Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PIP5KL1 Gene

Aliases for PIP5KL1 Gene

  • Phosphatidylinositol-4-Phosphate 5-Kinase Like 1 2 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase-Like 1 2 3 5
  • PtdIns(4)P-5-Kinase-Like Protein 1 3 4
  • PI(4)P 5-Kinase-Like Protein 1 3 4
  • Phosphatidylinositol-4-Phosphate 5-Kinase-Like Protein 1 3
  • Phosphatidylinositol Phosphate Kinase Homolog 3
  • EC 2.7.1.68 4
  • BA203J24.5 3
  • PIPKH 3

External Ids for PIP5KL1 Gene

Previous GeneCards Identifiers for PIP5KL1 Gene

  • GC09M126060
  • GC09M127763
  • GC09M129723
  • GC09M130683
  • GC09M100300

Summaries for PIP5KL1 Gene

Entrez Gene Summary for PIP5KL1 Gene

  • PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]

GeneCards Summary for PIP5KL1 Gene

PIP5KL1 (Phosphatidylinositol-4-Phosphate 5-Kinase Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). GO annotations related to this gene include phosphatidylinositol phosphate kinase activity and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP4K2B.

UniProtKB/Swiss-Prot for PIP5KL1 Gene

  • May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP5KL1 Gene

Genomics for PIP5KL1 Gene

Regulatory Elements for PIP5KL1 Gene

Enhancers for PIP5KL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Promoters for PIP5KL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIP5KL1 Gene

Chromosome:
9
Start:
127,920,879 bp from pter
End:
127,930,797 bp from pter
Size:
9,919 bases
Orientation:
Minus strand

Genomic View for PIP5KL1 Gene

Genes around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP5KL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP5KL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP5KL1 Gene

Proteins for PIP5KL1 Gene

  • Protein details for PIP5KL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9C9-PI5L1_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
    Protein Accession:
    Q5T9C9
    Secondary Accessions:
    • Q8IVS3

    Protein attributes for PIP5KL1 Gene

    Size:
    394 amino acids
    Molecular mass:
    44572 Da
    Quaternary structure:
    • Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.

    Alternative splice isoforms for PIP5KL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP5KL1 Gene

Proteomics data for PIP5KL1 Gene at MOPED

Post-translational modifications for PIP5KL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP5KL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PIP5KL1 Gene

Domains & Families for PIP5KL1 Gene

Suggested Antigen Peptide Sequences for PIP5KL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T9C9

UniProtKB/Swiss-Prot:

PI5L1_HUMAN :
  • Contains 1 PIPK domain.
Domain:
  • Contains 1 PIPK domain.
genes like me logo Genes that share domains with PIP5KL1: view

No data available for Gene Families for PIP5KL1 Gene

Function for PIP5KL1 Gene

Molecular function for PIP5KL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

Enzyme Numbers (IUBMB) for PIP5KL1 Gene

genes like me logo Genes that share phenotypes with PIP5KL1: view

Animal Model Products

CRISPR Products

miRNA for PIP5KL1 Gene

miRTarBase miRNAs that target PIP5KL1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP5KL1 Gene

Localization for PIP5KL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP5KL1 Gene

Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIP5KL1 Gene COMPARTMENTS Subcellular localization image for PIP5KL1 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PIP5KL1 Gene

Pathways & Interactions for PIP5KL1 Gene

genes like me logo Genes that share pathways with PIP5KL1: view

Gene Ontology (GO) - Biological Process for PIP5KL1 Gene

None

No data available for SIGNOR curated interactions for PIP5KL1 Gene

Drugs & Compounds for PIP5KL1 Gene

(2) Drugs for PIP5KL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for PIP5KL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIP5KL1: view

Transcripts for PIP5KL1 Gene

Unigene Clusters for PIP5KL1 Gene

Phosphatidylinositol-4-phosphate 5-kinase-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIP5KL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for PIP5KL1 Gene

GeneLoc Exon Structure for
PIP5KL1
ECgene alternative splicing isoforms for
PIP5KL1

Expression for PIP5KL1 Gene

mRNA expression in normal human tissues for PIP5KL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIP5KL1 Gene

This gene is overexpressed in Monocytes (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIP5KL1 Gene



SOURCE GeneReport for Unigene cluster for PIP5KL1 Gene Hs.734928

genes like me logo Genes that share expression patterns with PIP5KL1: view

Protein tissue co-expression partners for PIP5KL1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIP5KL1 Gene

Orthologs for PIP5KL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIP5KL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIP5KL1 35
  • 88.92 (n)
  • 89.85 (a)
PIP5KL1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIP5KL1 35
  • 90.44 (n)
  • 91.62 (a)
PIP5KL1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pip5kl1 35
  • 78.8 (n)
  • 73.28 (a)
Pip5kl1 16
Pip5kl1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIP5KL1 35
  • 99.32 (n)
  • 99.75 (a)
PIP5KL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pip5kl1 35
  • 81.18 (n)
  • 77.55 (a)
oppossum
(Monodelphis domestica)
Mammalia PIP5KL1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIP5KL1 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pip5kl1 36
  • 48 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSS4 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8691 36
  • 32 (a)
OneToOne
Species with no ortholog for PIP5KL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIP5KL1 Gene

ENSEMBL:
Gene Tree for PIP5KL1 (if available)
TreeFam:
Gene Tree for PIP5KL1 (if available)

Paralogs for PIP5KL1 Gene

Paralogs for PIP5KL1 Gene

genes like me logo Genes that share paralogs with PIP5KL1: view

Variants for PIP5KL1 Gene

Sequence variations from dbSNP and Humsavar for PIP5KL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113120035 -- 127,925,272(+) GAGCA(C/T)CAGTG intron-variant
rs113222383 -- 127,925,308(+) CCAGC(C/T)ACGGT intron-variant
rs113250553 -- 127,928,155(+) CCTCC(A/G/T)CCAGG upstream-variant-2KB, reference, missense
rs113486049 -- 127,925,248(+) ACCAG(C/T)TCCGC reference, missense
rs114211240 -- 127,921,145(+) GCCAA(A/G)ACCTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PIP5KL1 Gene

Variant ID Type Subtype PubMed ID
nsv893859 CNV Loss 21882294
nsv893860 CNV Gain 21882294
nsv893865 CNV Loss 21882294
dgv8287n71 CNV Loss 21882294
dgv8291n71 CNV Loss 21882294
dgv8293n71 CNV Loss 21882294
nsv466577 CNV Loss 19166990
nsv6722 CNV Insertion 18451855
nsv831727 CNV Loss 17160897

Variation tolerance for PIP5KL1 Gene

Gene Damage Index Score: 1.16; 23.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PIP5KL1 Gene

Disorders for PIP5KL1 Gene

Relevant External Links for PIP5KL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP5KL1

No disorders were found for PIP5KL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP5KL1 Gene

Publications for PIP5KL1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Identification and characterization of a phosphoinositide phosphate kinase homolog. (PMID: 14701839) Chang J.D. … Cantley L.C. (J. Biol. Chem. 2004) 3 23
  3. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. (PMID: 19680787) Shi L. … Huang C.Z. (Mol. Biol. Rep. 2010) 3
  4. Phosphoinositide 3-kinase signaling in the vertebrate retina. (PMID: 19638643) Rajala R.V. (J. Lipid Res. 2010) 23
  5. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitro and in vivo. (PMID: 19947914) Shi L. … Huang C. (Cell Biol. Int. 2010) 23

Products for PIP5KL1 Gene

Sources for PIP5KL1 Gene

Content