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Aliases for PIN4 Gene

Aliases for PIN4 Gene

  • Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4 2 3 5
  • Peptidyl-Prolyl Cis-Trans Isomerase Pin4 3 4
  • Peptidyl-Prolyl Cis/Trans Isomerase EPVH 3 4
  • Parvulin-14 3 4
  • Parvulin-17 3 4
  • Parvulin 2 3
  • HPar14 3 4
  • HPar17 3 4
  • PAR14 3 4
  • PAR17 3 4
  • HEPVH 3 4
  • Protein (Peptidyl-Prolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin) 2
  • Protein (Peptidylprolyl Cis/Trans Isomerase) NIMA-Interacting, 4 (Parvulin) 3
  • Peptidylprolyl Cis/Trans Isomerase NIMA-Interacting, 4 2
  • Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4 3
  • Eukaryotic Parvulin Homolog 3
  • Rotamase PIN4 3
  • Rotamase Pin4 4
  • PPIase PIN4 3
  • PPIase Pin4 4
  • EC 5.2.1.8 4
  • EPVH 3

External Ids for PIN4 Gene

Previous GeneCards Identifiers for PIN4 Gene

  • GC0XP067133
  • GC0XP068641
  • GC0XP069634
  • GC0XP070268
  • GC0XP071184
  • GC0XP071318
  • GC0XP071401
  • GC0XP065157

Summaries for PIN4 Gene

Entrez Gene Summary for PIN4 Gene

  • This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

GeneCards Summary for PIN4 Gene

PIN4 (Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 4) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and peptidyl-prolyl cis-trans isomerase activity.

UniProtKB/Swiss-Prot for PIN4 Gene

  • Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.

  • Isoform 2 binds to double-stranded DNA.

Gene Wiki entry for PIN4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PIN4 Gene

Genomics for PIN4 Gene

Regulatory Elements for PIN4 Gene

Enhancers for PIN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF072238 0.7 ENCODE 36.3 +57.6 57579 1.4 ATF1 WRNIP1 ARID4B SIN3A ZNF48 SP3 GTF2B NFYC REST ZNF592 PIN4 ERCC6L GC0XM072223
GH0XF072257 0.6 ENCODE 31.1 +77.0 76962 0.9 SAP130 ZEB1 RARA TEAD3 GLIS2 ZBTB48 PATZ1 ZNF639 ZNF680 MAZ PIN4 ERCC6L RPS4X
GH0XF072201 0.8 Ensembl ENCODE 28.7 +21.0 20959 2.1 ZNF121 JUN ZBTB33 PIN4 ERCC6L RN7SL388P GC0XM072223
GH0XF072141 1.2 Ensembl ENCODE 26.9 -38.8 -38819 3.1 ZNF121 JUND RFX1 SMARCA4 JUNB CEBPB ZBTB33 ZBTB40 SPI1 PIN4 RGAG4 ENSG00000269911 FLJ44635
GH0XF072120 1.3 FANTOM5 Ensembl ENCODE 20.4 -57.2 -57178 7.2 GTF2F1 CTCF ESRRA JUN FEZF1 EBF1 ZIC2 ZNF2 RAD21 RFX5 PIN4 FLJ44635 RGAG4 NHSL2 PIR46676 PIR32507
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PIN4 on UCSC Golden Path with GeneCards custom track

Promoters for PIN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000479579 447 2001 SIN3A FEZF1 ZNF2 YY1 GLIS2 FOS ZNF263 SP3 YY2 NFYC

Genomic Location for PIN4 Gene

Chromosome:
X
Start:
72,181,353 bp from pter
End:
72,302,926 bp from pter
Size:
121,574 bases
Orientation:
Plus strand

Genomic View for PIN4 Gene

Genes around PIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PIN4 Gene

Proteins for PIN4 Gene

  • Protein details for PIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y237-PIN4_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
    Protein Accession:
    Q9Y237
    Secondary Accessions:
    • A8E0G6
    • B3KXM0
    • F5H1P5
    • Q0D2H3
    • Q3MHV0
    • Q52M21
    • Q5HYW6
    • Q6IRW4

    Protein attributes for PIN4 Gene

    Size:
    131 amino acids
    Molecular mass:
    13810 Da
    Quaternary structure:
    • Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes.
    SequenceCaution:
    • Sequence=AAH05234.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH70288.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI11395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG54532.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PIN4 Gene

    Alternative splice isoforms for PIN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PIN4 Gene

Post-translational modifications for PIN4 Gene

  • Isoform 2 is sumoylated with SUMO2 and SUMO3.
  • Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PIN4 Gene

Domains & Families for PIN4 Gene

Gene Families for PIN4 Gene

Protein Domains for PIN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y237

UniProtKB/Swiss-Prot:

PIN4_HUMAN :
  • The PPIase domain enhances mitochondrial targeting.
  • Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
Domain:
  • The PPIase domain enhances mitochondrial targeting.
  • Contains 1 PpiC domain.
Family:
  • Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
genes like me logo Genes that share domains with PIN4: view

Function for PIN4 Gene

Molecular function for PIN4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.
UniProtKB/Swiss-Prot Function:
Isoform 2 binds to double-stranded DNA.

