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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIP4K2A Gene

protein-coding   GIFtS: 62
GCID: GC10M022823

phosphatidylinositol-5-phosphate 4-kinase, type II, alpha

(Previous names: phosphatidylinositol-4-phosphate 5-kinase, type II, alpha...)
(Previous symbol: PIP5K2A)
 Explore 6 diseases affiliated with
PIP4K2A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PIP4K2A    

Aliases
for PIP4K2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Alpha1 2     PtdIns(4)P-5-Kinase B Isoform2 3
PIP5K2A1 2 3 5     EC 2.7.1.1493 8
PIP5KIIA1 2     PI5P4KA2 5
PIP5KIIalpha1 2     1-Phosphatidylinositol-4-Phosphate Kinase2
Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Alpha1 2     1-Phosphatidylinositol-4-Phosphate-5-Kinase1
Diphosphoinositide Kinase 2-Alpha2 3     1-Phosphatidylinositol-5-Phosphate 4-Kinase 2-Alpha2
Phosphatidylinositol 5-Phosphate 4-Kinase Type II Alpha2 3     PIP5KII-Alpha1
PtdIns(4)P-5-Kinase C Isoform2 3     PIPK2
PtdIns(5)P-4-Kinase Isoform 2-Alpha2 3     Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Alpha2
1-Phosphatidylinositol 5-Phosphate 4-Kinase 2-Alpha2 3     Phosphatidylinositol-5-Phosphate 4-Kinase Type-2 Alpha2
PIP4KII-Alpha1     Type II Phosphatidylinositol-4-Phosphate 5-Kinase 53 K Isoform2
PIP5KIII2 3     PIP5K23
PI(5)P 4-Kinase Type II Alpha2 3     EC 2.7.18

External Ids:    HGNC: 89971   Entrez Gene: 53052   Ensembl: ENSG000001508677   OMIM: 6031405   UniProtKB: P484263   

Export aliases for PIP4K2A gene to outside databases

Previous GC identifers: GC10M022866 GC10M022484


Summaries
for PIP4K2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PIP4K2A:
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction
pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility.
The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of
phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form
phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases,
but the recombinant protein does exhibit kinase activity. This gene is a member of the
phosphatidylinositol-5-phosphate 4-kinase family. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: PI42A_HUMAN, P48426
Function: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the
myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating
the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through
ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May
negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in
thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size

Gene Wiki entry for PIP4K2A


Genomic Views
for PIP4K2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_008705.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIP4K2A gene promoter:
         COUP-TF1   oct-B3   oct-B2   COUP   HNF-4alpha2   HNF-4alpha1   PPAR-gamma1   POU2F1   COUP-TF   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIP4K2A promoter sequence
   Search SABiosciences Chromatin IP Primers for PIP4K2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIP4K2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12.2   Ensembl cytogenetic band:  10p12.2   HGNC cytogenetic band: 10p12.2

PIP4K2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP4K2A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M022823:  view genomic region     (about GC identifiers)

Start:
 22,823,766 bp from pter      End:
 23,003,503 bp from pter
Size:
 179,738 bases      Orientation:
 minus strand

Proteins
for PIP4K2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PI42A_HUMAN, P48426 (See protein sequence)
Recommended Name: Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha  
Size: 406 amino acids; 46225 Da
Subunit: Homodimer (By similarity). Interacts with PIP4K2B. Interaction with PIP4K2B may regulate localization to the
nucleus
Subcellular location: Cell membrane (By similarity). Nucleus. Cytoplasm. Note=May translocate from the cytosol to the
cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the
rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the
interaction with PIP4K2B
Caution: This protein was previously thought to be a phosphatidylinositol 4-phosphate 5-kinase
1 PDB 3D structure from and Proteopedia for PIP4K2A:
2YBX (3D)    
Secondary accessions: B0YJ66 D3DRV1 P53807 Q5VUX3

Explore the universe of human proteins at neXtProt for PIP4K2A: NX_P48426

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P48426

    • 4/18 DME Specific Peptides for PIP4K2A (P48426) (see all 18)
     KDNDFIN  DYSLLVG  KRFLDFI  NHLFNKEN 

    PIP4K2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005019.2  
    ENSEMBL proteins: 
     ENSP00000365757   ENSP00000388889   ENSP00000400230   ENSP00000442098   ENSP00000326294  
    Reactome Protein details: P48426
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant PIP4K2A Protein
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    OriGene Protein Over-expression Lysate: PIP4K2A
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    Novus Biologicals PIP4K2A Proteins
    Novus Biologicals PIP4K2A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--


