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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

PIP5K1B Gene

protein-coding GIFtS: 65
GCID: GC09P071320

phosphatidylinositol-4-phosphate 5-kinase, type I, beta

Explore 5 diseases affiliated with
PIP5K1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, Beta¹ ²		PIP5K1-Beta¹
STM7¹ ² ³ ⁵		PIP5KIbeta² ³
MSS4¹ ² ⁵		EC 2.7.1.68³ ⁸
Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta² ³		Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta²
Protein STM-7² ³		Phosphatidylinositol-4-Phosphate 5-Kinase Type-1 Beta²
PtdIns(4)P-5-Kinase 1 Beta² ³		Type I Phosphatidylinositol-4-Phosphate 5-Kinase Beta²
Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta² ³		EC 2.7.1⁸

External Ids:	HGNC: 8995¹	Entrez Gene: 8395²	Ensembl: ENSG00000107242⁷	OMIM: 602745⁵	UniProtKB: O14986³

Export aliases for PIP5K1B gene to outside databases

Previous GC identifers: GC09P062364 GC09P063177 GC09P064890 GC09P066777 GC09P068550 GC09P070510 GC09P041166

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PI51B_HUMAN, O14986

Function: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent

reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after

stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity)

Gene Wiki entry for PIP5K1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PIP5K1B gene promoter:
HFH-3 C/EBPbeta Pax-2 Nkx2-5 Pax-2a E47 FOXI1 GATA-6 Pax-2b c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIP5K1B promoter sequence

Search SABiosciences Chromatin IP Primers for PIP5K1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIP5K1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q13 Ensembl cytogenetic band: 9q21.11 HGNC cytogenetic band: 9q13

PIP5K1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP5K1B gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P071320: view genomic region (about GC identifiers)

Start:	71,320,575 bp from pter	End:	71,624,092 bp from pter
Size:	303,518 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PI51B_HUMAN, O14986 (See protein sequence)

Recommended Name: Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Size: 540 amino acids; 61036 Da

Subunit: Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1 (By similarity)

Subcellular location: Endomembrane system (By similarity). Note=Associated with membranes (By similarity)

Caution: There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature due to

the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha

Secondary accessions: A8K9L9 P78518 P78519 Q5T5K6 Q5T5K8 Q5T5K9 Q5VZ00 Q7KYT5 Q8NHQ5 Q92749

Alternative splicing: 2 isoforms: O14986-1 O14986-2

Explore the universe of human proteins at neXtProt for PIP5K1B: NX_O14986

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14986

4/22 DME Specific Peptides for PIP5K1B (O14986) (see all 22)

GIIDILQ

DYSLLLG

IMDYSLL

KTLQRDC

PIP5K1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003549.1

ENSEMBL proteins:

ENSP00000366505 ENSP00000366498 ENSP00000398587 ENSP00000435778 ENSP00000411477

ENSP00000438082 ENSP00000265382

Reactome Protein details: O14986
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals PIP5K1B Proteins Novus Biologicals PIP5K1B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001931	uropod	IDA	--
GO:0005829	cytosol	TAS	--
GO:0012505	endomembrane system	IEA	--
GO:0016020	membrane	IEA	--

PIP5K1B for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PIP5K1B for domains About GeneDecksing

3 InterPro domains/families:

IPR002498 PInositol-4-P-5-kinase_core

IPR016034 PInositol-4P-5-kinase_core_sub

IPR023610 PInositol-4-P-5-kinase

Graphical View of Domain Structure for InterPro Entry O14986

ProtoNet protein and cluster: O14986

1 Blocks protein family: IPB002498 Phosphatidylinositol-4-phosphate 5-kinase

UniProtKB/Swiss-Prot: PI51B_HUMAN, O14986

Similarity: Contains 1 PIPK domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PI51B_HUMAN, O14986

Function: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent

reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after

stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity)

Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol

4,5-bisphosphate

Genatlas biochemistry entry for PIP5K1B:

phosphatidylinositol-4-phosphate-5-kinase,type 1 beta,sequence,widely expressed,with an open reading frame of

