Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PIP Gene

protein-coding   GIFtS: 57
GCID: GC07P142829

Prolactin-Induced Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prolactin-Induced Protein1 2 3     GCDFP152 3
Prolactin-Inducible Protein1 2     GPIP42 3
Gross Cystic Disease Fluid Protein 152 3     SABP2 3
Secretory Actin-Binding Protein2 3     gp173
GCDFP-152 3     

External Ids:    HGNC: 89931   Entrez Gene: 53042   Ensembl: ENSG000001597637   OMIM: 1767205   UniProtKB: P122733   

Export aliases for PIP gene to outside databases

Previous GC identifers: GC07P141155 GC07P142221 GC07P142300 GC07P142346 GC07P142539 GC07P137167


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PIP Gene: 
PIP (prolactin-induced protein) is a protein-coding gene. Diseases associated with PIP include florid papillomatosis of the nipple, and eccrine adenocarcinoma, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Rho Family GTPases. GO annotations related to this gene include actin binding.

Gene Wiki entry for PIP (Prolactin-induced protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PIP gene promoter:
         TBP   p53   NCX/Ncx   MyoD   STAT5A   Ik-3   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIP promoter sequence
   Search SABiosciences Chromatin IP Primers for PIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142829:  view genomic region     (about GC identifiers)

Start:
142,829,170 bp from pter      End:
142,836,839 bp from pter
Size:
7,670 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,231,068-142,238,728     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PIP_HUMAN, P12273 (See protein sequence)
Recommended Name: Prolactin-inducible protein precursor  
Size: 146 amino acids; 16572 Da
Subunit: Monomer. Interacts with AZGP1
Subcellular location: Secreted
1 PDB 3D structure from and Proteopedia for PIP:
3ES6 (3D)    
Secondary accessions: A0A963 A0A9C3 A0A9F3 A4D2I1

Explore the universe of human proteins at neXtProt for PIP: NX_P12273

Explore proteomics data for PIP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P12273

  • PIP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PIP Protein Expression
    REFSEQ proteins: NP_002643.1  
    ENSEMBL proteins: 
     ENSP00000291009  

    Human Recombinant Protein Products for PIP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for PIP
    OriGene Protein Over-expression Lysate for PIP
    OriGene MassSpec for PIP 
    OriGene Custom Protein Services for PIP
    GenScript Custom Purified and Recombinant Proteins Services for PIP
    Novus Biologicals PIP Proteins
    Novus Biologicals PIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for PIP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--
    GO:0016324apical plasma membrane IEA--

    PIP for ontologies           About GeneDecksing



    PIP Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for PIP
    OriGene Custom Antibody Services for PIP
    GenScript Superior Antibodies for PIP
    Novus Biologicals PIP Antibodies
    Abcam antibodies for PIP
    Cloud-Clone Corp. Antibodies for PIP 
    ThermoFisher Antibody for PIP
    LSBio Antibodies in human, mouse, rat for PIP 

    Assay Products for PIP: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for PIP
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PIP 
    Cloud-Clone Corp. CLIAs for PIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007990 SV_autoAg

    Graphical View of Domain Structure for InterPro Entry P12273

    ProtoNet protein and cluster: P12273

    UniProtKB/Swiss-Prot: PIP_HUMAN, P12273
    Similarity: Belongs to the PIP family


    PIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIP_HUMAN, P12273
    Induction: By prolactin and androgen; inhibited by estrogen

         Genatlas biochemistry entry for PIP:
    prolactin-induced protein

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS2013294
    GO:0005515protein binding ----
         
    PIP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PIP:
     Decreased influenza A virus in  Increased cell death HMECs cel  Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PIP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIP
    Sirion Biotech Customized adenovirus for overexpression of PIP

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for PIP (see all 6)
    OriGene ORF clones in mouse, rat for PIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIP (NM_002652)
    Sino Biological Human cDNA Clone for PIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP
    Sirion Biotech Customized lentivirus for stable overexpression of PIP 
                         Customized lentivirus expression plasmids for stable overexpression of PIP 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for PIP
    Search LifeMap BioReagents cell lines for PIP
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    RAR-Gamma-RXR-Alpha Degradation0.62
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PIP (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/23 Interacting proteins for PIP (P122731, 3 ENSP000002910094) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WBP5Q9UHQ71, 3, ENSP000003617404EBI-1049746,EBI-1051372 I2D: score=1 STRING: ENSP00000361740
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SPI1P179473, ENSP000002271634I2D: score=1 STRING: ENSP00000227163
    USP25Q9UHP33, ENSP000002856794I2D: score=2 STRING: ENSP00000285679
    USPL1Q5W0Q73, ENSP000002553044I2D: score=2 STRING: ENSP00000255304
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    PIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    PIP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PIP

