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PIP4K2C Gene

protein-coding   GIFtS: 53
GCID: GC12P057985

Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Gamma

(Previous names: phosphatidylinositol-4-phosphate 5-kinase, type II, gamma)
(Previous symbol: PIP5K2C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Gamma1 2     EC 2.7.1.1493 8
PIP5K2C1 2 3     Phosphatidylinositol 4-Phosphate 5-Kinase2
Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Gamma1 2     Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma2
Phosphatidylinositol 5-Phosphate 4-Kinase Type II Gamma2 3     Phosphatidylinositol-5-Phosphate 4-Kinase Type-2 Gamma2
PIP4KII-gamma2 3     EC 2.7.18
PI(5)P 4-Kinase Type II Gamma2 3     

External Ids:    HGNC: 237861   Entrez Gene: 798372   Ensembl: ENSG000001669087   UniProtKB: Q8TBX83   

Export aliases for PIP4K2C gene to outside databases

Previous GC identifers: GC12P056272 GC12P055022


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PIP4K2C Gene:
PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase, type II, gamma) is a protein-coding gene. GO annotations related to this gene include 1-phosphatidylinositol-5-phosphate 4-kinase activity and identical protein binding. An important paralog of this gene is PIP4K2A.

UniProtKB/Swiss-Prot: PI42C_HUMAN, Q8TBX8
Function: May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the
endoplasmic reticulum (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the PIP4K2C gene promoter:
         Egr-3   Sox5   Spz1   AML1a   MyoD   IRF-1   RORalpha1   ARP-1   ZID   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIP4K2C promoter sequence
   Search Chromatin IP Primers for PIP4K2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIP4K2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.2

PIP4K2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP4K2C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057985:  view genomic region     (about GC identifiers)

Start:
57,984,942 bp from pter      End:
57,997,211 bp from pter
Size:
12,270 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PI42C_HUMAN, Q8TBX8 (See protein sequence)
Recommended Name: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma  
Size: 421 amino acids; 47300 Da
Sequence caution: Sequence=BAB15223.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for PIP4K2C:
2GK9 (3D)    
Secondary accessions: B2RDL3 B4DM11 B4DY44 Q9H6N2
Alternative splicing: 3 isoforms:  Q8TBX8-1   Q8TBX8-2   Q8TBX8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PIP4K2C: NX_Q8TBX8

Explore proteomics data for PIP4K2C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for PIP4K2C (Q8TBX8) (see all 21)
     PLGPGEF  DYSLLLG  IMDYSLL  KRFLDFI 


    See PIP4K2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001139730.1  NP_001139731.1  NP_001139732.1  NP_079055.3  

    ENSEMBL proteins: 
     ENSP00000412035   ENSP00000439878   ENSP00000450197   ENSP00000447390   ENSP00000449335  
     ENSP00000448042   ENSP00000347032   ENSP00000449538  

    PIP4K2C Human Recombinant Protein Products:

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    Novus Biologicals PIP4K2C Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIP4K2C

     
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    antibodies-online proteins for PIP4K2C (10 products) 

     
    antibodies-online peptides for PIP4K2C

    PIP4K2C Antibody Products:

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    PIP4K2C Assay Products:

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    antibodies-online kits for PIP4K2C (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
    1-phosphatidylinositol-5-phosphate 4-kinase family

    5 InterPro protein domains:
     IPR027484 PInositol-4-P-5-kinase_N
     IPR002498 PInositol-4-P-5-kinase_core
     IPR027483 PInositol-4-P-5-kinase_C
     IPR016034 PInositol-4P-5-kinase_core_sub
     IPR023610 PInositol-4-P-5-kinase

    Graphical View of Domain Structure for InterPro Entry Q8TBX8

    ProtoNet protein and cluster: Q8TBX8

    1 Blocks protein domain: IPB002498 Phosphatidylinositol-4-phosphate 5-kinase

    UniProtKB/Swiss-Prot: PI42C_HUMAN, Q8TBX8
    Similarity: Contains 1 PIPK domain


    Find genes that share domains with PIP4K2C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PI42C_HUMAN, Q8TBX8
    Function: May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the
    endoplasmic reticulum (By similarity)
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    4,5-bisphosphate

