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Aliases for PIP4K2C Gene

Aliases for PIP4K2C Gene

  • Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Gamma 2 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Gamma 2 3
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type II Gamma 3 4
  • PI(5)P 4-Kinase Type II Gamma 3 4
  • PIP4KII-Gamma 3 4
  • EC 4 63
  • PIP5K2C 3 4
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma 3
  • Phosphatidylinositol-5-Phosphate 4-Kinase Type-2 Gamma 3
  • Phosphatidylinositol 4-Phosphate 5-Kinase 3
  • EC 2.7.1 63

External Ids for PIP4K2C Gene

Previous HGNC Symbols for PIP4K2C Gene

  • PIP5K2C

Previous GeneCards Identifiers for PIP4K2C Gene

  • GC12P056272
  • GC12P057985
  • GC12P055022

Summaries for PIP4K2C Gene

GeneCards Summary for PIP4K2C Gene

PIP4K2C (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Gamma) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include identical protein binding and 1-phosphatidylinositol-5-phosphate 4-kinase activity. An important paralog of this gene is PIP5KL1.

UniProtKB/Swiss-Prot for PIP4K2C Gene

  • May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4K2C Gene

Genomics for PIP4K2C Gene

Regulatory Elements for PIP4K2C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIP4K2C Gene

57,591,159 bp from pter
57,603,428 bp from pter
12,270 bases
Plus strand

Genomic View for PIP4K2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIP4K2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4K2C Gene

Proteins for PIP4K2C Gene

  • Protein details for PIP4K2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
    Protein Accession:
    Secondary Accessions:
    • B2RDL3
    • B4DM11
    • B4DY44
    • Q9H6N2

    Protein attributes for PIP4K2C Gene

    421 amino acids
    Molecular mass:
    47300 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB15223.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIP4K2C Gene

    Alternative splice isoforms for PIP4K2C Gene


neXtProt entry for PIP4K2C Gene

Proteomics data for PIP4K2C Gene at MOPED

Post-translational modifications for PIP4K2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for PIP4K2C Gene

Gene Families for PIP4K2C Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PIPK domain.
  • Contains 1 PIPK domain.
genes like me logo Genes that share domains with PIP4K2C: view

Function for PIP4K2C Gene

Molecular function for PIP4K2C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
UniProtKB/Swiss-Prot Function:
May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for PIP4K2C Gene

Gene Ontology (GO) - Molecular Function for PIP4K2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity --
GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA --
GO:0042802 identical protein binding IPI 18255255
genes like me logo Genes that share ontologies with PIP4K2C: view

Phenotypes for PIP4K2C Gene

GenomeRNAi human phenotypes for PIP4K2C:
genes like me logo Genes that share phenotypes with PIP4K2C: view

Animal Model Products

miRNA for PIP4K2C Gene

miRTarBase miRNAs that target PIP4K2C

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP4K2C

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4K2C Gene

Localization for PIP4K2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2C Gene

Cytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PIP4K2C Gene COMPARTMENTS Subcellular localization image for PIP4K2C gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PIP4K2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with PIP4K2C: view

Pathways for PIP4K2C Gene

genes like me logo Genes that share pathways with PIP4K2C: view

Gene Ontology (GO) - Biological Process for PIP4K2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046488 phosphatidylinositol metabolic process --
GO:0046854 phosphatidylinositol phosphorylation IEA --
genes like me logo Genes that share ontologies with PIP4K2C: view

Drugs for PIP4K2C Gene

(3) HMDB Compounds for PIP4K2C Gene

Compound Synonyms Cas Number PubMed IDs
  • (3-Phosphatidyl)-1-D-inositol
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Adenosindiphosphorsaeure
genes like me logo Genes that share compounds with PIP4K2C: view

Transcripts for PIP4K2C Gene

Unigene Clusters for PIP4K2C Gene

Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP4K2C

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4K2C Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP2: -
SP4: -
SP5: - -
SP6: - -

