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Aliases for PIP4K2A Gene

Aliases for PIP4K2A Gene

  • Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Alpha 2 3
  • PIP5K2A 3 4 6
  • Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Alpha 2 3
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type II Alpha 3 4
  • 1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Alpha 3 4
  • PtdIns(5)P-4-Kinase Isoform 2-Alpha 3 4
  • Diphosphoinositide Kinase 2-Alpha 3 4
  • PtdIns(4)P-5-Kinase C Isoform 3 4
  • PI(5)P 4-Kinase Type II Alpha 3 4
  • PtdIns(4)P-5-Kinase B Isoform 3 4
  • PIP4KII-Alpha 3 4
  • EC 2.7.1.149 4 63
  • PIP5KIII 3 4
  • PI5P4KA 3 6
  • Type II Phosphatidylinositol-4-Phosphate 5-Kinase 53 K Isoform 3
  • Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha 3
  • Phosphatidylinositol-5-Phosphate 4-Kinase Type-2 Alpha 3
  • 1-Phosphatidylinositol-5-Phosphate 4-Kinase 2-Alpha 3
  • 1-Phosphatidylinositol-4-Phosphate-5-Kinase 3
  • 1-Phosphatidylinositol-4-Phosphate Kinase 3
  • PIP5KII-Alpha 3
  • PIP5KIIalpha 3
  • PIP5KIIA 3
  • EC 2.7.1 63
  • PIP5K2 4
  • PIPK 3

External Ids for PIP4K2A Gene

Previous HGNC Symbols for PIP4K2A Gene

  • PIP5K2A

Previous GeneCards Identifiers for PIP4K2A Gene

  • GC10M022866
  • GC10M022823

Summaries for PIP4K2A Gene

Entrez Gene Summary for PIP4K2A Gene

  • Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

GeneCards Summary for PIP4K2A Gene

PIP4K2A (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Alpha) is a Protein Coding gene. Diseases associated with PIP4K2A include precursor b-cell acute lymphoblastic leukemia. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include 1-phosphatidylinositol-4-phosphate 5-kinase activity and 1-phosphatidylinositol-5-phosphate 4-kinase activity. An important paralog of this gene is PIP5KL1.

UniProtKB/Swiss-Prot for PIP4K2A Gene

  • Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

Gene Wiki entry for PIP4K2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP4K2A Gene

Genomics for PIP4K2A Gene

Regulatory Elements for PIP4K2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PIP4K2A Gene

Start:
22,534,837 bp from pter
End:
22,714,574 bp from pter
Size:
179,738 bases
Orientation:
Minus strand

Genomic View for PIP4K2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIP4K2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP4K2A Gene

Proteins for PIP4K2A Gene

  • Protein details for PIP4K2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48426-PI42A_HUMAN
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
    Protein Accession:
    P48426
    Secondary Accessions:
    • B0YJ66
    • B4DGX2
    • D3DRV1
    • P53807
    • Q5VUX3

    Protein attributes for PIP4K2A Gene

    Size:
    406 amino acids
    Molecular mass:
    46225 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with PIP4K2B. Interaction with PIP4K2B may regulate localization to the nucleus.

    Three dimensional structures from OCA and Proteopedia for PIP4K2A Gene

    Alternative splice isoforms for PIP4K2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIP4K2A Gene

Proteomics data for PIP4K2A Gene at MOPED

Post-translational modifications for PIP4K2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PIP4K2A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PIP4K2A (PIP4K2A)

Domains for PIP4K2A Gene

Graphical View of Domain Structure for InterPro Entry

P48426

UniProtKB/Swiss-Prot:

PI42A_HUMAN :
  • P48426
Domain:
  • Contains 1 PIPK domain.
genes like me logo Genes that share domains with PIP4K2A: view

No data available for Gene Families for PIP4K2A Gene

Function for PIP4K2A Gene

Molecular function for PIP4K2A Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=50 uM for phosphatidylinositol-5- phosphate {ECO:0000269 PubMed:20583997}; Vmax=466 pmol/min/ug enzyme {ECO:0000269 PubMed:20583997};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
UniProtKB/Swiss-Prot Function: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.

Enzyme Numbers (IUBMB) for PIP4K2A Gene

Gene Ontology (GO) - Molecular Function for PIP4K2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016307 phosphatidylinositol phosphate kinase activity --
GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity NAS 7639683
GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA --
genes like me logo Genes that share ontologies with PIP4K2A: view

Phenotypes for PIP4K2A Gene

GenomeRNAi human phenotypes for PIP4K2A:
genes like me logo Genes that share phenotypes with PIP4K2A: view

Animal Model Products

CRISPR Products

miRNA for PIP4K2A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP4K2A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PIP4K2A Gene

Localization for PIP4K2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP4K2A Gene

Cell membrane. Nucleus. Cytoplasm. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIP4K2A Gene COMPARTMENTS Subcellular localization image for PIP4K2A gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PIP4K2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with PIP4K2A: view

Pathways for PIP4K2A Gene

genes like me logo Genes that share pathways with PIP4K2A: view

Gene Ontology (GO) - Biological Process for PIP4K2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process TAS --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0035855 megakaryocyte development IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0046488 phosphatidylinositol metabolic process --
genes like me logo Genes that share ontologies with PIP4K2A: view