1620bp,extending upon 220kb,overlapping D9S887,D9S888,D9S889,with the 3'utr of PRKACG contributing to exon

17,extending distally in the Friedreich critical region strongly homolog to yeast MSS4,putatively involved in signal

transduction,excluded as a candidate gene for FRDA

Enzyme Numbers (IUBMB): EC 2.7.1.68¹ ² EC 2.7.1²

miRNA Products:		OriGene 3'-UTR Clone: PIP5K1B Browse MicroRNA Expression Plasmids
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		6 QIAGEN miScript miRNA Assays for microRNAs that regulate PIP5K1B:
		hsa-miR-3142 hsa-miR-625* hsa-miR-27a hsa-miR-3121-3p hsa-miR-340 hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: PIP5K1B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP5K1B

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005524	ATP binding	IEA	--
GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity	NAS	8955136

PIP5K1B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for PIP5K1B:

G0/1 arrest

Increased G1 DNA content

Animal Models:
Mouse knock-out Pip5k1b^tm1Tssk for PIP5K1B
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Pip5k1b):

endocrine/exocrine gland

hematopoietic system

immune system

reproductive system

PIP5K1B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PI Metabolism

	PI Metabolism	1.00			3-phosphoinositide biosynthesis	0.48
	Synthesis of PIPs at the plasma membrane	0.66

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

G-protein signaling_RAC1 in cellular process

	G-protein signaling RAC1 in cellular process	1.00			RAC1 signaling pathway	0.34
	G-protein signaling_RAC1 in cellular process	1.00

Inositol phosphate metabolism

	Inositol phosphate metabolism	1.00			Phosphatidylinositol signaling system	0.59
	superpathway of inositol phosphate compounds	0.59

Immune response CD28 signaling

Immune response CD28 signaling

1.00

Immune response_CD28 signaling

0.92

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for PIP5K1B

	G-protein signaling RAC1 in cellular process
	Immune response CD28 signaling

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIP5K1B (see all 7)

	Rac1 Pathway
	RhoA Pathway
	Actin-Based Motility by Rho Family GTPases
	Integrin Pathway
	Aldosterone Signaling in Epithelial Cells

3 GeneGo (Thomson Reuters) Pathways for PIP5K1B

	Inhibitory action of Lipoxins on neutrophil migration
	G-protein signaling RAC1 in cellular process
	Immune response CD28 signaling

5/8 BioSystems Pathways for PIP5K1B (see all 8)

	Regulation of Actin Cytoskeleton
	3-phosphoinositide biosynthesis
	B Cell Receptor Signaling Pathway
	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
	RAC1 signaling pathway

5 Reactome Pathways for PIP5K1B

	Metabolism
	Synthesis of PIPs at the plasma membrane
	Phospholipid metabolism
	Metabolism of lipids and lipoproteins
	PI Metabolism

5/6 Kegg Pathways (Kegg details for PIP5K1B) (see all 6):

	Inositol phosphate metabolism
	Metabolic pathways
	Phosphatidylinositol signaling system
	Endocytosis
	Fc gamma R-mediated phagocytosis

PIP5K1B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PIP5K1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/75 Interacting proteins for PIP5K1B (O14986³ ENSP00000265382⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 75)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BTK	Q06187³, ENSP00000308176⁴	I2D: score=1 STRING: ENSP00000308176
MCRS1	Q96EZ8³, ENSP00000349640⁴	I2D: score=1 STRING: ENSP00000349640
PIP5KL1	Q5T9C9³, ENSP00000373399⁴	I2D: score=1 STRING: ENSP00000373399
SPOP	O43791³, ENSP00000240327⁴	I2D: score=2 STRING: ENSP00000240327
CLIC1	O00299³	I2D: score=2

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006661	phosphatidylinositol biosynthetic process	TAS	--
GO:0016310	phosphorylation	NAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046488	phosphatidylinositol metabolic process	--	--

