PINK1 Gene

Aliases
for PINK1 gene

Previous GC identifers: GC01P020530 GC01P019995 GC01P020105 GC01P020429 GC01P020705 GC01P020832 GC01P019206

Summaries
for PINK1 gene

Genomic Views
for PINK1 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_004610.19  

Browse SwitchGear Promoter luciferase reporter plasmids

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PINK1

PINK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P020959:  view genomic region     (about GC identifiers)

Proteins
for PINK1 gene

Explore the universe of human proteins at neXtProt for PINK1: NX_Q9BXM7

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PINK1 OriGene Custom Protein Services for PINK1
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	Novus Biologicals PINK1 Proteins Novus Biologicals PINK1 Lysates
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	ProSpec Recombinant Protein for PINK1
	Uscn Proteins for PINK1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of PINK1
	R&D Systems Antibodies for PINK1
	Cell Signaling Technology (CST) Antibodies for PINK1
	OriGene Antibodies (see all 2): PINK1 OriGene Custom Antibody Services for PINK1
	GenScript Custom Superior Antibodies Services for PINK1
	Novus Biologicals PINK1 Antibodies
	Abcam antibodies for PINK1
	Uscn Antibodies for PINK1
	ThermoFisher Antibodies for PINK1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PINK1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PINK1

Protein Domains /
Families
for PINK1 gene

ProtoNet protein and cluster: Q9BXM7

Function
for PINK1 gene

     Enzyme Number (IUBMB): EC 2.7.11.1¹

     Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

(inferred from 9 alleles) (MGI details for Pink1)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for PINK1

miRNA Products:		OriGene 3'-UTR Clone: PINK1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat PINK1
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate PINK1:
		hsa-miR-222* hsa-miR-532-3p
		SwitchGear 3'UTR luciferase reporter plasmid: PINK1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PINK1 (see all 7) OriGene shRNA RFP: PINK1 OriGene siRNA: PINK1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against PINK1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for PINK1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PINK1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PINK1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sirion Biotech Customized stable knockdown cell line services for PINK1  Sirion Biotech Customized inducible knockdown cell line services for PINK1 Sirion Biotech Customized stable overexpressing cell line services for PINK1 Sirion Biotech Customized inducible overexpressing cell line services for PINK1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PINK1

Pathways & Interactions
for PINK1 gene

	Super-pathway	contained gene-specific pathways
1	Neuroscience	Neuroscience 1.00
2	Parkinsons Disease Pathway	Parkinsons Disease Pathway 1.00
3	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	Parkinson's disease 0.61
4	Ubiquitinated Orc1 is degraded by the proteasome	Parkinson's Disease Pathway 0.31

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for PINK1

Parkinson's Disease Pathway

1 Cell Signaling Technology (CST) Pathway for PINK1

Neuroscience

1 BioSystems Pathway for PINK1

Parkinsons Disease Pathway

1         Kegg Pathway  (Kegg details for PINK1)

Parkinson's disease

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

Drugs & Compounds
for PINK1 gene

Transcripts
for PINK1 gene

Expression
for PINK1 gene

PINK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGCCTGGGC

About this image
See PINK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PINK1

SOURCE GeneReport for Unigene cluster: Hs.389171

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PINK1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PINK1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PINK1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PINK1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PINK1

Orthologs
for PINK1 gene

Paralogs
for PINK1 gene

Genomic Variants
for PINK1 gene

10/466 NCBI SNPs in PINK1 are shown (see all 466)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs743153601,2	C	pathogenic	19210719(+)	CTTGGA/CCATCA	2	D A	mis1		0	--	--	--	--
rs743153571,2	C	pathogenic	19212569(+)	CGAGCC/TGAGTG	2	R *	stg1		0	--	--	--	--
rs289402841,2	C	pathogenic	19217144(+)	CCTCAA/CCCCAA	2	Q H	mis1 ese3		0	--	--	--	--
rs743153551,2	C	pathogenic	19217257(+)	CCTGGA/GCCATG	2	D G	mis1		0	--	--	--	--
rs743153591,2	C	pathogenic	19217269(+)	CCGGAC/TGCTGT	2	T M	mis1		0	--	--	--	--
rs289402851,2	C	pathogenic	19218259(+)	GCTGCC/TGGAAG	2	P L	mis1 ese3		0	--	--	--	--
rs743153561,2	C	pathogenic	19221676(+)	GCCTGA/GGCAGT	2	* W	stg1		0	--	--	--	--
rs109168391,2	C,F	--	19204972(+)	tcatgA/Gacttc	1	--	us2k1 tfbs3		8		NA WA CSA EA	367
rs785137541,2		--	19205073(+)	GATTAA/GCCAGC	1	--	us2k1		1		WA	118
rs801185001,2		--	19205090(+)	GGAAGG/TCCTCT	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for PINK1 (20959948 - 20978004 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for PINK1: --
Human Gene Mutation Database (HGMD): PINK1

Locus Specific Mutation Databases (LSDB): PINK1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PINK1

DNA2.0 Custom Variant and Variant Library Synthesis for PINK1

Disorders / Diseases
for PINK1 gene

14 diseases for PINK1

9 Novoseek disease relationships for PINK1 gene    About this table

Publications
for PINK1 gene

PubMed articles for PINK1 gene, integrated from 9 sources (see all 312) (see top 10): (articles sorted by number of sources associating them with PINK1)