    PIP4K2A for ontologies           About GeneDecksing



    PIP4K2A Antibody Products: 
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    ThermoFisher Antibodies for PIP4K2A

    Assay Products for PIP4K2A: 
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    Protein Domains /
    Families
    for PIP4K2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PIP4K2A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002498 PInositol-4-P-5-kinase_core
     IPR016034 PInositol-4P-5-kinase_core_sub
     IPR023610 PInositol-4-P-5-kinase

    Graphical View of Domain Structure for InterPro Entry P48426

    ProtoNet protein and cluster: P48426

    1 Blocks protein family: IPB002498 Phosphatidylinositol-4-phosphate 5-kinase

    UniProtKB/Swiss-Prot: PI42A_HUMAN, P48426
    Similarity: Contains 1 PIPK domain


    Function
    for PIP4K2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PI42A_HUMAN, P48426
    Function: Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the
    myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating
    the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through
    ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May
    negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in
    thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol
    4,5-bisphosphate
    Biophysicochemical properties: Kinetic parameters: KM=50 uM for phosphatidylinositol-5- phosphate; Vmax=466 pmol/min/ug
    enzyme;

    Enzyme Numbers (IUBMB): EC 2.7.1.1491 2 EC 2.7.12

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIP4K2A
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate PIP4K2A (see all 55):
    hsa-miR-3685 hsa-miR-4317 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-640 hsa-miR-3664-5p hsa-miR-188-5p
    SwitchGear 3'UTR luciferase reporter plasmid: PIP4K2A 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIP4K2A (see all 4)
    OriGene shRNA RFP: PIP4K2A
    OriGene siRNA: PIP4K2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIP4K2A

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PIP4K2A

    Clone
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    GenScript: all cDNA clones in your preferred vector: PIP4K2A (NM_005028)
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    Cell Line
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    Search LifeMap BioReagents cell lines for PIP4K2A

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP4K2A

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0016307phosphatidylinositol phosphate kinase activity ----
    GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activity NAS7639683
    GO:00163091-phosphatidylinositol-5-phosphate 4-kinase activity IEA--


    PIP4K2A for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for PIP4K2A:
     Decreased focal adhesion (FA)   Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Pip4k2atm1Lex for PIP4K2A
         1 MGI phenotypic allele for Pip4k2a (no phenotypes)

    PIP4K2A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for PIP4K2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Inositol phosphate metabolism
    		Inositol phosphate metabolism1.00
    		Phosphatidylinositol signaling system0.59
    		superpathway of inositol phosphate compounds0.59
    2Metabolism
    		Metabolism1.00
    		Metabolism of lipids and lipoproteins0.34
    3D-myo-inositol-5-phosphate metabolism
    		D-myo-inositol-5-phosphate metabolism1.00
    		D-myo-inositol (1,4,5)-trisphosphate biosynthesis0.50
    4Regulation of Actin Cytoskeleton
    		Regulation of Actin Cytoskeleton1.00
    		Regulation of actin cytoskeleton0.58
    5PI Metabolism
    		PI Metabolism1.00
    		Synthesis of PIPs at the plasma membrane0.66

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for PIP4K2A
        Ca, cAMP and Lipid Signaling

    5/6 BioSystems Pathways for PIP4K2A (see all 6) 
        G13 Signaling Pathway
    B Cell Receptor Signaling Pathway
    D-myo-inositol-5-phosphate metabolism
    D-myo-inositol (1,4,5)-trisphosphate biosynthesis
    Regulation of Actin Cytoskeleton

    5        Reactome Pathways for PIP4K2A
        Metabolism
    Synthesis of PIPs at the plasma membrane
    Phospholipid metabolism
    Metabolism of lipids and lipoproteins
    PI Metabolism


    3         Kegg Pathways  (Kegg details for PIP4K2A):
        Inositol phosphate metabolism
    Phosphatidylinositol signaling system
    Regulation of actin cytoskeleton


    PIP4K2A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PIP4K2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for PIP4K2A (P484262, 3 ENSP000003657574) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTKQ061873, ENSP000003081764I2D: score=2 STRING: ENSP00000308176
    TECP426803, ENSP000003709124I2D: score=2 STRING: ENSP00000370912
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    GIT1Q9Y2X73I2D: score=1 
    INPP5BENSP000003621154STRING: ENSP00000362115
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006644phospholipid metabolic process TAS--
    GO:0006661phosphatidylinositol biosynthetic process TAS--
    GO:0016310phosphorylation NAS--
    GO:0035855megakaryocyte development IEA--
    GO:0044281small molecule metabolic process TAS--


