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Aliases for PIP4P2 Gene

Aliases for PIP4P2 Gene

  • Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2 2 3
  • Transmembrane Protein 55A 2 3 4 5
  • TMEM55A 3 4 5
  • Type II PtdIns-4,5-P(2) 4-Phosphatase 2 3
  • Type 2 PtdIns-4,5-P2 4-Ptase 3 4
  • PtdIns-4,5-P2 4-Ptase II 3 4
  • EC 3.1.3.78 4 58
  • Type II Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2
  • Type II Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3
  • Type 2 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3
  • PtdIns-4,5-P(2) 4-Phosphatase Type II 3

External Ids for PIP4P2 Gene

Previous HGNC Symbols for PIP4P2 Gene

  • TMEM55A

Summaries for PIP4P2 Gene

Entrez Gene Summary for PIP4P2 Gene

  • TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PIP4P2 Gene

PIP4P2 (Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2) is a Protein Coding gene. Among its related pathways are Inositol phosphate metabolism (KEGG). An important paralog of this gene is PIP4P1.

UniProtKB/Swiss-Prot for PIP4P2 Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Additional gene information for PIP4P2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4P2 Gene

Genomics for PIP4P2 Gene

Regulatory Elements for PIP4P2 Gene

Enhancers for PIP4P2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H091033 0.3 FANTOM5 4.6 +7.4 7374 0 PIP4P2 ENSG00000253358
GH08H091039 1.1 ENCODE 0.7 +0.9 920 4 ARID4B SIN3A ZNF2 ETS1 GLIS2 GATA2 SP3 SP5 NCOA1 SMARCB1 OTUD6B-AS1 SLC26A7 LRRC69 LOC105375634 PIP4P2 ENSG00000253358
GH08H091032 0.9 Ensembl ENCODE 0.4 +8.7 8664 0 HLF CEBPB CEBPG DPF2 NFIL3 IKZF1 CEBPA HNF4A MLLT1 RUNX3 OTUD6B-AS1 PIP4P2 ENSG00000253358
GH08H091037 0.4 ENCODE 0.7 +3.5 3507 0 CEBPB CEBPG SLC26A7 PIP4P2 ENSG00000253358
GH08H091036 0.4 ENCODE 0.7 +4.4 4436 0 ZNF558 OTUD6B-AS1 PIP4P2 ENSG00000253358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIP4P2 on UCSC Golden Path with GeneCards custom track

Promoters for PIP4P2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000226887 664 2001 ARNT ARID4B SIN3A ZNF2 ETS1 TCF12 GLIS2 GATA2 RUNX3 SP3

Genomic Location for PIP4P2 Gene

Chromosome:
8
Start:
90,993,796 bp from pter
End:
91,041,064 bp from pter
Size:
47,269 bases
Orientation:
Minus strand

Genomic View for PIP4P2 Gene

Genes around PIP4P2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP4P2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP4P2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4P2 Gene

Proteins for PIP4P2 Gene

  • Protein details for PIP4P2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4L2-TM55A_HUMAN
    Recommended name:
    Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q8N4L2
    Secondary Accessions:
    • B2R9H4
    • Q68CU2

    Protein attributes for PIP4P2 Gene

    Size:
    257 amino acids
    Molecular mass:
    28081 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PIP4P2 Gene

Selected DME Specific Peptides for PIP4P2 Gene

Q8N4L2:
  • VCNEATPIK
  • GKKYVRCPCNCLLICK
  • RIINLGP
  • SSVGSALPRRRCC
  • RACYWGAI
  • HQHVVKC
  • ERSPLLS

Post-translational modifications for PIP4P2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP4P2 Gene

Domains & Families for PIP4P2 Gene

Gene Families for PIP4P2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PIP4P2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIP4P2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIP4P2: view

No data available for UniProtKB/Swiss-Prot for PIP4P2 Gene

Function for PIP4P2 Gene

Molecular function for PIP4P2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for PIP4P2 Gene

Gene Ontology (GO) - Molecular Function for PIP4P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IDA,IEA 16365287
genes like me logo Genes that share ontologies with PIP4P2: view