Utopia: connect your pdf to the dynamic world of online information

1. PINK1 mutations are associated with sporadic early-onset parkinsonism. (PubMed id 15349860)^{1, 2, 3, 4, 9} Valente E.M.... Bentivoglio A.R. (2004)
2. PINK1, Parkin, and DJ-1 mutations in Italian patients with early- onset parkinsonism. (PubMed id 15970950)^{1, 2, 4, 9} Klein C.... Pramstaller P.P. (2005)
3. PINK1 (PARK6) associated Parkinson disease in Ireland. (PubMed id 15505171)^{1, 2, 4, 9} Healy D.G.... Lynch T. (2004)
4. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. (PubMed id 15596610)^{1, 2, 4, 9} Rogaeva E....Singleton A.B. (2004)
5. Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan. (PubMed id 16257123)^{1, 2, 4} Fung H.-C....Wu Y.-R. (2006)
6. Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. (PubMed id 16009891)^{1, 2, 4} Bonifati V.... Oostra B.A. (2005)
7. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. (PubMed id 11494141)^{1, 2, 3} Unoki M. and Nakamura Y. (2001)
8. Association of PINK1 and DJ-1 confers digenic inheritance of early- onset Parkinson's disease. (PubMed id 16632486)^{1, 2, 9} Tang B.... Zhang Z. (2006)
9. Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson's disease in two European populations. (PubMed id 16354302)^{1, 4, 9} Schlitter A.M....Dekomien G. (2005)
10. PINK1 stabilized by mitochondrial depolarization recr uits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. (PubMed id 20404107)^{1, 2, 9} Matsuda N....Tanaka K. (2010)
11. Juvenile-onset Parkinsonism as a result of the first mutation in the adenosine triphosphate orientation domain of PINK1. (PubMed id 16966503)^{1, 2, 9} Leutenegger A.-L.... Brice A. (2006)
12. The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism. (PubMed id 15349859)^{1, 4, 9} Healy D.G....Wood N.W. (2004)
13. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. (PubMed id 16207731)^{1, 2, 9} Silvestri L....Casari G. (2005)
14. Genetic association study of PINK1 coding polymorphisms in Parkinson's disease. (PubMed id 15542245)^{1, 4, 9} Groen J.L....Rogaeva E. (2004)
15. G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients. (PubMed id 15876334)^{1, 4, 9} Deng H....Jankovic J. (2005)
16. PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. (PubMed id 22910362)^{1, 2} Okatsu K.... Matsuda N. (2012)
17. The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations. (PubMed id 20798600)^{1, 2} Geisler S.... Springer W. (2010)
18. PINK1 heterozygous rare variants: prevalence, significance and phenotypic spectrum. (PubMed id 18330912)^{1, 2} Marongiu R.... Valente E.M. (2008)
19. Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation. (PubMed id 18286320)^{1, 2} Prestel J....Gasser T. (2008)
20. Assessment of PINK1 (PARK6) polymorphisms in Finnish PD. (PubMed id 16046032)^{1, 4} Clarimon J....Singleton A.B. (2006)
21. PINK1 mutations in sporadic early-onset Parkinson's disease. (PubMed id 16482571)^{1, 2} Tan E.-K.... Tan L. (2006)
22. A heterozygous effect for PINK1 mutations in Parkinson's disease? (PubMed id 16969854)^{1, 2} Abou-Sleiman P.M.... Wood N.W. (2006)
23. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
24. Clinicogenetic study of PINK1 mutations in autosomal recessive early-onset parkinsonism. (PubMed id 15955953)^{1, 2} Li Y....Hattori N. (2005)
25. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
26. Novel PINK1 mutations in early-onset parkinsonism. (PubMed id 15349870)^{1, 2} Hatano Y.... Hattori N. (2004)
27. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. (PubMed id 15087508)^{1, 2} Valente E.M.... Wood N.W. (2004)
28. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
29. BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. (PubMed id 14607334)^{1, 2} Nakajima A.... Huh N.-H. (2003)
30. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. (PubMed id 19152501)^{1, 9} Weihofen A....Selkoe D.J. (2009)
31. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. (PubMed id 16672981)^{1, 9} Clark I.E....Guo M. (2006)
32. Characterization of PINK1 processing, stability, and subcellular localization. (PubMed id 18397367)^{1, 9} Lin W. and Kang U.J. (2008)
33. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. (PubMed id 18003639)^{1, 9} Weihofen A....Selkoe D.J. (2008)
34. FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. (PubMed id 19276113)^{1, 9} Mei Y....You H. (2009)
35. Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. (PubMed id 16079129)^{1, 9} Petit A....Tandon A. (2005)
36. Mitochondrial alterations in PINK1 deficient cells ar e influenced by calcineurin-dependent dephosphorylation of dynamin-related prot ein 1. (PubMed id 19492085)^{1, 9} Sandebring A....Cookson M.R. (2009)
37. C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1. (PubMed id 17000703)^{1, 9} Sim C.H....Cheng H.C. (2006)
38. Parkin stabilizes PINK1 through direct interaction. (PubMed id 19358826)^{1, 9} Shiba K....Hattori N. (2009)
39. Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1. (PubMed id 18031932)^{1, 9} Takatori S....Iwatsubo T. (2008)
40. Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission. (PubMed id 19279012)^{1, 9} Dagda R.K....Chu C.T. (2009)
