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Aliases for PIP Gene

Aliases for PIP Gene

  • Prolactin Induced Protein 2 3
  • Prolactin-Induced Protein 2 3 4 5
  • Gross Cystic Disease Fluid Protein 15 3 4
  • Secretory Actin-Binding Protein 3 4
  • GCDFP-15 3 4
  • GCDFP15 3 4
  • GPIP4 3 4
  • SABP 3 4
  • Prolactin-Inducible Protein 2
  • Gp17 4

External Ids for PIP Gene

Previous GeneCards Identifiers for PIP Gene

  • GC07P141155
  • GC07P142221
  • GC07P142300
  • GC07P142346
  • GC07P142539
  • GC07P142829
  • GC07P137167

Summaries for PIP Gene

GeneCards Summary for PIP Gene

PIP (Prolactin Induced Protein) is a Protein Coding gene. Diseases associated with PIP include Microglandular Adenosis and Breast Cyst. Among its related pathways are ERK Signaling and PEDF Induced Signaling. GO annotations related to this gene include actin binding and glycoprotein binding.

Gene Wiki entry for PIP Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP Gene

Genomics for PIP Gene

Regulatory Elements for PIP Gene

Enhancers for PIP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIP on UCSC Golden Path with GeneCards custom track

Genomic Location for PIP Gene

Chromosome:
7
Start:
143,132,077 bp from pter
End:
143,139,746 bp from pter
Size:
7,670 bases
Orientation:
Plus strand

Genomic View for PIP Gene

Genes around PIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP Gene

Proteins for PIP Gene

  • Protein details for PIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12273-PIP_HUMAN
    Recommended name:
    Prolactin-inducible protein
    Protein Accession:
    P12273
    Secondary Accessions:
    • A0A963
    • A0A9C3
    • A0A9F3
    • A4D2I1

    Protein attributes for PIP Gene

    Size:
    146 amino acids
    Molecular mass:
    16572 Da
    Quaternary structure:
    • Monomer. Interacts with AZGP1.

    Three dimensional structures from OCA and Proteopedia for PIP Gene

neXtProt entry for PIP Gene

Proteomics data for PIP Gene at MOPED

Post-translational modifications for PIP Gene

  • Glycosylation at Asn 105
  • Modification sites at PhosphoSitePlus

Other Protein References for PIP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PIP Gene

Domains & Families for PIP Gene

Protein Domains for PIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12273

UniProtKB/Swiss-Prot:

PIP_HUMAN :
  • Belongs to the PIP family.
Family:
  • Belongs to the PIP family.
genes like me logo Genes that share domains with PIP: view

No data available for Gene Families for PIP Gene

Function for PIP Gene

Molecular function for PIP Gene

GENATLAS Biochemistry:
prolactin-induced protein
UniProtKB/Swiss-Prot Induction:
By prolactin and androgen; inhibited by estrogen.
genes like me logo Genes that share phenotypes with PIP: view

Animal Models for PIP Gene

MGI Knock Outs for PIP:

Animal Model Products

  • Taconic Biosciences Mouse Models for PIP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PIP Gene

Localization for PIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIP Gene COMPARTMENTS Subcellular localization image for PIP gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
plasma membrane 2
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for PIP Gene

Pathways & Interactions for PIP Gene

genes like me logo Genes that share pathways with PIP: view

Gene Ontology (GO) - Biological Process for PIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002682 regulation of immune system process IEA --
GO:0010628 positive regulation of gene expression IDA 10072505
GO:0070233 negative regulation of T cell apoptotic process IMP 10072505
genes like me logo Genes that share ontologies with PIP: view

No data available for SIGNOR curated interactions for PIP Gene

Drugs & Compounds for PIP Gene

(9) Drugs for PIP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for PIP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PIP: view

Transcripts for PIP Gene

mRNA/cDNA for PIP Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIP Gene

Prolactin-induced protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIP Gene

No ASD Table

Relevant External Links for PIP Gene

GeneLoc Exon Structure for
PIP
ECgene alternative splicing isoforms for
PIP

Expression for PIP Gene

mRNA expression in normal human tissues for PIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIP Gene

This gene is overexpressed in Minor Salivary Gland (x47.3).

