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Aliases for PIP5K1B Gene

Aliases for PIP5K1B Gene

  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, Beta 2 3
  • STM7 3 4 6
  • Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta 3 4
  • Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta 3 4
  • PtdIns(4)P-5-Kinase 1 Beta 3 4
  • Protein STM-7 3 4
  • PIP5K1-Beta 3 4
  • EC 2.7.1.68 4 63
  • PIP5KIbeta 3 4
  • MSS4 3 6
  • Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase Type-1 Beta 3
  • Type I Phosphatidylinositol-4-Phosphate 5-Kinase Beta 3
  • EC 2.7.1 63

External Ids for PIP5K1B Gene

Previous GeneCards Identifiers for PIP5K1B Gene

  • GC09P062364
  • GC09P063177
  • GC09P064890
  • GC09P066777
  • GC09P068550
  • GC09P070510
  • GC09P071320
  • GC09P041166

Summaries for PIP5K1B Gene

GeneCards Summary for PIP5K1B Gene

PIP5K1B (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, Beta) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP5KL1.

UniProtKB/Swiss-Prot for PIP5K1B Gene

  • Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).

Gene Wiki entry for PIP5K1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP5K1B Gene

Genomics for PIP5K1B Gene

Regulatory Elements for PIP5K1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIP5K1B Gene

Start:
68,705,332 bp from pter
End:
69,009,176 bp from pter
Size:
303,845 bases
Orientation:
Plus strand

Genomic View for PIP5K1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIP5K1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP5K1B Gene

Proteins for PIP5K1B Gene

  • Protein details for PIP5K1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14986-PI51B_HUMAN
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
    Protein Accession:
    O14986
    Secondary Accessions:
    • A8K9L9
    • B4DIG7
    • P78518
    • P78519
    • Q5T5K6
    • Q5T5K8
    • Q5T5K9
    • Q5VZ00
    • Q7KYT5
    • Q8NHQ5
    • Q92749

    Protein attributes for PIP5K1B Gene

    Size:
    540 amino acids
    Molecular mass:
    61036 Da
    Quaternary structure:
    • Interacts with RAC1, AJUBA, PLD1, PLD2 and ARF1.

    Alternative splice isoforms for PIP5K1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP5K1B Gene

Proteomics data for PIP5K1B Gene at MOPED

Post-translational modifications for PIP5K1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP5K1B Gene

Domains for PIP5K1B Gene

Graphical View of Domain Structure for InterPro Entry

O14986

UniProtKB/Swiss-Prot:

PI51B_HUMAN :
  • O14986
Domain:
  • Contains 1 PIPK domain.
genes like me logo Genes that share domains with PIP5K1B: view

No data available for Gene Families for PIP5K1B Gene

Function for PIP5K1B Gene

Molecular function for PIP5K1B Gene

GENATLAS Biochemistry: phosphatidylinositol-4-phosphate-5-kinase,type 1 beta,sequence,widely expressed,with an open reading frame of 1620bp,extending upon 220kb,overlapping D9S887,D9S888,D9S889,with the 3utr of PRKACG contributing to exon 17,extending distally in the Friedreich critical region strongly homolog to yeast MSS4,putatively involved in signal transduction,excluded as a candidate gene for FRDA
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
UniProtKB/Swiss-Prot Function: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion (By similarity).

Enzyme Numbers (IUBMB) for PIP5K1B Gene

Gene Ontology (GO) - Molecular Function for PIP5K1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20442317
GO:0005524 ATP binding IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity --
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity NAS 8955136
genes like me logo Genes that share ontologies with PIP5K1B: view
genes like me logo Genes that share phenotypes with PIP5K1B: view

Animal Models for PIP5K1B Gene

MGI Knock Outs for PIP5K1B:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP5K1B

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for PIP5K1B Gene

Localization for PIP5K1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP5K1B Gene

Endomembrane system. Note=Associated with membranes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIP5K1B Gene COMPARTMENTS Subcellular localization image for PIP5K1B gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for PIP5K1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 20442317
GO:0005829 cytosol TAS --
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PIP5K1B: view

Pathways for PIP5K1B Gene

genes like me logo Genes that share pathways with PIP5K1B: view

Gene Ontology (GO) - Biological Process for PIP5K1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046488 phosphatidylinositol metabolic process --
GO:0046854 phosphatidylinositol phosphorylation NAS 8955136
genes like me logo Genes that share ontologies with PIP5K1B: view

Compounds for PIP5K1B Gene

(3) HMDB Compounds for PIP5K1B Gene

Compound Synonyms Cas Number PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Novoseek inferred chemical compound relationships for PIP5K1B Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 66.3 1
lipid 19.4 1
genes like me logo Genes that share compounds with PIP5K1B: view

Transcripts for PIP5K1B Gene

Unigene Clusters for PIP5K1B Gene

Phosphatidylinositol-4-phosphate 5-kinase, type I, beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP5K1B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PIP5K1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP5K1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - - - -
SP2: -
SP3: -
SP4: - -
SP5: - - - - - -
SP6: -