    10/14 Novoseek inferred chemical compound relationships for PIP gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 62.8 23 10672061 (1), 11447997 (1), 15365364 (1), 10576657 (1) (see all 20)
    estrogen 62.6 37 20173733 (3), 2269395 (2), 9426521 (2), 11117786 (2) (see all 28)
    b 723 61.3 13 17004974 (5), 1370877 (2), 1556271 (1), 11940224 (1)
    mucicarmine 53.8 1 9870855 (1)
    progestins 40.5 6 2142871 (1), 1446056 (1), 1551135 (1)
    bicalutamide 35.9 1 10402478 (1)
    tamoxifen 31.7 3 1930624 (3)
    dihydrotestosterone 30.2 7 7927949 (2), 7558422 (2), 10402478 (1)
    testosterone 19.2 11 1955075 (3), 9111629 (1), 10402478 (1), 9831198 (1) (see all 5)
    androstenedione 8.73 1 9111629 (1)

    Search CenterWatch for drugs/clinical trials and news about PIP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PIP gene: 
    NM_002652.2  

    Unigene Cluster for PIP:

    Prolactin-induced protein
    Hs.99949  [show with all ESTs]
    Unigene Representative Sequence: BF965123
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000291009(uc003wcf.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PIP
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate PIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIP
    Clone
    Products:
         
    OriGene clones in human, mouse for PIP (see all 6)
    OriGene ORF clones in mouse, rat for PIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIP (NM_002652)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP
    Sirion Biotech Customized lentivirus for stable overexpression of PIP 
                         Customized lentivirus expression plasmids for stable overexpression of PIP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for PIP
    OriGene qSTAR qPCR primer pairs in human, mouse for PIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIP

    Additional mRNA sequence: 

    AK312227.1 BC010950.1 BC010951.1 J03460.1 Y10179.1 

    6 DOTS entries:

    DT.99946855  DT.408915  DT.100678499  DT.100717527  DT.75156109  DT.91667251 

    5 AceView cDNA sequences:

    NM_002652 Y10179 BC010950 J03460 BC010951 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PIP expression in normal human tissues (normalized intensities)      PIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAAAAAAA
    PIP Expression
    About this image


    PIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 3 entries
             salivary gland ; glandular cells   
             salivary gland   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ; glandular cells   
             breast epithelium   
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Gingival Fibroblasts (HGF)   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             seminal vesicle ; glandular cells   
     
     Epithelium
             bronchial epithelia   

    See PIP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PIP

    SOURCE GeneReport for Unigene cluster: Hs.99949

    UniProtKB/Swiss-Prot: PIP_HUMAN, P12273
    Tissue specificity: Expressed in pathological conditions of the mammary gland and in several exocrine tissues,
    such as the lacrimal, salivary, and sweat glands

        SABiosciences Custom PCR Arrays for PIP
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for PIP
    OriGene qSTAR qPCR primer pairs in human, mouse for PIP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PIP
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIP
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for PIP gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pip1 , 5 prolactin induced protein1, 5 60.24(n)1
    48.57(a)1
      6 (20.05 cM)5
    187161  NM_008843.31  NP_032869.21 
     418475495 


    ENSEMBL Gene Tree for PIP (if available)
    TreeFam Gene Tree for PIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/226 SNPs in PIP are shown (see all 226)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883861341,2
    --142827267(+) GTCAGG/TAATGT 1 -- us2k10--------
    rs3152861,2
    C,A,H--142827282(+) TCAGCT/CTGGCC 1 -- us2k17Minor allele frequency- C:0.12WA NA CSA EA 248
    rs1388909341,2
    --142827332(+) TAGCCA/GGGTAT 1 -- us2k10--------
    rs1920783771,2
    --142827346(+) GGCACC/TTGCCT 1 -- us2k10--------
    rs2018077991,2
    C--142827367(+) CTACTC/TGGGTG 1 -- us2k10--------
    rs3152851,2
    C,F--142827433(+) tcatgC/Tcactg 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1448455661,2
    C--142827435(+) ATGCCA/GCTGCA 1 -- us2k10--------
    rs1384582181,2
    --142827904(+) CTGAAC/GTTCTG 1 -- us2k10--------
    rs3152841,2
    C,F,A,H--142827954(+) GAGAAG/AGTAGA 1 -- us2k1 tfbs3 trp322Minor allele frequency- A:0.33NS EA NA WA CSA 2249
    rs1415528171,2
    --142828069(+) GAGGCA/GGTAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIP (142829170 - 142836839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PIP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675537CNV Deletion23128226
    nsv465176CNV Loss19166990
    nsv465175CNV Loss19166990
    dgv432n21CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing PIP
    DNA2.0 Custom Variant and Variant Library Synthesis for PIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 176720    OMIM disorders: --

    20/34 diseases for PIP (see all 34):    About MalaCards
    florid papillomatosis of the nipple    eccrine adenocarcinoma    fox fordyce disease    cribriform carcinoma
    rectum adenocarcinoma    apocrine adenocarcinoma    hidrocystoma    syringocystadenoma papilliferum
    microglandular adenosis    cell type cancer    mixed cell type cancer    papillary adenocarcinoma
    breast cyst    ductal carcinoma in situ    sweat gland carcinoma    phyllode tumor
    merkel cell carcinoma    hidradenoma    hidradenitis suppurativa    hidradenitis

