-Like Protein 1 3 4
  • PI(4)P 5-Kinase-Like Protein 1 3 4
  • Phosphatidylinositol 4-Phosphate 5-Kinase-Like Protein 1 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase-Like 1 2
  • Phosphatidylinositol Phosphate Kinase Homolog 3
  • EC 2.7.1.68 4
  • PIPKH 3

External Ids for PIP5KL1 Gene

Previous GeneCards Identifiers for PIP5KL1 Gene

  • GC09M126060
  • GC09M127763
  • GC09M129723
  • GC09M130683
  • GC09M100300

Summaries for PIP5KL1 Gene

Entrez Gene Summary for PIP5KL1 Gene

  • PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]

GeneCards Summary for PIP5KL1 Gene

PIP5KL1 (Phosphatidylinositol-4-Phosphate 5-Kinase Like 1) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Endocytosis. Gene Ontology (GO) annotations related to this gene include phosphatidylinositol phosphate kinase activity and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP5K1A.

UniProtKB/Swiss-Prot for PIP5KL1 Gene

  • May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

Additional gene information for PIP5KL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP5KL1 Gene

Genomics for PIP5KL1 Gene

GeneHancer (GH) Regulatory Elements for PIP5KL1 Gene

Promoters and enhancers for PIP5KL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I127929 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 574.1 -0.4 -394 2.6 HDGF FOXA2 ZFP64 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 POLR2B E2F8 PIP5KL1 ENSG00000227218
GH09I127926 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 570.9 +3.2 3201 2.1 NCOA3 HDAC1 KLF1 RB1 KLF17 SIN3A ZFHX2 POLR2A VEZF1 KLF8 PIP5KL1 ST6GALNAC4
GH09I127962 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.9 -42.6 -42551 22.2 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPARGC1A MEF2D FAM102A PIP5KL1 NAIF1 DPM2 ENSG00000272593 NUP188 ENSG00000227218 ZNF79 ODF2 GLE1
GH09I127914 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.9 +12.3 12297 7.5 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A ZNF2 YY1 ST6GALNAC4 SNORA65 ZNF79 PIP5KL1 NAIF1 GLE1 ODF2 FPGS LOC102723566 RPL12
GH09I127935 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 28.4 -6.5 -6546 4.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 POLR2B E2F8 ZNF143 SP3 DPM2 PIP5KL1 ST6GALNAC6 AK1 FAM102A ENSG00000230848 ENSG00000227218
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PIP5KL1 gene promoter:

Genomic Locations for PIP5KL1 Gene

Genomic Locations for PIP5KL1 Gene
chr9:127,920,879-127,930,797
(GRCh38/hg38)
Size:
9,919 bases
Orientation:
Minus strand
chr9:130,683,158-130,693,076
(GRCh37/hg19)

Genomic View for PIP5KL1 Gene

Genes around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP5KL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP5KL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP5KL1 Gene

Proteins for PIP5KL1 Gene

  • Protein details for PIP5KL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9C9-PI5L1_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
    Protein Accession:
    Q5T9C9
    Secondary Accessions:
    • Q8IVS3

    Protein attributes for PIP5KL1 Gene

    Size:
    394 amino acids
    Molecular mass:
    44572 Da
    Quaternary structure:
    • Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.

    Alternative splice isoforms for PIP5KL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP5KL1 Gene

Post-translational modifications for PIP5KL1 Gene

No Post-translational modifications

Other Protein References for PIP5KL1 Gene

No data available for DME Specific Peptides for PIP5KL1 Gene

Domains & Families for PIP5KL1 Gene

Gene Families for PIP5KL1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PIP5KL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIP5KL1: view

No data available for UniProtKB/Swiss-Prot for PIP5KL1 Gene

Function for PIP5KL1 Gene

Molecular function for PIP5KL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

Enzyme Numbers (IUBMB) for PIP5KL1 Gene

Phenotypes From GWAS Catalog for PIP5KL1 Gene

Gene Ontology (GO) - Molecular Function for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity IEA --
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view
genes like me logo Genes that share phenotypes with PIP5KL1: view