    PIP4K2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for PIP4K2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIP4K2A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIP4K2A

    3 HMDB Compounds for PIP4K2A    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Phosphatidyl-D-myo-inositol1-Phosphatidyl-1D-myo-inositol (see all 6)----
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    2 Novoseek chemical compound relationships for PIP4K2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphoinositide 72.1 3 16801950 (1), 18222042 (1)
    lipid 10.4 1 11087761 (1)

    Search CenterWatch for drugs/clinical trials and news about PIP4K2A / PI42A 

    Transcripts
    for PIP4K2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PIP4K2A gene: 
    NM_005028.4  

    Unigene Cluster for PIP4K2A:

    Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
    Hs.57079  [show with all ESTs]
    Unigene Representative Sequence: NM_005028
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376573(uc010qcu.2 uc001irl.4) ENST00000474335 ENST00000422321
    ENST00000432610 ENST00000545335 ENST00000323883

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIP4K2A
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate PIP4K2A (see all 55):
    hsa-miR-3685 hsa-miR-4317 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-640 hsa-miR-3664-5p hsa-miR-188-5p
    SwitchGear 3'UTR luciferase reporter plasmid: PIP4K2A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIP4K2A (see all 4)
    OriGene shRNA RFP: PIP4K2A
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIP4K2A
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK023329.1 AK294817.1 AK294867.1 BC018034.1 S78798.1 U14957.2 

    8 DOTS entries:

    DT.452504  DT.100780695  DT.99999778  DT.121216779  DT.417804  DT.92039564  DT.121216739  DT.95270713 

    24/52 AceView cDNA sequences (see all 52):

    NM_005028 H93932 AW500300 BM828998 U14957 BG744111 BQ898815 BE766698 
    BF115318 AA059418 BP348857 BM051386 BX496635 AI684735 BC018034 AW242832 
    BX283131 AW614795 BQ939723 BV204907 BU429163 N33825 N24948 BG217124 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PIP4K2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                                                                                
    SP2:        -     -     -     -     -                                                               
    SP3:                                                                                                
    SP4:                                                                                                


    ECgene alternative splicing isoforms for PIP4K2A

    Expression
    for PIP4K2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIP4K2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCGGGCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PIP4K2A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

    See PIP4K2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIP4K2A

    SOURCE GeneReport for Unigene cluster: Hs.57079

    UniProtKB/Swiss-Prot: PI42A_HUMAN, P48426
    Tissue specificity: Expressed ubiquitously, with high levels in the brain. Present in most tissues, except notably
    skeletal muscle and small intestine

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    Orthologs
    for PIP4K2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PIP4K2A gene from 5/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves PIP4K2A1 phosphatidylinositol-5-phosphate 4-kinase, type II, more 84.53(n)
    93.58(a)    		   420504  NM_001030971.1  NP_001026142.1 
    lizard
    (Anolis carolinensis)    		 Reptilia PIP4K2A6
    		 --
    		 92(a)
    		 1 ↔ 1
    		 6(16137901-16206911)
    zebrafish
    (Danio rerio)    		 Actinopterygii pip4k2aa1 phosphatidylinositol-5-phosphate 4-kinase, type II, more 76.84(n)
    87.59(a)    		   560360  NM_001128702.1  NP_001122174.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG174716
    		 --
    		 55(a)
    		 1 → many
    		 4(1213042-1217466)
    worm
    (Caenorhabditis elegans)    		 Secernentea ppk-26
    		 PIP Kinase family member (ppk-2)
    		 50(a)
    		 1 → many
    		 III(2102285-2107460)


    ENSEMBL Gene Tree for PIP4K2A (if available)
    TreeFam Gene Tree for PIP4K2A (if available) 

    Paralogs
    for PIP4K2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PIP4K2A gene
    PIP5K1B2  PIP4K2C2  PIP5K1C2  PIP4K2B2  PIP5KL12  PIP5K1A2  
    6 SIMAP similar genes for PIP4K2A using alignment to 6 protein entries:     PI42A_HUMAN (see all proteins):
    PIP4K2B    PIP4K2C    PIPSL    PIP5K1A    PIP5K1B    PIP5K1C

