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PINK1 Gene(Protein Coding)

PTEN Induced Putative Kinase 1

GCID:
GC01P020634
GIFtS:
58
Genes Participants
UDN Logo

Aliases for PINK1 Gene

Aliases for PINK1 Gene

  • PTEN Induced Putative Kinase 1 2 3 5
  • PTEN-Induced Putative Kinase Protein 1 3 4
  • BRPK 3 4
  • Serine/Threonine-Protein Kinase PINK1, Mitochondrial 3
  • Parkinson Disease (Autosomal Recessive) 6 2
  • Protein Kinase BRPK 3
  • EC 2.7.11.1 4
  • PARK6 3

External Ids for PINK1 Gene

Previous HGNC Symbols for PINK1 Gene

  • PARK6

Previous GeneCards Identifiers for PINK1 Gene

  • GC01P020530
  • GC01P019995
  • GC01P020105
  • GC01P020429
  • GC01P020705
  • GC01P020832
  • GC01P020959
  • GC01P019206

Summaries for PINK1 Gene

Entrez Gene Summary for PINK1 Gene

  • This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for PINK1 Gene

PINK1 (PTEN Induced Putative Kinase 1) is a Protein Coding gene. Diseases associated with PINK1 include Parkinson Disease 6, Autosomal Recessive Early-Onset and Parkinson Disease 2, Autosomal Recessive Juvenile. Among its related pathways are Pink/Parkin Mediated Mitophagy and Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.

UniProtKB/Swiss-Prot for PINK1 Gene

  • Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at Ser-65 of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).

Gene Wiki entry for PINK1 Gene

Additional gene information for PINK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PINK1 Gene

Genomics for PINK1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for PINK1 Gene

Promoters and enhancers for PINK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01I020632 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 580.4 +0.6 559 2.5 PKNOX1 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF766 ZNF213 ZNF143 KLF13 PINK1 MIR6084 CDA PIR40855
GH01I020610 Enhancer 1.3 Ensembl ENCODE dbSUPER 37.5 -20.5 -20470 4.2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 FOS DEK PINK1 CDA OTUD3 FAM43B DDOST GC01P020619
GH01I020588 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 17.9 -43.4 -43424 3.5 HDAC1 PKNOX1 ATF1 FOXA2 KLF17 ZBTB7B RAD21 YY1 ZNF335 EGR1 CDA PINK1 FAM43B MUL1 GC01P020619
GH01I020601 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -30.1 -30140 4.2 USF1 FOXA2 NFRKB JUN ZNF266 MAX YY1 POLR2A HNF4G ZNF143 CDA PINK1 HP1BP3 DDOST GC01P020619
GH01I020575 Enhancer 1.1 ENCODE dbSUPER 12.3 -58.0 -58022 0.2 PKNOX1 ARNT ARID4B SIN3A ZNF2 GLIS2 GATA2 ZNF143 DEK RXRA PINK1 CDA MUL1 FAM43B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PINK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PINK1 gene promoter:

Genomic Locations for PINK1 Gene

Genomic Locations for PINK1 Gene
chr1:20,633,455-20,651,511
(GRCh38/hg38)
Size:
18,057 bases
Orientation:
Plus strand
chr1:20,959,948-20,978,004
(GRCh37/hg19)

Genomic View for PINK1 Gene

Genes around PINK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PINK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PINK1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PINK1 Gene

Proteins for PINK1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for PINK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXM7-PINK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase PINK1, mitochondrial
    Protein Accession:
    Q9BXM7
    Secondary Accessions:
    • Q8N6T9
    • Q8NBU3
    • Q96DE4

    Protein attributes for PINK1 Gene

    Size:
    581 amino acids
    Molecular mass:
    62769 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PRKN. Interacts with FBXO7. Forms a complex with PRKN and PARK7 (PubMed:19229105).

    Alternative splice isoforms for PINK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PINK1 Gene

Protein Expression for PINK1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PINK1 Gene

  • Autophosphorylation at Ser-228 and Ser-402 is essential for Parkin/PRKN recruitment to depolarized mitochondria.
  • Two shorter forms of 55 kDa and 48 kDa seem to be produced by proteolytic cleavage and localize mainly in cytosol.

Other Protein References for PINK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PINK1 Gene

Domains & Families for PINK1 Gene

Gene Families for PINK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PINK1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PINK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXM7

UniProtKB/Swiss-Prot:

PINK1_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PINK1: view

Function for PINK1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for PINK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at Ser-65 of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).