Compounds for PIP4K2A Gene

(3) HMDB Compounds for PIP4K2A Gene

Compound Synonyms Cas Number PubMed IDs
1-Phosphatidyl-D-myo-inositol
  • 1-Phosphatidyl-1D-myo-inositol
Not Available
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Novoseek inferred chemical compound relationships for PIP4K2A Gene

Compound -log(P) Hits PubMed IDs
phosphoinositide 72.1 2
lipid 10.4 1
genes like me logo Genes that share compounds with PIP4K2A: view

Transcripts for PIP4K2A Gene

Unigene Clusters for PIP4K2A Gene

Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP4K2A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP4K2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2: - - - - -
SP3:
SP4:

Relevant External Links for PIP4K2A Gene

GeneLoc Exon Structure for
PIP4K2A
ECgene alternative splicing isoforms for
PIP4K2A

Expression for PIP4K2A Gene

mRNA expression in normal human tissues for PIP4K2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIP4K2A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.6) and Brain - Substantia nigra (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIP4K2A Gene

SOURCE GeneReport for Unigene cluster for PIP4K2A Gene Hs.57079

mRNA Expression by UniProt/SwissProt for PIP4K2A Gene

P48426-PI42A_HUMAN
Tissue specificity: Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably skeletal muscle and small intestine.
genes like me logo Genes that share expressions with PIP4K2A: view

In Situ Assay Products

Orthologs for PIP4K2A Gene

This gene was present in the common ancestor of animals.

Orthologs for PIP4K2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIP4K2A 35
  • 99.9 (n)
  • 100 (a)
PIP4K2A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PIP4K2A 35
  • 92.59 (n)
  • 99.26 (a)
PIP4K2A 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
PIP4K2A 35
  • 91.79 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Pip4k2a 35
  • 89.47 (n)
  • 98.27 (a)
Pip4k2a 16
Pip4k2a 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIP4K2A 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PIP4K2A 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pip4k2a 35
  • 87.93 (n)
  • 97.54 (a)
chicken
(Gallus gallus)
Aves PIP4K2A 35
  • 84.53 (n)
  • 93.58 (a)
PIP4K2A 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PIP4K2A 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pip4k2b 35
  • 80.94 (n)
  • 93.2 (a)
zebrafish
(Danio rerio)
Actinopterygii pip4k2aa 35
  • 76.84 (n)
  • 87.59 (a)
pip4k2aa 36
  • 87 (a)
OneToMany
pip4k2ab 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17471 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ppk-2 36
  • 52 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7002 36
  • 55 (a)
OneToMany
Species with no ortholog for PIP4K2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIP4K2A Gene

ENSEMBL:
Gene Tree for PIP4K2A (if available)
TreeFam:
Gene Tree for PIP4K2A (if available)

Paralogs for PIP4K2A Gene

Paralogs for PIP4K2A Gene

Selected SIMAP similar genes for PIP4K2A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with PIP4K2A: view

Variants for PIP4K2A Gene

Sequence variations from dbSNP and Humsavar for PIP4K2A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1158 -- 22,536,359(-) GGAGC(C/T)TTCAT utr-variant-3-prime
rs1159 -- 22,536,424(-) TCTCT(A/C/G)TACAT utr-variant-3-prime
rs8341 -- 22,536,204(-) TTACC(A/G)AATGC utr-variant-3-prime
rs8412 -- 22,535,175(-) AGTAA(C/T)TGTTT utr-variant-3-prime
rs746203 -- 22,541,612(-) AAGGC(A/G)ATCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIP4K2A Gene

Variant ID Type Subtype PubMed ID
esv272641 CNV Insertion 20981092
esv2661976 CNV Deletion 23128226
nsv831809 CNV Gain 17160897
esv2733984 CNV Deletion 23290073
esv2659118 CNV Deletion 23128226

Relevant External Links for PIP4K2A Gene

HapMap Linkage Disequilibrium report
PIP4K2A
Human Gene Mutation Database (HGMD)
PIP4K2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP4K2A Gene

Disorders for PIP4K2A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for PIP4K2A Gene including...

Search for PIP4K2A Gene in MalaCards »

(1) University of Copenhagen DISEASES for PIP4K2A Gene

(2) Novoseek inferred disease relationships for PIP4K2A Gene

Disease -log(P) Hits PubMed IDs
bipolar disorder 64.9 4
schizophrenia 59.3 12

Relevant External Links for PIP4K2A

Genetic Association Database (GAD)
PIP4K2A
Human Genome Epidemiology (HuGE) Navigator
PIP4K2A
genes like me logo Genes that share disorders with PIP4K2A: view

No data available for UniProtKB/Swiss-Prot for PIP4K2A Gene

Publications for PIP4K2A Gene

  1. Association analysis of the PIP4K2A gene on chromosome 10p12 and schizophrenia in the Irish study of high density schizophrenia families (ISHDSF) and the Irish case-control study of schizophrenia (ICCSS). (PMID: 19475563) Thiselton D.L. … Riley B.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 48
  2. A new pathway for synthesis of phosphatidylinositol-4,5- bisphosphate. (PMID: 9367159) Rameh L.E. … Cantley L.C. (Nature 1997) 2 3 4
  3. The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases. (PMID: 7852364) Boronenkov I.V. … Anderson R.A. (J. Biol. Chem. 1995) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for PIP4K2A Gene

Sources for PIP4K2A Gene

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