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Aliases for PIP5K1B Gene

Aliases for PIP5K1B Gene

  • Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta 2 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, Beta 2 3 5
  • Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta 3 4
  • Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta 3 4
  • PtdIns(4)P-5-Kinase 1 Beta 3 4
  • Protein STM-7 3 4
  • PIP5K1-Beta 3 4
  • EC 2.7.1.68 4 63
  • PIP5KIbeta 3 4
  • STM7 3 4
  • Phosphatidylinositol-4-Phosphate 5-Kinase Type-1 Beta 3
  • Type I Phosphatidylinositol-4-Phosphate 5-Kinase Beta 3
  • EC 2.7.1 63
  • MSS4 3

External Ids for PIP5K1B Gene

Previous GeneCards Identifiers for PIP5K1B Gene

  • GC09P062364
  • GC09P063177
  • GC09P064890
  • GC09P066777
  • GC09P068550
  • GC09P070510
  • GC09P071320
  • GC09P041166

Summaries for PIP5K1B Gene

GeneCards Summary for PIP5K1B Gene

PIP5K1B (Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include phosphatidylinositol phosphate kinase activity and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP4K2B.

UniProtKB/Swiss-Prot for PIP5K1B Gene

  • Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).

Gene Wiki entry for PIP5K1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP5K1B Gene

Genomics for PIP5K1B Gene

Regulatory Elements for PIP5K1B Gene

Promoters for PIP5K1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIP5K1B on UCSC Golden Path with GeneCards custom track

Genomic Location for PIP5K1B Gene

Chromosome:
9
Start:
68,705,217 bp from pter
End:
69,009,176 bp from pter
Size:
303,960 bases
Orientation:
Plus strand

Genomic View for PIP5K1B Gene

Genes around PIP5K1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP5K1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP5K1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP5K1B Gene

Proteins for PIP5K1B Gene

  • Protein details for PIP5K1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14986-PI51B_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
    Protein Accession:
    O14986
    Secondary Accessions:
    • A8K9L9
    • B4DIG7
    • P78518
    • P78519
    • Q5T5K6
    • Q5T5K8
    • Q5T5K9
    • Q5VZ00
    • Q7KYT5
    • Q8NHQ5
    • Q92749

    Protein attributes for PIP5K1B Gene

    Size:
    540 amino acids
    Molecular mass:
    61036 Da
    Quaternary structure:
    • Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.

    Alternative splice isoforms for PIP5K1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP5K1B Gene

Proteomics data for PIP5K1B Gene at MOPED

Post-translational modifications for PIP5K1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP5K1B Gene

Antibody Products

Domains & Families for PIP5K1B Gene

Graphical View of Domain Structure for InterPro Entry

O14986

UniProtKB/Swiss-Prot:

PI51B_HUMAN :
  • Contains 1 PIPK domain.
Domain:
  • Contains 1 PIPK domain.
genes like me logo Genes that share domains with PIP5K1B: view

No data available for Gene Families for PIP5K1B Gene

Function for PIP5K1B Gene

Molecular function for PIP5K1B Gene

GENATLAS Biochemistry:
phosphatidylinositol-4-phosphate-5-kinase,type 1 beta,sequence,widely expressed,with an open reading frame of 1620bp,extending upon 220kb,overlapping D9S887,D9S888,D9S889,with the 3utr of PRKACG contributing to exon 17,extending distally in the Friedreich critical region strongly homolog to yeast MSS4,putatively involved in signal transduction,excluded as a candidate gene for FRDA
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).

Enzyme Numbers (IUBMB) for PIP5K1B Gene

Gene Ontology (GO) - Molecular Function for PIP5K1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity TAS --
GO:0005515 protein binding IPI 20442317
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity NAS,TAS --
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity TAS --
genes like me logo Genes that share ontologies with PIP5K1B: view
genes like me logo Genes that share phenotypes with PIP5K1B: view

Animal Models for PIP5K1B Gene

MGI Knock Outs for PIP5K1B:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PIP5K1B Gene

Localization for PIP5K1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP5K1B Gene

Endomembrane system. Note=Associated with membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIP5K1B Gene COMPARTMENTS Subcellular localization image for PIP5K1B gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PIP5K1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 20442317
genes like me logo Genes that share ontologies with PIP5K1B: view

Pathways & Interactions for PIP5K1B Gene

SuperPathways for PIP5K1B Gene

genes like me logo Genes that share pathways with PIP5K1B: view

SIGNOR curated interactions for PIP5K1B Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PIP5K1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
genes like me logo Genes that share ontologies with PIP5K1B: view

Drugs & Compounds for PIP5K1B Gene

(2) Additional Compounds for PIP5K1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIP5K1B: view

Transcripts for PIP5K1B Gene

Unigene Clusters for PIP5K1B Gene

Phosphatidylinositol-4-phosphate 5-kinase, type I, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIP5K1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for PIP5K1B Gene