Enzyme Numbers (IUBMB) for PINK1 Gene

Phenotypes From GWAS Catalog for PINK1 Gene

Gene Ontology (GO) - Molecular Function for PINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA,IDA 14607334
GO:0002020 protease binding TAS 24522549
GO:0004672 protein kinase activity IMP 25527497
GO:0004674 protein serine/threonine kinase activity TAS 24522549
genes like me logo Genes that share ontologies with PINK1: view
genes like me logo Genes that share phenotypes with PINK1: view

Human Phenotype Ontology for PINK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PINK1 Gene

MGI Knock Outs for PINK1:

miRNA for PINK1 Gene

miRTarBase miRNAs that target PINK1

No data available for Transcription Factor Targets and HOMER Transcription for PINK1 Gene

Localization for PINK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PINK1 Gene

Mitochondrion outer membrane; Single-pass membrane protein. Mitochondrion inner membrane; Single-pass membrane protein. Cytoplasm, cytosol. Note=Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol. {ECO:0000269 PubMed:19229105}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PINK1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
cytoskeleton 4
lysosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 colocalizes_with ubiquitin ligase complex ISS --
GO:0000785 chromatin IDA 24798695
GO:0005634 nucleus IDA 24798695
GO:0005737 cytoplasm IDA 16702191
GO:0005739 colocalizes_with mitochondrion IMP 24184327
genes like me logo Genes that share ontologies with PINK1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PINK1 Gene

Pathways & Interactions for PINK1 Gene

genes like me logo Genes that share pathways with PINK1: view

Pathways by source for PINK1 Gene

1 Cell Signaling Technology pathway for PINK1 Gene
1 BioSystems pathway for PINK1 Gene
2 Reactome pathways for PINK1 Gene
2 KEGG pathways for PINK1 Gene
1 Qiagen pathway for PINK1 Gene

SIGNOR curated interactions for PINK1 Gene

Activates:

Gene Ontology (GO) - Biological Process for PINK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 autophagy of mitochondrion IMP 20798600
GO:0001934 positive regulation of protein phosphorylation IEA,IDA 25244949
GO:0002082 regulation of oxidative phosphorylation IDA 20871098
GO:0002931 response to ischemia IEA --
GO:0006468 protein phosphorylation TAS 24522549
genes like me logo Genes that share ontologies with PINK1: view

Drugs & Compounds for PINK1 Gene

Products:

  1. Drug

(7) Drugs for PINK1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for PINK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PINK1: view

Transcripts for PINK1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for PINK1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(368) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PINK1 Gene

PTEN induced putative kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PINK1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: -
SP3:

Relevant External Links for PINK1 Gene

GeneLoc Exon Structure for
PINK1
ECgene alternative splicing isoforms for
PINK1

Expression for PINK1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PINK1 Gene

mRNA expression in normal human tissues for PINK1 Gene
mRNA expression by BioGPS for PINK1 GenemRNA expression by GTEx for PINK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PINK1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PINK1 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PINK1 Gene



Protein tissue co-expression partners for PINK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of PINK1 Gene:

PINK1

SOURCE GeneReport for Unigene cluster for PINK1 Gene:

Hs.389171

mRNA Expression by UniProt/SwissProt for PINK1 Gene:

Q9BXM7-PINK1_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.

Evidence on tissue expression from TISSUES for PINK1 Gene

  • Nervous system(4.7)
  • Muscle(3.2)
  • Heart(2.9)
  • Kidney(2.4)
  • Lung(2.3)
  • Liver(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PINK1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • skeletal muscle
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • eye
  • eyelid
  • face
  • head
Pelvis:
  • urethra
  • urinary bladder
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with PINK1: view

Orthologs for PINK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PINK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PINK1 33 34
  • 99.54 (n)
cow
(Bos Taurus)
 Mammalia PINK1 33 34
  • 85.72 (n)
dog
(Canis familiaris)
 Mammalia PINK1 33 34
  • 85.5 (n)
mouse
(Mus musculus)
 Mammalia Pink1 33 16 34
  • 81.98 (n)
rat
(Rattus norvegicus)
 Mammalia Pink1 33
  • 81.39 (n)
oppossum
(Monodelphis domestica)
 Mammalia PINK1 34
  • 78 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia PINK1 34
  • 71 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves PINK1 33 34
  • 66.08 (n)
zebrafish
(Danio rerio)
 Actinopterygii pink1 33 34
  • 58.32 (n)
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.10399 33
fruit fly
(Drosophila melanogaster)
 Insecta CG4523 35
  • 43 (a)
Pink1 34
  • 25 (a)
 OneToOne
worm
(Caenorhabditis elegans)
 Secernentea pink-1 33 34
  • 43.7 (n)
EEED8.9 35
  • 31 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8949 34
  • 30 (a)
 OneToOne
Species where no ortholog for PINK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PINK1 Gene