PIP5K1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

PIP5K1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PIP5K1B

3 HMDB Compounds for PIP5K1B About this table

Compound	Synonyms	CAS #	PubMed Ids
1-Phosphatidyl-D-myo-inositol	1-Phosphatidyl-1D-myo-inositol (see all 6)	--	--
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

2 Novoseek chemical compound relationships for PIP5K1B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphoinositide	66.3	1	8841185 (1)
lipid	19.4	1	16943196 (1)

Search CenterWatch for drugs/clinical trials and news about PIP5K1B / PI51B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for PIP5K1B gene (2 alternative transcripts):

NM_001031687.1 NM_003558.2

Unigene Cluster for PIP5K1B:

Phosphatidylinositol-4-phosphate 5-kinase, type I, beta

Hs.534371 [show with all ESTs]

Unigene Representative Sequence: BC030587

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377290 ENST00000472907 ENST00000474356 ENST00000377284 ENST00000437200

ENST00000478500(uc004agv.3) ENST00000440050 ENST00000541509 ENST00000265382(uc004agu.3 uc011lrq.2)

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		hsa-miR-3142 hsa-miR-625* hsa-miR-27a hsa-miR-3121-3p hsa-miR-340 hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: PIP5K1B 3' UTR sequence

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Additional cDNA sequence:

AK292734.1 AK295587.1 BC030587.2 U78579.1 U78580.1 U78581.1

10 DOTS entries:

DT.80101308 DT.91751831 DT.100755498 DT.121167033 DT.95208667 DT.91649497 DT.95167072 DT.100755500

DT.121166964 DT.75185935

24/104 AceView cDNA sequences (see all 104):

BQ638622 AA598845 BF590740 AI581828 CB216055 U78581 BF590756 AL600893

BF591050 BM725564 AI280175 F13210 U78580 BQ006894 U78579 BG190955

AA694328 AL705046 AI309914 CK299479 AI089739 AI281276 AI249027 BF590418

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PIP5K1B (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21
SP1:					-		-		-		-				-
SP2:																																											-
SP3:							-
SP4:																							-		-
SP5:					-		-		-		-		-		-

ECgene alternative splicing isoforms for PIP5K1B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

PIP5K1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATTGAAAG

About this image

PIP5K1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See PIP5K1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PIP5K1B

SOURCE GeneReport for Unigene cluster: Hs.534371

UniProtKB/Swiss-Prot: PI51B_HUMAN, O14986

Tissue specificity: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung

SABiosciences Custom PCR Arrays for PIP5K1B

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP5K1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIP5K1B gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PIP5K1B¹	phosphatidylinositol-4-phosphate 5-kinase, type I, more	79.94(n) 86.67(a)		427243 NM_001031422.1 NP_001026593.1
lizard (Anolis carolinensis)	Reptilia	PIP5K1B⁶	--	83(a)	1 ↔ 1	2(49743269-49782878)
African clawed frog (Xenopus laevis)	Amphibia	LOC398687²	hypothetical protein LOC398687	78.72(n)		BC055973.1
zebrafish (Danio rerio)	Actinopterygii	Dr.14775²	Transcribed sequences	76.14(n)		CK239124.1
fruit fly (Drosophila melanogaster)	Insecta	sktl³	peripheral nervous system development 1-phosphatidylinositol-4-phosphate more	53(a)		2 57B3 --
worm (Caenorhabditis elegans)	Secernentea	ppk-1³	--	53(a)		I(5358529-5364151) --
thale cress (Arabidopsis thaliana)	eudicotyledons	PIPK11⁶ ATPIPK10⁶ (see all 11)	1-phosphatidylinositol-4-phosphate 5-kinase (see all 11)	22(a) 21(a) (see all 11)	many ↔ many many ↔ many (see all 11)	1(168723-171165) 4(504211-506131)
rice (Oryza sativa)	Liliopsida	Os12g0141100¹	hypothetical protein	49.02(n) 37.17(a)		4351470 NM_001072658.1 NP_001066126.1

ENSEMBL Gene Tree for PIP5K1B (if available)
TreeFam Gene Tree for PIP5K1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for PIP5K1B gene