41. The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. (PubMed id 17362513)^{1, 9} Scheele C....Timmons J.A. (2007)
42. PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c. (PubMed id 17707122)^{1, 9} Wang H.L....Yu S.T. (2007)
43. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. (PubMed id 17579517)^{1, 9} Pridgeon J.W....Li L. (2007)
44. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. (PubMed id 17989306)^{1, 9} Exner N....Haass C. (2007)
45. Perturbations in mitochondrial dynamics induced by hu man mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1 . (PubMed id 20164189)^{1, 9} Cui M....Tieu K. (2010)
46. [Establishment and application of an analytical metho d for PINK1 gene exon copy number] (PubMed id 20376796)^{1, 9} Zhang H.N....Tang B.S. (2010)
47. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. (PubMed id 19966284)^{2, 9} Vives-Bauza C....Przedborski S. (2010)
48. Parkin and PINK1 mutations in early-onset Parkinson's disease: comprehensive screening in publicly available cases and control. (PubMed id 19351622)^{1, 9} Brooks J....Scholz S.W. (2009)
49. Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. (PubMed id 16805805)^{1, 9} Muqit M.M....Latchman D.S. (2006)
50. Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit? (PubMed id 16769864)^{1, 9} Hedrich K....Klein C. (2006)
51. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. (PubMed id 16226715)^{1, 9} Deng H....Le W. (2005)
52. A comparative study of LRRK2, PINK1 and genetically u ndefined familial Parkinson's disease. (PubMed id 19726410)^{1, 9} Nishioka K....Hentati F. (2010)
53. Molecular interaction between parkin and PINK1 in mammalian neuronal cells. (PubMed id 19167501)^{1, 9} Um J.W....Chung K.C. (2009)
54. PINK1 defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease. (PubMed id 19242547)^{1, 9} Liu W....Li C. (2009)
55. Familial Parkinsonism with digenic parkin and PINK1 mutations. (PubMed id 18546294)^{1, 9} Funayama M....Hattori N. (2008)
56. L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. (PubMed id 18359116)^{1, 9} Moriwaki Y....Takahashi R. (2008)
57. Significance of the parkin and PINK1 gene in Jordanian families with incidences of young-onset and juvenile parkinsonism. (PubMed id 19087301)^{1, 9} Myhre R....Klungland H. (2008)
58. Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa. (PubMed id 16401616)^{2, 9} Ibanez P....Brice A. (2006)
59. PINK1 is recruited to mitochondria with parkin and as sociates with LC3 in mitophagy. (PubMed id 20153330)^{1, 9} Kawajiri S....Hattori N. (2010)
60. Formation of parkin aggregates and enhanced PINK1 acc umulation during the pathogenesis of Parkinson's disease. (PubMed id 20171192)^{1, 9} Um J.W....Chung K.C. (2010)
61. PINK1 mutations in a Brazilian cohort of early-onset Parkinson's disease patients. (PubMed id 19562775)^{1, 9} Godeiro-Junior C....Ferraz H.B. (2009)
62. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. (PubMed id 19229105)^{1, 9} Xiong H....Zhang Z. (2009)
63. Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells. (PubMed id 19270741)^{1, 9} Gegg M.E....Taanman J.W. (2009)
64. Transcranial sonography findings in a large family with homozygous and heterozygous PINK1 mutations. (PubMed id 18469032)^{1, 9} Hagenah J.M....Seidel G. (2008)
65. Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease. (PubMed id 18541801)^{1, 9} Kumazawa R....Hattori N. (2008)
66. Subclinical sensory abnormalities in unaffected PINK1 heterozygotes. (PubMed id 18584234)^{1, 9} Fiorio M....Tinazzi M. (2008)
67. Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease. (PubMed id 17950257)^{1, 9} Blackinton J.G....Galter D. (2007)
68. Mutation analysis of parkin and PINK1 genes in early- onset Parkinson's disease in China. (PubMed id 20399249)^{1, 9} Zhang B.R....Luo W. (2010)
69. Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. (PubMed id 19880420)^{1, 9} Sha D....Li L. (2010)
70. Differential effects of PINK1 nonsense and missense m utations on mitochondrial function and morphology. (PubMed id 19500570)^{1, 9} GrA1newald A....Schapira A.H. (2009)
71. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. (PubMed id 18957282)^{1, 9} Kim Y....Chung J. (2008)
72. The kinase domain of mitochondrial PINK1 faces the cytoplasm. (PubMed id 18687899)^{2, 9} Zhou C....Przedborski S. (2008)
73. Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease. (PubMed id 18973254)^{1, 9} Macedo M.G....Heutink P. (2008)
74. PINK1 mutation heterozygosity and the risk of Parkinson's disease. (PubMed id 17172567)^{1, 9} Toft M....Farrer M.J. (2007)
75. Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia. (PubMed id 17724286)^{1, 9} Binkofski F....Klein C. (2007)
76. T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease. (PubMed id 17030667)^{2, 9} Chishti M.A.... Rogaeva E. (2006)
77. Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype. (PubMed id 19038850)^{1, 9} van Nuenen B.F....Siebner H.R. (2009)
78. Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism. (PubMed id 18378882)^{1, 9} Moro E....Klein C. (2008)