Relevant External Links for PIP4K2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIP4K2C Gene

mRNA expression in normal human tissues for PIP4K2C Gene

Protein differential expression in normal tissues for PIP4K2C Gene

This gene is overexpressed in Cervix (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIP4K2C Gene

SOURCE GeneReport for Unigene cluster for PIP4K2C Gene Hs.745011

genes like me logo Genes that share expressions with PIP4K2C: view

Expression partners for PIP4K2C Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PIP4K2C Gene

Orthologs for PIP4K2C Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4K2C Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIP4K2C 35
  • 93.35 (n)
  • 96.44 (a)
PIP4K2C 36
  • 97 (a)
(Canis familiaris)
Mammalia PIP4K2C 35
  • 93.39 (n)
  • 97.25 (a)
PIP4K2C 36
  • 97 (a)
(Mus musculus)
Mammalia Pip4k2c 35
  • 90.42 (n)
  • 95.96 (a)
Pip4k2c 16
Pip4k2c 36
  • 96 (a)
(Pan troglodytes)
Mammalia PIP4K2C 35
  • 99.68 (n)
  • 99.52 (a)
PIP4K2C 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Pip4k2c 35
  • 90.89 (n)
  • 96.44 (a)
(Monodelphis domestica)
Mammalia PIP4K2C 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia PIP4K2C 36
  • 74 (a)
(Anolis carolinensis)
Reptilia PIP4K2C 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pip4k2c 35
  • 72.71 (n)
  • 78.5 (a)
Str.3445 35
(Danio rerio)
Actinopterygii LOC100535634 35
  • 69.98 (n)
  • 71.94 (a)
pip5k2 35
PIP4K2C (2 of 2) 36
  • 67 (a)
pip5k2 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17471 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea ppk-2 36
  • 46 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10982 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7002 36
  • 49 (a)
Species with no ortholog for PIP4K2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP4K2C Gene

Gene Tree for PIP4K2C (if available)
Gene Tree for PIP4K2C (if available)

Paralogs for PIP4K2C Gene

Paralogs for PIP4K2C Gene

(7) SIMAP similar genes for PIP4K2C Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PIP4K2C: view

Variants for PIP4K2C Gene

Sequence variations from dbSNP and Humsavar for PIP4K2C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs775235 -- 57,600,960(-) CCCAC(A/C/G)AGAGC synonymous-codon, reference
rs799830 -- 57,599,900(-) CGCCC(A/G)GCTAA intron-variant
rs812315 -- 57,599,707(-) AAACA(C/T)TTTGC intron-variant
rs812873 -- 57,601,306(-) TTCTT(A/G)GCATC synonymous-codon, reference
rs1078109 -- 57,592,583(+) ATGGG(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIP4K2C Gene

Variant ID Type Subtype PubMed ID
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914
nsv725 CNV Loss 18451855

Relevant External Links for PIP4K2C Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP4K2C Gene

Disorders for PIP4K2C Gene

Relevant External Links for PIP4K2C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for PIP4K2C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PIP4K2C Gene

Publications for PIP4K2C Gene

  1. A new pathway for synthesis of phosphatidylinositol-4,5- bisphosphate. (PMID: 9367159) Rameh L.E. … Cantley L.C. (Nature 1997) 2 3
  2. Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis. (PMID: 19644859) van der Linden M.P. … van der Helm-Van Mil A.H. (Arthritis Rheum. 2009) 3 48
  3. Genetic variants in the prediction of rheumatoid arthritis. (PMID: 20439292) van der Helm-van Mil A.H. … Huizinga T.W. (Ann. Rheum. Dis. 2010) 3 48
  4. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PMID: 18794853) Raychaudhuri S. … Plenge R.M. (Nat. Genet. 2008) 3 48
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3

Products for PIP4K2C Gene

Sources for PIP4K2C Gene

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