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Aliases for PIP4P1 Gene

Aliases for PIP4P1 Gene

  • Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1 2 3
  • Transmembrane Protein 55B 2 3 4 5
  • TMEM55B 3 4 5
  • Type I Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2 3
  • Type I PtdIns-4,5-P(2) 4-Phosphatase 2 3
  • Type 1 PtdIns-4,5-P2 4-Ptase 3 4
  • PtdIns-4,5-P2 4-Ptase I 3 4
  • EC 3.1.3.78 4 58
  • C14orf9 3 4
  • Type 1 Phosphatidylinositol 4,5-Bisphosphate 4-Phosphatase 3
  • PtdIns-4,5-P(2) 4-Phosphatase Type I 3
  • Chromosome 14 Open Reading Frame 9 2

External Ids for PIP4P1 Gene

Previous HGNC Symbols for PIP4P1 Gene

  • C14orf9
  • TMEM55B

Summaries for PIP4P1 Gene

Entrez Gene Summary for PIP4P1 Gene

  • TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

GeneCards Summary for PIP4P1 Gene

PIP4P1 (Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Inositol phosphate metabolism (KEGG). An important paralog of this gene is PIP4P2.

UniProtKB/Swiss-Prot for PIP4P1 Gene

  • Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Additional gene information for PIP4P1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4P1 Gene

Genomics for PIP4P1 Gene

Regulatory Elements for PIP4P1 Gene

Enhancers for PIP4P1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H020679 1.9 FANTOM5 ENCODE dbSUPER 20.8 -222.9 -222921 9.8 MLX ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A SSRP1 ZNF610 METTL3 ENSG00000258515 SUPT16H CHD8 PARP2 TTC5 PIP4P1 METTL17 RNASE4 ENSG00000258768
GH14H020612 1.4 Ensembl ENCODE 19.9 -152.1 -152095 3.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B METTL3 SUPT16H ENSG00000258515 CHD8 METTL17 PARP2 ENSG00000258768 OSGEP TTC5 PIP4P1
GH14H020622 1.3 Ensembl ENCODE 19.8 -163.1 -163137 3.9 HNRNPUL1 SIN3A FEZF1 ZNF2 ZNF143 FOS ZC3H11A ZNF592 SSRP1 ZNF610 METTL3 SUPT16H CHD8 PARP2 METTL17 ENSG00000258515 TEP1 ENSG00000258768 OSGEP TOX4
GH14H020657 1.3 Ensembl ENCODE 19.8 -196.1 -196116 1.1 HDGF PKNOX1 SIN3A GLI4 ZNF2 GTF3C2 GLIS2 FOS KLF7 ZNF548 METTL3 SUPT16H METTL17 ENSG00000258515 CHD8 TEP1 ENSG00000258768 TTC5 PARP2 PIP4P1
GH14H020662 1.3 Ensembl ENCODE 19.8 -202.1 -202089 1.8 ARID4B SIN3A ZNF2 ZNF143 ZNF207 SP3 REST ZNF592 KAT8 SSRP1 SUPT16H PARP2 METTL3 CHD8 TTC5 ENSG00000258515 METTL17 PIP4P1 ENSG00000258768 ENSG00000260830
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PIP4P1 on UCSC Golden Path with GeneCards custom track

Promoters for PIP4P1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066363 112 1801 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1

Genomic Locations for PIP4P1 Gene

Genomic Locations for PIP4P1 Gene
chr14:20,457,719-20,461,612
(GRCh38/hg38)
Size:
3,894 bases
Orientation:
Minus strand
chr14:20,925,878-20,929,771
(GRCh37/hg19)

Genomic View for PIP4P1 Gene

Genes around PIP4P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP4P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP4P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4P1 Gene

Proteins for PIP4P1 Gene

  • Protein details for PIP4P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T03-TM55B_HUMAN
    Recommended name:
    Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Protein Accession:
    Q86T03
    Secondary Accessions:
    • B2RA35
    • Q86U09
    • Q8WUC0
    • Q9BU67
    • Q9NSU8

    Protein attributes for PIP4P1 Gene

    Size:
    277 amino acids
    Molecular mass:
    29470 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB70896.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD62347.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PIP4P1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP4P1 Gene

Selected DME Specific Peptides for PIP4P1 Gene

Q86T03:
  • GEDPPPYSPLTSP
  • DRTLARCPHCRKVSSIG
  • VCNEATPIK
  • GKKYVRCPCNCLLICK
  • GVRVICGHCKN
  • RIINLGP
  • GPLSPEPQP
  • HQHVVKC
  • ERSPLLS

Post-translational modifications for PIP4P1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP4P1 Gene

Domains & Families for PIP4P1 Gene

Gene Families for PIP4P1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PIP4P1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIP4P1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PIP4P1: view

No data available for UniProtKB/Swiss-Prot for PIP4P1 Gene

Function for PIP4P1 Gene

Molecular function for PIP4P1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.