79. Mutation analysis of the parkin and PINK1 genes in American Caucasian early-onset Parkinson disease families. (PubMed id 18068301)^{1, 9} Deng H....Jankovic J. (2008)
80. Late onset sporadic Parkinson's disease caused by PINK1 mutations: clinical and functional study. (PubMed id 18307263)^{1, 9} Gelmetti V....Valente E.M. (2008)
81. Mutation analysis of Parkin, PINK1, DJ-1 and ATP13A2 genes in Chinese patients with autosomal recessive early-onset Parkinsonism. (PubMed id 18785233)^{1, 9} Guo J.F....Tang B.S. (2008)
82. What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinson's disease? (PubMed id 19076428)^{1, 9} Plun-Favreau H....Wood N.W. (2008)
83. Whole gene deletion and splicing mutations expand the PINK1 genotypic spectrum. (PubMed id 17154281)^{1, 9} Marongiu R....Valente E.M. (2007)
84. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. (PubMed id 15824318)^{1, 9} Beilina A....Cookson M.R. (2005)
85. Decreased expression of Drp1 and Fis1 mediates mitoch ondrial elongation in senescent cells and enhances resistance to oxidative stre ss through PINK1. (PubMed id 20179104)^{1, 9} Mai S....Jendrach M. (2010)
86. Responsiveness to distracting stimuli, though increas ed in Parkinson's disease, is decreased in asymptomatic PINK1 and Parkin mutati on carriers. (PubMed id 19822161)^{1, 9} Verleger R....Klein C. (2010)
87. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. (PubMed id 20098416)^{1, 9} Geisler S....Springer W. (2010)
88. Mitochondrial quality control: insights on how Parkin son's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain m itochondrial homeostasis. (PubMed id 20012177)^{1, 9} Dagda R.K. and Chu C.T. (2009)
89. Leucine-Rich Repeat Kinase 2 interacts with Parkin, D J-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. (PubMed id 19692353)^{1, 9} Venderova K....Park D.S. (2009)
90. Genotype-phenotype correlates in Taiwanese patients with early-onset recessive parkinsonism. (PubMed id 19006224)^{1, 9} Lee M.J....Wu R.M. (2008)
91. Analysis of PARK genes in a Korean cohort of early-onset Parkinson disease. (PubMed id 18704525)^{1, 9} Choi J.M....Kim Y.J. (2008)
92. Co-occurrence of affective and schizophrenia spectrum disorders with PINK1 mutations. (PubMed id 17202228)^{1, 9} Steinlechner S....Lencer R. (2007)
93. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. (PubMed id 17906618)^{1, 9} Plun-Favreau H....Downward J. (2007)
94. A common A340T variant in PINK1 gene associated with late-onset Parkinson's disease in Chinese. (PubMed id 17084972)^{1, 9} Wang F....Chan P. (2006)
95. PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism. (PubMed id 16700027)^{1, 9} Criscuolo C....De Michele G. (2006)
96. Coexistence of mutations in PINK1 and mitochondrial DNA in early onset parkinsonism. (PubMed id 18524835)^{1, 9} Piccoli C....Capitanio N. (2008)
97. The PINK1 phenotype can be indistinguishable from idiopathic Parkinson disease. (PubMed id 15955954)^{1, 9} Albanese A....Dallapiccola B. (2005)
98. LRRK2 gene in Parkinson disease: mutation analysis and case control association study. (PubMed id 16157901)^{1, 9} Paisan-Ruiz C....Rogaeva E. (2005)
99. Genetic bases and phenotypes of autosomal recessive Pa rkinson disease in a Turkish population. (PubMed id 22233331)¹ Lohmann E....Emre M. (2012)
100. Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. (PubMed id 22238344)¹ Matenia D....Mandelkow E.M. (2012)
101. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Seri ne 65. (PubMed id 22724072)¹ Kondapalli C....Muqit M.M. (2012)
102. Pink1 kinase and its membrane potential (Deltaq)-depen dent cleavage product both localize to outer mitochondrial membrane by unique ta rgeting mode. (PubMed id 22547060)¹ Becker D....Voos W. (2012)
103. Partial sensitization of human bladder cancer cells to a gene-therapeutic adenovirus carrying REIC/Dkk-3 by downregulation of BRPK/PIN K1. (PubMed id 22076283)¹ Jin Y....Huh N.H. (2012)
104. Regulation of parkin and PINK1 by neddylation. (PubMed id 22388932)¹ Choo Y.S....Zhang Z. (2012)
105. Compensatory premotor activity during affective face p rocessing in subclinical carriers of a single mutant Parkin allele. (PubMed id 22434215)¹ Anders S....Binkofski F. (2012)
106. Mitochondrial processing peptidase regulates PINK1 pro cessing, import and Parkin recruitment. (PubMed id 22354088)¹ Greene A.W....Fon E.A. (2012)
107. Mutation analysis of the PINK1 gene in Southern Italia n patients with early- and late-onset parkinsonism. (PubMed id 21925922)¹ Scornaienchi V....Quattrone A. (2012)
108. Parkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondria. (PubMed id 22396657)¹ Liu S....Lu B. (2012)
109. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. (PubMed id 22280891)¹ Lazarou M....Youle R.J. (2012)
110. Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Za mbian patients with Parkinson's disease. (PubMed id 22445250)¹ Yonova-Doing E....Bonifati V. (2012)
111. PINK1 stimulates interleukin-1b-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1. (PubMed id 22643835)¹ Lee H.J....Chung K.C. (2012)
