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Aliases for PIP Gene

Aliases for PIP Gene

  • Prolactin-Induced Protein 2 3 4
  • Gross Cystic Disease Fluid Protein 15 3 4
  • Secretory Actin-Binding Protein 3 4
  • Prolactin-Inducible Protein 2 3
  • GCDFP-15 3 4
  • GCDFP15 3 4
  • GPIP4 3 4
  • SABP 3 4
  • Gp17 4

External Ids for PIP Gene

Previous GeneCards Identifiers for PIP Gene

  • GC07P141155
  • GC07P142221
  • GC07P142300
  • GC07P142346
  • GC07P142539
  • GC07P142829
  • GC07P137167

Summaries for PIP Gene

GeneCards Summary for PIP Gene

PIP (Prolactin-Induced Protein) is a Protein Coding gene. Diseases associated with PIP include fox fordyce disease and eccrine adenocarcinoma. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include actin binding.

Gene Wiki entry for PIP Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIP Gene

Genomics for PIP Gene

Regulatory Elements for PIP Gene

Genomic Location for PIP Gene

143,132,077 bp from pter
143,139,746 bp from pter
7,670 bases
Plus strand

Genomic View for PIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIP Gene

Proteins for PIP Gene

  • Protein details for PIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Prolactin-inducible protein
    Protein Accession:
    Secondary Accessions:
    • A0A963
    • A0A9C3
    • A0A9F3
    • A4D2I1

    Protein attributes for PIP Gene

    146 amino acids
    Molecular mass:
    16572 Da
    Quaternary structure:
    • Monomer. Interacts with AZGP1.

    Three dimensional structures from OCA and Proteopedia for PIP Gene

neXtProt entry for PIP Gene

Proteomics data for PIP Gene at MOPED

Post-translational modifications for PIP Gene

  • Glycosylation at Asn105
  • Modification sites at PhosphoSitePlus

Other Protein References for PIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PIP Gene

Domains for PIP Gene

Protein Domains for PIP Gene


Suggested Antigen Peptide Sequences for PIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P12273
  • Belongs to the PIP family.
genes like me logo Genes that share domains with PIP: view

No data available for Gene Families for PIP Gene

Function for PIP Gene

Molecular function for PIP Gene

GENATLAS Biochemistry: prolactin-induced protein
UniProtKB/Swiss-Prot Induction: By prolactin and androgen; inhibited by estrogen

Gene Ontology (GO) - Molecular Function for PIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 18930737
GO:0003779 actin binding NAS 2013294
GO:0004190 aspartic-type endopeptidase activity IMP 10713110
GO:0005515 protein binding IPI 22720776
GO:0019864 IgG binding IDA 14638438
genes like me logo Genes that share ontologies with PIP: view
genes like me logo Genes that share phenotypes with PIP: view

Animal Models for PIP Gene

MGI Knock Outs for PIP:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for PIP Gene

Localization for PIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIP Gene


Subcellular locations from

Jensen Localization Image for PIP Gene COMPARTMENTS Subcellular localization image for PIP gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 10713110
GO:0005634 nucleus IDA 21630459
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PIP: view

Pathways for PIP Gene

genes like me logo Genes that share pathways with PIP: view

Pathways by source for PIP Gene

Gene Ontology (GO) - Biological Process for PIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0001895 retina homeostasis IEP 23580065
GO:0002682 regulation of immune system process IEA --
GO:0006508 proteolysis IMP 10713110
GO:0010628 positive regulation of gene expression IDA 10072505
genes like me logo Genes that share ontologies with PIP: view

Compounds for PIP Gene

(14) Novoseek inferred chemical compound relationships for PIP Gene

Compound -log(P) Hits PubMed IDs
progesterone 62.8 20
estrogen 62.6 33
b 723 61.3 9
mucicarmine 53.8 1
progestins 40.5 3
genes like me logo Genes that share compounds with PIP: view

Transcripts for PIP Gene

mRNA/cDNA for PIP Gene

(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PIP Gene

Prolactin-induced protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PIP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIP Gene

No ASD Table

Relevant External Links for PIP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIP Gene

mRNA expression in normal human tissues for PIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PIP Gene

This gene is overexpressed in Minor Salivary Gland (47.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIP Gene

SOURCE GeneReport for Unigene cluster for PIP Gene Hs.99949

mRNA Expression by UniProt/SwissProt for PIP Gene

Tissue specificity: Expressed in pathological conditions of the mammary gland and in several exocrine tissues, such as the lacrimal, salivary, and sweat glands
genes like me logo Genes that share expressions with PIP: view

In Situ Assay Products

Orthologs for PIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for PIP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PIP 35
  • 98.4 (n)
  • 97.26 (a)
PIP 36
  • 97 (a)
(Bos Taurus)
Mammalia PIP 36
  • 64 (a)
(Canis familiaris)
Mammalia PIP 35
  • 66.67 (n)
  • 50 (a)
PIP 36
  • 50 (a)
(Mus musculus)
Mammalia Pip 35
  • 60.24 (n)
  • 48.57 (a)
Pip 16
Pip 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
-- 36
  • 36 (a)
(Rattus norvegicus)
Mammalia Pip 35
  • 58.21 (n)
  • 45.52 (a)
Species with no ortholog for PIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PIP Gene

Gene Tree for PIP (if available)
Gene Tree for PIP (if available)

Paralogs for PIP Gene

No data available for Paralogs for PIP Gene

Variants for PIP Gene

Sequence variations from dbSNP and Humsavar for PIP Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs186401 -- 143,134,718(-) CACTT(C/T)CTGAT intron-variant
rs315281 -- 143,134,546(+) gatta(C/T)ggcca intron-variant
rs315282 -- 143,134,445(+) gtttt(A/C)catag intron-variant
rs315283 -- 143,133,530(-) TTTCT(C/T)GTCCC intron-variant
rs315284 -- 143,130,861(+) GAGAA(A/G)GTAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PIP Gene

Variant ID Type Subtype PubMed ID
nsv465175 CNV Loss 19166990
dgv432n21 CNV Loss 19592680
esv2675537 CNV Deletion 23128226
nsv465176 CNV Loss 19166990

Relevant External Links for PIP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIP Gene

Disorders for PIP Gene

(33) Novoseek inferred disease relationships for PIP Gene

Disease -log(P) Hits PubMed IDs
carcinoma lobular 76.4 5
breast carcinoma 75.7 44
fibrocystic breast disease 75.3 7
extramammary pagets disease 74.1 1
breast cysts 73.4 2

Relevant External Links for PIP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PIP: view

No data available for UniProtKB/Swiss-Prot for PIP Gene

Publications for PIP Gene

  1. The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. (PMID: 1955075) Myal Y. … Shiu R.P.C. (Mol. Cell. Endocrinol. 1991) 2 3 4 23
  2. Primary structure of a new actin-binding protein from human seminal plasma. (PMID: 2013294) Schaller J. … Rickli E.E. (Eur. J. Biochem. 1991) 3 4 23
  3. Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PMID: 18930737) Hassan M.I. … Singh T.P. (J. Mol. Biol. 2008) 3 4 23
  4. CLC- a novel susceptibility gene for allergic rhinitis? (PMID: 19650845) Bryborn M. … Cardell L.O. (Allergy 2010) 3 23 48
  5. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. (PMID: 19217055) Yan Z. … Chhieng D.C. (Diagn. Cytopathol. 2009) 3 23

Products for PIP Gene

Sources for PIP Gene

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