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Aliases for PIN4 Gene

Aliases for PIN4 Gene

  • Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4 2 3 5
  • Peptidylprolyl Cis/Trans Isomerase NIMA-Interacting, 4 2 3
  • Peptidyl-Prolyl Cis-Trans Isomerase Pin4 3 4
  • Peptidyl-Prolyl Cis/Trans Isomerase EPVH 3 4
  • Parvulin-14 3 4
  • Parvulin-17 3 4
  • Parvulin 2 3
  • HPar14 3 4
  • HPar17 3 4
  • PAR14 3 4
  • PAR17 3 4
  • HEPVH 3 4
  • Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin) 2
  • Protein (Peptidylprolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin) 3
  • Eukaryotic Parvulin Homolog 3
  • Rotamase PIN4 3
  • Rotamase Pin4 4
  • PPIase PIN4 3
  • PPIase Pin4 4
  • EC 4
  • EPVH 3

External Ids for PIN4 Gene

Previous GeneCards Identifiers for PIN4 Gene

  • GC0XP067133
  • GC0XP068641
  • GC0XP069634
  • GC0XP070268
  • GC0XP071184
  • GC0XP071318
  • GC0XP071401
  • GC0XP065157

Summaries for PIN4 Gene

Entrez Gene Summary for PIN4 Gene

  • This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

GeneCards Summary for PIN4 Gene

PIN4 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and peptidyl-prolyl cis-trans isomerase activity.

UniProtKB/Swiss-Prot for PIN4 Gene

  • Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.

  • Isoform 2 binds to double-stranded DNA.

Gene Wiki entry for PIN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIN4 Gene

Genomics for PIN4 Gene

Regulatory Elements for PIN4 Gene

Enhancers for PIN4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PIN4 on UCSC Golden Path with GeneCards custom track

Promoters for PIN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PIN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PIN4 Gene

72,181,353 bp from pter
72,302,926 bp from pter
121,574 bases
Plus strand

Genomic View for PIN4 Gene

Genes around PIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIN4 Gene

Proteins for PIN4 Gene

  • Protein details for PIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
    Protein Accession:
    Secondary Accessions:
    • A8E0G6
    • B3KXM0
    • F5H1P5
    • Q0D2H3
    • Q3MHV0
    • Q52M21
    • Q5HYW6
    • Q6IRW4

    Protein attributes for PIN4 Gene

    131 amino acids
    Molecular mass:
    13810 Da
    Quaternary structure:
    • Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes.
    • Sequence=AAH05234.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH70288.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI11395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG54532.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIN4 Gene

    Alternative splice isoforms for PIN4 Gene


neXtProt entry for PIN4 Gene

Proteomics data for PIN4 Gene at MOPED

Post-translational modifications for PIN4 Gene

  • Isoform 2 is sumoylated with SUMO2 and SUMO3.
  • Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIN4 Gene

Domains & Families for PIN4 Gene

Gene Families for PIN4 Gene

Protein Domains for PIN4 Gene

Graphical View of Domain Structure for InterPro Entry



  • The PPIase domain enhances mitochondrial targeting.
  • Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
  • The PPIase domain enhances mitochondrial targeting.
  • Contains 1 PpiC domain.
  • Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
genes like me logo Genes that share domains with PIN4: view

Function for PIN4 Gene

Molecular function for PIN4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.
UniProtKB/Swiss-Prot Function:
Isoform 2 binds to double-stranded DNA.

Enzyme Numbers (IUBMB) for PIN4 Gene

Gene Ontology (GO) - Molecular Function for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IDA 17875217
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with PIN4: view
genes like me logo Genes that share phenotypes with PIN4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIN4

miRNA for PIN4 Gene

miRTarBase miRNAs that target PIN4

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIN4 Gene

Localization for PIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIN4 Gene

Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.
Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.

