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PIP5K1A Gene

protein-coding   GIFtS: 66
GCID: GC01P151170

Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, Alpha1 2     EC 2.7.1.683 8
Phosphatidylinositol 4-Phosphate 5-Kinase Type I Alpha2 3     68 KDa Type I Phosphatidylinositol-4-Phosphate 5-Kinase Alpha2
PtdIns(4)P-5-Kinase 1 Alpha2 3     Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Alpha2
68 KDa Type I Phosphatidylinositol 4-Phosphate 5-Kinase Alpha2 3     Phosphatidylinositol-4-Phosphate 5-Kinase Type-1 Alpha2
PIP5K1-alpha2 3     EC 2.7.18
PIP5KIalpha2 3     

External Ids:    HGNC: 89941   Entrez Gene: 83942   Ensembl: ENSG000001433987   OMIM: 6032755   UniProtKB: Q997553   
ORGUL members:         

Export aliases for PIP5K1A gene to outside databases

Previous GC identifers: GC01P149012 GC01P146918 GC01P147946 GC01P148387 GC01P147984 GC01P149437 GC01P122549


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PIP5K1A Gene:
PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase, type I, alpha) is a protein-coding gene. Diseases associated with PIP5K1A include prostate cancer, and hiv-1. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding. An important paralog of this gene is PIP4K2A.

UniProtKB/Swiss-Prot: PI51A_HUMAN, Q99755
Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form
phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular
processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second
messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate
5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin
cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation,
actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced
translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they
regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS
that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is
required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during
calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin
complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and
inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with
PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1
adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of
mRNAs

Gene Wiki entry for PIP5K1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIP5K1A gene promoter:
         MAZR   Sp1   FOXO3   FOXO3b   C/EBPalpha   HOXA5   FOXO3a   SEF-1 (1)   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIP5K1A promoter sequence
   Search Chromatin IP Primers for PIP5K1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIP5K1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

PIP5K1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP5K1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151170:  view genomic region     (about GC identifiers)

Start:
151,170,425 bp from pter      End:
151,222,012 bp from pter
Size:
51,588 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PI51A_HUMAN, Q99755 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha  
Size: 562 amino acids; 62633 Da
Subunit: Interacts with RAC1 (By similarity). Interacts with TUT1. Forms a complex with CDH1/E-cadherin,
CTNNB1/beta-catenin and CTNND1 at the plasma membrane upon calcium stimulation
Caution: There is confusion in the literature with phosphatidylinositol 4-phosphate 5-kinase type I nomenclature
due to the fact that frequently mouse PIP5K1B is named Phosphatidylinositol 4-phosphate 5-kinase type I alpha
Secondary accessions: A8K4Q0 B4DIN0 Q99754 Q99756
Alternative splicing: 4 isoforms:  Q99755-1   Q99755-2   Q99755-3   Q99755-4   

Explore the universe of human proteins at neXtProt for PIP5K1A: NX_Q99755

Explore proteomics data for PIP5K1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys103
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIP5K1A (Q99755) (see all 15)
     GIIDILQ  IMDYSLL  KTLQRDC  QKALYSTA 


    See PIP5K1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001129108.1  NP_001129109.1  NP_001129110.1  NP_003548.1  

    ENSEMBL proteins: 
     ENSP00000401228   ENSP00000271663   ENSP00000386432   ENSP00000415648   ENSP00000357885  
     ENSP00000392780   ENSP00000357883   ENSP00000416196   ENSP00000414632   ENSP00000388800  
    Reactome Protein details: Q99755

    PIP5K1A Human Recombinant Protein Products:

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    Novus Biologicals PIP5K1A Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    PIP5K1A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    PIP5K1A Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
    1-phosphatidylinositol-4-phosphate 5-kinase family

    5 InterPro protein domains:
     IPR027484 PInositol-4-P-5-kinase_N
     IPR002498 PInositol-4-P-5-kinase_core
     IPR027483 PInositol-4-P-5-kinase_C
     IPR016034 PInositol-4P-5-kinase_core_sub
     IPR023610 PInositol-4-P-5-kinase

