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Aliases for PIP4K2B Gene

Aliases for PIP4K2B Gene

  • Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta 2 3
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta 2 3
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type II Beta 3 4
  • 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta 3 4
  • PtdIns(5)P-4-Kinase Isoform 2-Beta 3 4
  • Diphosphoinositide Kinase 2-Beta 3 4
  • PI(5)P 4-Kinase Type II Beta 3 4
  • PIP4KII-Beta 3 4
  • EC 2.7.1.149 4 63
  • PIP5K2B 3 4
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Beta 3
  • Phosphatidylinositol-5-Phosphate 4-Kinase Type-2 Beta 3
  • 1-Phosphatidylinositol-5-Phosphate 4-Kinase 2-Beta 3
  • 1-Phosphatidylinositol-4-Phosphate Kinase 3
  • PTDINS(4)P-5-Kinase 3
  • PIP5KIIbeta 3
  • PIP5KIIB 3
  • PIP5P4KB 3
  • EC 2.7.1 63
  • PI5P4KB 3

External Ids for PIP4K2B Gene

Previous HGNC Symbols for PIP4K2B Gene

  • PIP5K2B

Previous GeneCards Identifiers for PIP4K2B Gene

  • GC17M034175
  • GC17M036921
  • GC17M032718

Summaries for PIP4K2B Gene

Entrez Gene Summary for PIP4K2B Gene

  • The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIP4K2B Gene

PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include receptor signaling protein activity and 1-phosphatidylinositol-5-phosphate 4-kinase activity.

UniProtKB/Swiss-Prot for PIP4K2B Gene

  • Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.

Gene Wiki entry for PIP4K2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4K2B Gene

Genomics for PIP4K2B Gene

Regulatory Elements for PIP4K2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIP4K2B Gene

Start:
38,765,689 bp from pter
End:
38,800,126 bp from pter
Size:
34,438 bases
Orientation:
Minus strand

Genomic View for PIP4K2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIP4K2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4K2B Gene

Proteins for PIP4K2B Gene

  • Protein details for PIP4K2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78356-PI42B_HUMAN
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
    Protein Accession:
    P78356
    Secondary Accessions:
    • Q5U0E8
    • Q8TBP2

    Protein attributes for PIP4K2B Gene

    Size:
    416 amino acids
    Molecular mass:
    47378 Da
    Quaternary structure:
    • Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex.

    Three dimensional structures from OCA and Proteopedia for PIP4K2B Gene

    Alternative splice isoforms for PIP4K2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP4K2B Gene

Proteomics data for PIP4K2B Gene at MOPED

Post-translational modifications for PIP4K2B Gene

  • Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP4K2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIP4K2B (PIP4K2B)

Domains for PIP4K2B Gene

Suggested Antigen Peptide Sequences for PIP4K2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78356

UniProtKB/Swiss-Prot:

PI42B_HUMAN :
  • P78356
Domain:
  • Contains 1 PIPK domain.
genes like me logo Genes that share domains with PIP4K2B: view

Function for PIP4K2B Gene

Molecular function for PIP4K2B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate {ECO:0000269 PubMed:20583997}; Vmax=0.2 pmol/min/ug enzyme {ECO:0000269 PubMed:20583997};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
UniProtKB/Swiss-Prot Function:
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.

Enzyme Numbers (IUBMB) for PIP4K2B Gene

Gene Ontology (GO) - Molecular Function for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 9038203
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity --
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA 9038203
genes like me logo Genes that share ontologies with PIP4K2B: view
genes like me logo Genes that share phenotypes with PIP4K2B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP4K2B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PIP4K2B Gene

Localization for PIP4K2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2B Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIP4K2B Gene COMPARTMENTS Subcellular localization image for PIP4K2B gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 5
cytosol 4
mitochondrion 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PIP4K2B: view

Pathways for PIP4K2B Gene

genes like me logo Genes that share pathways with PIP4K2B: view

Interacting Proteins for PIP4K2B Gene

Gene Ontology (GO) - Biological Process for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9038203
GO:0035556 intracellular signal transduction TAS 9038203
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PIP4K2B: view

Compounds for PIP4K2B Gene

(3) HMDB Compounds for PIP4K2B Gene

Compound Synonyms Cas Number PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with PIP4K2B: view

