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Aliases for PIP5KL1 Gene

Aliases for PIP5KL1 Gene

  • Phosphatidylinositol-4-Phosphate 5-Kinase Like 1 2 3 5
  • PtdIns(4)P-5-Kinase-Like Protein 1 3 4
  • PI(4)P 5-Kinase-Like Protein 1 3 4
  • Phosphatidylinositol 4-Phosphate 5-Kinase-Like Protein 1 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase-Like 1 2
  • Phosphatidylinositol Phosphate Kinase Homolog 3
  • EC 2.7.1.68 4
  • BA203J24.5 3
  • PIPKH 3

External Ids for PIP5KL1 Gene

Previous GeneCards Identifiers for PIP5KL1 Gene

  • GC09M126060
  • GC09M127763
  • GC09M129723
  • GC09M130683
  • GC09M100300

Summaries for PIP5KL1 Gene

Entrez Gene Summary for PIP5KL1 Gene

  • PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]

GeneCards Summary for PIP5KL1 Gene

PIP5KL1 (Phosphatidylinositol-4-Phosphate 5-Kinase Like 1) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG) and Endocytosis. GO annotations related to this gene include phosphatidylinositol phosphate kinase activity and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP5K1A.

UniProtKB/Swiss-Prot for PIP5KL1 Gene

  • May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP5KL1 Gene

Genomics for PIP5KL1 Gene

Regulatory Elements for PIP5KL1 Gene

Enhancers for PIP5KL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G127962 2 FANTOM5 Ensembl ENCODE dbSUPER 27.9 -42.6 -42551 22.2 CREB3L1 FEZF1 DMAP1 YY1 ZNF263 SP3 NFYC TBX21 PPARGC1A MEF2D PIP5KL1 DPM2 SPOUT1 LOC101929270 ENSG00000227218 SLC25A25 NAIF1 ENSG00000230848 ODF2-AS1 CDK9
GH09G127914 2 FANTOM5 Ensembl ENCODE dbSUPER 24.9 +12.3 12297 7.5 HDGF PKNOX1 MLX ARNT AGO1 ZFP64 ARID4B SIN3A ZNF2 ZBTB7B PIP5KL1 FAM129B ENSG00000227218 CDK9 FAM102A TOR2A ST6GALNAC4
GH09G127951 1.6 Ensembl ENCODE dbSUPER 28.4 -23.7 -23688 5.4 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 PIP5KL1 SPOUT1 FAM102A ENSG00000230848 CDK9 PTRH1 LCN2 C9orf16 CIZ1 LOC101929270
GH09G127946 1.4 ENCODE dbSUPER 29.3 -18.2 -18213 5.2 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PIP5KL1 ZNF79 SNORA65 NAIF1 COQ4 WDR34 DPM2 GC09P127942 FAM102A
GH09G127935 1.4 ENCODE dbSUPER 28.4 -6.5 -6546 4.3 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ZFP64 SIN3A ARID4B PIP5KL1 ANGPTL2 URM1 LOC102723566 RPL12 ENSG00000272696 ST6GALNAC6 AK1 ENSG00000272593 ZNF79
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Promoters for PIP5KL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241778 97 601 AGO1 ZFP64 SIN3A ZNF2 YY1 ETS1 GLIS2 FOS KLF13 SP3

Genomic Location for PIP5KL1 Gene

Chromosome:
9
Start:
127,920,879 bp from pter
End:
127,930,797 bp from pter
Size:
9,919 bases
Orientation:
Minus strand

Genomic View for PIP5KL1 Gene

Genes around PIP5KL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP5KL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP5KL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP5KL1 Gene

Proteins for PIP5KL1 Gene

  • Protein details for PIP5KL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T9C9-PI5L1_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
    Protein Accession:
    Q5T9C9
    Secondary Accessions:
    • Q8IVS3

    Protein attributes for PIP5KL1 Gene

    Size:
    394 amino acids
    Molecular mass:
    44572 Da
    Quaternary structure:
    • Heterodimerizes with other type I phosphatidylinositol 4-phosphate 5-kinase.

    Alternative splice isoforms for PIP5KL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP5KL1 Gene

Post-translational modifications for PIP5KL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP5KL1 Gene

No data available for DME Specific Peptides for PIP5KL1 Gene

Domains & Families for PIP5KL1 Gene

Suggested Antigen Peptide Sequences for PIP5KL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIP5KL1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PIP5KL1 Gene

Function for PIP5KL1 Gene

Molecular function for PIP5KL1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3.