Subcellular locations from

Jensen Localization Image for PIN4 Gene COMPARTMENTS Subcellular localization image for PIN4 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12144781
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with PIN4: view

Pathways & Interactions for PIN4 Gene

SuperPathways for PIN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PIN4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PIN4 Gene

Drugs & Compounds for PIN4 Gene

No Compound Related Data Available

Transcripts for PIN4 Gene

Unigene Clusters for PIN4 Gene

Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PIN4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -

Relevant External Links for PIN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PIN4 Gene

mRNA expression in normal human tissues for PIN4 Gene

Protein differential expression in normal tissues from HIPED for PIN4 Gene

This gene is overexpressed in Heart (11.6), Skin (9.7), Peripheral blood mononuclear cells (7.8), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PIN4 Gene

SOURCE GeneReport for Unigene cluster for PIN4 Gene Hs.655623

mRNA Expression by UniProt/SwissProt for PIN4 Gene

Tissue specificity: Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.
genes like me logo Genes that share expression patterns with PIN4: view

Protein tissue co-expression partners for PIN4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PIN4 Gene

Orthologs for PIN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PIN4 35
  • 92.11 (n)
  • 92.37 (a)
PIN4 36
  • 92 (a)
(Canis familiaris)
Mammalia LOC100856504 35
  • 90.84 (n)
  • 90.84 (a)
-- 36
  • 82 (a)
-- 36
  • 88 (a)
-- 36
  • 92 (a)
(Mus musculus)
Mammalia Pin4 35
  • 94.4 (n)
  • 96.95 (a)
Pin4 16
Pin4 36
  • 97 (a)
(Pan troglodytes)
Mammalia PIN4 35
  • 98.94 (n)
  • 98.94 (a)
(Rattus norvegicus)
Mammalia Pin4 35
  • 93.13 (n)
  • 96.95 (a)
(Monodelphis domestica)
Mammalia PIN4 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia PIN4 36
  • 88 (a)
(Gallus gallus)
Aves PIN4 35
  • 77.27 (n)
  • 88.18 (a)
PIN4 36
  • 87 (a)
(Anolis carolinensis)
Reptilia PIN4 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75904 35
pin4 35
  • 78.29 (n)
  • 90.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.11342 35
(Danio rerio)
Actinopterygii pin4 35
  • 74.14 (n)
  • 86.92 (a)
pin4 36
  • 84 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6696 35
fruit fly
(Drosophila melanogaster)
Insecta CG11858 37
  • 80 (a)
CG11858 35
  • 65.42 (n)
  • 77.57 (a)
CG11858 36
  • 73 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013296 35
  • 65.12 (n)
  • 73.15 (a)
(Caenorhabditis elegans)
Secernentea Y48C3A.16 37
  • 84 (a)
Y48C3A.16 35
  • 71.67 (n)
  • 84 (a)
pinn-4 36
  • 74 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3715 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06433 35
  • 58.16 (n)
  • 55.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 77 (a)
Species with no ortholog for PIN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIN4 Gene

Gene Tree for PIN4 (if available)
Gene Tree for PIN4 (if available)

Paralogs for PIN4 Gene

(1) SIMAP similar genes for PIN4 Gene using alignment to 6 proteins: Pseudogenes for PIN4 Gene

genes like me logo Genes that share paralogs with PIN4: view

No data available for Paralogs for PIN4 Gene

Variants for PIN4 Gene

Sequence variations from dbSNP and Humsavar for PIN4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747681098 -- 72,245,645(+) GCTGC(C/T)CCAGC intron-variant
rs747765752 -- 72,189,081(+) GATTG(C/T)TTGAG intron-variant
rs747778219 -- 72,255,045(+) CAGGG(C/G)GGGGG intron-variant
rs747797027 -- 72,246,131(+) CCCTA(C/G)ACCTG intron-variant
rs747844237 -- 72,256,818(+) ACTTC(C/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIN4 Gene

Variant ID Type Subtype PubMed ID
esv2673799 CNV Deletion 23128226
esv21569 CNV Loss 19812545

Variation tolerance for PIN4 Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PIN4 Gene

Disorders for PIN4 Gene

Relevant External Links for PIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIN4 Gene

Publications for PIN4 Gene

  1. The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. (PMID: 17875217) Kessler D. … Mueller J.W. (BMC Biol. 2007) 2 3 4 67
  2. Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation. (PMID: 16522211) Mueller J.W. … Bayer P. (BMC Mol. Biol. 2006) 2 3
  3. Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14. (PMID: 12860119) Reimer T. … Fischer G. (J. Mol. Biol. 2003) 3 23
  4. Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14. (PMID: 11162102) Terada T. … Uchida T. (J. Mol. Biol. 2001) 3 23
  5. Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1. (PMID: 25595659) Innes B.T. … Shilton B.H. (Biochim. Biophys. Acta 2015) 3

Products for PIN4 Gene

Sources for PIN4 Gene