    PIP4K2A for paralogs           About GeneDecksing



    Genomic Variants
    for PIP4K2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3616 NCBI SNPs in PIP4K2A are shown (see all 3616)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1881586551,2
    		--22823292(+) ACAATA/TGGGTT 1 -- ds50010--------
    rs110130421,2
    		--22823301(+) TTCGCA/GCTCCT 1 -- ds50010--------
    rs1494957331,2
    		--22823353(+) ATAGGC/TGGTAA 1 -- ds50010--------
    rs1178369711,2
    		--22823408(+) CAGGCC/TATGGA 1 -- ds50011Minor allele frequency- T:0.01EA 120
    rs1928939621,2
    		--22823434(+) GGCCCA/GGGGTT 1 -- ds50010--------
    rs779893141,2
    		F,--22823438(+) CGGGGT/CTTGGG 1 -- ds50011Minor allele frequency- C:0.05NA 120
    rs615933251,2
    		F,--22823538(+) CCAAGT/GGGAAT 1 -- ds50011Minor allele frequency- G:0.12WA 118
    rs1845682691,2
    		--22823540(+) AAGTGG/TAATGC 1 -- ds50010--------
    rs1486730831,2
    		--22823697(+) TCTTGC/TGGCAA 1 -- ds50010--------
    rs47488091,2
    		C,A,--22823797(+) ACTTTT/CATTTC 1 -- ut3113Minor allele frequency- C:0.02NA WA CSA EA 375

    HapMap Linkage Disequilibrium report for PIP4K2A (22823766 - 23003503 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PIP4K2A
         1 CNV: 4670
    Human Gene Mutation Database (HGMD): PIP4K2A

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    Disorders / Diseases
    for PIP4K2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PIP4K2A for disorders           About GeneDecksing

    OMIM gene information: 603140    OMIM disorders: --

    6 diseases for PIP4K2A:    About MalaCards
    bipolar affective disorder    bipolar disorder    alzheimer's disease    schizophrenia
    breast cancer    neuronitis

    1 disease from the University of Copenhagen DISEASES database for PIP4K2A:
    Schizophrenia

    2 Novoseek disease relationships for PIP4K2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bipolar disorder 64.9 5 16094259 (2), 16823801 (2)
    schizophrenia 59.3 17 16823801 (4), 17555944 (3), 16094259 (2), 16801950 (1) (see all 6)

    Human Genome Epidemiology (HuGE) Navigator: PIP4K2A (13 documents)

    Export disorders for PIP4K2A gene to outside databases

    Publications
    for PIP4K2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIP4K2A gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with PIP4K2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A new pathway for synthesis of phosphatidylinositol-4,5- bisphosphate. (PubMed id 9367159)1, 2, 3 Rameh L.E.... Cantley L.C. (1997)
    2. The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases. (PubMed id 7852364)1, 2, 3 Boronenkov I.V. and Anderson R.A. (1995)
    3. PIP4Kbeta interacts with and modulates nuclear locali zation of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha. (PubMed id 20583997)1, 2 Bultsma Y....Divecha N. (2010)
    4. Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha. (PubMed id 18364242)1, 2 Wilcox A. and Hinchliffe K.A. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    7. The cloning and sequence of the C isoform of PtdIns4P 5-kinase. (PubMed id 7639683)1, 2 Divecha N.... Irvine R.F. (1995)
    8. Association study between genetic variants at the PIP5K2A gene locus and schizophrenia and bipolar affective disorder. (PubMed id 16823801)1, 9 Jamra R.A....Schumacher J. (2006)
    9. A schizophrenia-linked mutation in PIP5K2A fails to activate neuronal M channels. (PubMed id 18545987)1, 9 Fedorenko O....Lang U.E. (2008)
    10. PIP5K2A-dependent regulation of excitatory amino acid transporter EAAT3. (PubMed id 19644675)1, 9 Fedorenko O....Lang U.E. (2009)

    External Searches for PIP4K2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PIP4K2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5305 HGNC: 8997 AceView: PIP5K2A Ensembl:ENSG00000150867 euGenes: HUgn5305
    ECgene: PIP4K2A Kegg: 5305 H-InvDB: PIP4K2A

    Other Databases showing PIP4K2A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PIP4K2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIP4K2A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PIP4K2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PIP4K2A gene:
    Search GeneIP for patents involving PIP4K2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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