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Aliases for PIP4K2B Gene

Aliases for PIP4K2B Gene

  • Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta 2 3
  • Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta 2 3 5
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta 2 3
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type II Beta 3 4
  • 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Beta 3 4
  • PtdIns(5)P-4-Kinase Isoform 2-Beta 3 4
  • Diphosphoinositide Kinase 2-Beta 3 4
  • PI(5)P 4-Kinase Type II Beta 3 4
  • PIP4KII-Beta 3 4
  • EC 4 63
  • PIP5K2B 3 4
  • Phosphatidylinositol-5-Phosphate 4-Kinase Type-2 Beta 3
  • 1-Phosphatidylinositol-5-Phosphate 4-Kinase 2-Beta 3
  • 1-Phosphatidylinositol-4-Phosphate Kinase 3
  • PTDINS(4)P-5-Kinase 3
  • PIP5KIIbeta 3
  • PIP5KIIB 3
  • PIP5P4KB 3
  • EC 2.7.1 63
  • PI5P4KB 3

External Ids for PIP4K2B Gene

Previous HGNC Symbols for PIP4K2B Gene

  • PIP5K2B

Previous GeneCards Identifiers for PIP4K2B Gene

  • GC17M034175
  • GC17M036921
  • GC17M032718

Summaries for PIP4K2B Gene

Entrez Gene Summary for PIP4K2B Gene

  • The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIP4K2B Gene

PIP4K2B (Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PI3K events in ERBB4 signaling. GO annotations related to this gene include receptor signaling protein activity and 1-phosphatidylinositol-4-phosphate 5-kinase activity. An important paralog of this gene is PIP5KL1.

UniProtKB/Swiss-Prot for PIP4K2B Gene

  • Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.

Gene Wiki entry for PIP4K2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4K2B Gene

Genomics for PIP4K2B Gene

Regulatory Elements for PIP4K2B Gene

Enhancers for PIP4K2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIP4K2B on UCSC Golden Path with GeneCards custom track

Promoters for PIP4K2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIP4K2B on UCSC Golden Path with GeneCards custom track

Genomic Location for PIP4K2B Gene

38,765,689 bp from pter
38,800,126 bp from pter
34,438 bases
Minus strand

Genomic View for PIP4K2B Gene

Genes around PIP4K2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP4K2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP4K2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4K2B Gene

Proteins for PIP4K2B Gene

  • Protein details for PIP4K2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
    Protein Accession:
    Secondary Accessions:
    • Q5U0E8
    • Q8TBP2

    Protein attributes for PIP4K2B Gene

    416 amino acids
    Molecular mass:
    47378 Da
    Quaternary structure:
    • Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex.

    Three dimensional structures from OCA and Proteopedia for PIP4K2B Gene

    Alternative splice isoforms for PIP4K2B Gene


neXtProt entry for PIP4K2B Gene

Proteomics data for PIP4K2B Gene at MOPED

Post-translational modifications for PIP4K2B Gene

  • Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP4K2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PIP4K2B Gene

Gene Families for PIP4K2B Gene

Suggested Antigen Peptide Sequences for PIP4K2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PIPK domain.
  • Contains 1 PIPK domain.
genes like me logo Genes that share domains with PIP4K2B: view

Function for PIP4K2B Gene

Molecular function for PIP4K2B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=30 uM for phosphatidylinositol-5- phosphate {ECO:0000269 PubMed:20583997}; Vmax=0.2 pmol/min/ug enzyme {ECO:0000269 PubMed:20583997};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function:
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate.

Enzyme Numbers (IUBMB) for PIP4K2B Gene

Gene Ontology (GO) - Molecular Function for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 9038203
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA 9038203
genes like me logo Genes that share ontologies with PIP4K2B: view
genes like me logo Genes that share phenotypes with PIP4K2B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIP4K2B

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIP4K2B Gene

Localization for PIP4K2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2B Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for PIP4K2B Gene COMPARTMENTS Subcellular localization image for PIP4K2B gene
Compartment Confidence
cytosol 5
nucleus 5
endoplasmic reticulum 3
mitochondrion 3
plasma membrane 3
vacuole 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for PIP4K2B Gene

Pathways & Interactions for PIP4K2B Gene

SuperPathways for PIP4K2B Gene

genes like me logo Genes that share pathways with PIP4K2B: view

Interacting Proteins for PIP4K2B Gene

SIGNOR curated interactions for PIP4K2B Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PIP4K2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9038203
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with PIP4K2B: view