112. Kinase signaling dysfunction in Parkinson's disease: a reverse genetic approach in Drosophila. (PubMed id 22486164)¹ Huang Y....Li C. (2012)
113. Combined expression of BUB1B, DLGAP5, and PINK1 as predictors of poor outcome in adrenocortical tumors: validation in a Brazilian co hort of adult and pediatric patients. (PubMed id 22048964)¹ Fragoso M.C....Lerario A.M. (2012)
114. Parkin, PINK1 and mitochondrial integrity: emerging co ncepts of mitochondrial dysfunction in Parkinson's disease. (PubMed id 22057787)¹ Pilsl A. and Winklhofer K.F. (2012)
115. Phylogenetic and in silico structural analysis of the Parkinson disease-related kinase PINK1. (PubMed id 21412950)¹ Cardona F....PAcrez-Tur J. (2011)
116. Genetic mutations and functions of PINK1. (PubMed id 21784538)¹ Kawajiri S....Hattori N. (2011)
117. Impairment of oxidative stress-induced heme oxygenase -1 expression by the defect of Parkinson-related gene of PINK1. (PubMed id 21366594)¹ Chien W.L....Fu W.M. (2011)
118. Association of Parkinson disease-related protein PINK 1 with Alzheimer disease and multiple sclerosis brain lesions. (PubMed id 21145388)¹ Wilhelmus M.M....Van Horssen J. (2011)
119. Variation in the PTEN-induced putative kinase 1 gene associated with the increase risk of type 2 diabetes in northern Chinese. (PubMed id 21677397)¹ Qu Y....Han R. (2011)
120. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. (PubMed id 22078885)¹ Wang X....Schwarz T.L. (2011)
121. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
122. Bioenergetic consequences of PINK1 mutations in Parkin son disease. (PubMed id 22043288)¹ Abramov A.Y....Schapira A.H. (2011)
123. PINK1 displays tissue-specific subcellular location a nd regulates apoptosis and cell growth in breast cancer cells. (PubMed id 20971498)¹ Berthier A....Pulido R. (2011)
124. A new cytosolic pathway from a Parkinson disease-asso ciated kinase, BRPK/PINK1: activation of AKT via mTORC2. (PubMed id 21177249)¹ Murata H....Huh N.H. (2011)
125. PTEN-inducible kinase 1 (PINK1)/Park6 is indispensabl e for normal heart function. (PubMed id 21606348)¹ Billia F....Mak T.W. (2011)
126. Regulation of PINK1-Parkin-mediated mitophagy. (PubMed id 21187721)¹ Springer W. and Kahle P.J. (2011)
127. Functional alteration of PARL contributes to mitochon drial dysregulation in Parkinson's disease. (PubMed id 21355049)¹ Shi G....Bulman D.E. (2011)
128. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. (PubMed id 21426348)¹ Meissner C....Lemberg M.K. (2011)
129. PRKN, DJ-1, and PINK1 screening identifies novel spli ce site mutation in PRKN and two novel DJ-1 mutations. (PubMed id 21322020)¹ Ghazavi F....Elahi E. (2011)
130. PINK1 cleavage at position A103 by the mitochondrial protease PARL. (PubMed id 21138942)¹ Deas E....Wood N.W. (2011)
131. Mutation analysis of PINK1 gene in patients with early -onset Parkinsonism. (PubMed id 21743139)¹ Zhang X....Tang B. (2011)
132. Mutations in PINK1 and Parkin impair ubiquitination o f Mitofusins in human fibroblasts. (PubMed id 21408142)¹ Rakovic A....Klein C. (2011)
133. Parallel high-throughput RNA interference screens ide ntify PINK1 as a potential therapeutic target for the treatment of DNA mismatch repair-deficient cancers. (PubMed id 21242281)¹ Martin S.A....Ashworth A. (2011)
134. Inhibition of mitochondrial fusion by I+-synuclein is rescued by PINK1, Parkin and DJ-1. (PubMed id 20842103)¹ Kamp F....Haass C. (2010)
135. Assessing the prevalence of PINK1 genetic variants in South African patients diagnosed with early- and late-onset Parkinson's disease. (PubMed id 20558144)¹ Keyser R.J....Bardien S. (2010)
136. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
137. Evaluation of PINK1 variants in Indian Parkinson's di sease patients. (PubMed id 19889566)¹ Biswas A....Ray J. (2010)
138. Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update . (PubMed id 20506312)¹ Nuytemans K....Van Broeckhoven C. (2010)
139. Progression of subtle motor signs in PINK1 mutation c arriers with mild dopaminergic deficit. (PubMed id 20513816)¹ Eggers C....Klein C. (2010)
140. R492X mutation in PTEN-induced putative kinase 1 indu ced cellular mitochondrial dysfunction and oxidative stress. (PubMed id 20547144)¹ Yuan X.L....Tang B.S. (2010)
141. PINK1-linked parkinsonism is associated with Lewy bod y pathology. (PubMed id 20356854)¹ Samaranch L....Pastor P. (2010)
142. PINK1 polymorphism IVS1-7 A-->G, exposure to envir onmental risk factors and anticipation of disease onset in Brazilian patients w ith early-onset Parkinson's Disease. (PubMed id 19944740)¹ Godeiro C....Ferraz H.B. (2010)
143. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
144. The loss of PGAM5 suppresses the mitochondrial degener ation caused by inactivation of PINK1 in Drosophila. (PubMed id 21151955)¹ Imai Y....Takahashi R. (2010)
145. Effect of endogenous mutant and wild-type PINK1 on Pa rkin in fibroblasts from Parkinson disease patients. (PubMed id 20508036)¹ Rakovic A....Klein C. (2010)
146. Clinical and demographic characteristics of PINK1 mut ation carriers--a meta-analysis. (PubMed id 20461815)¹ Kasten M....Klein C. (2010)