Enzyme Numbers (IUBMB) for PIP4P1 Gene

Phenotypes From GWAS Catalog for PIP4P1 Gene

Gene Ontology (GO) - Molecular Function for PIP4P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA,TAS --
genes like me logo Genes that share ontologies with PIP4P1: view

Phenotypes for PIP4P1 Gene

genes like me logo Genes that share phenotypes with PIP4P1: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4P1 Gene

Localization for PIP4P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4P1 Gene

Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PIP4P1 gene
Compartment Confidence
lysosome 5
endosome 5
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PIP4P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IDA 16365287
GO:0005768 endosome IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PIP4P1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PIP4P1 Gene

Pathways & Interactions for PIP4P1 Gene

genes like me logo Genes that share pathways with PIP4P1: view

Gene Ontology (GO) - Biological Process for PIP4P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0046856 phosphatidylinositol dephosphorylation IDA,IEA 16365287
genes like me logo Genes that share ontologies with PIP4P1: view

No data available for SIGNOR curated interactions for PIP4P1 Gene

Drugs & Compounds for PIP4P1 Gene

(2) Drugs for PIP4P1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(379) Additional Compounds for PIP4P1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol-3,4,5-trisphosphate
  • 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate)
  • 1-Phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
  • Phosphatidylinositol-3,4,5-trisphosphate
PI(16:0/16:0)
  • 1,2-Dihexadecanoyl-rac-glycero-3-phospho-(1'-myo-inositol)
  • 1,2-Dipalmitoyl-rac-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:0)
  • Phosphatidylinositol(32:0)
  • PI(16:0/16:0)
PI(16:0/16:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-palmitoleoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/16:1)
  • Phosphatidylinositol(16:0/16:1n7)
  • Phosphatidylinositol(16:0/16:1w7)
PI(16:0/16:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Hexadecanoyl-2-(9Z,12Z-hexadecadienoic acid
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate
  • 1-Palmitoyl-2-(9Z,12Z-hexadecadienoate)-sn-glycero-3-phosphoinositol
PI(16:0/18:0)
  • 1-Hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-myo-inositol)
  • 1-Palmitoyl-2-stearoyl-sn-glycero-3-phosphoinositol
  • Phosphatidylinositol(16:0/18:0)
  • Phosphatidylinositol(34:0)
  • PI(16:0/18:0)
genes like me logo Genes that share compounds with PIP4P1: view

Transcripts for PIP4P1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4P1 Gene

No ASD Table

Relevant External Links for PIP4P1 Gene

GeneLoc Exon Structure for
PIP4P1
ECgene alternative splicing isoforms for
PIP4P1

Expression for PIP4P1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PIP4P1 Gene:

PIP4P1

mRNA Expression by UniProt/SwissProt for PIP4P1 Gene:

Q86T03-TM55B_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for PIP4P1 Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Blood(4.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PIP4P1 Gene

Orthologs for PIP4P1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4P1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM55B 34 33
  • 99.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM55B 34 33
  • 93.98 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM55B 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem55b 33
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Tmem55b 34 16 33
  • 89.44 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM55B 34 33
  • 86.15 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM55B 34
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM55B 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem55b 33
  • 67.51 (n)
Str.11869 33
zebrafish
(Danio rerio)
Actinopterygii TMEM55B (2 of 2) 34
  • 73 (a)
OneToMany
TMEM55B (1 of 2) 34
  • 70 (a)
OneToMany
zgc:123304 33
  • 65.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006243 33
  • 56.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6707 33 34
  • 53.33 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.2 33 34
  • 50.85 (n)
Species where no ortholog for PIP4P1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP4P1 Gene

ENSEMBL:
Gene Tree for PIP4P1 (if available)
TreeFam:
Gene Tree for PIP4P1 (if available)

Paralogs for PIP4P1 Gene

Paralogs for PIP4P1 Gene

Pseudogenes.org Pseudogenes for PIP4P1 Gene

genes like me logo Genes that share paralogs with PIP4P1: view

Variants for PIP4P1 Gene

Sequence variations from dbSNP and Humsavar for PIP4P1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000042220 -- 20,459,401(+) GCAGT(A/G)AGGAC reference, missense
rs1000166545 -- 20,463,520(+) CACTT(C/G)TAGCT upstream-variant-2KB
rs1000440103 -- 20,462,969(+) CTAAG(A/G)AAGCT upstream-variant-2KB
rs1000544014 -- 20,459,530(+) CATAG(A/C/G)ACAGA intron-variant
rs1000930278 -- 20,458,274(+) AAGGA(C/G)AAGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PIP4P1 Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV gain+loss 19812545

Variation tolerance for PIP4P1 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIP4P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIP4P1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP4P1 Gene

Disorders for PIP4P1 Gene

Relevant External Links for PIP4P1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP4P1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP4P1

No disorders were found for PIP4P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP4P1 Gene

Publications for PIP4P1 Gene

  1. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. (PMID: 16365287) Ungewickell A … Majerus PW (Proceedings of the National Academy of Sciences of the United States of America 2005) 2 3 4 60
  2. Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosis. (PMID: 17940011) Zou J … Majerus PW (Proceedings of the National Academy of Sciences of the United States of America 2007) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for PIP4P1 Gene

Sources for PIP4P1 Gene

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