Drugs & Compounds for PIP4K2B Gene

(1) Drugs for PIP4K2B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for PIP4K2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (3-Phosphatidyl)-1-D-inositol
  • 1,2-Diacyl-sn-glycero-3-phosphoinositol
  • 1-Phosphatidyl-1D-myo-inositol
  • 1-Phosphatidyl-myo-inositol
  • Phosphatidyl-1D-myo-inositol
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PIP4K2B: view

Transcripts for PIP4K2B Gene

Unigene Clusters for PIP4K2B Gene

Phosphatidylinositol-5-phosphate 4-kinase, type II, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4K2B Gene

No ASD Table

Relevant External Links for PIP4K2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIP4K2B Gene

mRNA expression in normal human tissues for PIP4K2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PIP4K2B Gene

This gene is overexpressed in Fetal Brain (15.9), Brain (9.4), and Frontal cortex (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for PIP4K2B Gene

SOURCE GeneReport for Unigene cluster for PIP4K2B Gene Hs.260603

mRNA Expression by UniProt/SwissProt for PIP4K2B Gene

Tissue specificity: Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver.
genes like me logo Genes that share expression patterns with PIP4K2B: view

Protein tissue co-expression partners for PIP4K2B Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for PIP4K2B Gene

Orthologs for PIP4K2B Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4K2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIP4K2B 35
  • 94.31 (n)
  • 99.04 (a)
(Canis familiaris)
Mammalia PIP4K2B 35
  • 93.59 (n)
  • 99.28 (a)
(Mus musculus)
Mammalia Pip4k2b 35
  • 91.75 (n)
  • 99.04 (a)
Pip4k2b 16
(Pan troglodytes)
Mammalia PIP4K2B 35
  • 99.36 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Pip4k2b 35
  • 91.19 (n)
  • 98.32 (a)
(Gallus gallus)
Aves PIP4K2B 35
  • 85.4 (n)
  • 95.87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia pip4k2a 35
  • 80.55 (n)
  • 91.53 (a)
Str.2617 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1824 35
(Danio rerio)
Actinopterygii pip4k2ab 35
  • 73.09 (n)
  • 73.66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17471 35
  • 58.24 (n)
  • 59.57 (a)
(Caenorhabditis elegans)
Secernentea ppk-2 35
  • 55.29 (n)
  • 54.5 (a)
Species with no ortholog for PIP4K2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP4K2B Gene

Gene Tree for PIP4K2B (if available)
Gene Tree for PIP4K2B (if available)

Paralogs for PIP4K2B Gene

Paralogs for PIP4K2B Gene

(6) SIMAP similar genes for PIP4K2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PIP4K2B: view

Variants for PIP4K2B Gene

Sequence variations from dbSNP and Humsavar for PIP4K2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs25540 -- 38,771,437(-) TAGAG(-/CT/CTTA)GAGAG intron-variant
rs115327 -- 38,797,748(+) AAGGA(C/T)TGACT intron-variant
rs228231 -- 38,799,501(+) ctccc(C/G)cggac upstream-variant-2KB, utr-variant-5-prime
rs228232 -- 38,798,792(+) GATGG(A/G)AGAAT intron-variant
rs228233 -- 38,796,155(+) acaaa(A/C)aaaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIP4K2B Gene

Variant ID Type Subtype PubMed ID
nsv833438 CNV Loss 17160897
nsv833439 CNV Loss 17160897
esv2678000 CNV Deletion 23128226

Variation tolerance for PIP4K2B Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PIP4K2B Gene

Disorders for PIP4K2B Gene

Relevant External Links for PIP4K2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PIP4K2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIP4K2B Gene

Publications for PIP4K2B Gene

  1. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5- kinase. (PMID: 9038203) Castellino A.M. … Chao M.V. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage. (PMID: 14691457) Luoh S.W. … Tripathi R. (Oncogene 2004) 2 3
  3. A new pathway for synthesis of phosphatidylinositol-4,5- bisphosphate. (PMID: 9367159) Rameh L.E. … Cantley L.C. (Nature 1997) 2 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. The function of phosphatidylinositol 5-phosphate 4-kinase I^ (PI5P4KI^) explored using a specific inhibitor that targets the PI5P-binding site. (PMID: 25495341) Clarke J.H. … Irvine R.F. (Biochem. J. 2015) 3

Products for PIP4K2B Gene

Sources for PIP4K2B Gene