    Graphical View of Domain Structure for InterPro Entry Q99755

    ProtoNet protein and cluster: Q99755

    1 Blocks protein domain: IPB002498 Phosphatidylinositol-4-phosphate 5-kinase

    UniProtKB/Swiss-Prot: PI51A_HUMAN, Q99755
    Similarity: Contains 1 PIPK domain


    PIP5K1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI51A_HUMAN, Q99755
    Function: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form
    phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular
    processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second
    messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate
    5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin
    cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation,
    actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced
    translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they
    regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS
    that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is
    required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during
    calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin
    complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and
    inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with
    PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1
    adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of
    mRNAs
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    4,5-bisphosphate

         Genatlas biochemistry entry for PIP5K1A:
    phosphatidylinositol-4-phosphate-5 kinase,type 1 alpha,widely expressed,noteworthy in erythrocytes,activated by
    the small G protein ADP-ribosylation factor ARF6,and putatively involved in membrane ruffle formation

         Enzyme Numbers (IUBMB): EC 2.7.1.681 2 EC 2.7.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18288197
    GO:0005524ATP binding IEA--
    GO:0016307phosphatidylinositol phosphate kinase activity ----
    GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activity TAS18305108
    GO:0019900kinase binding IDA15157668
         
    PIP5K1A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for PIP5K1A:
     Increased cell death HMECs cel  Increases Tamoxifen sensitivit 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Pip5k1a):
     endocrine/exocrine gland  hematopoietic system  mortality/aging  normal  reproductive system 

    PIP5K1A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Pip5k1atm1.1Tba for PIP5K1A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIP5K1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIP5K1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIP5K1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIP5K1A

    miRNA
    Products:
        
    miRTarBase miRNAs that target PIP5K1A:
    hsa-mir-132-3p (MIRT021718), hsa-mir-615-3p (MIRT039898), hsa-mir-769-3p (MIRT039096), hsa-mir-1226-3p (MIRT036493), hsa-mir-222-3p (MIRT046769), hsa-mir-744-5p (MIRT037733)

    Block miRNA regulation of human, mouse, rat PIP5K1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIP5K1A (see all 45):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-3938 hsa-miR-642a hsa-miR-607 hsa-miR-3664-5p hsa-miR-1224-3p hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidPIP5K1A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIP5K1A
    Predesigned siRNA for gene silencing in human, mouse, rat PIP5K1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIP5K1A

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PIP5K1A (NM_003557)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP5K1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP5K1A

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PIP5K1A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP5K1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PI51A_HUMAN, Q99755: Cell membrane. Cytoplasm (By similarity). Nucleus speckle. Cell projection, ruffle.
    Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1
    to regulate polyadenylation of selected mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol4
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005847colocalizes with mRNA cleavage and polyadenylation specificity factor complex IDA18305108

    PIP5K1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIP5K1A About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    superpathway of inositol phosphate compounds0.60
    Phosphatidylinositol signaling system0.61
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
    2PI Metabolism
    PI Metabolism0.65
    3-phosphoinositide biosynthesis0.47
    Synthesis of PIPs at the plasma membrane0.65
    3Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    4Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    5Apoptotic Pathways in Synovial Fibroblasts
    Rac1 Pathway0.65
    Actin-Based Motility by Rho Family GTPases0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIP5K1A (see all 7)
        Rac1 Pathway
    RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    Integrin Pathway
    Aldosterone Signaling in Epithelial Cells

    1 Cell Signaling Technology (CST) Pathway for PIP5K1A
        Ca, cAMP and Lipid Signaling

    4 GeneGo (Thomson Reuters) Pathways for PIP5K1A
        Inhibitory action of Lipoxins on neutrophil migration
    G-protein signaling RAC1 in cellular process
    Immune response CD28 signaling
    Immune response CD16 signaling in NK cells

    Selected BioSystems Pathways for PIP5K1A (see all 11)
        Regulation of Actin Cytoskeleton
    B Cell Receptor Signaling Pathway
    3-phosphoinositide biosynthesis
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    Arf1 pathway

    1 Reactome Pathway for PIP5K1A
        Synthesis of PIPs at the plasma membrane


    Selected Kegg Pathways  (Kegg details for PIP5K1A) (see all 6):
        Inositol phosphate metabolism
    Metabolic pathways
    Phosphatidylinositol signaling system
    Endocytosis
    Fc gamma R-mediated phagocytosis


    PIP5K1A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIP5K1A
    Interactions:

        Search GeneGlobe Interaction Network for PIP5K1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIP5K1A (Q997552, 3 ENSP000003578834) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CADPSQ9ULU82, 3, ENSP000003732154MINT-65290 I2D: score=4 STRING: ENSP00000373215
    BTKQ061873, ENSP000003081764I2D: score=2 STRING: ENSP00000308176
    CASP3P425743, ENSP000003110324I2D: score=2 STRING: ENSP00000311032
    PIP5KL1Q5T9C93, ENSP000003733994I2D: score=2 STRING: ENSP00000373399
    PLD2O149393, ENSP000002630884I2D: score=2 STRING: ENSP00000263088
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006650glycerophospholipid metabolic process TAS8955136
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0006909phagocytosis TAS19889969
    GO:0007165signal transduction TAS8955136

    PIP5K1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIP5K1A (PI51A)

    3 Novoseek inferred chemical compound relationships for PIP5K1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol phosphate 86.6 1 11042212 (1)
    pip2 72.2 3 11042212 (2), 12913109 (1)
    lipid 28.3 2 17623810 (2)



    PIP5K1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PIP5K1A gene (4 alternative transcripts): 
    NM_001135636.1  NM_001135637.1  NM_001135638.1  NM_003557.2  

    Unigene Clusters for PIP5K1A:

    Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
    Hs.655131  [show with all ESTs], Hs.661888  [show with all ESTs]
    Unigene Representative Sequences: NM_001135638, AF085856
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447555 ENST00000349792(uc001exj.3 uc001exi.3 uc010pcu.2 uc001exk.3)
    ENST00000409426(uc021oyo.1) ENST00000441902 ENST00000368890(uc010pcv.2)
    ENST00000424999 ENST00000368888 ENST00000454769 ENST00000418435 ENST00000468772
    ENST00000461816 ENST00000481713 ENST00000486048 ENST00000464105 ENST00000460157
    ENST00000486866 ENST00000489625 ENST00000414290
    miRNA
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    Block miRNA regulation of human, mouse, rat PIP5K1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIP5K1A (see all 45):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-3938 hsa-miR-642a hsa-miR-607 hsa-miR-3664-5p hsa-miR-1224-3p hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidPIP5K1A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for PIP5K1A
    Predesigned siRNA for gene silencing in human, mouse, rat PIP5K1A
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    GenScript: all cDNA clones in your preferred vector (see all 4): PIP5K1A (NM_003557)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP5K1A
    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat PIP5K1A

    Additional mRNA sequence: AF085856.1 

    22 DOTS entries:

    DT.452324  DT.100787647  DT.92442101  DT.92068195  DT.95298809  DT.121363780  DT.86854573  DT.95298812 
    DT.91963498  DT.95298781  DT.100802965  DT.121363793  DT.75169856  DT.91639857  DT.91795726  DT.100787650 
    DT.100787652  DT.121351949  DT.121363785  DT.121363830  DT.91651375  DT.95081455 

    Selected AceView cDNA sequences (see all 234):

    BE222047 CR596609 AW771750 CA419881 AI299653 BQ894466 AA045059 AI041040 
    U78575 BX952930 BU619104 BM455340 AI619495 NM_003557 U78576 AI954280 
    AW026190 AW241418 AW439342 CA396771 U78578 BM562816 BP357708 AI654610 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIP5K1A (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                                -                 -                           
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                -                                             
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for PIP5K1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PIP5K1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTTACAA
    PIP5K1A Expression
    About this image


    PIP5K1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
     
     Placenta (Extraembryonic Tissues)
    PIP5K1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIP5K1A Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.655131 Hs.661888

    UniProtKB/Swiss-Prot: PI51A_HUMAN, Q99755
    Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower
    levels in brain, lung and liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for PIP5K1A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pip5k1a1 , 5 phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha less1, 5 87.3(n)1
    91.13(a)1
      3 (40.74 cM)5
    187201  NM_008847.21  NP_032873.21 
     950585305 
    chicken
    (Gallus gallus)
    Aves LOC1008578461 phosphatidylinositol-4-phosphate 5-kinase type-1 alpha-like less 74.65(n)
    85(a)
      100857846  XM_004948356.1  XP_004948413.1 
    lizard
    (Anolis carolinensis)
    Reptilia PIP5K1A6
    phosphatidylinositol-4-phosphate 5-kinase, type I,...
    79(a)
    1 ↔ 1
    GL343668.1(31042-83106)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY062923.12   -- 78.43(n)    AY062923.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pip5k1ab1 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b less 67.37(n)
    76.21(a)
      492549  NM_001089353.1  NP_001082822.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sktl3
    PIP5K59B1
    peripheral nervous system development
    1-phosphatidylinositol-4-phosphate
    5-kinase less3
    PIP5K59B1
    53(a)3
    62.33(n)1
    67.5(a)1
      2 57B33
    376331  NM_137885.31  NP_611729.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ppk-11 , 3 ppk-11 57(a)3
    56.69(n)1
    61.13(a)1
      I(5358529-5364151)3
    1721841  NM_059175.41  NP_491576.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSS46
    Phosphatidylinositol-4-phosphate 5-kinase, involve...
    22(a)
    1 → many
    IV(868224-870563) YDR208W