Animal Model Products

CRISPR Products

miRNA for PIP5KL1 Gene

miRTarBase miRNAs that target PIP5KL1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP5KL1 Gene

Localization for PIP5KL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP5KL1 Gene

Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIP5KL1 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view

Pathways & Interactions for PIP5KL1 Gene

genes like me logo Genes that share pathways with PIP5KL1: view

Pathways by source for PIP5KL1 Gene

Gene Ontology (GO) - Biological Process for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0046488 phosphatidylinositol metabolic process IEA --
GO:0046854 phosphatidylinositol phosphorylation IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view

No data available for SIGNOR curated interactions for PIP5KL1 Gene

Drugs & Compounds for PIP5KL1 Gene

(2) Drugs for PIP5KL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for PIP5KL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIP5KL1: view

Transcripts for PIP5KL1 Gene

Unigene Clusters for PIP5KL1 Gene

Phosphatidylinositol-4-phosphate 5-kinase-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP5KL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for PIP5KL1 Gene

GeneLoc Exon Structure for
PIP5KL1
ECgene alternative splicing isoforms for
PIP5KL1

Expression for PIP5KL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIP5KL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIP5KL1 Gene

This gene is overexpressed in Monocytes (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIP5KL1 Gene



Protein tissue co-expression partners for PIP5KL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIP5KL1 Gene:

PIP5KL1

SOURCE GeneReport for Unigene cluster for PIP5KL1 Gene:

Hs.734928

Evidence on tissue expression from TISSUES for PIP5KL1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PIP5KL1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP5KL1 Gene

Orthologs for PIP5KL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIP5KL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIP5KL1 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia PIP5KL1 33 34
  • 90.44 (n)
cow
(Bos Taurus)
Mammalia PIP5KL1 33 34
  • 88.92 (n)
rat
(Rattus norvegicus)
Mammalia Pip5kl1 33
  • 81.18 (n)
mouse
(Mus musculus)
Mammalia Pip5kl1 33 16 34
  • 78.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIP5KL1 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIP5KL1 34
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pip5kl1 34
  • 48 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSS4 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8691 34
  • 32 (a)
OneToOne
Species where no ortholog for PIP5KL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIP5KL1 Gene

ENSEMBL:
Gene Tree for PIP5KL1 (if available)
TreeFam:
Gene Tree for PIP5KL1 (if available)

Paralogs for PIP5KL1 Gene

Paralogs for PIP5KL1 Gene

genes like me logo Genes that share paralogs with PIP5KL1: view

Variants for PIP5KL1 Gene

Sequence variations from dbSNP and Humsavar for PIP5KL1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000048528 -- 127,923,478(-) C/G intron_variant
rs1000268301 -- 127,923,662(-) CAA/ intron_variant
rs1000997704 -- 127,930,149(-) G/A genic_upstream_transcript_variant, intron_variant
rs1001032846 -- 127,923,707(-) G/C intron_variant
rs1001035524 -- 127,921,812(-) A/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PIP5KL1 Gene

Variant ID Type Subtype PubMed ID
esv3621797 CNV gain 21293372
nsv466577 CNV loss 19166990
nsv615381 CNV loss 21841781
nsv6722 CNV insertion 18451855
nsv831727 CNV loss 17160897

Variation tolerance for PIP5KL1 Gene

Gene Damage Index Score: 1.16; 23.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PIP5KL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIP5KL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP5KL1 Gene

Disorders for PIP5KL1 Gene

Additional Disease Information for PIP5KL1

No disorders were found for PIP5KL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP5KL1 Gene

Publications for PIP5KL1 Gene

  1. Identification and characterization of a phosphoinositide phosphate kinase homolog. (PMID: 14701839) Chang JD … Cantley LC (The Journal of biological chemistry 2004) 3 22 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. (PMID: 19680787) Shi L … Huang CZ (Molecular biology reports 2010) 3 58
  4. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitro and in vivo. (PMID: 19947914) Shi L … Huang C (Cell biology international 2010) 22 58
  5. Phosphoinositide 3-kinase signaling in the vertebrate retina. (PMID: 19638643) Rajala RV (Journal of lipid research 2010) 22 58

Products for PIP5KL1 Gene

Sources for PIP5KL1 Gene

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