    9 diseases from the University of Copenhagen DISEASES database for PIP:
    Breast cancer     Carcinoma     Hidradenoma     Hidrocystoma
    Syringocystadenoma papilliferum     Skin cancer     Breast cyst     Fox fordyce disease
    Breast disease

    PIP for disorders           About GeneDecksing

    10/33 Novoseek inferred disease relationships for PIP gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma lobular 76.4 5 10672061 (3), 19556822 (1), 1592388 (1)
    breast carcinoma 75.7 52 19217055 (5), 17145637 (4), 18251583 (4), 7722013 (4) (see all 26)
    fibrocystic breast disease 75.3 9 7829219 (2), 2357014 (1), 7850069 (1), 2058763 (1) (see all 6)
    extramammary pagets disease 74.1 1 8599433 (1)
    breast cysts 73.4 2 11992405 (1), 11029771 (1)
    carcinoma ductal 72.2 2 15569980 (1), 18753974 (1)
    carcinoma 61.6 39 16045781 (7), 17004974 (3), 18339419 (3), 8248106 (3) (see all 15)
    ductal breast carcinoma 60.9 1 8248106 (1)
    breast cancer 60.1 56 11029771 (5), 7558422 (3), 11992405 (2), 10576657 (2) (see all 27)
    metastatic carcinoma 59.7 5 18251583 (2), 7945916 (1), 7722013 (1)

    Genetic Association Database (GAD): PIP
    Human Genome Epidemiology (HuGE) Navigator: PIP (7 documents)

    Export disorders for PIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PIP gene, integrated from 9 sources (see all 200):
    (articles sorted by number of sources associating them with PIP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. (PubMed id 1955075)1, 2, 3, 9 Myal Y....Shiu R.P. (1991)
    2. Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)1, 2, 9 Hassan M.I....Singh T.P. (2008)
    3. Primary structure of a new actin-binding protein from human seminal plasma. (PubMed id 2013294)1, 2, 9 Schaller J.... Rickli E.E. (1991)
    4. CLC- a novel susceptibility gene for allergic rhiniti s? (PubMed id 19650845)1, 4, 9 Bryborn M....Cardell L.O. (2010)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    8. Isolation from a human seminal vesicle library of the cDNA for gp17, a CD4 binding factor. (PubMed id 9218538)1, 2 Autiero M.... Piatier-Tonneau D. (1997)
    9. The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7. (PubMed id 2727805)1, 3 Myal Y....Shiu R.P. (1989)
    10. Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D. (PubMed id 3667631)1, 2 Murphy L.C.... Shiu R.P.C. (1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5304 HGNC: 8993 AceView: PIP Ensembl:ENSG00000159763 euGenes: HUgn5304
    ECgene: PIP H-InvDB: PIP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PIP gene:
    Search GeneIP for patents involving PIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for PIP   OriGene RNAi products in human, mouse, rat for PIP  
     OriGene qPCR primer pairs and template standards for PIP   OriGene Protein Over-expression Lysate for PIP  
     OriGene MassSpec something-or-other for PIP   OriGene clones in human, mouse for PIP  
     OriGene qSTAR qPCR primer pairs in human, mouse for PIP   OriGene Purified Protein for PIP  
     OriGene ORF clones in mouse, rat for PIP   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for PIP   OriGene Custom Protein Services for PIP  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PIP
     QIAGEN SeqTarget long-range PCR primers for resequencing PIP
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PIP
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PIP
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PIP
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PIP
     GenScript Custom Purified and Recombinant Proteins Services for PIP GenScript cDNA clones with any tag delivered in your preferred vector for PIP
     GenScript Custom Assay Services for PIP GenScript Superior Antibodies for PIP
     GenScript Custom overexpressing Cell Line Services for PIP CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PIP promoter
     Search Chromatin IP Primers for PIP
     RT2 qPCR Primer Assay in human, mouse, rat PIP
     GNC Network for PIP
     SABiosciences PCR Arrays including human, mouse, rat PIP
     Search Tocris compounds for PIP
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for PIP
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     PIP antibodies
     PIP proteins
     PIP lysates
     Antibodies for PIP
     See all of Abcam's Antibodies, Kits and Proteins for PIP
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for PIP
     Antibodies for PIP
     ELISAs for PIP
     CLIAs for PIP
     Search LifeMap BioReagents cell lines for PIP
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP
     Browse SwitchGear 3'UTR luciferase reporter plasmids for PIP
     SwitchGear Promoter luciferase reporter plasmids for PIP
     ThermoFisher Antibody for PIP
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP
     inGenious Targeting Laboratory - Custom generated mouse model solutions for PIP
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PIP
    Customized:
     lentivirus for stable overexpression of PIP
     lentivirus expression plasmids for stable overexpression of PIP
     adenovirus for overexpression of PIP
     LSBio Antibodies in human, mouse, rat for PIP
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      PIP gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4