PIP4K2A² PIP4K2C² PIP4K2B² PIP5K1C² PIP5KL1² PIP5K1A²

7 SIMAP similar genes for PIP5K1B using alignment to 2 protein entries: PI51B_HUMAN (see all proteins):

STM7 PIP5K1A PIP5K1C PIPSL PIP4K2A PIP4K2C

PIP4K2B

PIP5K1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74412569^1,2		--	41239207(+)	`TATCAG/ATCCCC`	1	--	us2k¹		1		EA	120
rs78845386^1,2	C,F,	--	41239546(+)	`TTTCCC/ACTCAG`	1	--	us2k¹		1		WA	118
rs12349968^1,2	C,F,H,	--	41241997(+)	`TAGTTA/GTATCT`	1	--	ut3¹		15		NS EA NA CSA WA	1870
rs75979727^1,2	C,F,	--	41242224(+)	`AATAAA/CATTTT`	1	--	ut3¹		1		WA	118
rs73646760^1,2	C,	--	41242526(+)	`TTTCTG/ACTCTG`	1	--	ut3¹		1		WA	2
rs75064770^1,2	C,	--	41242758(+)	`ATTAAG/AGGGTG`	1	--	ut3¹		3		CSA WA NA	240
rs41287413^1,2		--	41243494(+)	`CTGTTA/GCCCCT`	1	--	ut3¹		0	--	--	--	--
rs12006032^1,2	C,F,H,	--	41243657(+)	`TTCCTA/GCTCTT`	1	--	ut3¹		16		NS EA NA CSA WA	1884
rs12006549^1,2	C,F,H,	--	41243775(+)	`TCTTAT/CTCTGC`	1	--	ut3¹		12		NS EA NA CSA WA	1214
rs200950009^1,2	C	--	41243842(-)	`TATCCA/CAAAGA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for PIP5K1B (71320575 - 71570575 bp, first 250kb of PIP5K1B)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PIP5K1B
2 CNVs: 5262 2820

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIP5K1B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

PIP5K1B for disorders           About GeneDecksing

OMIM gene information: 602745    OMIM disorders: --

5 diseases for PIP5K1B:    About MalaCards

friedreich ataxia ataxia kidney disease schizophrenia

neuronitis

1 disease from the University of Copenhagen DISEASES database for PIP5K1B:

Friedreich ataxia

1 Novoseek disease relationship for PIP5K1B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
friedreich ataxia	71.4	2	8841185 (1), 9177790 (1)

Human Genome Epidemiology (HuGE) Navigator: PIP5K1B (4 documents)

Export disorders for PIP5K1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for PIP5K1B gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with PIP5K1B)

Utopia: connect your pdf to the dynamic
world of online information

Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity. (PubMed id 9177790)^{1, 2, 3, 9} Pook M.A.... Chamberlain S. (1997)
The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase. (PubMed id 8841185)^{1, 2, 3, 9} Carvajal J.J.... Chamberlain S. (1996)
Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. (PubMed id 8955136)^{1, 2, 9} Loijens J.C. and Anderson R.A. (1996)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement. (PubMed id 18158329)^{1, 9} Lacalle R.A....Manes S. (2007)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Type I phosphatidylinositol phosphate kinase beta reg ulates focal adhesion disassembly by promoting beta1 integrin endocytosis. (PubMed id 20624912)¹ Chao W.T....Kunz J. (2010)
Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analy sis among pharmacogenomics, mouse expression, and genetic case-control associat ion approaches. (PubMed id 19850283)¹ Ikeda M....Iwata N. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8395	HGNC: 8995	AceView: PIP5K1B	Ensembl:ENSG00000107242	euGenes: HUgn8395
ECgene: PIP5K1B	Kegg: 8395	H-InvDB: PIP5K1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for PIP5K1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for PIP5K1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for PIP5K1B gene:
Search GeneIP for patents involving PIP5K1B

GeneCards and IP:
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PIP5K1B Gene

phosphatidylinositol-4-phosphate 5-kinase, type I, beta

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PIP5K1B Gene

phosphatidylinositol-4-phosphate 5-kinase, type I, beta

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