    ENSEMBL Gene Tree for PIP5K1A (if available)
    TreeFam Gene Tree for PIP5K1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIP5K1A gene
    PIP4K2A2  PIP5K1B2  PIP4K2B2  PIP4K2C2  PIP5K1C2  PIP5KL12  
    7 SIMAP similar genes for PIP5K1A using alignment to 7 protein entries:     PI51A_HUMAN (see all proteins):
    PIPSL    PIP5K1B    PIP5K1C    STM7    PIP4K2A    PIP4K2B
    PIP4K2C

    PIP5K1A for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for PIP5K1A
    PGOHUM00000251253 PGOHUM00000243483 PGOHUM00000233661


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PIP5K1A (see all 1046)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1931456771,2
    C--122547261(+) GCCTCC/TGGCGT 4 -- us2k10--------
    rs42915011,2
    C,F,A,H--122547264(+) tccggG/Cgtagc 4 -- us2k111Minor allele frequency- C:0.36NA WA CSA EA 375
    rs1842901381,2
    --122547494(+) GGCTGA/GAGTGC 4 -- us2k10--------
    rs1890565371,2
    C--122547593(+) GCACCC/TGCCAC 4 -- us2k10--------
    rs1157883771,2
    F--122547665(+) TGTCTC/TGTACT 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1915733981,2
    --122547738(+) ACGGCG/TCCCGG 4 -- us2k10--------
    rs2014170061,2
    C--122547851(+) ACCTG-/TTTTTT 4 -- us2k10--------
    rs115843881,2
    C,F,A,H--122547860(+) tttttG/Ttttgt 4 -- us2k1 tfbs34Minor allele frequency- T:0.22NA WA 130
    rs1840550081,2
    --122547894(+) GTTTCA/GCTCTG 4 -- us2k10--------
    rs1879946621,2
    --122547898(+) CGCTCC/TGTCGT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIP5K1A (151170425 - 151222012 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PIP5K1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717840CNV Deletion23290073
    dgv2n68CNV Loss17160897
    nsv522840CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIP5K1A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603275    OMIM disorders: --

    5 diseases for PIP5K1A:    
    About MalaCards
    prostate cancer    hiv-1    prostatitis    cerebritis
    breast cancer


    PIP5K1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): PIP5K1A

    Export disorders for PIP5K1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIP5K1A gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with PIP5K1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family. (PubMed id 8955136)1, 2, 3, 9 Loijens J.C. and Anderson R.A. (J. Biol. Chem. 1996)
    2. Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--&gt; q24 by in situ hybridization. (PubMed id 10828584)1, 3, 9 Xie Y....Zhao G. (Cytogenet. Cell Genet. 2000)
    3. Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activation. (PubMed id 20660631)1, 2 Chao W.-T.... Kunz J. (J. Cell Biol. 2010)
    4. Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation. (PubMed id 19158393)1, 2 Xie Z.... Bikle D.D. (Mol. Biol. Cell 2009)
    5. A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. (PubMed id 18288197)1, 2 Mellman D.L.... Anderson R.A. (Nature 2008)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases. (PubMed id 11042212)1, 9 Mejillano M....Yin H.L. (J. Biol. Chem. 2001)
    9. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    10. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. (PubMed id 23382074)1 Armour S.M....Sinclair D.A. (Mol. Cell. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8394 HGNC: 8994 AceView: PIP5K1A Ensembl:ENSG00000143398 euGenes: HUgn8394
    ECgene: PIP5K1A Kegg: 8394 H-InvDB: PIP5K1A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PIP5K1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PIP5K1A gene:
    Search GeneIP for patents involving PIP5K1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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