Enzyme Numbers (IUBMB) for PIP5KL1 Gene

Gene Ontology (GO) - Molecular Function for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity IEA --
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view
genes like me logo Genes that share phenotypes with PIP5KL1: view

Animal Model Products

CRISPR Products

miRNA for PIP5KL1 Gene

miRTarBase miRNAs that target PIP5KL1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP5KL1 Gene

Localization for PIP5KL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP5KL1 Gene

Cytoplasm. Membrane. Note=Localized to large cytoplasmic vesicular structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIP5KL1 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view

Pathways & Interactions for PIP5KL1 Gene

genes like me logo Genes that share pathways with PIP5KL1: view

Pathways by source for PIP5KL1 Gene

Gene Ontology (GO) - Biological Process for PIP5KL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0046488 phosphatidylinositol metabolic process IEA --
GO:0046854 phosphatidylinositol phosphorylation IEA --
genes like me logo Genes that share ontologies with PIP5KL1: view

No data available for SIGNOR curated interactions for PIP5KL1 Gene

Drugs & Compounds for PIP5KL1 Gene

(2) Drugs for PIP5KL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for PIP5KL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIP5KL1: view

Transcripts for PIP5KL1 Gene

Unigene Clusters for PIP5KL1 Gene

Phosphatidylinositol-4-phosphate 5-kinase-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP5KL1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - -
SP6: -

Relevant External Links for PIP5KL1 Gene

GeneLoc Exon Structure for
PIP5KL1
ECgene alternative splicing isoforms for
PIP5KL1

Expression for PIP5KL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PIP5KL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIP5KL1 Gene

This gene is overexpressed in Monocytes (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PIP5KL1 Gene



Protein tissue co-expression partners for PIP5KL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIP5KL1 Gene:

PIP5KL1

SOURCE GeneReport for Unigene cluster for PIP5KL1 Gene:

Hs.734928

Evidence on tissue expression from TISSUES for PIP5KL1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PIP5KL1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP5KL1 Gene

Orthologs for PIP5KL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIP5KL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIP5KL1 34 35
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia PIP5KL1 34 35
  • 90.44 (n)
cow
(Bos Taurus)
Mammalia PIP5KL1 34 35
  • 88.92 (n)
rat
(Rattus norvegicus)
Mammalia Pip5kl1 34
  • 81.18 (n)
mouse
(Mus musculus)
Mammalia Pip5kl1 34 16 35
  • 78.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PIP5KL1 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIP5KL1 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pip5kl1 35
  • 48 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSS4 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8691 35
  • 32 (a)
OneToOne
Species where no ortholog for PIP5KL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PIP5KL1 Gene

ENSEMBL:
Gene Tree for PIP5KL1 (if available)
TreeFam:
Gene Tree for PIP5KL1 (if available)

Paralogs for PIP5KL1 Gene

Paralogs for PIP5KL1 Gene

genes like me logo Genes that share paralogs with PIP5KL1: view

Variants for PIP5KL1 Gene

Sequence variations from dbSNP and Humsavar for PIP5KL1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000048528 -- 127,923,478(+) ACTGA(C/G)TGAAT intron-variant
rs1000268301 -- 127,923,662(+) CATAC(-/CAA)GTTCT intron-variant
rs1000997704 -- 127,930,149(+) GGACC(A/G)TCTCT intron-variant
rs1001032846 -- 127,923,707(+) GGAGG(C/G)GTGGC intron-variant
rs1001035524 -- 127,921,812(+) AGCCC(A/T)TCGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PIP5KL1 Gene

Variant ID Type Subtype PubMed ID
esv3621797 CNV gain 21293372
nsv466577 CNV loss 19166990
nsv615381 CNV loss 21841781
nsv6722 CNV insertion 18451855
nsv831727 CNV loss 17160897

Variation tolerance for PIP5KL1 Gene

Gene Damage Index Score: 1.16; 23.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIP5KL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIP5KL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP5KL1 Gene

Disorders for PIP5KL1 Gene

Relevant External Links for PIP5KL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP5KL1

No disorders were found for PIP5KL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP5KL1 Gene

Publications for PIP5KL1 Gene

  1. Identification and characterization of a phosphoinositide phosphate kinase homolog. (PMID: 14701839) Chang J.D. … Cantley L.C. (J. Biol. Chem. 2004) 3 22 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. (PMID: 19680787) Shi L. … Huang C.Z. (Mol. Biol. Rep. 2010) 3 64
  4. Overexpression of PIP5KL1 suppresses the growth of human cervical cancer cells in vitro and in vivo. (PMID: 19947914) Shi L. … Huang C. (Cell Biol. Int. 2010) 22 64
  5. Phosphoinositide 3-kinase signaling in the vertebrate retina. (PMID: 19638643) Rajala R.V. (J. Lipid Res. 2010) 22 64

Products for PIP5KL1 Gene

Sources for PIP5KL1 Gene

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