         Enzyme Numbers (IUBMB): EC 2.7.1.1491 2 EC 2.7.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016307phosphatidylinositol phosphate kinase activity ----
    GO:00163091-phosphatidylinositol-5-phosphate 4-kinase activity IEA--
    GO:0042802identical protein binding IPI18255255
         
    Find genes that share ontologies with PIP4K2C           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PIP4K2C:
     Increased G2M DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIP4K2C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIP4K2C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIP4K2C

    miRNA
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    miRTarBase miRNAs that target PIP4K2C:
    hsa-mir-877-3p (MIRT036860), hsa-mir-193b-3p (MIRT016341), hsa-mir-125b-5p (MIRT045985)

    Block miRNA regulation of human, mouse, rat PIP4K2C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PIP4K2C (see all 71):
    hsa-miR-15a hsa-miR-1224-3p hsa-miR-106a hsa-miR-519a hsa-miR-1273d hsa-miR-1244 hsa-miR-637 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidPIP4K2C 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIP4K2C
    Predesigned siRNA for gene silencing in human, mouse, rat PIP4K2C

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): PIP4K2C (NM_001146259)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP4K2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP4K2C
    Addgene plasmids for PIP4K2C 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PIP4K2C 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP4K2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PI42C_HUMAN, Q8TBX8: Cytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane.
    However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm IEA--
    GO:0016020membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with PIP4K2C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIP4K2C About    
    See pathways by source

    SuperPathContained pathways About
    1Inositol phosphate metabolism (KEGG)
    Inositol phosphate metabolism0.61
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.36
    Phosphatidylinositol signaling system0.61
    D-myo-inositol-5-phosphate metabolism0.00
    superpathway of inositol phosphate compounds0.60
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3B Cell Receptor Signaling Pathway (WikiPathways)
    B Cell Receptor Signaling Pathway


    Find genes that share SuperPaths with PIP4K2C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIP4K2C (see all 7)
        Rac1 Pathway
    RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    Integrin Pathway
    Aldosterone Signaling in Epithelial Cells

    5 BioSystems Pathways for PIP4K2C
        Regulation of Actin Cytoskeleton
    B Cell Receptor Signaling Pathway
    D-myo-inositol-5-phosphate metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    superpathway of inositol phosphate compounds


    3 Kegg Pathways  (Kegg details for PIP4K2C):
        Inositol phosphate metabolism
    Phosphatidylinositol signaling system
    Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIP4K2C
    Interactions:

        Search GeneGlobe Interaction Network for PIP4K2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PIP4K2C (Q8TBX81, 3 ENSP000003470324) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    STK11Q158313I2D: score=1 
    PIP4K2CQ8TBX81EBI-1383637,EBI-1383637
    PIK3R1ENSP000002743354STRING: ENSP00000274335
    PIK3R2ENSP000002222544STRING: ENSP00000222254
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046488phosphatidylinositol metabolic process ----

    Find genes that share ontologies with PIP4K2C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIP4K2C (PI42C)

    3 HMDB Compounds for PIP4K2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PIP4K2C gene (4 alternative transcripts): 
    NM_001146258.1  NM_001146259.1  NM_001146260.1  NM_024779.4  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422156 ENST00000540759(uc001sou.3) ENST00000551772 ENST00000550465
    ENST00000550360 ENST00000550095 ENST00000354947(uc001sot.3 uc010srs.2 uc010srt.2)
    ENST00000548264
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate PIP4K2C (see all 71):
    hsa-miR-15a hsa-miR-1224-3p hsa-miR-106a hsa-miR-519a hsa-miR-1273d hsa-miR-1244 hsa-miR-637 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidPIP4K2C 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat PIP4K2C
      QuantiFast Probe-based Assays in human, mouse, rat PIP4K2C

    Selected AceView cDNA sequences (see all 94):

    AI872266 AA897785 CA416301 AL561242 BX098965 AW613378 AK125526 AL119465 
    AW629819 CR617906 AI701315 BG259815 AX754970 BQ720571 AW006936 BE867387 
    BI824026 AI823398 BM472229 AI280964 AU280027 BE892851 AK075553 BX952026 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PIP4K2C (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                -                       -                                                   
    SP2:                                                        -                                                   
    SP3:                                                                                                            
    SP4:                                                                                -                           
    SP5:                                                  -     -                                                   


    ECgene alternative splicing isoforms for PIP4K2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIP4K2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCCATAGG
    PIP4K2C Expression
    About this image