Transcripts for PIP4K2B Gene

Unigene Clusters for PIP4K2B Gene

Phosphatidylinositol-5-phosphate 4-kinase, type II, beta:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP4K2B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4K2B Gene

No ASD Table

Relevant External Links for PIP4K2B Gene

GeneLoc Exon Structure for
PIP4K2B
ECgene alternative splicing isoforms for
PIP4K2B

Expression for PIP4K2B Gene

mRNA expression in normal human tissues for PIP4K2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PIP4K2B Gene

This gene is overexpressed in Fetal Brain (15.9), Brain (9.4), and Frontal cortex (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PIP4K2B Gene

SOURCE GeneReport for Unigene cluster for PIP4K2B Gene Hs.260603

mRNA Expression by UniProt/SwissProt for PIP4K2B Gene

P78356-PI42B_HUMAN
Tissue specificity: Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
genes like me logo Genes that share expressions with PIP4K2B: view

Expression partners for PIP4K2B Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PIP4K2B Gene

Orthologs for PIP4K2B Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4K2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PIP4K2B 35
  • 94.31 (n)
  • 99.04 (a)
dog
(Canis familiaris)
Mammalia PIP4K2B 35
  • 93.59 (n)
  • 99.28 (a)
mouse
(Mus musculus)
Mammalia Pip4k2b 35
  • 91.75 (n)
  • 99.04 (a)
Pip4k2b 16
chimpanzee
(Pan troglodytes)
Mammalia PIP4K2B 35
  • 99.36 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Pip4k2b 35
  • 91.19 (n)
  • 98.32 (a)
chicken
(Gallus gallus)
Aves PIP4K2B 35
  • 85.4 (n)
  • 95.87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pip4k2a 35
  • 80.55 (n)
  • 91.53 (a)
Str.2617 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1824 35
zebrafish
(Danio rerio)
Actinopterygii pip4k2ab 35
  • 73.09 (n)
  • 73.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17471 35
  • 58.24 (n)
  • 59.57 (a)
worm
(Caenorhabditis elegans)
Secernentea ppk-2 35
  • 55.29 (n)
  • 54.5 (a)
Species with no ortholog for PIP4K2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP4K2B Gene

ENSEMBL:
Gene Tree for PIP4K2B (if available)
TreeFam:
Gene Tree for PIP4K2B (if available)

Paralogs for PIP4K2B Gene

Selected SIMAP similar genes for PIP4K2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIP4K2B: view

No data available for Paralogs for PIP4K2B Gene

Variants for PIP4K2B Gene

Sequence variations from dbSNP and Humsavar for PIP4K2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs25540 -- 38,771,437(-) TAGAG(-/CTTA)GAGAG intron-variant
rs115327 -- 38,797,748(+) AAGGA(C/T)TGACT intron-variant
rs228231 -- 38,799,501(+) ctccc(C/G)cggac utr-variant-5-prime, upstream-variant-2KB
rs228232 -- 38,798,792(+) GATGG(A/G)AGAAT intron-variant
rs228233 -- 38,796,155(+) acaaa(A/C)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIP4K2B Gene

Variant ID Type Subtype PubMed ID
nsv833438 CNV Loss 17160897
nsv833439 CNV Loss 17160897
esv2678000 CNV Deletion 23128226

Relevant External Links for PIP4K2B Gene

HapMap Linkage Disequilibrium report
PIP4K2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP4K2B Gene

Disorders for PIP4K2B Gene

Relevant External Links for PIP4K2B

Genetic Association Database (GAD)
PIP4K2B
Human Genome Epidemiology (HuGE) Navigator
PIP4K2B

No disorders were found for PIP4K2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PIP4K2B Gene

Publications for PIP4K2B Gene

  1. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5- kinase. (PMID: 9038203) Castellino A.M. … Chao M.V. (J. Biol. Chem. 1997) 2 3 4 23
  2. A new pathway for synthesis of phosphatidylinositol-4,5- bisphosphate. (PMID: 9367159) Rameh L.E. … Cantley L.C. (Nature 1997) 2 3
  3. Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. (PMID: 9753329) Rao V.D. … Hurley J.H. (Cell 1998) 3 4
  4. Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage. (PMID: 14691457) Luoh S.W. … Tripathi R. (Oncogene 2004) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PIP4K2B Gene

Sources for PIP4K2B Gene

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