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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PION Gene

protein-coding   GIFtS: 44
GCID: GC07M076940

pigeon homolog (Drosophila)
 Explore 4 diseases affiliated with
PION via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for PION    

Aliases
for PION gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Pigeon Homolog (Drosophila)1 2
GSAP2 3 5
Protein Pigeon Homolog2 3
LOC541031
Gamma-Secretase-Activating Protein2

External Ids:    HGNC: 280421   Entrez Gene: 541032   Ensembl: ENSG000001860887   OMIM: 6135525   UniProtKB: A4D1B53   

Export aliases for PION gene to outside databases

Previous GC identifers: GC07M076779 GC07M071542


Summaries
for PION gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for PION:
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of
amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or
GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both
gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF)
(He et al., 2010 (PubMed 20811458)).(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: GSAP_HUMAN, A4D1B5
Function: Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein
(beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets
such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of
integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the
gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it
reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD

Gene Wiki entry for PION (Protein pigeon homolog)


Genomic Views
for PION gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PION gene promoter:
         ER-alpha   AhR   LCR-F1   E47   YY1   Arnt   POU2F1   POU2F1a   Sox9   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): PION promoter sequence
   Search SABiosciences Chromatin IP Primers for PION

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PION


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

PION Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PION gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M076940:  view genomic region     (about GC identifiers)

Start:
 76,940,068 bp from pter      End:
 77,046,115 bp from pter
Size:
 106,048 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 76,273,131-76,378,780     

Proteins
for PION gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GSAP_HUMAN, A4D1B5 (See protein sequence)
Recommended Name: Gamma-secretase-activating protein  
Size: 854 amino acids; 97802 Da
Subunit: Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the
gamma-secretase complex
Subcellular location: Golgi apparatus, trans-Golgi network
Miscellaneous: The gamma-secretase regulator activity is specifically inhibited by imatinib (also known as STI571 or
Gleevec), an anticancer drug that selectively decreases beta-amyloid protein production. Imatinib binds PION/GSAP and
acts by preventing PION/GSAP interaction with the gamma-secretase substrate, CTF-alpha (PubMed:20811458)
Miscellaneous: Its role as an activator of beta-amyloid protein production makes it a promising therapeutic target for
the treatment of Alzheimer disease (PubMed:20811458)
Sequence caution: Sequence=CAD39023.2; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D1B6 Q3MJC0 Q8ND73 Q9UMH3 Q9Y4L9
Alternative splicing: 4 isoforms:  A4D1B5-1   A4D1B5-2   A4D1B5-3   A4D1B5-4   

Explore the universe of human proteins at neXtProt for PION: NX_A4D1B5

Post-translational modifications:

  • The protein is first synthesized as a holoprotein form of 98 kDa and rapidly processed into the
    • gamma-secretase-activating protein 16 kDa C-terminal form, which constitutes the predominant form1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_A4D1B5

    • PION Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_059135.2  
    ENSEMBL proteins: 
     ENSP00000257626   ENSP00000396230   ENSP00000402748   ENSP00000415402  

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    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus IEA--
    GO:0005802trans-Golgi network IDA--


    PION for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for PION

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    Protein Domains /
    Families
    for PION gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PION for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026172 GSAP_fam

    Graphical View of Domain Structure for InterPro Entry A4D1B5

    ProtoNet protein and cluster: A4D1B5

    UniProtKB/Swiss-Prot: GSAP_HUMAN, A4D1B5
    Similarity: Belongs to the GSAP family


    Function
    for PION gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GSAP_HUMAN, A4D1B5
    Function: Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein
    (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets
    such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of
    integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the
    gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it
    reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PION
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate PION:
    hsa-miR-186 hsa-miR-205* hsa-miR-4263 hsa-miR-944 hsa-miR-551b* hsa-miR-340 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmid: PION 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PION (see all 3)
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001540beta-amyloid binding IDA--


    PION for ontologies           About GeneDecksing



    Pathways & Interactions
    for PION gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PION

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for PION (ENSP000002576264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPENSP000002849814STRING: ENSP00000284981
    PSENENENSP000002222664STRING: ENSP00000222266
    NCSTNENSP000002947854STRING: ENSP00000294785
    PSEN1ENSP000003263664STRING: ENSP00000326366
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030162regulation of proteolysis IDA--
    GO:0034205beta-amyloid formation IDA--


    PION for ontologies           About GeneDecksing



    Drugs & Compounds
    for PION gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PION
    Search CenterWatch for drugs/clinical trials and news about PION / GSAP 

    Transcripts
    for PION gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PION gene: 
    NM_017439.3  

    Unigene Cluster for PION:

    Pigeon homolog (Drosophila)
    Hs.186649  [show with all ESTs]
    Unigene Representative Sequence: NM_017439
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491796(uc011kgo.2 uc003ugd.3) ENST00000449779 ENST00000257626(uc003ugf.3)
    ENST00000482866 ENST00000474686 ENST00000440473 ENST00000415112 ENST00000426477
    ENST00000489920 ENST00000334003(uc003ugg.1) ENST00000434084 ENST00000430584
    ENST00000463274 ENST00000441833

    miRNA
    Products:             		 OriGene 3'-UTR Clone: PION
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PION
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate PION:
    hsa-miR-186 hsa-miR-205* hsa-miR-4263 hsa-miR-944 hsa-miR-551b* hsa-miR-340 hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmid: PION 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PION (see all 6)
    Browse OriGene siRNA
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    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PION
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PION
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PION