147. Structural imaging in the presymptomatic stage of gen etically determined parkinsonism. (PubMed id 20483373)¹ Reetz K....Binkofski F. (2010)
148. Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism. (PubMed id 20146068)¹ Guo J.F....Tang B.S. (2010)
149. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PI NK1/parkin-dependent manner upon induction of mitophagy. (PubMed id 20871098)¹ Gegg M.E....Taanman J.W. (2010)
150. Enhanced vulnerability of PARK6 patient skin fibrobla sts to apoptosis induced by proteasomal stress. (PubMed id 20045449)¹ Klinkenberg M....KAPgel D. (2010)
151. Oxidative stress alters the regulatory control of p66 Shc and Akt in PINK1 deficient cells. (PubMed id 20637729)¹ Maj M.C....Robinson B.H. (2010)
152. Mutational analysis of parkin and PINK1 in multiple s ystem atrophy. (PubMed id 20034704)¹ Brooks J.A....Scholz S.W. (2009)
153. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. (PubMed id 19139432)¹ de ReyniA"s A....Bertherat J. (2009)
154. Mitochondrial respiratory dysfunction and mutations i n mitochondrial DNA in PINK1 familial parkinsonism. (PubMed id 19904588)¹ Papa S....Piccoli C. (2009)
155. Clinically reported heterozygous mutations in the PIN K1 kinase domain exert a gene dosage effect. (PubMed id 19847793)¹ Tan E.K....Zhao Y. (2009)
156. A new complex homozygous large rearrangement of the P INK1 gene in a Sudanese family with early onset Parkinson's disease. (PubMed id 19214605)¹ Cazeneuve C....Salih M.A. (2009)
157. Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations. (PubMed id 19205068)¹ Camargos S.T....Cardoso F. (2009)
158. Relative contribution of simple mutations vs. copy number variations in five Parkinson disease genes in the Belgian population. (PubMed id 19405094)¹ Nuytemans K....Theuns J. (2009)
159. PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. (PubMed id 19285945)¹ Gandhi S....Abramov A.Y. (2009)
160. Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease? (PubMed id 19224617)¹ Sutherland G.T....Mellick G.D. (2009)
161. Olfactory dysfunction in Parkinsonism caused by PINK1 mutations. (PubMed id 19890973)¹ Ferraris A....Bentivoglio A.R. (2009)
162. Different saccadic abnormalities in PINK1 mutation ca rriers and in patients with non-genetic Parkinson's disease. (PubMed id 19330279)¹ Hertel S....Kimmig H. (2009)
163. [A little bit of PINK in Parkinson's disease] (PubMed id 18272063)¹ Berthier A. (2008)
164. PINK1 mutations and parkinsonism. (PubMed id 18685134)¹ Ishihara-Paul L....Farrer M.J. (2008)
165. [A case of a 30-year history of PARK6 --findings from functional imaging of the brain] (PubMed id 19048950)¹ Yamashita H....Matsumoto M. (2008)
166. Limbic and frontal cortical degeneration is associated with psychiatric symptoms in PINK1 mutation carriers. (PubMed id 18261714)¹ Reetz K....Binkofski F. (2008)
167. Analysis of Parkinson disease patients from Portugal for mutations in SNCA, PRKN, PINK1 and LRRK2. (PubMed id 18211709)¹ Bras J....Singleton A. (2008)
168. PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. (PubMed id 18560593)¹ Wood-Kaczmar A....Wood N.W. (2008)
169. Sleep quality in a family with hereditary parkinsonism (PARK6). (PubMed id 17766179)¹ Tuin I....Auburger G. (2008)
170. Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites. (PubMed id 18495756)¹ Franks P.W....Timmons J.A. (2008)
171. Screening PARK genes for mutations in early-onset Parkinson's disease patients from Queensland, Australia. (PubMed id 18486522)¹ Mellick G.D....Hattori N. (2008)
172. Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis. (PubMed id 17219214)¹ Grunewald A....Bonifati V. (2007)
173. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)² Greenman C.... Stratton M.R. (2007)
174. [PINK1 IVS5-5 G>A polymorphism may contribute to the risk of late onset Parkinson disease in Chinese] (PubMed id 17557243)¹ Wang F....Li Y.J. (2007)
175. Novel features in a patient homozygous for the L347P mutation in the PINK1 gene. (PubMed id 17055324)¹ Doostzadeh J....Schule B. (2007)
176. PINK1 mutation in Taiwanese early-onset parkinsonism : clinical, genetic, and dopamine transporter studies. (PubMed id 17960343)¹ Weng Y.H....Lu C.S. (2007)
177. Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. (PubMed id 17141510)¹ Hoepken H.H....Auburger G. (2007)
178. Phenotypic spectrum of PINK1-associated parkinsonism in 15 mutation carriers from 1 family. (PubMed id 17013904)¹ Hiller A....Klein C. (2007)
179. Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? (PubMed id 17567565)¹ Scheele C....Timmons J.A. (2007)
180. Homozygous and heterozygous PINK1 mutations: considerations for diagnosis and care of Parkinson's disease patients. (PubMed id 16547921)¹ Zadikoff C....Lang A.E. (2006)
181. PINK-1 and DJ-1--new genes for autosomal recessive Parkinson's disease. (PubMed id 17017532)¹ Heutink P. (2006)
182. Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. (PubMed id 15894486)¹ Bandopadhyay R....Lees A.J. (2005)
183. Analysis of PINK1 in Asian patients with familial parkinsonism. (PubMed id 16207217)² Tan E.K.... Tan L.C.S. (2005)
