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PIP Gene

protein-coding   GIFtS: 57
GCID: GC07P142829

Prolactin-Induced Protein

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Prolactin-Induced Protein1 2 3     GCDFP152 3
Prolactin-Inducible Protein1 2     GPIP42 3
Gross Cystic Disease Fluid Protein 152 3     SABP2 3
Secretory Actin-Binding Protein2 3     gp173
GCDFP-152 3     

External Ids:    HGNC: 89931   Entrez Gene: 53042   Ensembl: ENSG000001597637   OMIM: 1767205   UniProtKB: P122733   

Export aliases for PIP gene to outside databases

Previous GC identifers: GC07P141155 GC07P142221 GC07P142300 GC07P142346 GC07P142539 GC07P137167


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for PIP Gene:
PIP (prolactin-induced protein) is a protein-coding gene. Diseases associated with PIP include florid papillomatosis of the nipple, and eccrine adenocarcinoma. GO annotations related to this gene include actin binding.

Gene Wiki entry for PIP (Prolactin-induced protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the PIP gene promoter:
         TBP   p53   NCX/Ncx   MyoD   STAT5A   Ik-3   FOXL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPIP promoter sequence
   Search Chromatin IP Primers for PIP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PIP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

PIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PIP gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P142829:  view genomic region     (about GC identifiers)

Start:
142,829,170 bp from pter      End:
142,836,839 bp from pter
Size:
7,670 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 142,231,068-142,238,728     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PIP_HUMAN, P12273 (See protein sequence)
Recommended Name: Prolactin-inducible protein precursor  
Size: 146 amino acids; 16572 Da
Subunit: Monomer. Interacts with AZGP1
1 PDB 3D structure from and Proteopedia for PIP:
3ES6 (3D)    
Secondary accessions: A0A963 A0A9C3 A0A9F3 A4D2I1

Explore the universe of human proteins at neXtProt for PIP: NX_P12273

Explore proteomics data for PIP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn105

  • See PIP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002643.1  
    ENSEMBL proteins: 
     ENSP00000291009  

    PIP Human Recombinant Protein Products:

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    Novus Biologicals PIP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for PIP
    Cloud-Clone Corp. Proteins for PIP

    PIP Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals PIP Antibodies
    Abcam antibodies for PIP
    Cloud-Clone Corp. Antibodies for PIP
    ThermoFisher Antibody for PIP
    LSBio Antibodies in human, mouse, rat for PIP

    PIP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for PIP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for PIP
    Cloud-Clone Corp. CLIAs for PIP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007990 SV_autoAg
     IPR014756 Ig_E-set

    Graphical View of Domain Structure for InterPro Entry P12273

    ProtoNet protein and cluster: P12273

    UniProtKB/Swiss-Prot: PIP_HUMAN, P12273
    Similarity: Belongs to the PIP family


    PIP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PIP_HUMAN, P12273
    Induction: By prolactin and androgen; inhibited by estrogen

         Genatlas biochemistry entry for PIP:
    prolactin-induced protein

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IPI18930737
    GO:0003779actin binding NAS2013294
    GO:0004190aspartic-type endopeptidase activity IMP10713110
    GO:0005515protein binding ----
    GO:0019864IgG binding IDA14638438
         
    PIP for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for PIP:
     Decreased influenza A virus in  Increased cell death HMECs cel  Increased cell death in breast 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pip):
     cardiovascular system  cellular  digestive/alimentary  endocrine/exocrine gland  hematopoietic system 
     immune system  reproductive system 

    PIP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Piptm1Myal for PIP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PIP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for PIP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PIP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PIP

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat PIP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for PIP
    Predesigned siRNA for gene silencing in human, mouse, rat PIP

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for PIP

    Clone
    Products:
         
    OriGene clones in human, mouse for PIP (see all 5)
    OriGene ORF clones in mouse, rat for PIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIP (NM_002652)
    Sino Biological Human cDNA Clone for PIP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PIP

    Cell Line
    Products:
         
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    Browse ESI BIO Cell Lines and PureStem Progenitors for PIP 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PIP_HUMAN, P12273: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    plasma membrane2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA10713110
    GO:0016324apical plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    PIP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PIP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    RAR-Gamma-RXR-Alpha Degradation0.62
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PIP (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PIP
    Interactions:

        GeneGlobe Interaction Network for PIP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for PIP (P122731, 3 ENSP000002910094) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WBP5Q9UHQ71, 3, ENSP000003617404EBI-1049746,EBI-1051372 I2D: score=1 STRING: ENSP00000361740
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SPI1P179473, ENSP000002271634I2D: score=1 STRING: ENSP00000227163
    USP25Q9UHP33, ENSP000002856794I2D: score=2 STRING: ENSP00000285679
    USPL1Q5W0Q73, ENSP000002553044I2D: score=2 STRING: ENSP00000255304
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste IDA--
    GO:0001895retina homeostasis IEP--
    GO:0006508proteolysis IMP10713110
    GO:0010628positive regulation of gene expression IDA10072505
    GO:0070233negative regulation of T cell apoptotic process IMP10072505

    PIP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PIP

    Selected Novoseek inferred chemical compound relationships for PIP gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 62.8 23 10672061 (1), 11447997 (1), 15365364 (1), 10576657 (1) (see all 20)
    estrogen 62.6 37 20173733 (3), 2269395 (2), 9426521 (2), 11117786 (2) (see all 28)
    b 723 61.3 13 17004974 (5), 1370877 (2), 1556271 (1), 11940224 (1)
    mucicarmine 53.8 1 9870855 (1)
    progestins 40.5 6 2142871 (1), 1446056 (1), 1551135 (1)
    bicalutamide 35.9 1 10402478 (1)
    tamoxifen 31.7 3 1930624 (3)
    dihydrotestosterone 30.2 7 7927949 (2), 7558422 (2), 10402478 (1)
    testosterone 19.2 11 1955075 (3), 9111629 (1), 10402478 (1), 9831198 (1) (see all 5)
    androstenedione 8.73 1 9111629 (1)



    PIP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PIP gene: 
    NM_002652.2  

    Unigene Cluster for PIP:

    Prolactin-induced protein
    Hs.99949  [show with all ESTs]
    Unigene Representative Sequence: BF965123
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000291009(uc003wcf.1)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat PIP using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate PIP
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for PIP
    Predesigned siRNA for gene silencing in human, mouse, rat PIP
    Clone
    Products:
         
    OriGene clones in human, mouse for PIP (see all 5)
    OriGene ORF clones in mouse, rat for PIP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: PIP (NM_002652)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for PIP
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat PIP
      QuantiTect SYBR Green Assays in human, mouse, rat PIP
      QuantiFast Probe-based Assays in human, mouse, rat PIP

    Additional mRNA sequence: 

    AK312227.1 BC010950.1 BC010951.1 J03460.1 Y10179.1 

    6 DOTS entries:

    DT.99946855  DT.408915  DT.100678499  DT.100717527  DT.75156109  DT.91667251 

    5 AceView cDNA sequences:

    Y10179 NM_002652 BC010950 J03460 BC010951 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PIP expression in normal human tissues (normalized intensities)      PIP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTAAAAAAA
    PIP Expression
    About this image


    PIP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
    PIP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PIP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99949

    UniProtKB/Swiss-Prot: PIP_HUMAN, P12273
    Tissue specificity: Expressed in pathological conditions of the mammary gland and in several exocrine tissues,
    such as the lacrimal, salivary, and sweat glands

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PIP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for PIP gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pip1 , 5 prolactin induced protein1, 5 60.24(n)1
    48.57(a)1
      6 (20.05 cM)5
    187161  NM_008843.31  NP_032869.21 
     418475495 


    ENSEMBL Gene Tree for PIP (if available)
    TreeFam Gene Tree for PIP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PIP (see all 226)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1883861341,2
    --142827267(+) GTCAGG/TAATGT 1 -- us2k10--------
    rs3152861,2
    C,A,H--142827282(+) TCAGCT/CTGGCC 1 -- us2k17Minor allele frequency- C:0.12WA NA CSA EA 248
    rs1388909341,2
    --142827332(+) TAGCCA/GGGTAT 1 -- us2k10--------
    rs1920783771,2
    --142827346(+) GGCACC/TTGCCT 1 -- us2k10--------
    rs2018077991,2
    C--142827367(+) CTACTC/TGGGTG 1 -- us2k10--------
    rs3152851,2
    C,F--142827433(+) tcatgC/Tcactg 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1448455661,2
    C--142827435(+) ATGCCA/GCTGCA 1 -- us2k10--------
    rs1384582181,2
    --142827904(+) CTGAAC/GTTCTG 1 -- us2k10--------
    rs3152841,2
    C,F,A,H--142827954(+) GAGAAG/AGTAGA 1 -- us2k1 tfbs3 trp322Minor allele frequency- A:0.33NS EA NA WA CSA 2249
    rs1415528171,2
    --142828069(+) GAGGCA/GGTAAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for PIP (142829170 - 142836839 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PIP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675537CNV Deletion23128226
    nsv465176CNV Loss19166990
    nsv465175CNV Loss19166990
    dgv432n21CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PIP
    DNA2.0 Custom Variant and Variant Library Synthesis for PIP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 176720    OMIM disorders: --