Relevant External Links for PIP5K1B Gene

GeneLoc Exon Structure for
PIP5K1B
ECgene alternative splicing isoforms for
PIP5K1B

Expression for PIP5K1B Gene

mRNA expression in normal human tissues for PIP5K1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIP5K1B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.1) and Heart - Left Ventricle (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIP5K1B Gene

SOURCE GeneReport for Unigene cluster for PIP5K1B Gene Hs.534371

mRNA Expression by UniProt/SwissProt for PIP5K1B Gene

O14986-PI51B_HUMAN
Tissue specificity: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.
genes like me logo Genes that share expressions with PIP5K1B: view

In Situ Assay Products

Orthologs for PIP5K1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PIP5K1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIP5K1B 35
  • 99.51 (n)
  • 99.63 (a)
PIP5K1B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIP5K1B 35
  • 92.46 (n)
  • 96.85 (a)
PIP5K1B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PIP5K1B 35
  • 91.85 (n)
  • 97.04 (a)
PIP5K1B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pip5k1b 35
  • 88 (n)
  • 96.47 (a)
Pip5k1b 16
Pip5k1b 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIP5K1B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIP5K1B 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pip5k1b 35
  • 88.06 (n)
  • 95.92 (a)
chicken
(Gallus gallus)
Aves PIP5K1B 35
  • 79.94 (n)
  • 86.67 (a)
PIP5K1B 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIP5K1B 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398687 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pip5k1b 35
  • 74.55 (n)
  • 81.75 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13867 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14775 35
pip5k1ba 36
  • 67 (a)
OneToMany
pip5k1bb 35
  • 69.13 (n)
  • 74.57 (a)
pip5k1bb 36
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta PIP5K59B 36
  • 32 (a)
ManyToMany
sktl 36
  • 32 (a)
ManyToMany
sktl 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea ppk-1 36
  • 41 (a)
OneToMany
ppk-1 37
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSS4 36
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os03g0262000 35
  • 48.62 (n)
  • 41.45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02295 35
  • 45.97 (n)
  • 35.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for PIP5K1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP5K1B Gene

ENSEMBL:
Gene Tree for PIP5K1B (if available)
TreeFam:
Gene Tree for PIP5K1B (if available)

Paralogs for PIP5K1B Gene

Paralogs for PIP5K1B Gene

Selected SIMAP similar genes for PIP5K1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIP5K1B: view

Variants for PIP5K1B Gene

Sequence variations from dbSNP and Humsavar for PIP5K1B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs713057 -- 68,765,892(-) gataT(A/G)TATAG intron-variant
rs756326 -- 68,947,930(+) GTGAG(A/T)CTCCC intron-variant
rs883751 -- 68,997,975(+) TTTCT(C/T)TTTTT intron-variant
rs883951 -- 68,899,631(+) TTTGA(A/G)TCACT intron-variant
rs883952 -- 68,899,735(+) AAGCA(A/G)TGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIP5K1B Gene

Variant ID Type Subtype PubMed ID
nsv893414 CNV Gain 21882294
esv2422258 CNV Duplication 17116639
esv259862 OTHER Complex 20981092
dgv2386e1 CNV Complex 17122850
esv2664413 CNV Deletion 23128226
nsv893415 CNV Gain 21882294
nsv6548 CNV Loss 18451855
nsv466393 CNV Gain 19166990
nsv466397 CNV Gain 19166990
nsv893416 CNV Gain 21882294
dgv8243n71 CNV Loss 21882294

Relevant External Links for PIP5K1B Gene

HapMap Linkage Disequilibrium report
PIP5K1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP5K1B Gene

Disorders for PIP5K1B Gene

(1) University of Copenhagen DISEASES for PIP5K1B Gene

(1) Novoseek inferred disease relationships for PIP5K1B Gene

Disease -log(P) Hits PubMed IDs
friedreich ataxia 71.4 2

Relevant External Links for PIP5K1B

Genetic Association Database (GAD)
PIP5K1B
Human Genome Epidemiology (HuGE) Navigator
PIP5K1B
genes like me logo Genes that share disorders with PIP5K1B: view

No data available for UniProtKB/Swiss-Prot for PIP5K1B Gene

Publications for PIP5K1B Gene

  1. The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase. (PMID: 8841185) Carvajal J.J. … Chamberlain S. (Nat. Genet. 1996) 2 3 4 23
  2. Exon-intron structure of a 2.7-kb transcript of the STM7 gene with phosphatidylinositol-4-phosphate 5-kinase activity. (PMID: 9177790) Pook M.A. … Chamberlain S. (Genomics 1997) 2 3 4 23
  3. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. (PMID: 8955136) Loijens J.C. … Anderson R.A. (J. Biol. Chem. 1996) 3 4 23
  4. Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement. (PMID: 18158329) Lacalle R.A. … MaA+es S. (J. Cell Biol. 2007) 3 23
  5. Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches. (PMID: 19850283) Ikeda M. … Iwata N. (Biol. Psychiatry 2010) 3 48

Products for PIP5K1B Gene

Sources for PIP5K1B Gene

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