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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIP Gene

protein-coding   GIFtS: 55
GCID: GC07P142829

prolactin-induced protein
 Explore 38 diseases affiliated with
PIP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PIP    

Aliases
for PIP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Prolactin-Induced Protein1 2 3     Secretory Actin-Binding Protein2 3
GCDFP-151 2 3     SABP2 3
GCDFP151 2 3     Prolactin-Inducible Protein2
GPIP41 2 3     Gp171
Gross Cystic Disease Fluid Protein 152 3     

External Ids:    HGNC: 89931   Entrez Gene: 53042   Ensembl: ENSG000001597637   OMIM: 1767205   UniProtKB: P122733   

Export aliases for PIP gene to outside databases

Previous GC identifers: GC07P141155 GC07P142221 GC07P142300 GC07P142346 GC07P142539 GC07P137167


Summaries
for PIP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for PIP (Prolactin-induced protein)


Genomic Views
for PIP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIP gene promoter:
         TBP   p53   NCX/Ncx   MyoD   STAT5A   Ik-3   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: PIP promoter sequence
   Search SABiosciences Chromatin IP Primers for PIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q32-qter

PIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142829:  view genomic region     (about GC identifiers)

Start:
 142,829,170 bp from pter      End:
 142,836,839 bp from pter
Size:
 7,670 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,231,068-142,238,728     

Proteins
for PIP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PIP_HUMAN, P12273 (See protein sequence)
Recommended Name: Prolactin-inducible protein precursor  
Size: 146 amino acids; 16572 Da
Subunit: Monomer. Interacts with AZGP1
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for PIP:
3ES6 (3D)    
Secondary accessions: A0A963 A0A9C3 A0A9F3 A4D2I1

Explore the universe of human proteins at neXtProt for PIP: NX_P12273

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P12273

    • PIP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002643.1  
    ENSEMBL proteins: 
     ENSP00000291009  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: PIP
    OriGene Protein Over-expression Lysate: PIP
    OriGene Custom Protein Services for PIP 
    GenScript Custom Purified and Recombinant Proteins Services for PIP
    Novus Biologicals PIP Protein
    Novus Biologicals PIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for PIP

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0016324apical plasma membrane IEA--


    PIP for ontologies           About GeneDecksing



    PIP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Antibodies (see all 4): PIP
    OriGene Custom Antibody Services for PIP 
    GenScript Superior Antibodies for PIP
    Novus Biologicals PIP Antibodies
    Abcam antibodies for PIP 
    Uscn Antibodies for PIP
    ThermoFisher Antibodies for PIP

    Assay Products for PIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIP
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PIP

    Protein Domains /
    Families
    for PIP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PIP for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007990 SV_autoAg

    Graphical View of Domain Structure for InterPro Entry P12273

    ProtoNet protein and cluster: P12273

    UniProtKB/Swiss-Prot: PIP_HUMAN, P12273
    Similarity: Belongs to the PIP family


    Function
    for PIP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PIP_HUMAN, P12273
    Induction: By prolactin and androgen; inhibited by estrogen

         Genatlas biochemistry entry for PIP:
    prolactin-induced protein

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIP (see all 7)
    OriGene shRNA RFP: PIP
    OriGene siRNA: PIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for PIP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PIP (NM_002652)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for PIP
    Search LifeMap BioReagents cell lines for PIP

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PIP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS2013294
    GO:0005515protein binding ----


    PIP for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for PIP:
     Decreased influenza A virus in  Increased cell death HMECs cel  Increased cell death in breast 


    Pathways & Interactions
    for PIP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    		PEDF Induced Signaling1.00
    		all-trans-Retinoic Acid Signaling in Brain0.59
    		MIF Mediated Glucocorticoid Regulation0.73
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Regulation of Innate Immune Cells0.71
    		STAT3 Pathway0.47
    		IL-6 Pathway0.61
    		Endothelin-1 Signaling Pathway0.44
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    3PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56
    4Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIP (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/23 Interacting proteins for PIP (P122731, 3 ENSP000002910094) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WBP5Q9UHQ71, 3, ENSP000003617404EBI-1049746,EBI-1051372 I2D: score=1 STRING: ENSP00000361740
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SPI1P179473, ENSP000002271634I2D: score=1 STRING: ENSP00000227163
    USP25Q9UHP33, ENSP000002856794I2D: score=2 STRING: ENSP00000285679
    USPL1Q5W0Q73, ENSP000002553044I2D: score=2 STRING: ENSP00000255304
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    PIP for ontologies           About GeneDecksing