Phenotypes for PIP4P2 Gene

genes like me logo Genes that share phenotypes with PIP4P2: view

Animal Model Products

CRISPR Products

miRNA for PIP4P2 Gene

miRTarBase miRNAs that target PIP4P2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIP4P2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4P2 Gene

Localization for PIP4P2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4P2 Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIP4P2 gene
Compartment Confidence
lysosome 5
endosome 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PIP4P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 16365287
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031902 late endosome membrane IDA 16365287
genes like me logo Genes that share ontologies with PIP4P2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIP4P2 Gene

Pathways & Interactions for PIP4P2 Gene

genes like me logo Genes that share pathways with PIP4P2: view

Pathways by source for PIP4P2 Gene

Gene Ontology (GO) - Biological Process for PIP4P2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046856 phosphatidylinositol dephosphorylation IDA,IEA 16365287
genes like me logo Genes that share ontologies with PIP4P2: view

No data available for SIGNOR curated interactions for PIP4P2 Gene

Drugs & Compounds for PIP4P2 Gene

(2) Drugs for PIP4P2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(379) Additional Compounds for PIP4P2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with PIP4P2: view

Transcripts for PIP4P2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PIP4P2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4P2 Gene

No ASD Table

Relevant External Links for PIP4P2 Gene

GeneLoc Exon Structure for
PIP4P2
ECgene alternative splicing isoforms for
PIP4P2

Expression for PIP4P2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIP4P2 Gene:

PIP4P2

mRNA Expression by UniProt/SwissProt for PIP4P2 Gene:

Q8N4L2-TM55A_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PIP4P2 Gene

  • Nervous system(4.6)
  • Kidney(4.2)
  • Liver(4.1)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP4P2 Gene

Orthologs for PIP4P2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4P2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM55A 33 34
  • 99.74 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM55A 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM55A 33 34
  • 91.96 (n)
cow
(Bos Taurus)
Mammalia TMEM55A 33 34
  • 91.44 (n)
mouse
(Mus musculus)
Mammalia Tmem55a 33 16 34
  • 90.53 (n)
rat
(Rattus norvegicus)
Mammalia Tmem55a 33
  • 89.49 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55A 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM55A 34 33
  • 85.99 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM55A 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem55a 33
  • 79.95 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem55a 33 34
  • 75.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6707 34
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 34
  • 36 (a)
OneToMany
Species where no ortholog for PIP4P2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP4P2 Gene

ENSEMBL:
Gene Tree for PIP4P2 (if available)
TreeFam:
Gene Tree for PIP4P2 (if available)

Paralogs for PIP4P2 Gene

Paralogs for PIP4P2 Gene

genes like me logo Genes that share paralogs with PIP4P2: view

Variants for PIP4P2 Gene

Sequence variations from dbSNP and Humsavar for PIP4P2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000015540 -- 91,004,680(+) ATGAA(A/G)GTATA intron-variant
rs1000073242 -- 91,020,244(+) TGCCT(G/T)TTGGG reference, missense
rs1000139021 -- 91,010,635(+) CATCT(A/G)TTATT intron-variant
rs1000152019 -- 90,995,442(+) TAAGA(G/T)ATGTA utr-variant-3-prime
rs1000170808 -- 91,011,081(+) ACAAT(A/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIP4P2 Gene

Variant ID Type Subtype PubMed ID
esv2443764 CNV deletion 19546169
esv2759629 CNV loss 17122850
esv3618011 CNV loss 21293372
nsv1028201 CNV loss 25217958
nsv475564 CNV novel sequence insertion 20440878
nsv6300 CNV insertion 18451855
nsv831390 CNV gain 17160897

Variation tolerance for PIP4P2 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIP4P2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIP4P2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP4P2 Gene

Disorders for PIP4P2 Gene

Relevant External Links for PIP4P2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP4P2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP4P2

No disorders were found for PIP4P2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP4P2 Gene

Publications for PIP4P2 Gene

  1. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A … Majerus PW (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60

Products for PIP4P2 Gene

Sources for PIP4P2 Gene

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