Protein differential expression in normal tissues from HIPED for PIP Gene

This gene is overexpressed in Salivary gland (25.3), Saliva (15.9), and Lavage (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIP Gene



SOURCE GeneReport for Unigene cluster for PIP Gene Hs.99949

mRNA Expression by UniProt/SwissProt for PIP Gene

P12273-PIP_HUMAN
Tissue specificity: Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands.
genes like me logo Genes that share expression patterns with PIP: view

Primer Products

No data available for Protein tissue co-expression partners for PIP Gene

Orthologs for PIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for PIP Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PIP 35
  • 66.67 (n)
  • 50 (a)
PIP 36
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pip 35
  • 60.24 (n)
  • 48.57 (a)
Pip 16
Pip 36
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PIP 35
  • 98.4 (n)
  • 97.26 (a)
PIP 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pip 35
  • 58.21 (n)
  • 45.52 (a)
cow
(Bos Taurus)
Mammalia PIP 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
Species with no ortholog for PIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIP Gene

ENSEMBL:
Gene Tree for PIP (if available)
TreeFam:
Gene Tree for PIP (if available)

Paralogs for PIP Gene

No data available for Paralogs for PIP Gene

Variants for PIP Gene

Sequence variations from dbSNP and Humsavar for PIP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6959713 -- 143,139,347(+) GGGAA(A/G)GCACC intron-variant
rs17850704 -- 143,139,606(+) AACAA(C/T)CGGTT reference, synonymous-codon
rs28377711 -- 143,136,507(+) TTTCA(A/G)TCCAA intron-variant
rs28517794 -- 143,137,917(+) AAAAA(A/G)GGGAA intron-variant
rs34123553 -- 143,133,605(+) TCTCC(-/C)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIP Gene

Variant ID Type Subtype PubMed ID
nsv465175 CNV Loss 19166990
dgv432n21 CNV Loss 19592680
esv2675537 CNV Deletion 23128226
nsv465176 CNV Loss 19166990

Variation tolerance for PIP Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PIP Gene

Disorders for PIP Gene

MalaCards: The human disease database

(30) MalaCards diseases for PIP Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
microglandular adenosis
  • adenosis - breast
breast cyst
  • cyst of breast
breast cancer
  • breast cancer, invasive ductal
florid papillomatosis of the nipple
  • erosive adenomatosis of the nipple
breast signet ring cell adenocarcinoma
  • mammary signet ring cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search PIP in MalaCards View complete list of genes associated with diseases

Relevant External Links for PIP

Genetic Association Database (GAD)
PIP
Human Genome Epidemiology (HuGE) Navigator
PIP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIP
genes like me logo Genes that share disorders with PIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PIP Gene

Publications for PIP Gene

  1. The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. (PMID: 1955075) Myal Y. … Shiu R.P.C. (Mol. Cell. Endocrinol. 1991) 2 3 4 23 67
  2. CLC- a novel susceptibility gene for allergic rhinitis? (PMID: 19650845) Bryborn M. … Cardell L.O. (Allergy 2010) 3 23
  3. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. (PMID: 19217055) Yan Z. … Chhieng D.C. (Diagn. Cytopathol. 2009) 3 23
  4. GCDFP-15 positive and TTF-1 negative primary lung neoplasms: a tissue microarray study of 381 primary lung tumors. (PMID: 19620839) Wang L.J. … Resnick M.B. (Appl. Immunohistochem. Mol. Morphol. 2009) 3 23
  5. Analysis of expression patterns of breast cancer-specific markers (mammaglobin and gross cystic disease fluid protein 15) in lung and pleural tumors. (PMID: 18251583) Takeda Y. … Matsuno Y. (Arch. Pathol. Lab. Med. 2008) 3 23

Products for PIP Gene

Sources for PIP Gene

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