184. Analysis of phosphatase and tensin homolog tumor supp ressor interacting proteins by in vitro and in silico proteomics. (PubMed id 15717329)¹ Crockett D.K....Lim M.S. (2005)
185. PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations. (PubMed id 15505170)¹ Hatano Y....Hattori N. (2004)
186. Clinical and subclinical dopaminergic dysfunction in PARK6-linked parkinsonism: an 18F-dopa PET study. (PubMed id 12447943)¹ Khan N.L....Piccini P. (2002)
187. Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7. (PubMed id 12548343)¹ Bonifati V....Heutink P. (2002)
188. PARK6 is a common cause of familial parkinsonism. (PubMed id 12548371)¹ Valente E.M....Wood N.W. (2002)
189. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
190. Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36. (PubMed id 11254447)¹ Valente E.M....Wood N.W. (2001)
191. PINK1 Type of Young-Onset Park inson Disease (PubMed id 20301792)¹ Schneider S.A. and Klein C. (1993)
192. Parkinson Disease O verview (PubMed id 20301402)¹ Pankratz N.D....Foroud T. (1993)
193. (PubMed id 15958754)⁴ 
194. Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1). (PubMed id 18221368)⁹ Mills R.D....Cheng H.C. (2008)
195. [Molecular genetics of PINK1] (PubMed id 17713119)⁹ Funayama M. and Hattori N. (2007)
196. PINK1 protein in normal human brain and Parkinson's disease. (PubMed id 16702191)⁹ Gandhi S....Revesz T. (2006)
197. A pivotal role for PINK1 and autophagy in mitochondri al quality control: implications for Parkinson disease. (PubMed id 20385539)⁹ Chu C.T. (2010)
198. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. (PubMed id 20057503)⁹ Michiorri S....Casari G. (2010)
199. Regulation of PINK1 by NR2B-containing NMDA receptors in ischemic neuronal injury. (PubMed id 19780893)⁹ Shan Y....Wan Q. (2009)
200. Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease. (PubMed id 19088817)⁹ Todd A.M. and Staveley B.E. (2008)
201. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. (PubMed id 16672980)⁹ Park J....Chung J. (2006)
202. Tickled PINK1: mitochondrial homeostasis and autophag y in recessive Parkinsonism. (PubMed id 19595762)⁹ Chu C.T. (2010)
203. Existence of Pink1 antisense RNAs in mouse and their localization. (PubMed id 20068297)⁹ Chiba M....Yasue H. (2009)
204. Loss of parkin or PINK1 function increases Drp1-depen dent mitochondrial fragmentation. (PubMed id 19546216)⁹ Lutz A.K....Winklhofer K.F. (2009)
205. Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. (PubMed id 18218782)⁹ Haque M.E....Park D.S. (2008)
206. The mitochondrial fusion-promoting factor mitofusin i s a substrate of the PINK1/parkin pathway. (PubMed id 20383334)⁹ Poole A.C....Pallanck L. (2010)
207. Drosophila HtrA2 is dispensable for apoptosis but act s downstream of PINK1 independently from Parkin. (PubMed id 19282869)⁹ Tain L.S....Tapon N. (2009)
208. The PINK1/Parkin pathway regulates mitochondrial morphology. (PubMed id 18230723)⁹ Poole A.C....Pallanck L.J. (2008)
209. Loss of PINK1 function affects development and results in neurodegeneration in zebrafish. (PubMed id 18701682)⁹ Anichtchik O....Rubinsztein D.C. (2008)
210. [Mutation analysis of PINK1 gene in Chinese patients with autosomal recessive early-onset parkinsonism type 6] (PubMed id 16179113)⁹ Zhang Y.H....Long Z.G. (2005)
211. Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement. (PubMed id 19895857)⁹ Matsui H....Takahashi R. (2010)
212. Mitochondrial autophagy as a compensatory response to PINK1 deficiency. (PubMed id 19786829)⁹ Cherra S.J....Chu C.T. (2009)
213. Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? (PubMed id 15576821)⁹ Giasson B.I. (2004)
214. Drosophila parkin requires PINK1 for mitochondrial tr anslocation and ubiquitinates mitofusin. (PubMed id 20194754)⁹ Ziviani E....Whitworth A.J. (2010)
215. DJ-1 is critical for mitochondrial function and rescu es PINK1 loss of function. (PubMed id 20457924)⁹ Hao L.Y....Bonini N.M. (2010)
216. Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease. (PubMed id 17499497)⁹ Dodson M.W. and Guo M. (2007)
217. Deciphering the role of heterozygous mutations in genes associated with parkinsonism. (PubMed id 17582365)⁹ Klein C....Lang A.E. (2007)
218. Parkin blushed by PINK1. (PubMed id 16701203)⁹ Tan J.M. and Dawson T.M. (2006)
219. Impaired dopaminergic neuron development and locomoto r function in zebrafish with loss of pink1 function. (PubMed id 20141529)⁹ Xi Y....Ekker M. (2010)
220. Absence of nigral degeneration in aged parkin/DJ-1/PI NK1 triple knockout mice. (PubMed id 19694908)⁹ Kitada T....Shen J. (2009)
221. Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with BehAset's disease. (PubMed id 19796537)⁹ Vural B....Ozbek U. (2009)
222. The mitochondrial kinase PINK1, stress response and P arkinson's disease. (PubMed id 19941155)⁹ Jendrach M....Auburger G. (2009)
223. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. (PubMed id 19056353)⁹ Park J....Chung J. (2009)
224. Parkin and PINK1 parkinsonism may represent nigral mi tochondrial cytopathies distinct from Lewy body Parkinson's disease. (PubMed id 19815446)⁹ Ahlskog J.E. (2009)