    Drugs & Compounds
    for PIP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIP
    10/14 Novoseek chemical compound relationships for PIP gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 62.8 23 10672061 (1), 11447997 (1), 15365364 (1), 10576657 (1) (see all 20)
    estrogen 62.6 37 20173733 (3), 2269395 (2), 9426521 (2), 11117786 (2) (see all 28)
    b 723 61.3 13 17004974 (5), 1370877 (2), 1556271 (1), 11940224 (1)
    mucicarmine 53.8 1 9870855 (1)
    progestins 40.5 6 2142871 (1), 1446056 (1), 1551135 (1)
    bicalutamide 35.9 1 10402478 (1)
    tamoxifen 31.7 3 1930624 (3)
    dihydrotestosterone 30.2 7 7927949 (2), 7558422 (2), 10402478 (1)
    testosterone 19.2 11 1955075 (3), 9111629 (1), 10402478 (1), 9831198 (1) (see all 5)
    androstenedione 8.73 1 9111629 (1)

    Search CenterWatch for drugs/clinical trials and news about PIP 

    Transcripts
    for PIP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PIP gene: 
    NM_002652.2  

    Unigene Cluster for PIP:

    Prolactin-induced protein
    Hs.99949  [show with all ESTs]
    Unigene Representative Sequence: BF965123
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000291009(uc003wcf.1)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PIP (see all 7)
    OriGene shRNA RFP: PIP
    OriGene siRNA: PIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PIP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PIP
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: PIP (NM_002652)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PIP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIP

    Additional cDNA sequence: 

    AK312227.1 BC010950.1 BC010951.1 J03460.1 Y10179.1 

    6 DOTS entries:

    DT.99946855  DT.408915  DT.100678499  DT.100717527  DT.75156109  DT.91667251 

    5 AceView cDNA sequences:

    NM_002652 Y10179 J03460 BC010950 BC010951 

    GeneLoc Exon Structure


    Expression
    for PIP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTAAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PIP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIP

    SOURCE GeneReport for Unigene cluster: Hs.99949

    UniProtKB/Swiss-Prot: PIP_HUMAN, P12273
    Tissue specificity: Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as
    the lacrimal, salivary, and sweat glands

        SABiosciences Custom PCR Arrays for PIP
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIP
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for PIP

    Orthologs
    for PIP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for PIP gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pip1 , 5 prolactin induced protein1, 5 60.24(n)1
    48.57(a)1    		   6 (20.05 cM)5
    187161  NM_008843.31  NP_032869.21 
     418475495 


    ENSEMBL Gene Tree for PIP (if available)
    TreeFam Gene Tree for PIP (if available) 

    Paralogs
    for PIP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PIP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 NCBI SNPs in PIP are shown (see all 186)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1883861341,2
    		--142827267(+) GTCAGG/TAATGT 1 -- us2k10--------
    rs3152861,2
    		C,A,H,--142827282(+) TCAGCT/CTGGCC 1 -- us2k17Minor allele frequency- C:0.12WA NA CSA EA 248
    rs1388909341,2
    		--142827332(+) TAGCCA/GGGTAT 1 -- us2k10--------
    rs1920783771,2
    		--142827346(+) GGCACC/TTGCCT 1 -- us2k10--------
    rs3152851,2
    		--142827433(+) tcatgC/Tcactg 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1448455661,2
    		--142827435(+) ATGCCA/GCTGCA 1 -- us2k10--------
    rs1384582181,2
    		--142827904(+) CTGAAC/GTTCTG 1 -- us2k10--------
    rs3152841,2
    		C,F,A,H,--142827954(+) GAGAAG/AGTAGA 1 -- us2k1 tfbs3 trp322Minor allele frequency- A:0.33NS EA NA WA CSA 2249
    rs1415528171,2
    		--142828069(+) GAGGCA/GGTAAC 1 -- us2k10--------
    rs734526001,2
    		C,F,--142828104(+) GTTGCC/AAGAGA 1 -- us2k16Minor allele frequency- A:0.11WA NA EA 364