    Additional cDNA sequence: 

    AK026696.1 AK026747.1 AL079277.1 AL079297.1 BC101499.1 BC110797.1 BC143549.1 

    13 DOTS entries:

    DT.95362180  DT.100754581  DT.40108249  DT.112421  DT.121124714  DT.40193617  DT.95151960  DT.204563 
    DT.107632  DT.107633  DT.40131327  DT.91877891  DT.92421396 

    24/125 AceView cDNA sequences (see all 125):

    AA906285 AI864510 CA421451 AK027188 BM697969 AA278908 CD368605 N69305 
    BX113245 BQ270239 CF528284 BM974725 AA278436 AI076075 AI459242 BQ268290 
    AA812099 AI032544 AI866270 AW192082 BX280226 AW150708 AA515264 AI866927 

    GeneLoc Exon Structure


    Expression
    for PION gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PION expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCAGTACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PION expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PION Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PION

    SOURCE GeneReport for Unigene cluster: Hs.186649

    UniProtKB/Swiss-Prot: GSAP_HUMAN, A4D1B5
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:     
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    Orthologs
    for PION gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for PION gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Pion1 , 5 pigeon homolog (Drosophila)1, 5 79.92(n)1
    75.29(a)1    		   5 (9.83 cM)5
    2121671  NM_175437.31  NP_780646.21 
     211862675 
    chicken
    (Gallus gallus)    		 Aves PION1 pigeon homolog (Drosophila) 65.83(n)
    57.86(a)    		   417724  XM_415969.3  XP_415969.3 
    lizard
    (Anolis carolinensis)    		 Reptilia PION6
    		 --
    		 52(a)
    		 1 ↔ 1
    		 5(95027972-95086361)
    zebrafish
    (Danio rerio)    		 Actinopterygii pion1 pigeon homolog (Drosophila) 53.85(n)
    44.02(a)    		   100151358  XM_001923103.2  XP_001923138.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pigeon1 CG10739-PA 39.85(n)
    24.87(a)    		   35200  NM_057598.4  NP_476946.1 


    ENSEMBL Gene Tree for PION (if available)
    TreeFam Gene Tree for PION (if available) 

    Paralogs
    for PION gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for PION gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1921 NCBI SNPs in PION are shown (see all 1921)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1112692341,2
    		--71542882(+) ATGGCC/TAAACA 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs11398021,2
    		C,F,O,A,H,--71542942(-) CTCCTT/CTGAGA 1 -- int120Minor allele frequency- C:0.24NA NS EA WA CSA 2031
    rs767901231,2
    		F,--71543273(+) AATGGG/ACTTTA 1 -- int11Minor allele frequency- A:0.05NA 120
    rs737033221,2
    		C,--71543361(+) GTAAAC/TCAATT 1 -- int12Minor allele frequency- T:0.21WA 120
    rs737033231,2
    		C,--71543401(+) GATTTC/TGGAAA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs731419221,2
    		C,--71543431(+) GGGAAA/GGACTG 1 -- int10--------
    rs171515451,2
    		C,F,H,--71543669(+) AATTGC/TTGTCC 1 -- int124Minor allele frequency- T:0.05NA NS EA WA CSA 2234
    rs69740891,2
    		C,F,H,--71544213(+) CTTGCC/TTAGAA 1 -- int121Minor allele frequency- T:0.04NS EA NA CSA WA 1946
    rs178059361,2
    		C,F,H,--71544525(+) AGGCTC/TGGAAG 1 -- int116Minor allele frequency- T:0.04NA NS EA 1926
    rs763168641,2
    		F,--71544991(+) GGACGG/TGTGGG 1 -- int11Minor allele frequency- T:0.05NA 120

    HapMap Linkage Disequilibrium report for PION (76940068 - 77046115 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PION
         1 Indel: 12937

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PION
    DNA2.0 Custom Variant and Variant Library Synthesis for PION

    Disorders / Diseases
    for PION gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PION for disorders           About GeneDecksing

    OMIM gene information: 613552    OMIM disorders: --

    4 diseases for PION:    About MalaCards
    alzheimer's disease    ischemic optic neuropathy    temporal arteritis    neuropathy


    Export disorders for PION gene to outside databases

    Publications
    for PION gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PION gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PION)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2, 3 Scherer S.W.... Tsui L.-C. (2003)
    2. Gamma-secretase activating protein is a therapeutic t arget for Alzheimer's disease. (PubMed id 20811458)1, 2 He G....Greengard P. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 3 Ota T.... Sugano S. (2004)
    4. Purification and characterization of the human g-secre tase activating protein. (PubMed id 22681044)1 Deatherage C.L....Sanders C.R. (2012)
    5. Immunohistochemical characterization of g-secretase ac tivating protein expression in Alzheimer's disease brains. (PubMed id 21718343)1 Satoh J....Arima K. (2012)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for PION gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing PION gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54103 HGNC: 28042 AceView: LOC54103 Ensembl:ENSG00000186088 euGenes: HUgn54103
    ECgene: PION H-InvDB: PION

    Other Databases showing PION gene

    (According to HUGE)
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    Specialized Databases showing PION gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PION Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PION gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PION gene:
    Search GeneIP for patents involving PION

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