225. Mapping preclinical compensation in Parkinson's disea se: an imaging genomics approach. (PubMed id 19877238)⁹ van Nuenen B.F....Siebner H.R. (2009)
226. Mitochondrial dysfunction and Parkinson's disease gen es: insights from Drosophila. (PubMed id 19553694)⁹ Park J....Chung J. (2009)
227. Myocardial 123metaiodobenzylguanidine uptake in genetic Parkinson's disease. (PubMed id 17975812)⁹ Quattrone A....Condino F. (2008)
228. Mitochondrial respiratory dysfunction in familiar parkinsonism associated with PINK1 mutation. (PubMed id 18473170)⁹ Piccoli C....Papa S. (2008)
229. Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway? (PubMed id 19021753)⁹ Fitzgerald J.C. and Plun-Favreau H. (2008)
230. High-throughput homogeneous mass cleave assay technology for the diagnosis of autosomal recessive Parkinson's disease. (PubMed id 18403612)⁹ Schroeder C....Bonin M. (2008)
231. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo. (PubMed id 19118185)⁹ Yun J....Guo M. (2008)
232. Multiplex ligation-dependent probe amplification assay for simultaneous detection of Parkinson's disease gene rearrangements. (PubMed id 17914726)⁹ Scarciolla O....Dallapiccola B. (2007)
233. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. (PubMed id 17563363)⁹ Kitada T....Shen J. (2007)
234. DJ-1: a newcomer in Parkinson's disease pathology. (PubMed id 18045143)⁹ da Costa C.A. (2007)
235. Etiology of Parkinson's disease. (PubMed id 16717248)⁹ Schapira A.H. (2006)
236. The biochemistry of Parkinson's disease. (PubMed id 15952880)⁹ Cookson M.R. (2005)
237. Genetics of Parkinson's disease. (PubMed id 16175160)⁹ Bonifati V. (2005)
238. Homozygous PINK1 C-terminus mutation causing early-onset parkinsonism. (PubMed id 15349871)⁹ Rohe C.F....Bonifati V. (2004)
239. Mitochondrial metabolism modulation: a new therapeuti c approach for Parkinson's disease. (PubMed id 20201821)⁹ ArduA-no D.M....Cardoso S.M. (2010)
240. Genetic basis of Parkinson disease. (PubMed id 20043722)⁹ Xiromerisiou G....Hadjigeorgiou G.M. (2010)
241. Curcumin exposure induces expression of the Parkinson 's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. (PubMed id 19879924)⁹ Ortiz-Ortiz M.A....Fuentes J.M. (2010)
242. Parkinson's disease: insights from pathways. (PubMed id 20421364)⁹ Cookson M.R. and Bandmann O. (2010)
243. Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation. (PubMed id 19224863)⁹ Szargel R.... Engelender S. (2009)
244. Mutation analysis for DJ-1 in sporadic and familial parkinsonism: screening strategy in parkinsonism. (PubMed id 19429112)⁹ Tomiyama H....Hattori N. (2009)
245. Cell death pathways in Parkinson's disease: role of m itochondria. (PubMed id 19422283)⁹ Yao Z. and Wood N.W. (2009)
246. Etiology and pathogenesis of Parkinson disease. (PubMed id 19555823)⁹ Schapira A.H. (2009)
247. Imaging the impact of genes on Parkinson's disease. (PubMed id 19409223)⁹ van der Vegt J.P....Siebner H.R. (2009)
248. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. (PubMed id 19166511)⁹ Marongiu R....Masliah E. (2009)
249. Impaired mitochondrial dynamics and function in the p athogenesis of Parkinson's disease. (PubMed id 19303005)⁹ BA1eler H. (2009)
250. Caenorhabditits elegans LRK-1 and PINK-1 act antagoni stically in stress response and neurite outgrowth. (PubMed id 19251702)⁹ SAomann J....Schmidt E. (2009)
251. Molecular pathogenesis of Parkinson disease: insights from genetic studies. (PubMed id 19631006)⁹ Gasser T. (2009)
252. Protein degradation in Parkinson disease revisited: it's complex. (PubMed id 19306499)⁹ Li H. and Guo M. (2009)
253. Parkinson's disease: from monogenic forms to genetic susceptibility factors. (PubMed id 19297401)⁹ Lesage S. and Brice A. (2009)
254. Molecular basis of Parkinson's disease. (PubMed id 19151598)⁹ Yang Y.X....Latchman D.S. (2009)
255. Mitochondrial kinases in Parkinson's disease: converg ing insights from neurotoxin and genetic models. (PubMed id 19563915)⁹ Dagda R.K....Chu C.T. (2009)
256. Mitochondrial dysfunction and biogenesis in the patho genesis of Parkinson's disease. (PubMed id 20035637)⁹ Lin T.K....Chuang J.H. (2009)
257. From genes to proteins in mendelian Parkinson's disea se: an overview. (PubMed id 19943343)⁹ Pirkevi C....BaA9ak A.N. (2009)
258. Complicated recessive dystonia parkinsonism syndromes. (PubMed id 19185014)⁹ Schneider S.A....Hardy J. (2009)
259. The role of PTEN-induced kinase 1 in mitochondrial dy sfunction and dynamics. (PubMed id 19703660)⁹ Thomas K.J. and Cookson M.R. (2009)
260. Is there a pathogenic role for mitochondria in Parkin son's disease? (PubMed id 20083000)⁹ Vives-Bauza C....Przedborski S. (2009)
261. Neurodegeneration in Parkinson's disease: genetics en lightens physiopathology. (PubMed id 20411780)⁹ Corti O....Brice A. (2009)
262. Transgenic rodent models of Parkinson's disease. (PubMed id 18642640)⁹ Harvey B.K....Hoffer B.J. (2008)
263. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. (PubMed id 18978800)⁹ Henchcliffe C. and Beal M.F. (2008)
264. Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? (PubMed id 17680806)⁹ Bogaerts V....van Broeckhoven C. (2008)
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