Enzyme Numbers (IUBMB) for PIN4 Gene

Gene Ontology (GO) - Molecular Function for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016853 isomerase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with PIN4: view
genes like me logo Genes that share phenotypes with PIN4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for PIN4

miRNA for PIN4 Gene

miRTarBase miRNAs that target PIN4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PIN4 Gene

Localization for PIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PIN4 Gene

Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.
Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PIN4 Gene COMPARTMENTS Subcellular localization image for PIN4 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PIN4: view

Pathways & Interactions for PIN4 Gene

SuperPathways for PIN4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with PIN4: view

No data available for Pathways by source and SIGNOR curated interactions for PIN4 Gene

Transcripts for PIN4 Gene

Unigene Clusters for PIN4 Gene

Protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PIN4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: - - -
SP2: - -
SP3: - - - -
SP4: -
SP5: -

Relevant External Links for PIN4 Gene

GeneLoc Exon Structure for
PIN4
ECgene alternative splicing isoforms for
PIN4

Expression for PIN4 Gene

mRNA expression in normal human tissues for PIN4 Gene

Protein differential expression in normal tissues from HIPED for PIN4 Gene

This gene is overexpressed in Heart (11.6), Skin (9.7), Peripheral blood mononuclear cells (7.8), and Ovary (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PIN4 Gene



Protein tissue co-expression partners for PIN4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PIN4 Gene:

PIN4

SOURCE GeneReport for Unigene cluster for PIN4 Gene:

Hs.655623

mRNA Expression by UniProt/SwissProt for PIN4 Gene:

Q9Y237-PIN4_HUMAN
Tissue specificity: Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.
genes like me logo Genes that share expression patterns with PIN4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PIN4 Gene

Orthologs for PIN4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PIN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PIN4 34
  • 98.94 (n)
mouse
(Mus musculus)
Mammalia Pin4 34 16 35
  • 94.4 (n)
rat
(Rattus norvegicus)
Mammalia Pin4 34
  • 93.13 (n)
cow
(Bos Taurus)
Mammalia PIN4 34 35
  • 92.11 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 92 (a)
OneToMany
LOC100856504 34
  • 90.84 (n)
-- 35
  • 88 (a)
OneToMany
-- 35
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia PIN4 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PIN4 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves PIN4 34 35
  • 77.27 (n)
lizard
(Anolis carolinensis)
Reptilia PIN4 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pin4 34
  • 78.29 (n)
MGC75904 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.11342 34
zebrafish
(Danio rerio)
Actinopterygii pin4 34 35
  • 74.14 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6696 34
fruit fly
(Drosophila melanogaster)
Insecta CG11858 36 34 35
  • 65.42 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013296 34
  • 65.12 (n)
worm
(Caenorhabditis elegans)
Secernentea pinn-4 35
  • 74 (a)
OneToOne
Y48C3A.16 36 34
  • 71.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 77 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06433 34
  • 58.16 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3715 34
Species where no ortholog for PIN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PIN4 Gene

ENSEMBL:
Gene Tree for PIN4 (if available)
TreeFam:
Gene Tree for PIN4 (if available)

Paralogs for PIN4 Gene

(1) SIMAP similar genes for PIN4 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for PIN4 Gene

genes like me logo Genes that share paralogs with PIN4: view

No data available for Paralogs for PIN4 Gene

Variants for PIN4 Gene

Sequence variations from dbSNP and Humsavar for PIN4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10127269 -- 72,261,899(+) CCTCA(C/T)TCCCA intron-variant
rs1044552 -- 72,197,472(+) GACCC(A/C)CCGGT intron-variant, nc-transcript-variant, reference, synonymous-codon
rs10590020 -- 72,191,552(+) TCTCA(-/AAAAAC)AAAAA intron-variant
rs10603936 -- 72,255,795(+) GCACA(-/ACAG)ACAAA intron-variant
rs111390506 -- 72,220,935(+) GCAAC(C/T)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PIN4 Gene

Variant ID Type Subtype PubMed ID
esv21569 CNV loss 19812545
esv2673799 CNV deletion 23128226
nsv1125445 OTHER inversion 24896259

Variation tolerance for PIN4 Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PIN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PIN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PIN4 Gene

Disorders for PIN4 Gene

Relevant External Links for PIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PIN4

No disorders were found for PIN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PIN4 Gene

Publications for PIN4 Gene

  1. The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. (PMID: 17875217) Kessler D. … Mueller J.W. (BMC Biol. 2007) 2 3 4 64
  2. Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation. (PMID: 16522211) Mueller J.W. … Bayer P. (BMC Mol. Biol. 2006) 2 3 4 64
  3. Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14. (PMID: 12860119) Reimer T. … Fischer G. (J. Mol. Biol. 2003) 3 4 22 64
  4. Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14. (PMID: 11162102) Terada T. … Uchida T. (J. Mol. Biol. 2001) 3 4 22 64
  5. Parvulin (Par14), a peptidyl-prolyl cis-trans isomerase, is a novel rRNA processing factor that evolved in the metazoan lineage. (PMID: 19369196) Fujiyama-Nakamura S. … Takahashi N. (Mol. Cell. Proteomics 2009) 3 4 64

Products for PIN4 Gene

Sources for PIN4 Gene

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