GeneLoc Exon Structure for
PIP5K1B
ECgene alternative splicing isoforms for
PIP5K1B

Expression for PIP5K1B Gene

mRNA expression in normal human tissues for PIP5K1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIP5K1B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.1) and Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for PIP5K1B Gene

This gene is overexpressed in Testis (39.5) and Retina (23.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIP5K1B Gene



SOURCE GeneReport for Unigene cluster for PIP5K1B Gene Hs.534371

mRNA Expression by UniProt/SwissProt for PIP5K1B Gene

O14986-PI51B_HUMAN
Tissue specificity: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.
genes like me logo Genes that share expression patterns with PIP5K1B: view

Protein tissue co-expression partners for PIP5K1B Gene

Primer Products

In Situ Assay Products

Orthologs for PIP5K1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIP5K1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIP5K1B 35
  • 92.46 (n)
  • 96.85 (a)
PIP5K1B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIP5K1B 35
  • 91.85 (n)
  • 97.04 (a)
PIP5K1B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pip5k1b 35
  • 88 (n)
  • 96.47 (a)
Pip5k1b 16
Pip5k1b 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIP5K1B 35
  • 99.51 (n)
  • 99.63 (a)
PIP5K1B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pip5k1b 35
  • 88.06 (n)
  • 95.92 (a)
oppossum
(Monodelphis domestica)
Mammalia PIP5K1B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIP5K1B 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIP5K1B 35
  • 79.94 (n)
  • 86.67 (a)
PIP5K1B 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIP5K1B 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pip5k1b 35
  • 74.55 (n)
  • 81.75 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398687 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14775 35
pip5k1bb 35
  • 69.13 (n)
  • 74.57 (a)
pip5k1ba 36
  • 67 (a)
OneToMany
pip5k1bb 36
  • 74 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13867 35
fruit fly
(Drosophila melanogaster)
Insecta sktl 37
  • 53 (a)
PIP5K59B 36
  • 32 (a)
ManyToMany
sktl 36
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ppk-1 37
  • 53 (a)
ppk-1 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSS4 36
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0262000 35
  • 48.62 (n)
  • 41.45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02295 35
  • 45.97 (n)
  • 35.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for PIP5K1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP5K1B Gene

ENSEMBL:
Gene Tree for PIP5K1B (if available)
TreeFam:
Gene Tree for PIP5K1B (if available)

Paralogs for PIP5K1B Gene

Paralogs for PIP5K1B Gene

(7) SIMAP similar genes for PIP5K1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIP5K1B: view

Variants for PIP5K1B Gene

Sequence variations from dbSNP and Humsavar for PIP5K1B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs55897616 - 68,934,931(+) CAATC(A/G)CCGCC reference, missense
rs713057 -- 68,765,892(-) gataT(A/G)TATAG intron-variant
rs963707 -- 68,740,301(-) AGAGT(A/G)TCCAT intron-variant, upstream-variant-2KB
rs1107106 -- 68,703,974(-) TGGGT(C/T)TGGTT upstream-variant-2KB
rs1107107 -- 68,703,942(-) TTCAC(A/C)GCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PIP5K1B Gene

Variant ID Type Subtype PubMed ID
nsv893414 CNV Gain 21882294
esv2422258 CNV Duplication 17116639
esv259862 OTHER Complex 20981092
dgv2386e1 CNV Complex 17122850
esv2664413 CNV Deletion 23128226
nsv893415 CNV Gain 21882294
nsv6548 CNV Loss 18451855
nsv466393 CNV Gain 19166990
nsv466397 CNV Gain 19166990
nsv893416 CNV Gain 21882294
dgv8243n71 CNV Loss 21882294

Variation tolerance for PIP5K1B Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIP5K1B Gene

HapMap Linkage Disequilibrium report
PIP5K1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP5K1B Gene

Disorders for PIP5K1B Gene

Relevant External Links for PIP5K1B

Genetic Association Database (GAD)
PIP5K1B
Human Genome Epidemiology (HuGE) Navigator
PIP5K1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP5K1B

No disorders were found for PIP5K1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP5K1B Gene

Publications for PIP5K1B Gene

  1. Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity. (PMID: 9177790) Pook M.A. … Chamberlain S. (Genomics 1997) 2 3 4 23 67
  2. The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase. (PMID: 8841185) Carvajal J.J. … Chamberlain S. (Nat. Genet. 1996) 2 3 23
  3. Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement. (PMID: 18158329) Lacalle R.A. … MaA+es S. (J. Cell Biol. 2007) 3 23
  4. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. (PMID: 8955136) Loijens J.C. … Anderson R.A. (J. Biol. Chem. 1996) 3 23
  5. Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity. (PMID: 25713054) Lacalle R.A. … MaA+es S. (FASEB J. 2015) 3

Products for PIP5K1B Gene

Sources for PIP5K1B Gene

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