    HapMap Linkage Disequilibrium report for PIP (142829170 - 142836839 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PIP
         3 CNVs: 52136 52135 52137

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PIP
    DNA2.0 Custom Variant and Variant Library Synthesis for PIP

    Disorders / Diseases
    for PIP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PIP for disorders           About GeneDecksing

    OMIM gene information: 176720    OMIM disorders: --

    20/38 diseases for PIP (see all 38):    About MalaCards
    fox fordyce disease    florid papillomatosis of the nipple    syringocystadenoma papilliferum    microglandular adenosis
    hidradenitis suppurativa    sweat gland carcinoma    hidradenitis    mixed cell type cancer
    rectum adenocarcinoma    apocrine adenocarcinoma    eccrine adenocarcinoma    cribriform carcinoma
    vulva carcinoma    hidrocystoma    merkel cell carcinoma    breast cyst
    allergic rhinitis    carcinoma    hidradenoma    syringoma

    9 diseases from the University of Copenhagen DISEASES database for PIP:
    Breast cancer     Carcinoma     Hidradenoma     Hidrocystoma
    Syringocystadenoma papilliferum     Skin cancer     Breast cyst     Fox fordyce disease
    Breast disease

    10/33 Novoseek disease relationships for PIP gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma lobular 76.4 5 10672061 (3), 19556822 (1), 1592388 (1)
    breast carcinoma 75.7 52 19217055 (5), 17145637 (4), 18251583 (4), 7722013 (4) (see all 26)
    fibrocystic breast disease 75.3 9 7829219 (2), 2357014 (1), 7850069 (1), 2058763 (1) (see all 6)
    extramammary pagets disease 74.1 1 8599433 (1)
    breast cysts 73.4 2 11992405 (1), 11029771 (1)
    carcinoma ductal 72.2 2 15569980 (1), 18753974 (1)
    carcinoma 61.6 39 16045781 (7), 17004974 (3), 18339419 (3), 8248106 (3) (see all 15)
    ductal breast carcinoma 60.9 1 8248106 (1)
    breast cancer 60.1 56 11029771 (5), 7558422 (3), 11992405 (2), 10576657 (2) (see all 27)
    metastatic carcinoma 59.7 5 18251583 (2), 7945916 (1), 7722013 (1)

    Genetic Association Database (GAD): PIP
    Human Genome Epidemiology (HuGE) Navigator: PIP (7 documents)

    Export disorders for PIP gene to outside databases

    Publications
    for PIP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIP gene, integrated from 9 sources (see all 195):
    (articles sorted by number of sources associating them with PIP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. (PubMed id 1955075)1, 2, 3, 9 Myal Y....Shiu R.P. (1991)
    2. Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)1, 2, 9 Hassan M.I....Singh T.P. (2008)
    3. Primary structure of a new actin-binding protein from human seminal plasma. (PubMed id 2013294)1, 2, 9 Schaller J.... Rickli E.E. (1991)
    4. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    7. Isolation from a human seminal vesicle library of the cDNA for gp17, a CD4 binding factor. (PubMed id 9218538)1, 2 Autiero M.... Piatier-Tonneau D. (1997)
    8. The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7. (PubMed id 2727805)1, 3 Myal Y....Shiu R.P. (1989)
    9. Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D. (PubMed id 3667631)1, 2 Murphy L.C.... Shiu R.P.C. (1987)
    10. Differential antibody reactivity and CD4 binding of the mammary tumor marker protein GCDFP-15 from breast cyst and its counterparts from exocrine epithelia. (PubMed id 9724097)1, 9 Caputo E....Guardiola J. (1998)

    External Searches for PIP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PIP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5304 HGNC: 8993 AceView: PIP Ensembl:ENSG00000159763 euGenes: HUgn5304
    ECgene: PIP H-InvDB: PIP

    Other Databases showing PIP gene

    (According to HUGE)
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    Specialized Databases showing PIP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PIP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PIP gene:
    Search GeneIP for patents involving PIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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     Regulatory tfbs in PIP promoter
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