    Selected diseases for PIP (see all 37):    About MalaCards
    florid papillomatosis of the nipple    eccrine adenocarcinoma    fox fordyce disease    cribriform carcinoma
    rectum adenocarcinoma    apocrine adenocarcinoma    hidrocystoma    cell type cancer
    syringocystadenoma papilliferum    mixed cell type cancer    microglandular adenosis    breast cyst
    papillary adenocarcinoma    sweat gland carcinoma    ductal carcinoma in situ    hidradenitis suppurativa
    merkel cell carcinoma    hidradenoma    phyllode tumor    hidradenitis

    9 diseases from the University of Copenhagen DISEASES database for PIP:
    Breast cancer     Carcinoma     Hidradenoma     Hidrocystoma
    Syringocystadenoma papilliferum     Skin cancer     Breast cyst     Fox fordyce disease
    Breast disease

    PIP for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for PIP gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma lobular 76.4 5 10672061 (3), 19556822 (1), 1592388 (1)
    breast carcinoma 75.7 52 19217055 (5), 17145637 (4), 18251583 (4), 7722013 (4) (see all 26)
    fibrocystic breast disease 75.3 9 7829219 (2), 2357014 (1), 7850069 (1), 2058763 (1) (see all 6)
    extramammary pagets disease 74.1 1 8599433 (1)
    breast cysts 73.4 2 11992405 (1), 11029771 (1)
    carcinoma ductal 72.2 2 15569980 (1), 18753974 (1)
    carcinoma 61.6 39 16045781 (7), 17004974 (3), 18339419 (3), 8248106 (3) (see all 15)
    ductal breast carcinoma 60.9 1 8248106 (1)
    breast cancer 60.1 56 11029771 (5), 7558422 (3), 11992405 (2), 10576657 (2) (see all 27)
    metastatic carcinoma 59.7 5 18251583 (2), 7945916 (1), 7722013 (1)

    Genetic Association Database (GAD): PIP
    Human Genome Epidemiology (HuGE) Navigator: PIP (7 documents)

    Export disorders for PIP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PIP gene, integrated from 10 sources (see all 203):
    (articles sorted by number of sources associating them with PIP)
        Utopia: connect your pdf to the dynamic
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    1. The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation. (PubMed id 1955075)1, 2, 3, 9 Myal Y.... Shiu R.P.C. (Mol. Cell. Endocrinol. 1991)
    2. Crystal structure of the novel complex formed between zinc alpha2- glycoprotein (ZAG) and prolactin-inducible protein (PIP) from human seminal plasma. (PubMed id 18930737)1, 2, 9 Hassan M.I....Singh T.P. (J. Mol. Biol. 2008)
    3. Primary structure of a new actin-binding protein from human seminal plasma. (PubMed id 2013294)1, 2, 9 Schaller J.... Rickli E.E. (Eur. J. Biochem. 1991)
    4. CLC- a novel susceptibility gene for allergic rhinitis? (PubMed id 19650845)1, 4, 9 Bryborn M....Cardell L.O. (Allergy 2010)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    8. Isolation from a human seminal vesicle library of the cDNA for gp17, a CD4 binding factor. (PubMed id 9218538)1, 2 Autiero M.... Piatier-Tonneau D. (Immunogenetics 1997)
    9. The gene for prolactin-inducible protein (PIP), uniquely expressed in exocrine organs, maps to chromosome 7. (PubMed id 2727805)1, 3 Myal Y....Shiu R.P. (Somat. Cell Mol. Genet. 1989)
    10. Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D. (PubMed id 3667631)1, 2 Murphy L.C.... Shiu R.P.C. (J. Biol. Chem. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5304 HGNC: 8993 AceView: PIP Ensembl:ENSG00000159763 euGenes: HUgn5304
    ECgene: PIP H-InvDB: PIP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PIP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PIP gene:
    Search GeneIP for patents involving PIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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