    PIP4K2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIP4K2C Protein Expression
        Custom PCR Arrays for PIP4K2C
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat PIP4K2C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP4K2C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for PIP4K2C gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pip4k2c1 , 5 phosphatidylinositol-5-phosphate 4-kinase, type II, more1, 5 90.42(n)1
    95.96(a)1
      10 (74.50 cM)5
    1171501  NM_054097.31  NP_473438.11 
     1271970675 
    lizard
    (Anolis carolinensis)
    Reptilia PIP4K2C6
    phosphatidylinositol-5-phosphate 4-kinase, type II...
    79(a)
    1 ↔ 1
    GL343212.1(296895-340327)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.34452 Transcribed sequence with weak similarity to protein more 75.92(n)    142026509 
    zebrafish
    (Danio rerio)
    Actinopterygii pip5k22 phosphatidylinositol-4-phosphate 5-kinase, type II 77.53(n)   373124  BC045883.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG174716
    --
    51(a)
    1 → many
    4(1213042-1217466)
    worm
    (Caenorhabditis elegans)
    Secernentea ppk-26
    Protein PPK-2 (ppk-2) mRNA, complete cds
    46(a)
    1 → many
    III(2102295-2107470) WBGene00004088


    ENSEMBL Gene Tree for PIP4K2C (if available)
    TreeFam Gene Tree for PIP4K2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PIP4K2C gene
    PIP4K2A2  PIP5K1B2  PIP4K2B2  PIP5K1C2  PIP5KL12  PIP5K1A2  
    7 SIMAP similar genes for PIP4K2C using alignment to 5 protein entries:     PI42C_HUMAN (see all proteins):
    PIP4K2B    PIP4K2A    PIPSL    STM7    PIP5K1B    PIP5K1A
    PIP5K1C

    Find genes that share paralogs with PIP4K2C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIP4K2C (see all 317)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464720631,2
    C--55020679(+) CGTCA-/AGCATT 4 -- us2k10--------
    rs1467637481,2
    C--55020702(+) ACTTAA/TAAGAA 4 -- us2k10--------
    rs107477811,2
    C,F,A,H--55020745(+) TACCGA/CTATCT 4 -- us2k16Minor allele frequency- C:0.31NA WA CSA 130
    rs1922354671,2
    --55020812(+) AGCGTG/TACCAC 4 -- us2k10--------
    rs1846214161,2
    --55020876(+) CCTAGA/TTAATA 4 -- us2k10--------
    rs1905645791,2
    --55020915(+) CAGAGC/TGTTCC 4 -- us2k10--------
    rs1403299341,2
    --55021016(+) AGCCCA/TCAAAT 4 -- us2k10--------
    rs1926769151,2
    --55021240(+) CTACTC/TTTTAT 4 -- us2k10--------
    rs47603041,2
    C,F,A--55021362(+) GGCCCT/CGCAAA 4 -- us2k19Minor allele frequency- C:0.49NA WA CSA EA 372
    rs1843804081,2
    --55021433(+) ACAGAC/GTCTTG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIP4K2C (57984942 - 57997211 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for PIP4K2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv725CNV Loss18451855
    nsv428283CNV Gain18775914
    dgv513e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with PIP4K2C           About GenesLikeMe

    Genetic Association Database (GAD): PIP4K2C
    Human Genome Epidemiology (HuGE) Navigator: PIP4K2C (4 documents)

    Export disorders for PIP4K2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIP4K2C gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with PIP4K2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in the prediction of rheumatoid arthritis. (PubMed id 20439292)1, 4 van der Helm-van Mil A.H....Huizinga T.W. (Ann. Rheum. Dis. 2010)
    2. Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis. (PubMed id 19644859)1, 4 van der Linden M.P....van der Helm-Van Mil A.H. (Arthritis Rheum. 2009)
    3. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PubMed id 18794853)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2008)
    4. A new pathway for synthesis of phosphatidylinositol-4,5- bisphosphate. (PubMed id 9367159)1, 3 Rameh L.E.... Cantley L.C. (Nature 1997)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79837 HGNC: 23786 AceView: PIP5K2C Ensembl:ENSG00000166908 euGenes: HUgn79837
    ECgene: PIP4K2C Kegg: 79837 H-InvDB: PIP4K2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIP4K2C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIP4K2C gene:
    Search GeneIP for patents involving PIP4K2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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