ENSEMBL:
Gene Tree for PINK1 (if available)
TreeFam:
Gene Tree for PINK1 (if available)

Paralogs for PINK1 Gene

No data available for Paralogs for PINK1 Gene

Variants for PINK1 Gene

Sequence variations from dbSNP and Humsavar for PINK1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1027341650 uncertain-significance, Parkinson Disease, Recessive 20,651,304(+) A/G 3_prime_UTR_variant
rs1043424 likely-benign, Congenital disorder of glycosylation, Parkinson Disease, Recessive 20,650,507(+) A/C coding_sequence_variant, missense_variant
rs1043443 likely-benign, Parkinson Disease, Recessive, Congenital disorder of glycosylation 20,650,887(+) T/C 3_prime_UTR_variant
rs1043502 likely-benign, Parkinson Disease, Recessive, Congenital disorder of glycosylation 20,651,255(+) T/G 3_prime_UTR_variant
rs114112086 uncertain-significance, Parkinson Disease, Recessive 20,651,040(+) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for PINK1 Gene

Variant ID Type Subtype PubMed ID
nsv1003348 CNV gain 25217958
nsv1076232 CNV deletion 25765185
nsv1126183 CNV deletion 24896259
nsv1137740 CNV deletion 24896259
nsv545731 CNV gain 21841781
nsv834369 CNV loss 17160897

Variation tolerance for PINK1 Gene

Residual Variation Intolerance Score: 77.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.23; 90.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PINK1 Gene

Human Gene Mutation Database (HGMD)
PINK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PINK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PINK1 Gene

Disorders for PINK1 Gene

MalaCards: The human disease database

(15) MalaCards diseases for PINK1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search PINK1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PINK1_HUMAN
  • Parkinson disease 6 (PARK6) [MIM:605909]: An early-onset form of Parkinson disease, a neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep. PARK6 pathogenesis involves respiratory complex I deficiency causing mitochondrial depolarization and dysfunction. Inheritance is autosomal recessive. {ECO:0000269 PubMed:15087508, ECO:0000269 PubMed:15349860, ECO:0000269 PubMed:15349870, ECO:0000269 PubMed:15505171, ECO:0000269 PubMed:15596610, ECO:0000269 PubMed:15955953, ECO:0000269 PubMed:15970950, ECO:0000269 PubMed:16009891, ECO:0000269 PubMed:16207217, ECO:0000269 PubMed:16207731, ECO:0000269 PubMed:16257123, ECO:0000269 PubMed:16401616, ECO:0000269 PubMed:16482571, ECO:0000269 PubMed:16632486, ECO:0000269 PubMed:16966503, ECO:0000269 PubMed:17030667, ECO:0000269 PubMed:18286320, ECO:0000269 PubMed:19229105, ECO:0000269 PubMed:20798600, ECO:0000269 PubMed:22043288, ECO:0000269 PubMed:22956510, ECO:0000269 PubMed:24652937, ECO:0000269 PubMed:24784582}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for PINK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PINK1: view

No data available for Genatlas for PINK1 Gene

Publications for PINK1 Gene

  1. PINK1 mutations are associated with sporadic early-onset parkinsonism. (PMID: 15349860) Valente EM … Bentivoglio AR (Annals of neurology 2004) 2 3 4 22 44 58
  2. PINK1, Parkin, and DJ-1 mutations in Italian patients with early-onset parkinsonism. (PMID: 15970950) Klein C … Pramstaller PP (European journal of human genetics : EJHG 2005) 3 4 22 44 58
  3. PINK1 (PARK6) associated Parkinson disease in Ireland. (PMID: 15505171) Healy DG … Lynch T (Neurology 2004) 3 4 22 44 58
  4. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. (PMID: 15596610) Rogaeva E … Singleton AB (Archives of neurology 2004) 3 4 22 44 58
  5. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. (PMID: 19966284) Vives-Bauza C … Przedborski S (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 22 58

Products for PINK1 Gene

  • Addgene plasmids for PINK1

Sources for PINK1 Gene

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